The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Hamed Hamishehkar - One of the best experts on this subject based on the ideXlab platform.
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nano Phytosome a developing platform for herbal anti cancer agents in cancer therapy
Current Drug Targets, 2017Co-Authors: Afshin Babazadeh, Mahdi Zeinali, Hamed HamishehkarAbstract:Background Cancer is one of the main causes of death in the world. It has not yet been cured in an efficient manner and has remained a major challenge for current chemotherapy. Objective This review summarizes the latest investigations regarding the possible application of Phytosome complexes for cancer therapy, their formulation techniques, and mechanism of transportation through Phytosome. Results Nanotechnology opened a pioneer field in cancer therapy by modifying significant properties of drugs and their carriers. Nanotechnology utilizes various nanostructures to transport anti-cancer agents to the site of action. The greater stability of nanoPhytosomes is due to formation of chemical links between phospholipid molecules and phytoactive agents. Among several new drug delivery systems, Phytosomes depict an advanced technology to deliver phytoactive compounds to the target site of action, and at present, several Phytosome formulations are in clinical use. Conclusion Potential anti-cancer properties of phytoconstituents are enhanced by phytosomal formulations.
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nano Phytosome as a potential food grade delivery system
Food bioscience, 2016Co-Authors: Babak Ghanbarzadeh, Afshin Babazadeh, Hamed HamishehkarAbstract:Flavonoids have many nutritional-therapeutic and preservative features. Therefore, the aim of using them for fortifying food products could provide new horizon in developing new functional foods. However, there are several problems associated with the use of these phyto-active constituents in foods and food beverages. Nano-Phytosome is one of the newest lipid based nano-carrier and fast growing attractive way of delivering botanical based nutraceuticals. Although the nano-Phytosome technology has been developed for pharmaceutical applications, it could be potentially used in food products for designing novel functional foods and beverages. The current review represents physicochemical properties and potential applications of nano-Phytosome as a carrier of food bioactive compounds in development of functional foods.
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Phytosome and liposome the beneficial encapsulation systems in drug delivery and food application
Applied Food Biotechnology, 2015Co-Authors: Nayyer Karimi, Hamed Hamishehkar, Babak Ghanbarzadeh, Fatemeh Keivani, Akram Pezeshki, Mohammad Mahdi GholianAbstract:Due to poor solubility in lipids, many of bioactive components (Nutraceutical materials) show less bioactivity than optimal state in water solution. Phytosomes improve absorption and bioavailability of biomaterials. Liposomes, spherical shaped nanocarriers, were discovered in the 1960s by bangham. Due to their composition, variability and structural properties, liposomes and Phytosomes are extremely versatile, leading to a large number of applications including pharmaceutical, cosmetics and food industrial fields. They are advanced forms of herbal formulations containing the bioactive phytoconstituents of herb extracts such as flavonoids, glycosides and terpenoids, which have good ability to transit from a hydrophilic environment into the lipid friendly environment of the outer cell membrane. They have better bioavailability and actions than the conventional herbal extracts containing dosage. Phytosome technology has increasing effect on the bioavailability of herbal extracts including ginkgo biloba, grape seed, green tea, milk thistle, ginseng, etc., and can be developed for various therapeutic uses or dietary supplements. Liposomes are composed of bilayer membranes, which are made of lipid molecules. They form when phospholipids are dispersed in aqueous media and exposed to high shear rates by using micro-fluidization or colloid mill. The mechanism for formation of liposomes is mainly the hydrophilic-hydrophobic interactions between phospholipids and water molecules. Here, we attempt to review the features of Phytosomes and liposomes as well as their preparation methods and capacity in food and drug applications. Generally, it is believed that Phytosomes and liposomes are suitable delivery systems for nutraceuticals, and can be widely used in food industry.
Afshin Babazadeh - One of the best experts on this subject based on the ideXlab platform.
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nano Phytosome a developing platform for herbal anti cancer agents in cancer therapy
Current Drug Targets, 2017Co-Authors: Afshin Babazadeh, Mahdi Zeinali, Hamed HamishehkarAbstract:Background Cancer is one of the main causes of death in the world. It has not yet been cured in an efficient manner and has remained a major challenge for current chemotherapy. Objective This review summarizes the latest investigations regarding the possible application of Phytosome complexes for cancer therapy, their formulation techniques, and mechanism of transportation through Phytosome. Results Nanotechnology opened a pioneer field in cancer therapy by modifying significant properties of drugs and their carriers. Nanotechnology utilizes various nanostructures to transport anti-cancer agents to the site of action. The greater stability of nanoPhytosomes is due to formation of chemical links between phospholipid molecules and phytoactive agents. Among several new drug delivery systems, Phytosomes depict an advanced technology to deliver phytoactive compounds to the target site of action, and at present, several Phytosome formulations are in clinical use. Conclusion Potential anti-cancer properties of phytoconstituents are enhanced by phytosomal formulations.
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nano Phytosome as a potential food grade delivery system
Food bioscience, 2016Co-Authors: Babak Ghanbarzadeh, Afshin Babazadeh, Hamed HamishehkarAbstract:Flavonoids have many nutritional-therapeutic and preservative features. Therefore, the aim of using them for fortifying food products could provide new horizon in developing new functional foods. However, there are several problems associated with the use of these phyto-active constituents in foods and food beverages. Nano-Phytosome is one of the newest lipid based nano-carrier and fast growing attractive way of delivering botanical based nutraceuticals. Although the nano-Phytosome technology has been developed for pharmaceutical applications, it could be potentially used in food products for designing novel functional foods and beverages. The current review represents physicochemical properties and potential applications of nano-Phytosome as a carrier of food bioactive compounds in development of functional foods.
Antonella Riva - One of the best experts on this subject based on the ideXlab platform.
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bergamot Phytosome improved visceral fat and plasma lipid profiles in overweight and obese class i subject with mild hypercholesterolemia a randomized placebo controlled trial
Phytotherapy Research, 2021Co-Authors: Mariangela Rondanelli, Gabriella Peroni, Antonella Riva, Giovanna Petrangolini, Pietro Allegrini, Teresa Fazia, Luisa Bernardinelli, Maurizio Naso, Milena Anna Faliva, Alice TartaraAbstract:Bergamot has been traditionally used for the relief of diseases related to oxidative stress. Our aim was to investigate the effect of bergamot Phytosome on visceral adipose tissue (VAT) and on metabolic profile, in overweight and obese subjects with mild hypercholesterolemia. A total of 64 participants were randomized into two groups for 12 weeks: a supplemented group (33 individuals, BMI 27 ± 3 kg/m2 receiving 500 mg of bergamot Phytosome, two daily tablets) and placebo group (31 subjects, BMI 28 ± 3 kg/m2 , two daily tablets). As to the within differences, the parameters of VAT, total and LDL-cholesterol were significantly decreased in the bergamot Phytosome group, but not in the placebo group. As to between-group differences, a statistically significant interaction between time and group, that is, the change in score over time differs between the two groups was observed 30 days after supplementation for VAT (p-value = .005), total cholesterol (p-value <.0002), and LDL (p = .004) in respect to placebo. The other parameters (glucose, insulin, Homeostasis Model Assessment, high-density lipoprotein cholesterol, triglycerides, fat free mass, fat mass) were not significant. In conclusion, this clinical study gives evidence that bergamot Phytosome provides beneficial effects, such as decrease of VAT and modulation of metabolic alterations, after just 30 days of supplementation, resulting a very promising protection of cardiovascular health.
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in vitro poly phenol catabolism of unformulated and Phytosome formulated cranberry vaccinium macrocarpon extracts
Food Research International, 2021Co-Authors: Letizia Bresciani, Antonella Riva, Giovanna Petrangolini, Pietro Allegrini, Giuseppe Di Pede, Claudia Favari, Luca Calani, Veronica Francinelli, Pedro Mena, Daniele Del RioAbstract:Abstract Cranberries (Vaccinium macrocarpon) represent an important source of anthocyanins, flavan-3-ols and flavonols. This study aimed at investigating in vitro the human microbial metabolism of (poly)phenols, principally flavan-3-ols, of unformulated- and Phytosome-formulated cranberry extracts. After powder characterization, a 24-h fermentation with human faecal slurries was performed, standardizing the concentration of incubated proanthocyanidins. Cranberry (poly)phenol metabolites were quantified by uHPLC-MS2 analyses. The native compounds of both unformulated- and Phytosome-formulated cranberry extracts were metabolized under faecal microbiota activity, resulting in twenty-four microbial metabolites. Although some differences appeared when considering different classes of colonic metabolites, no significant differences in the total amount of metabolites were established after 24 h of incubation period. These results suggested that a different formulation had no effect on flavan-3-ol colonic metabolism of cranberry and both unformulated- and Phytosome-formulated extract. Both formulations displayed the capability to be a potential source of compounds which could lead to a wide array of gut microbiota metabolites in vitro.
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efficient muscle distribution reflects the positive influence of coenzyme q10 Phytosome in healthy aging athletes after stressing exercise
Journal of Food Science and Nutrition Research, 2020Co-Authors: Franchek Drobnic, J Riera, Rafael Artuch, Cristina Jou, A Codina, Raquel Montero, Abraham J Paredesfuentes, Joan Carles Domingo, Montse Banquells, Antonella RivaAbstract:Coenzyme Q10 (CoQ10) is an ubiquitously-distributed molecule with a key role in mitochondrial efficiency, involving protection against peroxidation induced by reactive oxygen species. In athletes during intense training and strenuous exercise, a reactive oxygen species overproduction occurs and can cause muscular stress and damage: a reduction of those undesired effects would be of benefit. CoQ10 antioxidant properties are described in several clinical studies, but efficacy of CoQ10 supplementation in pre-senescent athletes has not yet been clearly demonstrated. A randomized, intervention-controlled, single-center clinical trial was performed in healthy aging (pre-senescent) runners undergoing exercise training in conditions of high environmental stress. One group used an innovative food-grade CoQ10 Phytosome formulation (Ubiqsome) daily for 30 days, while the control group did not take supplementation. Phytosome technique applied to CoQ10 successfully increased CoQ10 bioavailability, as previously demonstrated. CoQ10 levels and oxidative with inflammatory markers were detected in both plasma and muscle. Data obtained highlighted that 500 mg of CoQ10 Phytosome (corresponding to 100 mg CoQ10), administered once a day for 30 days significantly improved CoQ10 bioavailability in healthy volunteer aging runners (50-65 years) by increasing both plasmatic and muscular CoQ10 levels, with a reduction of inflammatory cytokines and Malonyl Dialdehyde levels suggesting a protective effect induced by supplementation. The original CoQ10 Phytosome formulation results to be of benefit in increasing CoQ10 plasmatic and muscular levels when CoQ10 decrease occurred for oxidative stress conditions, aging or high training.
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improved oral absorption of quercetin from quercetin Phytosome a new delivery system based on food grade lecithin
European Journal of Drug Metabolism and Pharmacokinetics, 2019Co-Authors: Antonella Riva, Giovanna Petrangolini, Massimo Ronchi, Stefania Bosisio, Pietro AllegriniAbstract:The importance of quercetin and flavonoids in the diet and as food supplements is well known, and literature studies support their potential use to treat several human diseases. Many beneficial properties have been described for quercetin, so much effort has been directed into overcoming the major drawbacks of this natural compound—its poor solubility and low oral absorption. The aims of this study were to compare a new food-grade lecithin-based formulation of quercetin, Quercetin Phytosome®, to unformulated quercetin in terms of solubility in simulated gastrointestinal fluids and oral absorption in a randomized crossover pharmacokinetic study of healthy volunteers. The solubility of the new formulation was determined by in vitro incubation in simulated gastrointestinal fluids, and quercetin was detected by ultra performance liquid chromatography. A single-dose, randomized, six-sequence/three-period crossover clinical trial (3 × 3 × 3 crossover design) with a balanced carryover effect was conducted in healthy volunteers under fasting conditions. Twelve healthy volunteers of both sexes with an age range of 18–50 years were recruited; one dose of quercetin and two different doses of Quercetin Phytosome were administered orally as film-coated tablets. Pharmacokinetic samples were collected at twelve time points (from 0 h to 24 h) after administration, and quercetin levels were measured by HPLC/MS/MS. Data were analyzed using the Phoenix WinNonlin (v.6.4) software package, and the most significant pharmacokinetic parameters were calculated. Statistical analysis involved performing a two-way ANOVA with repeated measures followed by post hoc analysis (Tukey’s test). Significant improvements in both in vitro solubility and oral absorption (in terms of both exposure and maximum concentration achieved) by healthy volunteers in a human clinical study were obtained with the Quercetin Phytosome formulation as compared to unformulated quercetin. A more soluble formulation of quercetin based on lecithin, Quercetin Phytosome, has recently been developed, and was found to facilitate the attainment of very high plasma levels of quercetin—up to 20 times more than usually obtained following a dose of quercetin—when the novel formulation was administered orally in human volunteers, and it did not have any notable side effects. These results suggest that Quercetin Phytosome allows the oral administration of quercetin in a safe and bioavailable manner, thus facilitating the effective utilization of this natural compound to treat various human diseases.
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quercetin Phytosome in triathlon athletes a pilot registry study
Minerva Medica, 2018Co-Authors: Antonella Riva, Jacopo Antonino Vitale, Gianni Belcaro, Beatrice Feragalli, Giulia Vinciguerra, M Cacchio, Ezio Bonanni, Luca Giacomelli, R Eggenhoffner, Stefano TogniAbstract:BACKGROUND Oxidative stress is associated with delayed recovery and higher risk of post-training pain in triathlon athletes. Therefore, supplementation with antioxidant compounds may have a role in enhancing recovery. Quercetin presents marked antioxidant activity. In this pilot registry study, we evaluated the effects of the supplementation with a novel proprietary delivery form (Phytosome®) of quercetin in amateur triathlon athletes. METHODS We employed a specific study model of triathlon according to the "Sprint" distance. The individual triathlon training included repetition of the run 8 times in 14 days. A group of athletes used quercetin Phytosome® supplementation (one tablet of 250 mg quercetin Phytosome® twice daily). A control group did not use supplementation. All subjects attended a baseline measurement run and a second final measurement run at day 14. At the end of the study, subjective performance, post-training pain, cramps, time to full recovery and oxidative stress were measured. RESULTS In total, 23 subjects used the supplement and 25 did not. No side effects were reported. The improvement of time to complete the run was greater in subjects on quercetin supplementation compared with the control group (-11.3% vs. -3.9%; P<0.05). Training was considered more valuable in the quercetin group compared with controls (P<0.05). Similarly, post-run muscular pain, cramps, localized pain and the post-exercise recovery time were all considered better with the supplementation (P<0.05). Oxidative stress was also reduced (P<0.05). CONCLUSIONS This pilot study suggests that the oral supplementation with quercetin Phytosome® may result in improved training and performance in amateur triathlon athletes.
Roy Ram Kumar - One of the best experts on this subject based on the ideXlab platform.
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Comparative Antihyperlipidemic Activity of Methanolic Extract of Terminalia arjuna Bark and its Phytosome
2015Co-Authors: S Shalini, Roy Ram KumarAbstract:Phytosomes are lipid soluble advanced herbal complexes known to increase the bioavailability of water soluble constituents. Terminali aarjuna is a plant rich in polyphenols. Methanolic extract of bark of Terminalia arjuna is well known for its lipid lowering effects. Phytosomes of methanolic extract ofTerminalia arjuna were prepared.The antihyperlipidemic effect of orally administered methanolic extract of Terminalia arjuna bark and its Phytosomeswas investigated on cholesterol fed albino wistar rats. At the end of the experimental period, the animals were killed and their plasma and tissue lipid components were estimated. Histological studies show that both methanolic extract of Terminalia arjuna bark and Phytosomes of methanolic extract of Terminalia arjuna bark show negligible fatty infiltration and granular degeneration. The studies shows that complex was effective in decreasing the total cholesterol as well as triglycerides and raising high density cholesterol but the activity was low as compared to pure extract probably because of the presence of phospholipids.Thus phytosomal complexes of methanolic extract of Terminaliaarjuna should be prescribed to the patients accordingly.
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antiproliferative effect of Phytosome complex of methanolic extact ofterminalia arjuna bark on human breast cancer cell lines mcf 7
International Journal of Drug Development and Research, 2015Co-Authors: Sharma Shalini, Roy Ram Kumar, Shrivastava BirendraAbstract:Methanolic extract of Terminalia arjuna Roxb of family combretaceae is rich in flavonoids content which are responsible for its antiproliferative activity but these bioactive constituents have poor oral and topical absorption either due to the large molecular weight or poor miscibility with lipids. These poorly soluble herbal extracts can be converted into lipid compatible molecular complexes called Phytosomes by binding individual constituents of the herbal extract to phosphatidylcholine. Phytosomes are known to show improved oral and topical absorption followed by enhanced activity as compared to pure herbal extracts. This study was aimed at preparing methanolic extract of Terminalia arjuna bark and Terminalia arjuna bark Extract Phytosome and investigating their antiproliferative activity on human MCF-7 cell line by MTT assay. Comparison of the antiproliferative activity was done with with quercetin and its Phytosomes. IC50 of methanolic extract of Terminalia arjuna bark and Terminalia arjuna bark Extract Phytosome against cancer cell lines MCF-7 was found to be 25μg/ml and 15μg/ml respectively whereas that of quercetin and its Phytosomes was found to be 2μg/ml and 0.7μg/ml respectively. The results suggests that Terminalia arjuna bark Extract Phytosome & quercetin Phytosomes are active pharmacologically and exerts more antiproliferative effect on MCF-7 cells as compared to pure methanolic extract of plant and pure quercetin respectively.
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Antiproliferative effect of Phytosome complex of Met hanolic extact of Terminalia Arjuna bark on Human Breast Cancer Cell Lines (MCF-7)
Chauhan Publishers, 2015Co-Authors: Sharma Shalini 1, Roy Ram Kumar, Shrivastava BirendraAbstract:Methanolic extract of Terminalia arjuna Roxb of family combretaceae is rich in flavonoids content which are responsible for its antiproliferative activity but these bioactive constituents have poor oral and topical absorption either due to the large molecular weight or poor miscibility with lipids. These poorly soluble herbal extracts can be converted into lipid compatible molecular complexes called Phytosomes by binding individual constituents of the herbal extractto phosphatidylcholine. Phytosomes are known to show improved oral and topical absorption followed by enhanced activity as compared to pure herbal extracts. This study was aimed at preparing methanolic extract of Terminalia arjuna bark and Terminalia arjuna bark Extract Phytosome and investigating their antiproliferative activity on human MCF-7 cell line by MTT assay. Comparison of the antiproliferative activity was done with with quercetin and its Phytosomes. IC50of methanolic extract of Terminalia arjuna bark and Terminalia arjuna bark Extract Phytosome against cancer cell lines MCF-7 was found to be 25μg/ml and 15μg/ml respectively whereas that of quercetin and its Phytosomes was found to be 2μg/ml and 0.7μg/ml respectively. The results suggests that Terminalia arjuna bark Extract Phytosome & quercetin Phytosomes are active pharmacologically and exerts more antiproliferative effect on MCF-7 cells as compared to pure methanolic extract of plant and pure quercetin respectively
Shrivastava Birendra - One of the best experts on this subject based on the ideXlab platform.
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antiproliferative effect of Phytosome complex of methanolic extact ofterminalia arjuna bark on human breast cancer cell lines mcf 7
International Journal of Drug Development and Research, 2015Co-Authors: Sharma Shalini, Roy Ram Kumar, Shrivastava BirendraAbstract:Methanolic extract of Terminalia arjuna Roxb of family combretaceae is rich in flavonoids content which are responsible for its antiproliferative activity but these bioactive constituents have poor oral and topical absorption either due to the large molecular weight or poor miscibility with lipids. These poorly soluble herbal extracts can be converted into lipid compatible molecular complexes called Phytosomes by binding individual constituents of the herbal extract to phosphatidylcholine. Phytosomes are known to show improved oral and topical absorption followed by enhanced activity as compared to pure herbal extracts. This study was aimed at preparing methanolic extract of Terminalia arjuna bark and Terminalia arjuna bark Extract Phytosome and investigating their antiproliferative activity on human MCF-7 cell line by MTT assay. Comparison of the antiproliferative activity was done with with quercetin and its Phytosomes. IC50 of methanolic extract of Terminalia arjuna bark and Terminalia arjuna bark Extract Phytosome against cancer cell lines MCF-7 was found to be 25μg/ml and 15μg/ml respectively whereas that of quercetin and its Phytosomes was found to be 2μg/ml and 0.7μg/ml respectively. The results suggests that Terminalia arjuna bark Extract Phytosome & quercetin Phytosomes are active pharmacologically and exerts more antiproliferative effect on MCF-7 cells as compared to pure methanolic extract of plant and pure quercetin respectively.
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Antiproliferative effect of Phytosome complex of Met hanolic extact of Terminalia Arjuna bark on Human Breast Cancer Cell Lines (MCF-7)
Chauhan Publishers, 2015Co-Authors: Sharma Shalini 1, Roy Ram Kumar, Shrivastava BirendraAbstract:Methanolic extract of Terminalia arjuna Roxb of family combretaceae is rich in flavonoids content which are responsible for its antiproliferative activity but these bioactive constituents have poor oral and topical absorption either due to the large molecular weight or poor miscibility with lipids. These poorly soluble herbal extracts can be converted into lipid compatible molecular complexes called Phytosomes by binding individual constituents of the herbal extractto phosphatidylcholine. Phytosomes are known to show improved oral and topical absorption followed by enhanced activity as compared to pure herbal extracts. This study was aimed at preparing methanolic extract of Terminalia arjuna bark and Terminalia arjuna bark Extract Phytosome and investigating their antiproliferative activity on human MCF-7 cell line by MTT assay. Comparison of the antiproliferative activity was done with with quercetin and its Phytosomes. IC50of methanolic extract of Terminalia arjuna bark and Terminalia arjuna bark Extract Phytosome against cancer cell lines MCF-7 was found to be 25μg/ml and 15μg/ml respectively whereas that of quercetin and its Phytosomes was found to be 2μg/ml and 0.7μg/ml respectively. The results suggests that Terminalia arjuna bark Extract Phytosome & quercetin Phytosomes are active pharmacologically and exerts more antiproliferative effect on MCF-7 cells as compared to pure methanolic extract of plant and pure quercetin respectively