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Sohsuke Yamada - One of the best experts on this subject based on the ideXlab platform.

  • cytopathological findings of proliferating Pilomatricoma misdiagnosed as a malignant parotid gland tumor
    Diagnostic Pathology, 2018
    Co-Authors: Nozomu Kurose, Manabu Yamashita, Mariko Nakano, Xin Guo, Akihiro Shioya, Satoko Nakada, Hiroshi Minato, Sohsuke Yamada
    Abstract:

    Pilomatricoma is a relatively common benign cutaneous adnexal neoplasm with differentiation towards the hair matrix, inner sheath of hair follicle and hair cortex. Proliferating Pilomatricoma is a rare variant of Pilomatricoma that can rapidly increase and may be misidentified as a malignant tumor. We herein report the cytopathological findings of proliferating Pilomatricoma misdiagnosed as a malignant parotid tumor. A 64-year-old man noticed an acne-like nodule in the left parotid region. It was painless, but it increased to a maximum diameter of 4.5 cm over 2 years. Clinically, left parotid gland carcinoma was suspected, and fine-needle aspiration cytology was performed. Clusters of epithelial cells were observed in a necrotic background, and malignant epithelial cells derived from salivary glands were suspected. Histologically, the resected tumor was diagnosed as proliferating Pilomatricoma composed of basophilic cells and shadow cells apart from the parotid gland. However, on a re-evaluation of the cytological specimens, the irregular-shaped epithelial cells were considered to be from basophilic cells. Shadow cells with nuclear disappearance were also confirmed. Tumor recurrence and metastasis have not been observed in the four years since surgery. The present case was first interpreted as a malignant parotid gland tumor, but it was actually a benign skin appendage tumor. Pilomatricoma sometimes rapidly increases and may be mistaken for a malignant tumor. Although it is critical to recognize not only basophilic cells but also shadow cells, it cannot be diagnosed by cytological findings. The final diagnosis should be made on excision specimen only.

  • Cytopathological findings of proliferating Pilomatricoma misdiagnosed as a malignant parotid gland tumor
    BMC, 2018
    Co-Authors: Nozomu Kurose, Manabu Yamashita, Mariko Nakano, Xin Guo, Akihiro Shioya, Satoko Nakada, Hiroshi Minato, Sohsuke Yamada
    Abstract:

    Abstract Background Pilomatricoma is a relatively common benign cutaneous adnexal neoplasm with differentiation towards the hair matrix, inner sheath of hair follicle and hair cortex. Proliferating Pilomatricoma is a rare variant of Pilomatricoma that can rapidly increase and may be misidentified as a malignant tumor. We herein report the cytopathological findings of proliferating Pilomatricoma misdiagnosed as a malignant parotid tumor. Case presentation A 64-year-old man noticed an acne-like nodule in the left parotid region. It was painless, but it increased to a maximum diameter of 4.5 cm over 2 years. Clinically, left parotid gland carcinoma was suspected, and fine-needle aspiration cytology was performed. Clusters of epithelial cells were observed in a necrotic background, and malignant epithelial cells derived from salivary glands were suspected. Histologically, the resected tumor was diagnosed as proliferating Pilomatricoma composed of basophilic cells and shadow cells apart from the parotid gland. However, on a re-evaluation of the cytological specimens, the irregular-shaped epithelial cells were considered to be from basophilic cells. Shadow cells with nuclear disappearance were also confirmed. Tumor recurrence and metastasis have not been observed in the four years since surgery. Conclusion The present case was first interpreted as a malignant parotid gland tumor, but it was actually a benign skin appendage tumor. Pilomatricoma sometimes rapidly increases and may be mistaken for a malignant tumor. Although it is critical to recognize not only basophilic cells but also shadow cells, it cannot be diagnosed by cytological findings. The final diagnosis should be made on excision specimen only

Aravind Ravi S Kumar - One of the best experts on this subject based on the ideXlab platform.

  • fdg pet ct appearance of benign Pilomatricoma
    Clinical Nuclear Medicine, 2012
    Co-Authors: Manoj Bhatt, Ryan Sommerville, Aravind Ravi S Kumar
    Abstract:

    A 56-year-old patient was referred for FDG PET/CT with a right preauricular lymph node fine-needle biopsy, suggesting poorly differentiated carcinoma and no obvious primary lesion. There was intense FDG uptake in the right preauricular nodule. The node was excised, and formal histology demonstrated a benign Pilomatricoma rather than malignancy. Pilomatricoma is uncommon in adults and an unusual cause for marked FDG uptake, likely due to foreign body inflammation. Pilomatricoma can be either benign or malignant. The marked FDG uptake demonstrated in our patient with benign Pilomatricoma also suggests that FDG PET cannot reliably grade this rare condition.

Sung Hs - One of the best experts on this subject based on the ideXlab platform.

  • beta-Catenin expression in the transitional cell zone of Pilomatricoma.
    British Journal of Dermatology, 2001
    Co-Authors: Park Sw, Kim St, Wang Hy, Sung Hs
    Abstract:

    BACKGROUND: beta-Catenin, a participant in the Wnt pathway, has been shown to play an important role in the morphogenesis of hair follicles and the formation of hair follicle-related tumours, including Pilomatricomas. It has been observed that at least 75% of human Pilomatricomas possess activating mutations in beta-catenin. These findings suggested that beta-catenin plays an important role in the tumorigenesis of Pilomatricomas. However, the pattern of beta-catenin expression in Pilomatricoma tissues is still unclear. Objectives To examine the expression of beta-catenin in human Pilomatricomas by immunohistochemical staining. METHODS: Twenty-six formalin-fixed and paraffin-embedded samples of Pilomatricoma tissue were studied. RESULTS: Most transitional cells of Pilomatricoma expressed beta-catenin strongly, but the basophilic cells and shadow cells did not. beta-Catenin showed a prominent membranous immunoreactivity and a small amount of condensed cytoplasmic staining, but there was definitely no evidence of nuclear positivity. CONCLUSIONS: These findings imply that beta-catenin is primarily involved in cell-cell adhesion rather than cellular proliferation during Pilomatricoma pathogenesis, and suggest that if beta-catenin is involved in Pilomatricoma tumorigenesis and tumour growth, it plays an indirect role.

Sivaselvam Sivakumar - One of the best experts on this subject based on the ideXlab platform.

  • pilomatrixoma as a diagnostic pitfall in fine needle aspiration cytology a case report
    Acta Cytologica, 2007
    Co-Authors: Sivaselvam Sivakumar
    Abstract:

    Background Pilomatrixoma (pilomatrixoma, calcifying epithelioma of Malherbe) is a relatively uncommon, benign neoplasm arising from the skin adnexa. The tumor can cause diagnostic difficulty not only for the clinician but also for the cytologist. Case A 62-year-old woman presented with a right submandibular swelling of 4 months' duration. The clinical findings were highly suspicious for malignancy. A fine needle aspiration biopsy was performed. Three preliminary differential diagnoses were offered: mucoepidermoid carcinoma of the submandibular salivary gland, squamous cell carcinomatous deposit in a submandibular lymph node and calcifying odontogenic tumor. Computed tomography demonstrated no bony lesion. No primary site of squamous cell carcinoma could be identified. An excisional biopsy of the swelling was performed, and the histologic diagnosis of pilomatrixoma was made. Conclusion The cytologic presentation of pilomatrixoma of the right submandibular region can masquerade as that of a malignant tumor, in this case mucoepidermoid carcinoma, squamous cell carcinoma or odontogenic tumor. This case delineates the cytomorphologic features of pilomatrixoma that may mimic carcinoma.

Nozomu Kurose - One of the best experts on this subject based on the ideXlab platform.

  • cytopathological findings of proliferating Pilomatricoma misdiagnosed as a malignant parotid gland tumor
    Diagnostic Pathology, 2018
    Co-Authors: Nozomu Kurose, Manabu Yamashita, Mariko Nakano, Xin Guo, Akihiro Shioya, Satoko Nakada, Hiroshi Minato, Sohsuke Yamada
    Abstract:

    Pilomatricoma is a relatively common benign cutaneous adnexal neoplasm with differentiation towards the hair matrix, inner sheath of hair follicle and hair cortex. Proliferating Pilomatricoma is a rare variant of Pilomatricoma that can rapidly increase and may be misidentified as a malignant tumor. We herein report the cytopathological findings of proliferating Pilomatricoma misdiagnosed as a malignant parotid tumor. A 64-year-old man noticed an acne-like nodule in the left parotid region. It was painless, but it increased to a maximum diameter of 4.5 cm over 2 years. Clinically, left parotid gland carcinoma was suspected, and fine-needle aspiration cytology was performed. Clusters of epithelial cells were observed in a necrotic background, and malignant epithelial cells derived from salivary glands were suspected. Histologically, the resected tumor was diagnosed as proliferating Pilomatricoma composed of basophilic cells and shadow cells apart from the parotid gland. However, on a re-evaluation of the cytological specimens, the irregular-shaped epithelial cells were considered to be from basophilic cells. Shadow cells with nuclear disappearance were also confirmed. Tumor recurrence and metastasis have not been observed in the four years since surgery. The present case was first interpreted as a malignant parotid gland tumor, but it was actually a benign skin appendage tumor. Pilomatricoma sometimes rapidly increases and may be mistaken for a malignant tumor. Although it is critical to recognize not only basophilic cells but also shadow cells, it cannot be diagnosed by cytological findings. The final diagnosis should be made on excision specimen only.

  • Cytopathological findings of proliferating Pilomatricoma misdiagnosed as a malignant parotid gland tumor
    BMC, 2018
    Co-Authors: Nozomu Kurose, Manabu Yamashita, Mariko Nakano, Xin Guo, Akihiro Shioya, Satoko Nakada, Hiroshi Minato, Sohsuke Yamada
    Abstract:

    Abstract Background Pilomatricoma is a relatively common benign cutaneous adnexal neoplasm with differentiation towards the hair matrix, inner sheath of hair follicle and hair cortex. Proliferating Pilomatricoma is a rare variant of Pilomatricoma that can rapidly increase and may be misidentified as a malignant tumor. We herein report the cytopathological findings of proliferating Pilomatricoma misdiagnosed as a malignant parotid tumor. Case presentation A 64-year-old man noticed an acne-like nodule in the left parotid region. It was painless, but it increased to a maximum diameter of 4.5 cm over 2 years. Clinically, left parotid gland carcinoma was suspected, and fine-needle aspiration cytology was performed. Clusters of epithelial cells were observed in a necrotic background, and malignant epithelial cells derived from salivary glands were suspected. Histologically, the resected tumor was diagnosed as proliferating Pilomatricoma composed of basophilic cells and shadow cells apart from the parotid gland. However, on a re-evaluation of the cytological specimens, the irregular-shaped epithelial cells were considered to be from basophilic cells. Shadow cells with nuclear disappearance were also confirmed. Tumor recurrence and metastasis have not been observed in the four years since surgery. Conclusion The present case was first interpreted as a malignant parotid gland tumor, but it was actually a benign skin appendage tumor. Pilomatricoma sometimes rapidly increases and may be mistaken for a malignant tumor. Although it is critical to recognize not only basophilic cells but also shadow cells, it cannot be diagnosed by cytological findings. The final diagnosis should be made on excision specimen only