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Roberto Lorens Marback - One of the best experts on this subject based on the ideXlab platform.
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estudo clinico patologico do Pilomatrixoma palpebral experiencia no hospital universitario prof edgard santos
Arquivos Brasileiros De Oftalmologia, 2007Co-Authors: Eduardo Ferrari Marback, Camila Correa Cardoso, Livia Maria Nossa Moitinho, Roberto Lorens MarbackAbstract:PURPOSE: To report the experience with eyelid Pilomatrixoma during 30 years in a university hospital. METHODS: A review of the Ophthalmic Pathology Laboratory at the "Hospital Universitario Prof. Edgard Santos", was conducted to identify eyelid tumor cases from 1974 to 2004. After identification of Pilomatrixoma cases, a chart review retrieved data regarding gender, age, duration of symptoms, gross aspect, anatomic localization and clinical diagnosis. The hematoxilin and eosin stained sections were reviewed. RESULTS: Of a total of 621 eyelid tumors, four (0.64%) were Pilomatrixomas. Three patients were male. The mean age at diagnosis was 25 years (from 8 to 54). Mean duration of symptoms was 5 months (from 2 to 12). In three cases the lesion was located in the inferior lid. Only one patient had a correct clinical diagnosis. Two cases exhibited a pseudo-capsule on histology. The case with 12 months of history was composed mainly of shadow cells. Foreign body reaction was seen in all cases, calcification in only one. CONCLUSION: This is a very rare benign tumor of young patients. Due to its rarity and variable clinical presentation, clinical misdiagnosis is common.
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Estudo clínico-patológico do Pilomatrixoma palpebral: experiência no hospital universitário Prof. Edgard Santos Clinicopathologic study of eyelid Pilomatrixoma: the experience of the "Hospital Universitário Prof. Edgard Santos"
Conselho Brasileiro de Oftalmologia, 2007Co-Authors: Eduardo Ferrari Marback, Livia Maria Nossa Moitinho, Camila Cardoso, Roberto Lorens MarbackAbstract:OBJETIVO: Relatar a experiência com Pilomatrixoma palpebral no Hospital Universitário Profº. Edgard Santos, em período de 30 anos. MÉTODOS: Revisão no Registro do Laboratório de Patologia Ocular, de todos os casos de tumores palpebrais no período de 1974 a 2004. Após a identificação dos casos de Pilomatrixoma, foram coletados dados referentes a gênero, idade, tempo de sintomatologia, aspecto, localização e suspeita diagnóstica inicial. As lâminas coradas pela hematoxilina e eosina foram revisadas. RESULTADOS: Dentre os 621 casos de tumores palpebrais, quatro eram de Pilomatrixoma (0,64%). Três pacientes eram do sexo masculino. A idade média foi de 25 anos, variando de 8 a 54. O tempo de sintomatologia médio foi de cinco meses, variando de 2 a 12. Em três casos a lesão localizava-se na pálpebra inferior. Em apenas um caso o diagnóstico clínico foi correto. Ao exame anatomopatológico, dois casos apresentavam pseudocápsula. O caso cuja sintomatologia foi mais prolongada exibia predominância de células do tipo fantasma. Reação tipo corpo estranho foi vista em todos os casos, calcificação em apenas um. CONCLUSÕES: Trata-se de tumor benigno bastante raro, acometendo principalmente jovens. Devido a sua raridade e pleomorfismo à apresentação, dificilmente o diagnóstico clínico é correto.PURPOSE: To report the experience with eyelid Pilomatrixoma during 30 years in a university hospital. METHODS: A review of the Ophthalmic Pathology Laboratory at the "Hospital Universitario Prof. Edgard Santos", was conducted to identify eyelid tumor cases from 1974 to 2004. After identification of Pilomatrixoma cases, a chart review retrieved data regarding gender, age, duration of symptoms, gross aspect, anatomic localization and clinical diagnosis. The hematoxilin and eosin stained sections were reviewed. RESULTS: Of a total of 621 eyelid tumors, four (0.64%) were Pilomatrixomas. Three patients were male. The mean age at diagnosis was 25 years (from 8 to 54). Mean duration of symptoms was 5 months (from 2 to 12). In three cases the lesion was located in the inferior lid. Only one patient had a correct clinical diagnosis. Two cases exhibited a pseudo-capsule on histology. The case with 12 months of history was composed mainly of shadow cells. Foreign body reaction was seen in all cases, calcification in only one. CONCLUSION: This is a very rare benign tumor of young patients. Due to its rarity and variable clinical presentation, clinical misdiagnosis is common
Oslei Paes De Almeida - One of the best experts on this subject based on the ideXlab platform.
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ghost cells in Pilomatrixoma craniopharyngioma and calcifying cystic odontogenic tumor histological immunohistochemical and ultrastructural study
Journal of Oral Pathology & Medicine, 2015Co-Authors: Alicia Rumayor, Roman Carlos, Hernan Molina Kirsch, Bruno Augusto Benevenuto De Andrade, Mario Jose Romanach, Oslei Paes De AlmeidaAbstract:Background Pilomatrixoma, craniopharyngioma, and calcifying cystic odontogenic tumor are the main entities presenting ghost cells as an important histological feature, in spite their quite different clinical presentation; it seems that they share a common pathway in the formation of these cells. The aim of this study is to examine and compare the characteristics of ghost and other cells that form these lesions. Methods Forty-three cases including 21 Pilomatrixomas, 14 craniopharyngiomas, and eight calcifying cystic odontogenic tumors were evaluated by immunohistochemistry for cytokeratins, CD138, β-catenin, D2-40, Glut-1, FAS, CD10 and also by scanning electron microscopy. Results The CKs, CD138, β-catenin, Glut-1, FAS, and CD10 were more often expressed by transitional cells of craniopharyngioma and calcifying cystic odontogenic tumor, compared with Pilomatrixoma. Basaloid cells of Pilomatrixoma showed strong positivity for CD138 and CD10. Differences on expression pattern were identified in transitional and basal cells, as ghost cells were negative for most antibodies used, except by low expression for cytokeratins. By scanning electron microscopy, the morphology of ghost cells were similar in their fibrillar cytoplasm, but their pattern varied from sheets in Pilomatrixoma to small clusters in craniopharyngioma and calcifying cystic odontogenic tumor. Conclusions Mechanisms involved in formation of ghost cells are unknown, but probably they follow different pathways as protein expression in the basal/transitional cells was not uniform in the three tumors studied.
S. Bhuta - One of the best experts on this subject based on the ideXlab platform.
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Metastatic malignant Pilomatrixoma: a case report and review of the literature
Pathology, 2009Co-Authors: R. Bhuta, G. Wright, Q. Lau, S. BhutaAbstract:Pilomatrixoma is a common benign adnexal tumour with differentiation towards matrix of the hair follicle. It is typically located in the head and neck region. The tumour is well circumscribed, lobular, cystic and composed of three major cell types: proliferating basaloid cells, eosinophilic squamous cells and shadow cells which represent dead cells. We report a rare case of malignant Pilomatrixoma of the posterior occipital region in a 43-year-old female with metastases to C2 vertebra. The case was originally reported as proliferating Pilomatrixoma. Bones of the head and neck region are a common site for metastases in malignant Pilomatrixoma. Malignant Pilomatrixoma is extremely rare. There are 90 cases regarded as acceptable reported in the English literature and ninety cases of metastasis. Because of its rarity, the precise incidence and prevalence of malignant Pilomatrixoma are unknown. The diagnosis of malignancy is based on histological criteria which are not well defined and somewhat subjective. This includes cytological atypia, high mitotic activity with atypical mitosis, areas of confluent tumour necrosis, infiltrative growth pattern and vascular, lymphatic or perineural invasion.
Sudhanya Biswas - One of the best experts on this subject based on the ideXlab platform.
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cytodiagnosis of Pilomatrixoma from an uncommon site with unusual presentation
International Journal of Trichology, 2012Co-Authors: Jyoti Prakash Phukan, Anuradha Sinha, Sudhanya BiswasAbstract:Pilomatrixoma or pilomatricoma is an uncommon benign tumor of hair matrix origin, which most commonly occurs in the head and neck region and upper extremities. In this study, we report a case of Pilomatrixoma of a 35-year-old female presenting with left-leg swelling with surface ulceration, clinically thought to be malignant. Fine-needle aspiration cytology (FNAC) of the lesion showed clusters of basaloid cells with round to ovoid nuclei, nucleated squamous cells, and anucleated squames and clusters of shadow cells. Acytological diagnosis of Pilomatrixoma was made. Subsequent surgical excision and histopathological examination confirmed the diagnosis. This case highlights a rare site of presentation and the role of FNAC in preoperative diagnosis of this benign tumor for proper management.
Eduardo Ferrari Marback - One of the best experts on this subject based on the ideXlab platform.
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estudo clinico patologico do Pilomatrixoma palpebral experiencia no hospital universitario prof edgard santos
Arquivos Brasileiros De Oftalmologia, 2007Co-Authors: Eduardo Ferrari Marback, Camila Correa Cardoso, Livia Maria Nossa Moitinho, Roberto Lorens MarbackAbstract:PURPOSE: To report the experience with eyelid Pilomatrixoma during 30 years in a university hospital. METHODS: A review of the Ophthalmic Pathology Laboratory at the "Hospital Universitario Prof. Edgard Santos", was conducted to identify eyelid tumor cases from 1974 to 2004. After identification of Pilomatrixoma cases, a chart review retrieved data regarding gender, age, duration of symptoms, gross aspect, anatomic localization and clinical diagnosis. The hematoxilin and eosin stained sections were reviewed. RESULTS: Of a total of 621 eyelid tumors, four (0.64%) were Pilomatrixomas. Three patients were male. The mean age at diagnosis was 25 years (from 8 to 54). Mean duration of symptoms was 5 months (from 2 to 12). In three cases the lesion was located in the inferior lid. Only one patient had a correct clinical diagnosis. Two cases exhibited a pseudo-capsule on histology. The case with 12 months of history was composed mainly of shadow cells. Foreign body reaction was seen in all cases, calcification in only one. CONCLUSION: This is a very rare benign tumor of young patients. Due to its rarity and variable clinical presentation, clinical misdiagnosis is common.
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Estudo clínico-patológico do Pilomatrixoma palpebral: experiência no hospital universitário Prof. Edgard Santos Clinicopathologic study of eyelid Pilomatrixoma: the experience of the "Hospital Universitário Prof. Edgard Santos"
Conselho Brasileiro de Oftalmologia, 2007Co-Authors: Eduardo Ferrari Marback, Livia Maria Nossa Moitinho, Camila Cardoso, Roberto Lorens MarbackAbstract:OBJETIVO: Relatar a experiência com Pilomatrixoma palpebral no Hospital Universitário Profº. Edgard Santos, em período de 30 anos. MÉTODOS: Revisão no Registro do Laboratório de Patologia Ocular, de todos os casos de tumores palpebrais no período de 1974 a 2004. Após a identificação dos casos de Pilomatrixoma, foram coletados dados referentes a gênero, idade, tempo de sintomatologia, aspecto, localização e suspeita diagnóstica inicial. As lâminas coradas pela hematoxilina e eosina foram revisadas. RESULTADOS: Dentre os 621 casos de tumores palpebrais, quatro eram de Pilomatrixoma (0,64%). Três pacientes eram do sexo masculino. A idade média foi de 25 anos, variando de 8 a 54. O tempo de sintomatologia médio foi de cinco meses, variando de 2 a 12. Em três casos a lesão localizava-se na pálpebra inferior. Em apenas um caso o diagnóstico clínico foi correto. Ao exame anatomopatológico, dois casos apresentavam pseudocápsula. O caso cuja sintomatologia foi mais prolongada exibia predominância de células do tipo fantasma. Reação tipo corpo estranho foi vista em todos os casos, calcificação em apenas um. CONCLUSÕES: Trata-se de tumor benigno bastante raro, acometendo principalmente jovens. Devido a sua raridade e pleomorfismo à apresentação, dificilmente o diagnóstico clínico é correto.PURPOSE: To report the experience with eyelid Pilomatrixoma during 30 years in a university hospital. METHODS: A review of the Ophthalmic Pathology Laboratory at the "Hospital Universitario Prof. Edgard Santos", was conducted to identify eyelid tumor cases from 1974 to 2004. After identification of Pilomatrixoma cases, a chart review retrieved data regarding gender, age, duration of symptoms, gross aspect, anatomic localization and clinical diagnosis. The hematoxilin and eosin stained sections were reviewed. RESULTS: Of a total of 621 eyelid tumors, four (0.64%) were Pilomatrixomas. Three patients were male. The mean age at diagnosis was 25 years (from 8 to 54). Mean duration of symptoms was 5 months (from 2 to 12). In three cases the lesion was located in the inferior lid. Only one patient had a correct clinical diagnosis. Two cases exhibited a pseudo-capsule on histology. The case with 12 months of history was composed mainly of shadow cells. Foreign body reaction was seen in all cases, calcification in only one. CONCLUSION: This is a very rare benign tumor of young patients. Due to its rarity and variable clinical presentation, clinical misdiagnosis is common