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S Ghasi - One of the best experts on this subject based on the ideXlab platform.

  • cardioprotective effects of animal grade Piperazine Citrate on isoproterenol induced myocardial infarction in wistar rats biochemical and histopathological evaluation
    African Journal of Pharmacy and Pharmacology, 2020
    Co-Authors: S Ghasi, I K Umana, A O Ogbonna, M O Nwokike, Silas A Ufelle
    Abstract:

    The present study was designed to investigate the cardioprotective effect of animal grade Piperazine Citrate on isoproterenol-induced myocardial infarction in rats by studying cardiac marker enzymes and histopathological changes of the cardiac muscle. Isoproterenol administration showed significant (P<0.001) increase in the serum levels of cardiac injury markers (creatine kinase-MB and troponin-I), 358.98 ± 7.68 iu/l and 13.16 ± 0.35 ng/ml compared to the normal control group of 291.58 ± 3.56 iu/l and 9.66 ± 0.20 ng/ml respectively. Pretreatment with 15 and 30 mg/kg body weight of Piperazine Citrate showed a decrease in the troponin-I levels when compared with the isoproterenol group; 13.16 ± 0.35 to 12.39 ± 0.22 ng/ml in the group that received 15 mg/kg Piperazine Citrate (p = 0.0881) and 13.16 ± 0.35 to 11.79 ± 0.30 ng/ml (p = 0.0132) in case of the group pretreated with 30 mg/kg Piperazine Citrate. With regards to CK-MB, the treated groups with Piperazine Citrate 15 and 30 mg/kg body weight showed a reduction in the values, 340.76 ± 5.10 (p = 0.0763) and 344.17 ± 8.24 iu/l (p = 0.2178) respectively, compared to the isoproterenol group value of 358.98 ± 7.68 iu/l. Histopathological investigation showed that there was no significant architectural changes in the normal control group that received only normal saline. Structural aberrations caused by isoproterenol were also significantly reduced in the Piperazine Citrate treated groups. Therefore, the results of the present study suggest that low dose Piperazine Citrate has a significant effect on the protection of the heart. Key words: Piperazine Citrate, myocardial infarction, histopathology, Wistar rat.

  • impact of subchronic administration of Piperazine Citrate on the electrocardiogram of the rat
    American Journal of Therapeutics, 2012
    Co-Authors: S Ghasi, Anthony Ogbonna, Anthony Mbah
    Abstract:

    The effect of Piperazine Citrate on the electrocardiogram of the rat after treatment with PiperazineCitrate at 30, 60, and 100 mg/kg body weight for 16 weeks was investigated. The results werecompared with a control group. There was prolongation of P-R, Q-Tc, and J-T intervals, whereas theQRS interval remained virtually unchanged. The heart rate, on the other hand, decreased in thegroups that received Piperazine Citrate. The average heart rate in the control group was 334 6 17.20beats/min. In the group of rats that received the three doses of Piperazine, the average heart rate atthe end of a 15-minute observation period was 308 6 3.74 beats/min, 302 6 16.55 beats/min, and312 6 13.93 beats/min, respectively, and none of the values was statistically significant comparedwith the control. The P-R interval showed statistically significant increases in the groups treated withthe three doses of Piperazine over the control group. In both the 30- and 60-mg/kg groups, theaverage P-R interval was 92.0 6 0.5, which was statistically significant when compared with thecontrol average of 80.0 6 0.00 (P = 0.0427). For the 100-mg/kg group, the average P-R interval was96.0 6 0.4 ms. The difference between this value and the control average was equally statisticallysignificant (P = 0.0043). Both the Q-Tc and J-T intervals also showed statistically significant increasesin the Piperazine-treated groups and the P values compared with the control group were verysimilar. Even at the very high dose of 100 mg/kg given two times daily for 16 weeks, PiperazineCitrate appeared quite safe to the rat heart because it did not provoke any cardiac dysrhythmicphenomenon on the surface electrocardiogram.Keywords: Piperazine Citrate, subchronic treatment, electrocardiogram, rat

  • pharmacodynamic effect of Piperazine Citrate on the blood pressure of anaesthetized cat
    African Journal of Pharmacy and Pharmacology, 2009
    Co-Authors: S Ghasi, C P Chijioke, Raphael Anakwue
    Abstract:

    Piperazine Citrate produced a dose-dependent decrease in the blood pressure of the anaesthetized cat. Both 15 mg and 30 mg/kg Piperazine showed average significant reduction in blood pressure of 29.8 ± 1.65 and 78.3 ± 3.18 mm Hg respectively. The effect produced in each case was transient and returned to baseline value within 2 min. The reduction in blood pressure caused by Piperazine 30 mg/kg was statistically significant compared to the average due to Piperazine 15 mg/kg (P < 0.0001). The maximum falls over the baseline blood pressure were also determined to be 34 and 82 mm Hg respectively. Adrenaline 5 mg increased the blood pressure of the cat by 68 mmHg and this effect was antagonized by equipotent doses of Piperazine, nifedipine and propranolol to varying degrees. The antagonism produced by equipotent doses of Piperazine (15 mg/kg) or nifedipine (200 mg/kg) to blood pressure elevation by adrenaline was quite small (8.8%), compared to propranolol (10mg) which antagonized the vasopressive action by as much as 26.5% (68 - 50 mmHg). Piperazine although severely reducing the blood pressure when given intravenously to the anaesthetized cat as shown in this study, may not be an effective antihypertensive agent as its hypotensive effect is always very transient. This would rather be seen as an untoward effect and in any event that may demand that Piperazine be given intravenously, the patients should be warned of hypotension and dizziness as possible adverse effects.   Key words: Piperazine Citrate, anaesthetized cat, blood pressure.

  • interventional role of Piperazine Citrate in barium chloride induced ventricular arrhythmias in anaesthetized rats
    Biomedical Research-tokyo, 2009
    Co-Authors: S Ghasi, A O Ogbonna, Anthony Mbah, E Nwobodo, G. Onuaguluchi
    Abstract:

    Interventional potential of Piperazine in Barium Chloride (BC) -induced ventricular arrhythmias was investigated in the rats. Various forms of arrhythmias were induced in 10 rats and Piperazine (30mg/kg) was given in each case to reverse arrhythmia to sinus rhythm. Five out of six cases of induced ventricular tachycardia (83.3%) were reverted to sinus rhythm by Piperazine. Again, 33% success was seen when ventricular fibrillation was induced. One of the three cases was reverted to the sinus rhythm as was also the only case of pulsus bigeminus observed. Piperazine, therefore, has the potential of a good anti-arrhythmic agent. Piperazine was shown to be a more effective antiarrhythmic agent than propranolol against BCinduced ventricular fibrillation. Propranolol not only failed to revert any of the ventricular fibrillations to sinus rhythm, but in two of four cases was not able to reverse the induced ventricular tachycardia. Although Piperazine failed to control ventricular fibrillation with the same degree of effectiveness, Piperazine has a remarkable therapeutic value in the management of ventricular tachycardia.

  • Piperazine protects the rat heart against sudden cardiac death from barium chloride induced ventricular fibrillation
    American Journal of Therapeutics, 2008
    Co-Authors: S Ghasi
    Abstract:

    Fifteen of 20 Wistar albino rats were treated with various doses of the anthelmintic agent Piperazine Citrate (15, 30, and 60 mg/kg body weight). All 20 rats were subsequently given barium chloride, 20 mg/kg. The 5 rats (25%) that did not receive Piperazine Citrate developed ventricular fibrillations after barium chloride was administered to them, via one of the external jugular veins, and died shortly thereafter. The remaining 75% of the rats were fully protected by all the doses of Piperazine Citrate employed for the study. Barium chloride did not produce any dysrhythmic phenomenon in the Piperazine-protected rats. Conversely, sinus rhythm was maintained in the electrocardiogram of all the rats, with every P wave followed by a normal QRS-T complex. This may portend a novel application for an old drug.

Joaquín Sastre - One of the best experts on this subject based on the ideXlab platform.

  • Case Report Occupational asthma due to Piperazine Citrate
    2014
    Co-Authors: Santiago Quirce, R. Pelta, Joaquín Sastre
    Abstract:

    Summary. Background: Piperazine is a secondary heterocyclic amine that may give rise to occupational asthma of uncertain mechanism. Methods: We report on a 42-year-old woman, a process operator in a chemical factory, who developed workrelated symptoms of rhinitis and asthma upon exposure to Piperazine Citrate. She remained symptom free during holidays and days off work. Results: Skin prick test with Piperazine Citrate was positive. Specific inhalation challenge with Piperazine Citrate at a concentration of 5 mg/m 3 for 30 minutes elicited an isolated late asthmatic response. Airway hyperresponsiveness to methacholine significantly increased 3 hours after the Piperazine challenge, preceding the late asthmatic response. Conclusion: This patient had developed occupational asthma caused by Piperazine, as confirmed by the specific inhalation challenge test, possibly due to an immunological mechanism. Key words: Occupational asthma, Piperazine, amines, specific inhalation challenge. Resumen. La piperazina es una amina heterocíclica secundaria que puede producir asma profesional de mecanismo desconocido. Métodos: Se estudió el caso de una mujer de 42 años de edad, empleada como operadora de proceso en una fábrica química, que desarrolló síntomas de rinitis y asma relacionados con la actividad laboral tras la exposición a citrato de piperazina. Durante las vacaciones y los días libres no experimentó síntomas. Resultados: El prick test con citrato de piperazina obtuvo un resultado positivo. La prueba de provocación por inhalación específica con citrato de piperazina a una concentración de 5 mg/m 3 durante 30 minutos puso de manifiesto una respuesta asmática tardía aislada. La hiperreactividad bronquial a la metacolina aumentó de forma significativa al cabo de 3 horas tras la prueba de provocación con piperazina, que precedió a la respuesta asmática tardía

  • Occupational asthma due to Piperazine Citrate.
    Journal of investigational allergology & clinical immunology, 2006
    Co-Authors: Santiago Quirce, R. Pelta, Joaquín Sastre
    Abstract:

    Summary. Background: Piperazine is a secondary heterocyclic amine that may give rise to occupational asthma of uncertain mechanism. Methods: We report on a 42-year-old woman, a process operator in a chemical factory, who developed workrelated symptoms of rhinitis and asthma upon exposure to Piperazine Citrate. She remained symptom free during holidays and days off work. Results: Skin prick test with Piperazine Citrate was positive. Specific inhalation challenge with Piperazine Citrate at a concentration of 5 mg/m 3 for 30 minutes elicited an isolated late asthmatic response. Airway hyperresponsiveness to methacholine significantly increased 3 hours after the Piperazine challenge, preceding the late asthmatic response. Conclusion: This patient had developed occupational asthma caused by Piperazine, as confirmed by the specific inhalation challenge test, possibly due to an immunological mechanism.

R Preussmann - One of the best experts on this subject based on the ideXlab platform.

  • endogenous formation of n nitrosamines from Piperazine and their urinary excretion following antihelmintic treatment with Piperazine Citrate
    Carcinogenesis, 1991
    Co-Authors: A R Tricker, Rahul Kumar, Maqsood Siddiqi, M S Khuroo, R Preussmann
    Abstract:

    Antihelmintic treatment with Piperazine (1,4-diazacyclohexane) for microfilarie parasitism results in the endogenous formation of Piperazine-derived N-nitrosamines. The urinary excretion of these N-nitrosamines was determined by biochemical monitoring of 14 patients receiving 2 g Piperazine Citrate. The urinary excretion (mean +/- SD) of N-mononitrosoPiperazine (MNPz) was 27.0 +/- 26.7 micrograms/day (range 0.6-96.0 micrograms/day). Trace levels of 0.73 +/- 0.92 micrograms/day N,N'-dinitrosoPiperazine (DNPz) (range ND-2.8 micrograms/day) were also found in 7 of 14 urine samples. N-Nitroso-3-hydroxypyrrolidine (NHPYR), a metabolite of both MNPz and DNPz, was detected in 11 of 14 urine samples at a mean concentration of 1.74 +/- 1.72 micrograms/day (range ND-5.7 micrograms/day) and traces of N-nitrosodiethanolamine in two samples at levels of 0.3 and less than 0.1 micrograms/day. The results show that biochemical monitoring of urinary NHPYR may be a good indicator of endogenous MNPz formation. While DNPz was also detected in urine, conclusive validation for its endogenous formation could not be provided because no evidence was found for the presence of its major metabolite, N-nitroso-(2-hydroxyethyl)glycine in urine.

Santiago Quirce - One of the best experts on this subject based on the ideXlab platform.

  • Case Report Occupational asthma due to Piperazine Citrate
    2014
    Co-Authors: Santiago Quirce, R. Pelta, Joaquín Sastre
    Abstract:

    Summary. Background: Piperazine is a secondary heterocyclic amine that may give rise to occupational asthma of uncertain mechanism. Methods: We report on a 42-year-old woman, a process operator in a chemical factory, who developed workrelated symptoms of rhinitis and asthma upon exposure to Piperazine Citrate. She remained symptom free during holidays and days off work. Results: Skin prick test with Piperazine Citrate was positive. Specific inhalation challenge with Piperazine Citrate at a concentration of 5 mg/m 3 for 30 minutes elicited an isolated late asthmatic response. Airway hyperresponsiveness to methacholine significantly increased 3 hours after the Piperazine challenge, preceding the late asthmatic response. Conclusion: This patient had developed occupational asthma caused by Piperazine, as confirmed by the specific inhalation challenge test, possibly due to an immunological mechanism. Key words: Occupational asthma, Piperazine, amines, specific inhalation challenge. Resumen. La piperazina es una amina heterocíclica secundaria que puede producir asma profesional de mecanismo desconocido. Métodos: Se estudió el caso de una mujer de 42 años de edad, empleada como operadora de proceso en una fábrica química, que desarrolló síntomas de rinitis y asma relacionados con la actividad laboral tras la exposición a citrato de piperazina. Durante las vacaciones y los días libres no experimentó síntomas. Resultados: El prick test con citrato de piperazina obtuvo un resultado positivo. La prueba de provocación por inhalación específica con citrato de piperazina a una concentración de 5 mg/m 3 durante 30 minutos puso de manifiesto una respuesta asmática tardía aislada. La hiperreactividad bronquial a la metacolina aumentó de forma significativa al cabo de 3 horas tras la prueba de provocación con piperazina, que precedió a la respuesta asmática tardía

  • Occupational asthma due to Piperazine Citrate.
    Journal of investigational allergology & clinical immunology, 2006
    Co-Authors: Santiago Quirce, R. Pelta, Joaquín Sastre
    Abstract:

    Summary. Background: Piperazine is a secondary heterocyclic amine that may give rise to occupational asthma of uncertain mechanism. Methods: We report on a 42-year-old woman, a process operator in a chemical factory, who developed workrelated symptoms of rhinitis and asthma upon exposure to Piperazine Citrate. She remained symptom free during holidays and days off work. Results: Skin prick test with Piperazine Citrate was positive. Specific inhalation challenge with Piperazine Citrate at a concentration of 5 mg/m 3 for 30 minutes elicited an isolated late asthmatic response. Airway hyperresponsiveness to methacholine significantly increased 3 hours after the Piperazine challenge, preceding the late asthmatic response. Conclusion: This patient had developed occupational asthma caused by Piperazine, as confirmed by the specific inhalation challenge test, possibly due to an immunological mechanism.

M A Alam - One of the best experts on this subject based on the ideXlab platform.

  • COMPARATIVE EFFICACY OF Piperazine Citrate, LEVAMISOLE AND PINEAPPLE LEAVES EXTRACT AGAINST NATURALLY INFECTED ASCARIASIS IN INDIGENOUS CHICKENS
    2014
    Co-Authors: M E Hoque, M A Awal, M E Choudhury, Mohammad Anwar Hossain, M. Mostofa, M A Alam
    Abstract:

    The experiment was carried out to determine the comparative efficacy of Piperazine Citrate, levamisole and pineapple leaves extract as anthelmintics against ascariasis in chicken in the Department of Pharmacology in collaboration wit

  • comparative efficacy of Piperazine Citrate levamisole and pineapple leaves extract against naturally infected ascariasis in indigenous chickens
    Bangladesh Journal of Veterinary Medicine, 2008
    Co-Authors: M E Hoque, M Mostafa, M A Awal, M E Choudhury, Mohammad Anwar Hossain, M A Alam
    Abstract:

    akram 11.6568 Normal 0 false false false MicrosoftInternetExplorer4 st1\:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} The experiment was carried out to determine the comparative efficacy of Piperazine Citrate, levamisole and pineapple leaves extract as anthelmintics against ascariasis in chicken in the Department of Pharmacology in collaboration with Department of Parasitology, Bangladesh Agricultural University, Mymensingh, Bangladesh, during the period from July to October 2004. Accordingly forty chickens naturally infected with ascarid parasite were selected for this experiment. The chickens were equally divided into 4 (A, B, C and D) groups. Group A was kept as infected control, while groups B, C and D were treated with Piperazine Citrate, levamisole and pineapple leaves extract, respectively. Although pineapple leaves extract showed less effectiveness in reducing parasite count in postmortem examination than Piperazine Citrate and levamisole but its use may be encouraging because of less adverse effects. In all treated groups total erythrocyte count (TEC), hemoglobin estimation (Hb) and packed cell volume (PCV) significantly (p Key words: Piperazine Citrate, levamisole, pineapple leaves, ascariasis, chicken doi:10.3329/bjvm.v4i1.1521 Bangl. J. Vet. Med. (2006). 4 (1): 27-29