Piperonyl Butoxide

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Takanori Harada - One of the best experts on this subject based on the ideXlab platform.

  • immunotoxicity in mice induced by short term exposure to methoxychlor parathion or Piperonyl Butoxide
    Journal of Immunotoxicology, 2013
    Co-Authors: Tomoki Fukuyama, Tadashi Kosaka, Koichi Hayashi, Lisa Miyashita, Yukari Tajima, Kunio Wada, Risako Nishino, Hideo Ueda, Takanori Harada
    Abstract:

    Exposure to environmental agents can compromise numerous immunological functions. Immunotoxicology focuses on the evaluation of the potential adverse effects of xenobiotics on immune mechanisms that can lead to harmful changes in host responses such as: increased susceptibility to infectious diseases and tumorigenesis; the induction of hypersensitivity reactions; or an increased incidence of autoimmune disease. In order to assess the immunosuppressive response to short-term exposure to some commonly used pesticides, the studies here focused on the response of mice after exposures to the organochlorine pesticide methoxychlor, the organophosphorus pesticide parathion, or the agricultural insecticide synergist Piperonyl Butoxide. In these studies, 7-week-old mice were orally administered (by gavage) methoxychlor, parathion, or Piperonyl Butoxide daily for five consecutive days. On Day 2, all mice in each group were immunized with sheep red blood cells (SRBC), and their SRBC-specific IgM responses were subseq...

Frank H Arthur - One of the best experts on this subject based on the ideXlab platform.

D.k. Singh - One of the best experts on this subject based on the ideXlab platform.

  • effect of different combinations of mgk 264 or Piperonyl Butoxide with plant derived molluscicides on snail reproduction
    Archives of Environmental Contamination and Toxicology, 2000
    Co-Authors: Kiran Singh, D.k. Singh
    Abstract:

    Effect of sublethal treatment (20% and 60% of LC50/24 h) of plant-derived molluscicides, viz. Polianthes tuberosa, Trachyspermum ammi, Allium sativum powder; Azadirachta indica oil; oleoresin of Zingiber officinale; and their active molluscicidal component in combination (1:5) with MGK-264 or Piperonyl Butoxide on the reproduction of snail Lymnaea acuminata have been studied. It was observed that the combination of plant derived molluscicide and their active molluscicidal components, viz. tigogenin, hecogenin, azadirachtin, allicin, thymol, and [6]-gingerol combination with MGK-264 or Piperonyl Butoxide caused a significant reduction in fecundity, hatchability, and survival of young snails. Withdrawal of snails to fresh water after the above treatment caused a significant recovery in the fecundity of L. acuminata.

  • the use of Piperonyl Butoxide and mgk 264 to improve the efficacy of some plant derived molluscicides
    Pesticide Science, 1998
    Co-Authors: Kiran Singh, Ajay Singh, D.k. Singh
    Abstract:

    Synergism of an oil of Azadirachta indica, a powdered extract of Allium sativum bulbs and an oleoresin of Zingiber officinale rhizomes by Piperonyl Butoxide and MGK-264 was studied against the snails Lymnaea acuminata and Indoplanorbis exustus. The active components of these plant-derived molluscicides, respectively azadirachtin, allicin and [6]gingerol, were also combined with these synergists. Both Piperonyl Butoxide and MGK-264 enhanced the toxicity of all of the test compounds. The response of snails to the synergised mixtures was both time- and dose-dependent. © 1998 Society of Chemical Industry

  • The use of Piperonyl Butoxide and MGK‐264 to improve the efficacy of some plant‐derived molluscicides
    Pesticide Science, 1998
    Co-Authors: Kiran Singh, Ajay Singh, D.k. Singh
    Abstract:

    Synergism of an oil of Azadirachta indica, a powdered extract of Allium sativum bulbs and an oleoresin of Zingiber officinale rhizomes by Piperonyl Butoxide and MGK-264 was studied against the snails Lymnaea acuminata and Indoplanorbis exustus. The active components of these plant-derived molluscicides, respectively azadirachtin, allicin and [6]gingerol, were also combined with these synergists. Both Piperonyl Butoxide and MGK-264 enhanced the toxicity of all of the test compounds. The response of snails to the synergised mixtures was both time- and dose-dependent. © 1998 Society of Chemical Industry

Tomoki Fukuyama - One of the best experts on this subject based on the ideXlab platform.

  • immunotoxicity in mice induced by short term exposure to methoxychlor parathion or Piperonyl Butoxide
    Journal of Immunotoxicology, 2013
    Co-Authors: Tomoki Fukuyama, Tadashi Kosaka, Koichi Hayashi, Lisa Miyashita, Yukari Tajima, Kunio Wada, Risako Nishino, Hideo Ueda, Takanori Harada
    Abstract:

    Exposure to environmental agents can compromise numerous immunological functions. Immunotoxicology focuses on the evaluation of the potential adverse effects of xenobiotics on immune mechanisms that can lead to harmful changes in host responses such as: increased susceptibility to infectious diseases and tumorigenesis; the induction of hypersensitivity reactions; or an increased incidence of autoimmune disease. In order to assess the immunosuppressive response to short-term exposure to some commonly used pesticides, the studies here focused on the response of mice after exposures to the organochlorine pesticide methoxychlor, the organophosphorus pesticide parathion, or the agricultural insecticide synergist Piperonyl Butoxide. In these studies, 7-week-old mice were orally administered (by gavage) methoxychlor, parathion, or Piperonyl Butoxide daily for five consecutive days. On Day 2, all mice in each group were immunized with sheep red blood cells (SRBC), and their SRBC-specific IgM responses were subseq...

T Smeaton - One of the best experts on this subject based on the ideXlab platform.

  • role of Piperonyl Butoxide in the toxicity of chlorpyrifos to ceriodaphnia dubia and xenopus laevis
    Ecotoxicology and Environmental Safety, 2004
    Co-Authors: A Elmerhibi, A Kumar, T Smeaton
    Abstract:

    Abstract The use of chemical inhibitors/inducers is one of the strategies employed to determine whether a particular metabolic pathway is involved in the metabolism of a xenobiotic. The objective of this study was to assess the role of Piperonyl Butoxide (PBO) on the toxicity of an organophosphorus insecticide, chlorpyrifos (CPF) to two species, Ceriodaphnia dubia (waterflea) and Xenopus laevis (South African clawed frog). Chlorpyrifos was highly toxic to C. dubia (48-h LC50: 0.05 μg/L) in comparison with X. laevis (96-h LC50: 2410 μg/L). Piperonyl Butoxide at 200 μg/L reduced the toxicity of chlorpyrifos to C. dubia by a factor of 6. Piperonyl Butoxide at 3000 μg/L also reduced the toxicity of CPF to X. laevis with respect to mortality and malformations. Acetylcholinesterase (AChE) activity was used as a biomarker to further assess the role of PBO in chlorpyrifos toxicity. X. laevis exposed to CPF and PBO exhibited a biphasic response in terms of AChE activity with an initial increase in the AChE activity followed by a drastic decrease. The results from the present study indicate that C. dubia and X. laevis have the capability to metabolize chlorpyrifos via cytochromes P450 mediated reactions. The results also indicate that the use of the biomarker AChE is useful in determining metabolic processes of organophosphorus insecticides, which require metabolic activation.