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Ulku Semra - One of the best experts on this subject based on the ideXlab platform.
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Adsorption of NO in clinoptilolite-rich zeolitic mineral by concentration pulse chromatography method
'Elsevier BV', 2016Co-Authors: Narin Güler, Ulku SemraAbstract:WOS: 000383291400012The equilibrium and kinetic parameters for NO adsorption in a clinoptilolite-rich natural zeolitic material from Turkey were determined using the concentration pulse chromatography method. Under the experimental conditions (carrier gas velocities and adsorption temperatures) the micropore diffusion resistance was found to be the mass transfer controlling step. Matching the first moment of the response peaks to the mathematical model the Henry's Law constants and heat of adsorption at zero loading were determined. The axial dispersion, external film, macropore and micropore diffusion coefficients, and activation energy for diffusion of NO in the micropores were calculated from the analysis of the second moments of the response peaks. For successive NO pulses without regeneration between the pulses, the retention times of the response peaks decreased and peak areas increased with the injection number indicating irreversible adsorption. The reversibly adsorbed NO could be desorbed by purging with an inert gas at the adsorption pressure and temperature. Temperature programmed desorption profile obtained by heating the NO saturated adsorbent to 400 degrees C under inert flow revealed presence of multiple irreversibly adsorbed species in NZ with different thermal stabilities. Desorption of these species was not achieved during the heating up to 400 degrees C which makes the natural zeolitic material suitable for NO storage rather than for cyclic adsorptive separation processes. (C) 2016 Elsevier Inc. All rights reserved.Turkish Republic Prime Ministry State Planning Organization [DPT-2006K120690]This study was financially supported by Turkish Republic Prime Ministry State Planning Organization (DPT-2006K120690, Determination of Effects of Zeolite on Health on Cellular and Molecular Level)
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Adsorption of NO in clinoptilolite-rich zeolitic mineral by concentration pulse chromatography method
'Elsevier BV', 2016Co-Authors: Narin Güler, Ulku SemraAbstract:The equilibrium and kinetic parameters for NO adsorption in a clinoptilolite-rich natural zeolitic material from Turkey were determined using the concentration pulse chromatography method. Under the experimental conditions (carrier gas velocities and adsorption temperatures) the micropore diffusion resistance was found to be the mass transfer controlling step. Matching the first moment of the response peaks to the mathematical model the Henry's Law constants and heat of adsorption at zero loading were determined. The axial dispersion, external film, macropore and micropore diffusion coefficients, and activation energy for diffusion of NO in the micropores were calculated from the analysis of the second moments of the response peaks. For successive NO pulses without regeneration between the pulses, the retention times of the response peaks decreased and peak areas increased with the injection number indicating irreversible adsorption. The reversibly adsorbed NO could be desorbed by purging with an inert gas at the adsorption pressure and temperature. Temperature programmed desorption profile obtained by heating the NO saturated adsorbent to 400 °C under inert flow revealed presence of multiple irreversibly adsorbed species in NZ with different thermal stabilities. Desorption of these species was not achieved during the heating up to 400 °C which makes the natural zeolitic materıal suitable for NO storage rather than for cyclic adsorptive separation processes.Turkish Republic Prime Ministry State Planning Organization (DPT-2006K120690
Baloglu Esra - One of the best experts on this subject based on the ideXlab platform.
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Gemcitabine hydrochloride microspheres used for intravesical treatment of superficial bladder cancer: a comprehensive in vitro/ex vivo/in vivo evaluation
'Dove Medical Press Ltd.', 2018Co-Authors: Karavana, Sinem Yaprak, Zeynep Ay Şenyiğit, Caliskan Cagri, Sen Sait, Sevin Gulnur, Ozdemir, Derya Ilem, Erzurumlu Yalcin, Baloglu EsraAbstract:WOS: 000437166500001PubMed ID: 29997433Introduction: Bladder cancer is responsible for more than 130,000 deaths annually worldwide. Intravesical delivery of chemotherapeutic agents provides effective drug localization to the target area to reduce toxicity and increase efficacy. This study aimed to develop ail intravesical delivery system of gemcitabine HC1 (Gem-HCl) to provide a sustained-release profile, to prolong residence time, and to enhance its efficiency in the treatment of bladder cancer. Materials and methods: For this purpose, bioadhesive microspheres were successfully prepared with average particle size, encapsulation efficiency, and loading capacity of 98.4 mu m, 82.657%+/- 5.817%, and 12.501 +/- 0.881 mg, respectively. For intravesical administration, bioadhesive microspheres were dispersed in mucoadhesive chitosan or in situ poloxanier gels and characterized in terms of gelation temperature, viscosity, mechanical, syringeability. and bioadhesive and rhcological properties. The cytotoxic effects of Gem-HCl solution, Gem-HCl microspheres, and Gem-HCl microsphere-loaded gel formulations were evaluated in two different bladder cancer cell lines: T24 (ATCC HTB4TM) and RT4 (ATCC HTB2TM). Results: According to cell-culture studies. Gem-HCl microsphere-loaded poloxamer gel was more cytotoxic than Gem-HCl microspliere-loaded chitosan gel. Antitumor efficacy of newly developed formulations were investigated by in vivo studies using bladder-tumorinduced rats. Conclusion: According to in vivo studies, Gem-HCl microspliere-loaded poloxamer gel was found to be an effective and promising alternative for current intravesical delivery-system therapies.Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBITAK-112/S/293]; TR Prime Ministry State Planning Organization FoundationTurkiye Cumhuriyeti Kalkinma Bakanligi [09/DPT/001]This study was supported by the Scientific and Technological Research Council of Turkey (grant TUBITAK-112/S/293). The authors would also like to thank the TR Prime Ministry State Planning Organization Foundation (project 09/DPT/001)
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Radiolabeling and cell incorporation studies of gemcitabine HCl microspheres on bladder cancer and papilloma cell line
'Springer Science and Business Media LLC', 2016Co-Authors: Ilem-ozdemir Derya, Zeynep Ay Şenyiğit, Karavana, Sinem Yaprak, Caliskan Cagri, Ekinci Meliha, Asikoglu Makbule, Baloglu EsraAbstract:WOS: 000385201600004In the present study incorporation differences between the developed formulations for treatment for bladder cancer was investigated by radioactive cell culture studies. Developed bioadhesive microspheres (MS) and gemcitabinehydrochloride loaded MS (GHCl-MS) were radiolabeled. After observing the optimum labeling conditions, Tc-99m-MS and Tc-99m-GHCl-MS were loaded to the chitosan gel (CG) and poloxamer gel. The in vitro cell incorporation affinity of newly developed formulations to bladder papilloma (RT4) and the carcinoma (T24) cell lines was investigated. Cell culture studies results indicate that the use of prolonged release bioadhesive CG formulation was highly improved the targeting of the GHCl to the cancer cells.Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBITAK-112/S/293]; T.R. Prime Ministry State Planning Organization FoundationTurkiye Cumhuriyeti Kalkinma Bakanligi [09/DPT/001]This study was supported by The Scientific and Technological Research Council of Turkey (TUBITAK-112/S/293). The authors also would like to thank to the T.R. Prime Ministry State Planning Organization Foundation (Project Number: 09/DPT/001). Also the authors thank to Yalcin Erzurumlu for their technical assistance for the cell culture experiments
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Design and evaluation of an intravesical delivery system for superficial bladder cancer: preparation of gemcitabine HCl-loaded chitosan-thioglycolic acid nanoparticles and comparison of chitosan/poloxamer gels as carriers
'Dove Medical Press Ltd.', 2015Co-Authors: Zeynep Ay Şenyiğit, Ilem-ozdemir Derya, Karavana, Sinem Yaprak, Caliskan Cagri, Waldner Claudia, Sen Sait, Bernkop-schnurch Andreas, Baloglu EsraAbstract:WOS: 000363190800001PubMed ID: 26508855This study aimed to develop an intravesical delivery system of gemcitabine HCl for superficial bladder cancer in order to provide a controlled release profile, to prolong the residence time, and to avoid drug elimination via urination. For this aim, bioadhesive nanoparticles were prepared with thiolated chitosan (chitosan-thioglycolic acid conjugate) and were dispersed in bioadhesive chitosan gel or in an in situ gelling poloxamer formulation in order to improve intravesical residence time. In addition, nanoparticle-loaded gels were diluted with artificial urine to mimic in vivo conditions in the bladder and were characterized regarding changes in gel structure. The obtained results showed that chitosan-thioglycolic acid nanoparticles with a mean diameter of 174.5 +/- 3.762 nm and zeta potential of 32.100 +/- 0.575 mV were successfully developed via ionotropic gelation and that the encapsulation efficiency of gemcitabine HCl was nearly 20%. In vitro/ex vivo characterization studies demonstrated that both nanoparticles and nanoparticle-loaded chitosan and poloxamer gels might be alternative carriers for intravesical administration of gemcitabine HCl, prolonging its residence time in the bladder and hence improving treatment efficacy. However, when the gel formulations were diluted with artificial urine, poloxamer gels lost their in situ gelling properties at body temperature, which is in conflict with the aimed formulation property. Therefore, 2% chitosan gel formulation was found to be a more promising carrier system for intravesical administration of nanoparticles.Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBITAK-112/S/293]; TR Prime Ministry State Planning Organization FoundationTurkiye Cumhuriyeti Kalkinma Bakanligi [09/DPT/001]This study was supported by The Scientific and Technological Research Council of Turkey (grant number TUBITAK-112/S/293). The authors would also like to thank to the TR Prime Ministry State Planning Organization Foundation (Project Number 09/DPT/001)
Mary Beth Farquhar - One of the best experts on this subject based on the ideXlab platform.
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metropolitan Planning Organization voting structure and transit investment bias preliminary analysis with social equity implications
Transportation Research Record, 2004Co-Authors: Arthur C Nelson, Thomas W Sanchez, James F Wolf, Mary Beth FarquharAbstract:Metropolitan Planning Organizations (MPOs) are the conduit through which billions of federal and state transportation dollars are funneled annually for regional transportation facilities. MPO transportation investments are guided by long-term regional transportation plans that are implemented through short-term transportation improvement plans. Because transportation investments shape land use patterns, decisions by MPOs have important implications for regional land use patterns and, by implication, social equity. For their part, MPO decisions are made by a board whose composition varies widely across the nation. They are not elected to serve on the MPO, however, and MPOs are not required by federal law to have balance in voting. Therefore, the potential exists for MPO decisions to be biased and favor certain investments beneficial to particular metropolitan areas' interests at the expense of others. This study reviews MPOs generally, discusses variation in their voting structures, and reports results fro...
Brian J Fineman - One of the best experts on this subject based on the ideXlab platform.
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pedestrian travel potential in northern new jersey a metropolitan Planning Organization s approach to identifying investment priorities
Transportation Research Record, 2000Co-Authors: Ted Matley, Lois M Goldman, Brian J FinemanAbstract:At metropolitan Planning Organizations such as the North Jersey Transportation Planning Authority (NJTPA), Planning investments to support pedestrian trips for a large and diverse metropolitan area would be an intractable challenge without an open, coordinated, and cooperative approach and a strong information foundation. To address this challenge, NJTPA has adopted an innovative approach using regional analysis and priority setting to guide Planning activity for a very local scale. The design and initial applications of this approach are described. Areas with proximity and connectivity features supporting pedestrian activity were identified using data available at the regional level. The data were analyzed within a pedestrian potential index (PPI) comprising four key indicators: population densities, employment densities, land use mix, and street network density, all analyzed at the census tract level. Thresholds were set to begin to find priority areas in which investment in pedestrian strategies would be more likely to generate a high return in terms of walking trips generated. The analysis also allows local planners to understand how their communities compare in relative levels of density, land use mix, and network connectivity. This information can help planners identify areas for Planning activities that would address these factors and encourage walking trips. With the first results from application of the PPI, NJTPA has solicited feedback from state and local Planning partners. With subsequent refinement, this analysis will be finalized for the region and incorporated in the next update of the NJTPA Regional Transportation Plan.
Narin Güler - One of the best experts on this subject based on the ideXlab platform.
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Adsorption of NO in clinoptilolite-rich zeolitic mineral by concentration pulse chromatography method
'Elsevier BV', 2016Co-Authors: Narin Güler, Ulku SemraAbstract:WOS: 000383291400012The equilibrium and kinetic parameters for NO adsorption in a clinoptilolite-rich natural zeolitic material from Turkey were determined using the concentration pulse chromatography method. Under the experimental conditions (carrier gas velocities and adsorption temperatures) the micropore diffusion resistance was found to be the mass transfer controlling step. Matching the first moment of the response peaks to the mathematical model the Henry's Law constants and heat of adsorption at zero loading were determined. The axial dispersion, external film, macropore and micropore diffusion coefficients, and activation energy for diffusion of NO in the micropores were calculated from the analysis of the second moments of the response peaks. For successive NO pulses without regeneration between the pulses, the retention times of the response peaks decreased and peak areas increased with the injection number indicating irreversible adsorption. The reversibly adsorbed NO could be desorbed by purging with an inert gas at the adsorption pressure and temperature. Temperature programmed desorption profile obtained by heating the NO saturated adsorbent to 400 degrees C under inert flow revealed presence of multiple irreversibly adsorbed species in NZ with different thermal stabilities. Desorption of these species was not achieved during the heating up to 400 degrees C which makes the natural zeolitic material suitable for NO storage rather than for cyclic adsorptive separation processes. (C) 2016 Elsevier Inc. All rights reserved.Turkish Republic Prime Ministry State Planning Organization [DPT-2006K120690]This study was financially supported by Turkish Republic Prime Ministry State Planning Organization (DPT-2006K120690, Determination of Effects of Zeolite on Health on Cellular and Molecular Level)
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Adsorption of NO in clinoptilolite-rich zeolitic mineral by concentration pulse chromatography method
'Elsevier BV', 2016Co-Authors: Narin Güler, Ulku SemraAbstract:The equilibrium and kinetic parameters for NO adsorption in a clinoptilolite-rich natural zeolitic material from Turkey were determined using the concentration pulse chromatography method. Under the experimental conditions (carrier gas velocities and adsorption temperatures) the micropore diffusion resistance was found to be the mass transfer controlling step. Matching the first moment of the response peaks to the mathematical model the Henry's Law constants and heat of adsorption at zero loading were determined. The axial dispersion, external film, macropore and micropore diffusion coefficients, and activation energy for diffusion of NO in the micropores were calculated from the analysis of the second moments of the response peaks. For successive NO pulses without regeneration between the pulses, the retention times of the response peaks decreased and peak areas increased with the injection number indicating irreversible adsorption. The reversibly adsorbed NO could be desorbed by purging with an inert gas at the adsorption pressure and temperature. Temperature programmed desorption profile obtained by heating the NO saturated adsorbent to 400 °C under inert flow revealed presence of multiple irreversibly adsorbed species in NZ with different thermal stabilities. Desorption of these species was not achieved during the heating up to 400 °C which makes the natural zeolitic materıal suitable for NO storage rather than for cyclic adsorptive separation processes.Turkish Republic Prime Ministry State Planning Organization (DPT-2006K120690