The Experts below are selected from a list of 2232 Experts worldwide ranked by ideXlab platform
Kjell Toren - One of the best experts on this subject based on the ideXlab platform.
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restrictive spirometric pattern and true pulmonary restriction in a general population sample aged 50 64 years
BMC Pulmonary Medicine, 2020Co-Authors: Kjell Toren, Linus Schioler, Jonas Brisman, Andrei Malinovschi, Annacarin Olin, Goran Bergstrom, Bjorn BakeAbstract:There is low diagnostic accuracy of the proxy restrictive spirometric pattern (RSP) to identify true pulmonary restriction. This knowledge is based on patients referred for spirometry and total lung volume determination by plethysmograpy, single breath nitrogen washout technique or gas dilution and selected controls. There is, however, a lack of data from general populations analyzing whether RSP is a valid proxy for true pulmonary restriction. We have validated RSP in relation to true pulmonary restriction in a general population where we have access to measurements of total lung capacity (TLC) and spirometry. The data was from the Swedish CArdioPulmonary bioImage Study (SCAPIS Pilot), a general population-based study, comprising 983 adults aged 50–64. All subjects answered a respiratory questionnaire. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were obtained before and after bronchodilation. TLC and residual volume (RV) was recorded using a body Plethysmograph. All lung function values are generally expressed as percent predicted (% predicted) or in relation to lower limits of normal (LLN). True pulmonary restriction was defined as TLC < LLN5 defined as a Z score < − 1.645, i e the fifth percentile. RSP was defined as FEV1/FVC ≥ LLN and FVC < LLN after bronchodilation. Specificity, sensitivity, positive and negative likelihood ratios were calculated, and 95% confidence intervals (CIs) were calculated. The prevalence of true pulmonary restriction was 5.4%, and the prevalence of RSP was 3.4%. The sensitivity of RSP to identify true pulmonary restriction was 0.34 (0.20–0.46), the corresponding specificity was 0.98 (0.97–0.99), and the positive likelihood ratio was 21.1 (11.3–39.4) and the negative likelihood ratio was 0.67 (0.55–0.81). RSP has low accuracy for identifying true pulmonary restriction. The results support previous observations that RSP is useful for ruling out true pulmonary restriction.
Bjorn Bake - One of the best experts on this subject based on the ideXlab platform.
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restrictive spirometric pattern and true pulmonary restriction in a general population sample aged 50 64 years
BMC Pulmonary Medicine, 2020Co-Authors: Kjell Toren, Linus Schioler, Jonas Brisman, Andrei Malinovschi, Annacarin Olin, Goran Bergstrom, Bjorn BakeAbstract:There is low diagnostic accuracy of the proxy restrictive spirometric pattern (RSP) to identify true pulmonary restriction. This knowledge is based on patients referred for spirometry and total lung volume determination by plethysmograpy, single breath nitrogen washout technique or gas dilution and selected controls. There is, however, a lack of data from general populations analyzing whether RSP is a valid proxy for true pulmonary restriction. We have validated RSP in relation to true pulmonary restriction in a general population where we have access to measurements of total lung capacity (TLC) and spirometry. The data was from the Swedish CArdioPulmonary bioImage Study (SCAPIS Pilot), a general population-based study, comprising 983 adults aged 50–64. All subjects answered a respiratory questionnaire. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were obtained before and after bronchodilation. TLC and residual volume (RV) was recorded using a body Plethysmograph. All lung function values are generally expressed as percent predicted (% predicted) or in relation to lower limits of normal (LLN). True pulmonary restriction was defined as TLC < LLN5 defined as a Z score < − 1.645, i e the fifth percentile. RSP was defined as FEV1/FVC ≥ LLN and FVC < LLN after bronchodilation. Specificity, sensitivity, positive and negative likelihood ratios were calculated, and 95% confidence intervals (CIs) were calculated. The prevalence of true pulmonary restriction was 5.4%, and the prevalence of RSP was 3.4%. The sensitivity of RSP to identify true pulmonary restriction was 0.34 (0.20–0.46), the corresponding specificity was 0.98 (0.97–0.99), and the positive likelihood ratio was 21.1 (11.3–39.4) and the negative likelihood ratio was 0.67 (0.55–0.81). RSP has low accuracy for identifying true pulmonary restriction. The results support previous observations that RSP is useful for ruling out true pulmonary restriction.
Annacarin Olin - One of the best experts on this subject based on the ideXlab platform.
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restrictive spirometric pattern and true pulmonary restriction in a general population sample aged 50 64 years
BMC Pulmonary Medicine, 2020Co-Authors: Kjell Toren, Linus Schioler, Jonas Brisman, Andrei Malinovschi, Annacarin Olin, Goran Bergstrom, Bjorn BakeAbstract:There is low diagnostic accuracy of the proxy restrictive spirometric pattern (RSP) to identify true pulmonary restriction. This knowledge is based on patients referred for spirometry and total lung volume determination by plethysmograpy, single breath nitrogen washout technique or gas dilution and selected controls. There is, however, a lack of data from general populations analyzing whether RSP is a valid proxy for true pulmonary restriction. We have validated RSP in relation to true pulmonary restriction in a general population where we have access to measurements of total lung capacity (TLC) and spirometry. The data was from the Swedish CArdioPulmonary bioImage Study (SCAPIS Pilot), a general population-based study, comprising 983 adults aged 50–64. All subjects answered a respiratory questionnaire. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were obtained before and after bronchodilation. TLC and residual volume (RV) was recorded using a body Plethysmograph. All lung function values are generally expressed as percent predicted (% predicted) or in relation to lower limits of normal (LLN). True pulmonary restriction was defined as TLC < LLN5 defined as a Z score < − 1.645, i e the fifth percentile. RSP was defined as FEV1/FVC ≥ LLN and FVC < LLN after bronchodilation. Specificity, sensitivity, positive and negative likelihood ratios were calculated, and 95% confidence intervals (CIs) were calculated. The prevalence of true pulmonary restriction was 5.4%, and the prevalence of RSP was 3.4%. The sensitivity of RSP to identify true pulmonary restriction was 0.34 (0.20–0.46), the corresponding specificity was 0.98 (0.97–0.99), and the positive likelihood ratio was 21.1 (11.3–39.4) and the negative likelihood ratio was 0.67 (0.55–0.81). RSP has low accuracy for identifying true pulmonary restriction. The results support previous observations that RSP is useful for ruling out true pulmonary restriction.
Daphna Vilozni - One of the best experts on this subject based on the ideXlab platform.
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frc measurements using body Plethysmography in young children
Pediatric Pulmonology, 2009Co-Authors: Daphna Vilozni, Ori Efrati, Fahed Hakim, Adi Adler, Galit Livnat, Lea BenturAbstract:Background Measurement of FRC in whole body Plethysmography (FRCpleth) is not performed in young children (aged 3–5 years) because it involves sitting alone in a closed box and breathing attempts against occlusion. Objective To assess the feasibility of measuring FRCpleth in young children. Methods and Results Seventy-one of 102 children (age range 3.3–6.9 years) performed spirometry and FRCpleth measurements. Twenty-six children had controlled asthma (Group-A); 26 children were tested during asthma exacerbation had uncontrolled asthma (Group-UA), and 19 children were tested after receiving chemotherapy treatment (Group-C). Tests according to adult recommendations were first taught outside the Plethysmograph and then performed with minor technical adaptations. Each test included two consecutive FRC measurements obtained during 2–3 sec of occlusion. Total lung capacity (TLC) and residual volume (RV) were calculated. Values were compared to FRC measured by Helium-dilution (FRC-He) in healthy preschool children and to extrapolated FRCpleth values of school children, and between the groups. Results Group-A showed normal spirometry and normal TLC values, with mildly elevated FRCpleth and RV values (125 ± 20 and 153 ± 33 %predicted, respectively; P < 0.0001 for both values). Group-UA showed obstructed flows combined with high FRCpleth and RV (146 ± 26 and 189 ± 38 %predicted; P < 0.0001) and normal TLC. Group-C showed a restrictive spirometry pattern combined with lower than normal TLC (86 ± 15 %predicted; P < 0.0251). Conclusions Measuring absolute lung volumes by Plethysmography in young children is feasible and can detect abnormal lung volumes. It is essential to study a larger group of healthy children for reference values and to allow for standardization of the procedure. Pediatr Pulmonol. 2009; 44:885–891. © 2009 Wiley-Liss, Inc.
E M Bernauer - One of the best experts on this subject based on the ideXlab platform.
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body composition by air displacement Plethysmography by using predicted and measured thoracic gas volumes
Journal of Applied Physiology, 1998Co-Authors: Megan A Mccrory, Paul A Mole, Terri D Gomez, Kathryn G Dewey, E M BernauerAbstract:The BOD POD, a new air-displacement Plethysmograph for measuring human body composition, utilizes the inverse relationship between pressure and volume (Boyle’s law) to measure body volume directly....
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evaluation of a new air displacement Plethysmograph for measuring human body composition
Medicine and Science in Sports and Exercise, 1995Co-Authors: Megan A Mccrory, Terri D Gomez, E M Bernauer, Paul A MoleAbstract:MCCRORY, M. A., T. D. GOMEZ, E. M. BERNAUER, and P. A. MOLE. Evaluation of a new air displacement Plethysmograph for measuring human body composition. Med. Sci. Sports Exerc., Vol. 27, No. 12, pp. 1686–1691, 1995. A new air displacement Plethysmograph, the BOD POD® (BP), was evaluated in comparison