The Experts below are selected from a list of 21 Experts worldwide ranked by ideXlab platform
Hung Chiang - One of the best experts on this subject based on the ideXlab platform.
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Plurihormonal pituitary Adenomas immunostaining of all pituitary hormones is mandatory for correct classification
Histopathology, 2001Co-Authors: Chihyi Hsu, Lingtan Ting, Hung ChiangAbstract:Plurihormonal pituitary Adenomas: immunostaining of all pituitary hormones is mandatory for correct classification Aims: We studied the clinicopathological characteristics of Plurihormonal pituitary Adenomas. Methods and results: The study material included 167 Plurihormonal Adenomas, which consisted of 31% of the surgically removed pituitary Adenomas that we collected during a 12-year period. The mean age of patients with Plurihormonal Adenoma was 45.7 years (range 13–75 years). There were 86 men and 81 women. All tumours were fully classified by immunohistochemical staining for seven pituitary hormones or subunits. Thirty immunohistochemical subtypes of Plurihormonal Adenomas were recognized. Hormonal symptoms were present in 70% of patients, while serum hormonal levels were increased in 89% of patients. Most patients had symptoms related to only one of the hormones and only 7% of patients had symptoms related to two hormones. The most common hormonal symptom was acromegaly (50%); symptoms related to hyperprolactinaemia ranked second (20%). Double immunostaining of all the possible combinations of the hormones was performed in 30 selected tumours, and they all showed mixtures of hormones in individual Adenoma cells in any hormonal combinations studied. The latter finding supported the view that Plurihormonal Adenomas are monomorphous Adenomas. Conclusions: Plurihormonal Adenomas are common pituitary Adenomas. Immunohistochemical staining of all pituitary hormones is mandatory for correct classification.
Chihyi Hsu - One of the best experts on this subject based on the ideXlab platform.
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Plurihormonal pituitary Adenomas immunostaining of all pituitary hormones is mandatory for correct classification
Histopathology, 2001Co-Authors: Chihyi Hsu, Lingtan Ting, Hung ChiangAbstract:Plurihormonal pituitary Adenomas: immunostaining of all pituitary hormones is mandatory for correct classification Aims: We studied the clinicopathological characteristics of Plurihormonal pituitary Adenomas. Methods and results: The study material included 167 Plurihormonal Adenomas, which consisted of 31% of the surgically removed pituitary Adenomas that we collected during a 12-year period. The mean age of patients with Plurihormonal Adenoma was 45.7 years (range 13–75 years). There were 86 men and 81 women. All tumours were fully classified by immunohistochemical staining for seven pituitary hormones or subunits. Thirty immunohistochemical subtypes of Plurihormonal Adenomas were recognized. Hormonal symptoms were present in 70% of patients, while serum hormonal levels were increased in 89% of patients. Most patients had symptoms related to only one of the hormones and only 7% of patients had symptoms related to two hormones. The most common hormonal symptom was acromegaly (50%); symptoms related to hyperprolactinaemia ranked second (20%). Double immunostaining of all the possible combinations of the hormones was performed in 30 selected tumours, and they all showed mixtures of hormones in individual Adenoma cells in any hormonal combinations studied. The latter finding supported the view that Plurihormonal Adenomas are monomorphous Adenomas. Conclusions: Plurihormonal Adenomas are common pituitary Adenomas. Immunohistochemical staining of all pituitary hormones is mandatory for correct classification.
Lingtan Ting - One of the best experts on this subject based on the ideXlab platform.
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Plurihormonal pituitary Adenomas immunostaining of all pituitary hormones is mandatory for correct classification
Histopathology, 2001Co-Authors: Chihyi Hsu, Lingtan Ting, Hung ChiangAbstract:Plurihormonal pituitary Adenomas: immunostaining of all pituitary hormones is mandatory for correct classification Aims: We studied the clinicopathological characteristics of Plurihormonal pituitary Adenomas. Methods and results: The study material included 167 Plurihormonal Adenomas, which consisted of 31% of the surgically removed pituitary Adenomas that we collected during a 12-year period. The mean age of patients with Plurihormonal Adenoma was 45.7 years (range 13–75 years). There were 86 men and 81 women. All tumours were fully classified by immunohistochemical staining for seven pituitary hormones or subunits. Thirty immunohistochemical subtypes of Plurihormonal Adenomas were recognized. Hormonal symptoms were present in 70% of patients, while serum hormonal levels were increased in 89% of patients. Most patients had symptoms related to only one of the hormones and only 7% of patients had symptoms related to two hormones. The most common hormonal symptom was acromegaly (50%); symptoms related to hyperprolactinaemia ranked second (20%). Double immunostaining of all the possible combinations of the hormones was performed in 30 selected tumours, and they all showed mixtures of hormones in individual Adenoma cells in any hormonal combinations studied. The latter finding supported the view that Plurihormonal Adenomas are monomorphous Adenomas. Conclusions: Plurihormonal Adenomas are common pituitary Adenomas. Immunohistochemical staining of all pituitary hormones is mandatory for correct classification.
Aparna Pal - One of the best experts on this subject based on the ideXlab platform.
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Plurihormonal Pit-1 lineage Adenoma presenting as meningitis with recurrence after somatostatin analogue
Bioscientifica, 2019Co-Authors: Yoko Olmedilla, Shoaib Khan, Victoria Young, Robin Joseph, Simon Cudlip, Olaf Ansgorge, Ashley Grossman, Aparna PalAbstract:A 21 year-old woman was found to have a pituitary macroAdenoma following an episode of haemophilus meningitis. Biochemical TSH and GH excess was noted, although with no clear clinical correlates. She was treated with a somatostatin analogue (SSA), which restored the euthyroid state and controlled GH hypersecretion, but she re-presented with a further episode of cerebrospinal fluid (CSF) leak and recurrent meningitis. Histology following transsphenoidal adenomectomy revealed a Pit-1 lineage Plurihormonal Adenoma expressing GH, TSH and PRL. Such Plurihormonal pituitary tumours are uncommon and even more unusual to present with spontaneous bacterial meningitis. The second episode of CSF leak and meningitis appears to have been due to SSA therapy-induced tumour shrinkage, which is not a well-described phenomenon in the literature for this type of tumour
Kiupel M. - One of the best experts on this subject based on the ideXlab platform.
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Concurrent somatotroph and Plurihormonal pituitary Adenomas in a cat
W.B. Saunders Ltd, 2013Co-Authors: Sharman M., Fitzgerald L., Kiupel M.Abstract:An 8-year-old, male neutered, domestic longhair cat was referred for investigation of insulin-resistant diabetes mellitus. Routine haematology, serum biochemistry, urinalysis (including culture), total T4 and urine creatinine:cortisol ratio were unremarkable, but markedly increased insulin-like growth factor-1 concentration was identified and a pituitary mass was subsequently documented. The cat was treated conservatively with the dopamine agonist L-deprenyl and was re-presented 16 months later for worsening polyuria, polydipsia, polyphagia, marked lumbar muscle atrophy, development of a pendulous abdomen and marked thinning of the abdominal skin. Hyperadrenocorticism was diagnosed based on abdominal ultrasonography, dexamethasone suppression testing and endogenous adrenocorticotropic hormone (ACTH). The cat was treated with trilostane (30 mg q24h PO) and showed some clinical improvement, but developed an opportunistic fungal infection and skin fragility syndrome 4.5 months after commencing treatment, and was euthanased. A double-pituitary Adenoma comprising a discrete somatotroph Adenoma and a separate Plurihormonal Adenoma (positive immunoreactivity for ACTH, melanocyte-stimulating hormone and follicle-stimulating hormone) was identified on post-mortem examination. These two pituitary Adenomas were suspected to have arisen as independent neoplastic entities with the Plurihormonal tumour either being clinically silent at the initial presentation or having developed over the subsequent 16 months