The Experts below are selected from a list of 267 Experts worldwide ranked by ideXlab platform
Zhide Hu - One of the best experts on this subject based on the ideXlab platform.
-
Separation and determination of Podophyllum lignans by micellar electrokinetic chromatography
Journal of Chromatography A, 2001Co-Authors: Xuan Tian, Xingguo Chen, Zhide HuAbstract:A micellar electrokinetic chromatography method was established for the quantitative analysis of seven Podophyllum lignans in Podophyllum emodi Wall. var. chinesis sprague. The optimum buffer system was 10 mM NaH2PO4–5 mM borate–100 mM sodium dodecylsulfate–30% isopropanol (pH 7.20). Voltage was 18 kV and detection at 214 nm. The second derivative chromatogram was used to determine a low-content component and those not fully separated from adjacent ones. The RSD values of migration times and peak areas were
-
separation and determination of Podophyllum lignans by micellar electrokinetic chromatography
Journal of Chromatography A, 2001Co-Authors: Xuan Tian, Xingguo Chen, Zhide HuAbstract:A micellar electrokinetic chromatography method was established for the quantitative analysis of seven Podophyllum lignans in Podophyllum emodi Wall. var. chinesis sprague. The optimum buffer system was 10 mM NaH2PO4–5 mM borate–100 mM sodium dodecylsulfate–30% isopropanol (pH 7.20). Voltage was 18 kV and detection at 214 nm. The second derivative chromatogram was used to determine a low-content component and those not fully separated from adjacent ones. The RSD values of migration times and peak areas were <2.2 and <5.5%, respectively. The effects of several CE parameters on the resolutions were studied systematically.
Deng Qinwen - One of the best experts on this subject based on the ideXlab platform.
-
Construction of the Syngonium Podophyllum-Pseudomonas sp. XNN8 Symbiotic Purification System and Investigation of Its Capability of Remediating Uranium Wastewater
Environmental science and pollution research international, 2016Co-Authors: Deng Qinwen, Wang Yongdong, Dexin Ding, Jing SunAbstract:The endophyte Pseudomonas sp. XNN8 was separated from Typha orientalis which can secrete indole-3-acetic acid and 1-aminocyclopropane-1-carboxylate deaminase and siderophores and has strong resistance to uranium it was then colonized in the Syngonium Podophyllum; and the S. Podophyllum-Pseudomonas sp. XNN8 symbiotic purification system (SPPSPS) for uranium-containing wastewater was constructed. Afterwards, the hydroponic experiments to remove uranium from uranium-containing wastewater by the SPPSPS were conducted. After 24 days of treatment, the uranium concentrations of the wastewater samples with uranium concentrations between 0.5 and 5.0 mg/L were lowered to below 0.05 mg/L. Furthermore, the uranium in the plants was assayed using Fourier transform infrared spectroscopy (FTIR) and extended X-ray absorption fine structure (EXAFS) spectroscopy. The Pseudomonas sp. XNN8 was found to generate substantial organic groups in the roots of the Syngonium Podophyllum, which could improve the complexing capability of S. Podophyllum for uranium. The uranium in the roots of S. Podophyllum was found to be the uranyl phosphate (47.4 %) and uranyl acetate (52.6 %).
-
An artificially constructed Syngonium Podophyllum - Aspergillus niger combinate system for removal of uranium from wastewater
Environmental science and pollution research international, 2015Co-Authors: Wang Yongdong, Dexin Ding, Jing Sun, Deng QinwenAbstract:Aspergillus niger was inoculated to the roots of five plants, and the Syngonium Podophyllum-A. niger combinate system (SPANCS) was found to be the most effective in removing uranium from hydroponic liquid with initial uranium concentration of 5 mg L−1. Furthermore, the hydroponic experiments on the removal of uranium from the hydroponic liquids with initial uranium concentrations of 0.5, 1.0, and 3.0 mg L−1 by the SPANCS were conducted, the inhibitory effect of A. niger on the growth of S. Podophyllum in the SPANCS was studied, the accumulation characteristics of uranium by S. Podophyllum in the SPANCS were analyzed, and the Fourier transform infrared (FT-IR) and extended X-ray absorption fine structure (EXAFS) spectra were measured. The results show that the removal of uranium by the SPANCS from the hydroponic liquids with initial uranium concentrations of 0.5, 1.0, and 3.0 mg L−1 reached 98.20, 97.90, and 98.50 %, respectively, after 37 days of accumulation of uranium; that the uranium concentrations in the hydroponic liquids decreased to 0.009, 0.021, and 0.045 mg L−1, respectively, which are lower than the stipulated concentration for discharge of 0.050 mg L−1 by the People’s Republic of China; that A. niger helped to generate more groups in the root of S. Podophyllum which can improve the complexing capability of S. Podophyllum for uranium; and that the uranium accumulated in the root of S. Podophyllum was in the form of phosphate uranyl and carboxylic uranyl.
Ya-jie Tang - One of the best experts on this subject based on the ideXlab platform.
-
Fluoride-containing Podophyllum derivatives exhibit antitumor activities through enhancing mitochondrial apoptosis pathway by increasing the expression of caspase-9 in HeLa cells.
Scientific reports, 2015Co-Authors: Wei Zhao, Yong Yang, Ya-xuan Zhang, Chen Zhou, Ya-ling Tang, Xin-hua Liang, Tao Chen, Ya-jie TangAbstract:This work aims to provide sampling of halogen-containing aniline Podophyllum derivatives and their mode of action with an in-depth comparison among fluorine, chloride and bromide for clarifying the important role and impact of fluorine substitution on enhancing antitumor activity, with an emphasis on the development of drug rational design for antitumor drug. The tumor cytotoxicity of fluoride-containing aniline Podophyllum derivatives were in general improved by 10–100 times than those of the chloride and bromide-containing aniline Podophyllum derivatives since fluoride could not only strongly solvated in protic solvents but also forms tight ion pairs in most aprotic solvents. When compared with chloride and bromide, the higher electronegativity fluoride substituted derivatives significantly enhanced mitochondrial apoptosis pathway by remarkably increasing the expression of caspase-9 in HeLa cells. The current findings would stimulate an enormous amount of research directed toward exploiting novel leading compounds based on Podophyllum derivatives, especially for the fluoride-substituted structures with promising antitumor activity.
-
Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4β-S-aromatic heterocyclic Podophyllum derivatives display antitumor activity.
Scientific reports, 2015Co-Authors: Wei Zhao, Ya-xuan Zhang, Chen Zhou, Ya-ling Tang, Xin-hua Liang, Tao Chen, Ya-jie TangAbstract:Herein is a first effort to systematically study the significance of carbon-sulfur (C-S) and carbon-amine (C-NH) bonds on the antitumor proliferation activity of Podophyllum derivatives and their precise mechanism of apoptosis. Compared with the derivative modified by a C-NH bond, the derivative modified by a C-S bond exhibited superior antitumor activity, the inhibition activity of target proteins tubulin or Topo II, cell cycle arrest, and apoptosis induction. Antitumor mechanistic studies showed that the death receptor and the mitochondrial apoptotic pathways were simultaneously activated by the C-S bond modified aromatic heterocyclic Podophyllum derivatives with a higher cellular uptake percentage of 60-90% and induction of a higher level of reactive oxygen species (ROS). Only the mitochondrial apoptotic pathway was activated by the C-NH bond modified aromatic heterocyclic Podophyllum derivatives, with a lower cellular uptake percentage of 40-50%. This study provided insight into effects of the C-S and C-NH bond modification on the improvement of the antitumor activity of Podophyllum derivatives.
Jing Sun - One of the best experts on this subject based on the ideXlab platform.
-
Construction of the Syngonium Podophyllum-Pseudomonas sp. XNN8 Symbiotic Purification System and Investigation of Its Capability of Remediating Uranium Wastewater
Environmental science and pollution research international, 2016Co-Authors: Deng Qinwen, Wang Yongdong, Dexin Ding, Jing SunAbstract:The endophyte Pseudomonas sp. XNN8 was separated from Typha orientalis which can secrete indole-3-acetic acid and 1-aminocyclopropane-1-carboxylate deaminase and siderophores and has strong resistance to uranium it was then colonized in the Syngonium Podophyllum; and the S. Podophyllum-Pseudomonas sp. XNN8 symbiotic purification system (SPPSPS) for uranium-containing wastewater was constructed. Afterwards, the hydroponic experiments to remove uranium from uranium-containing wastewater by the SPPSPS were conducted. After 24 days of treatment, the uranium concentrations of the wastewater samples with uranium concentrations between 0.5 and 5.0 mg/L were lowered to below 0.05 mg/L. Furthermore, the uranium in the plants was assayed using Fourier transform infrared spectroscopy (FTIR) and extended X-ray absorption fine structure (EXAFS) spectroscopy. The Pseudomonas sp. XNN8 was found to generate substantial organic groups in the roots of the Syngonium Podophyllum, which could improve the complexing capability of S. Podophyllum for uranium. The uranium in the roots of S. Podophyllum was found to be the uranyl phosphate (47.4 %) and uranyl acetate (52.6 %).
-
An artificially constructed Syngonium Podophyllum - Aspergillus niger combinate system for removal of uranium from wastewater
Environmental science and pollution research international, 2015Co-Authors: Wang Yongdong, Dexin Ding, Jing Sun, Deng QinwenAbstract:Aspergillus niger was inoculated to the roots of five plants, and the Syngonium Podophyllum-A. niger combinate system (SPANCS) was found to be the most effective in removing uranium from hydroponic liquid with initial uranium concentration of 5 mg L−1. Furthermore, the hydroponic experiments on the removal of uranium from the hydroponic liquids with initial uranium concentrations of 0.5, 1.0, and 3.0 mg L−1 by the SPANCS were conducted, the inhibitory effect of A. niger on the growth of S. Podophyllum in the SPANCS was studied, the accumulation characteristics of uranium by S. Podophyllum in the SPANCS were analyzed, and the Fourier transform infrared (FT-IR) and extended X-ray absorption fine structure (EXAFS) spectra were measured. The results show that the removal of uranium by the SPANCS from the hydroponic liquids with initial uranium concentrations of 0.5, 1.0, and 3.0 mg L−1 reached 98.20, 97.90, and 98.50 %, respectively, after 37 days of accumulation of uranium; that the uranium concentrations in the hydroponic liquids decreased to 0.009, 0.021, and 0.045 mg L−1, respectively, which are lower than the stipulated concentration for discharge of 0.050 mg L−1 by the People’s Republic of China; that A. niger helped to generate more groups in the root of S. Podophyllum which can improve the complexing capability of S. Podophyllum for uranium; and that the uranium accumulated in the root of S. Podophyllum was in the form of phosphate uranyl and carboxylic uranyl.
Xuan Tian - One of the best experts on this subject based on the ideXlab platform.
-
Separation and determination of Podophyllum lignans by micellar electrokinetic chromatography
Journal of Chromatography A, 2001Co-Authors: Xuan Tian, Xingguo Chen, Zhide HuAbstract:A micellar electrokinetic chromatography method was established for the quantitative analysis of seven Podophyllum lignans in Podophyllum emodi Wall. var. chinesis sprague. The optimum buffer system was 10 mM NaH2PO4–5 mM borate–100 mM sodium dodecylsulfate–30% isopropanol (pH 7.20). Voltage was 18 kV and detection at 214 nm. The second derivative chromatogram was used to determine a low-content component and those not fully separated from adjacent ones. The RSD values of migration times and peak areas were
-
separation and determination of Podophyllum lignans by micellar electrokinetic chromatography
Journal of Chromatography A, 2001Co-Authors: Xuan Tian, Xingguo Chen, Zhide HuAbstract:A micellar electrokinetic chromatography method was established for the quantitative analysis of seven Podophyllum lignans in Podophyllum emodi Wall. var. chinesis sprague. The optimum buffer system was 10 mM NaH2PO4–5 mM borate–100 mM sodium dodecylsulfate–30% isopropanol (pH 7.20). Voltage was 18 kV and detection at 214 nm. The second derivative chromatogram was used to determine a low-content component and those not fully separated from adjacent ones. The RSD values of migration times and peak areas were <2.2 and <5.5%, respectively. The effects of several CE parameters on the resolutions were studied systematically.
