The Experts below are selected from a list of 504 Experts worldwide ranked by ideXlab platform
Edgardo Alberto - One of the best experts on this subject based on the ideXlab platform.
-
especies toxicas de agaricales halladas en la argentina nueva cita de amanita pantherina y reevaluacion de la comestibilidad de tricholoma equestre
Boletin de la Sociedad Argentina de Botanica, 2008Co-Authors: Bernardo E Lechner, Edgardo AlbertoAbstract:Summary: Poisonous species of Agaricales found in Argentina: new record of Amanita pantherina and revaluation of the edibility of Tricholoma equestre. Mushrooms are not usually included in the traditional eating habits of the Argentinean population. Nevertheless, there are some people that consume wild species. This practice has caused poisoning to important number of adults and children over the last years. In the present paper we describe the Poisonous Mushroom Amanita pantherina as a new record for Argentina and we provide a key for the identification of the species of Amanita belonging to Secc. Amanita found in our country. We also describe and explain a new poisoning syndrome caused by Tricholoma equestre. This species was recently prohibited in some countries of Europe.
-
Especies tóxicas de Agaricales halladas en la Argentina: nueva cita de Amanita pantherina y reevaluación de la comestibilidad de Tricholoma equestre Poisonous species of Agaricales found in Argentina: new record of Amanita pantherina and revaluation
Sociedad Argentina de Botánica, 2008Co-Authors: Bernardo E Lechner, Edgardo AlbertoAbstract:Si bien los hongos comestibles en la Argentina no constituyen una parte importante de la dieta, algunas personas colectan y consumen especies silvestres. Esto ha ocasionado en los últimos años la intoxicación de un número importante de adultos y niños. En el presente trabajo se cita por primera vez para la Argentina el hongo tóxico Amanita pantherina, se describen las colecciones halladas y se provee una clave para la determinación de las especies de Amanita Secc. Amanita. A su vez se describe y se reevalúa la comestibilidad de Tricholoma equestre causante de un nuevo síndrome de intoxicación, por lo cual fue recientemente prohibido en varios países de la comunidad Europea.Mushrooms are not usually included in the traditional eating habits of the Argentinean population. Nevertheless, there are some people that consume wild species. This practice has caused poisoning to important number of adults and children over the last years. In the present paper we describe the Poisonous Mushroom Amanita pantherina as a new record for Argentina and we provide a key for the identification of the species of Amanita belonging to Secc. Amanita found in our country. We also describe and explain a new poisoning syndrome caused by Tricholoma equestre. This species was recently prohibited in some countries of Europe
Shigeo Nozoe - One of the best experts on this subject based on the ideXlab platform.
-
new opine type amino acids from a Poisonous Mushroom clitocybe acromelalga
Tetrahedron, 1996Co-Authors: S Fushiya, Shohei Yamada, M Matsuda, Shigeo NozoeAbstract:Four new opine type amino acids, valinopine, epileucinopine, isoleucinopine and phenylalaninopine, were isolated from a Poisonous Mushroom, Clitocybe acromelalga. The structures were determined to be 1, 2, 3 and 4, respectively, by spectroscopic analysis and chemical synthesis.
-
three new amino acids from a Poisonous Mushroom clitocybe acromelalga
Tetrahedron Letters, 1994Co-Authors: S Fushiya, Shohei Yamada, M Matsuda, Shigeo NozoeAbstract:Abstract Three new amino acids, valinopine, epi -leucinopine and isoleucinopine, were isolated from a Poisonous Mushroom, Clitocybe acromelalga . The structures were determined to be 1, 2 and 3 , respectively, by spectroscopic analysis and chemical synthesis.
-
l stizolobic acid and l stizolobinic acid from clitocybe acromelalga precursors of acromelic acids
Phytochemistry, 1992Co-Authors: Shinji Fushiya, Seiichi Sato, Shigeo NozoeAbstract:Abstract l -Stizolobic acid and l -Stizolobinic acid were isolated from the Poisonous Mushroom, Clitocybe acromelalga. The co-occurrence of these compounds and acromelic acids in the same Mushroom strongly suggests that the pyridone moieties of acromelic acids are derived biosynthetically from d -DOPA.
Bernardo E Lechner - One of the best experts on this subject based on the ideXlab platform.
-
especies toxicas de agaricales halladas en la argentina nueva cita de amanita pantherina y reevaluacion de la comestibilidad de tricholoma equestre
Boletin de la Sociedad Argentina de Botanica, 2008Co-Authors: Bernardo E Lechner, Edgardo AlbertoAbstract:Summary: Poisonous species of Agaricales found in Argentina: new record of Amanita pantherina and revaluation of the edibility of Tricholoma equestre. Mushrooms are not usually included in the traditional eating habits of the Argentinean population. Nevertheless, there are some people that consume wild species. This practice has caused poisoning to important number of adults and children over the last years. In the present paper we describe the Poisonous Mushroom Amanita pantherina as a new record for Argentina and we provide a key for the identification of the species of Amanita belonging to Secc. Amanita found in our country. We also describe and explain a new poisoning syndrome caused by Tricholoma equestre. This species was recently prohibited in some countries of Europe.
-
Especies tóxicas de Agaricales halladas en la Argentina: nueva cita de Amanita pantherina y reevaluación de la comestibilidad de Tricholoma equestre Poisonous species of Agaricales found in Argentina: new record of Amanita pantherina and revaluation
Sociedad Argentina de Botánica, 2008Co-Authors: Bernardo E Lechner, Edgardo AlbertoAbstract:Si bien los hongos comestibles en la Argentina no constituyen una parte importante de la dieta, algunas personas colectan y consumen especies silvestres. Esto ha ocasionado en los últimos años la intoxicación de un número importante de adultos y niños. En el presente trabajo se cita por primera vez para la Argentina el hongo tóxico Amanita pantherina, se describen las colecciones halladas y se provee una clave para la determinación de las especies de Amanita Secc. Amanita. A su vez se describe y se reevalúa la comestibilidad de Tricholoma equestre causante de un nuevo síndrome de intoxicación, por lo cual fue recientemente prohibido en varios países de la comunidad Europea.Mushrooms are not usually included in the traditional eating habits of the Argentinean population. Nevertheless, there are some people that consume wild species. This practice has caused poisoning to important number of adults and children over the last years. In the present paper we describe the Poisonous Mushroom Amanita pantherina as a new record for Argentina and we provide a key for the identification of the species of Amanita belonging to Secc. Amanita found in our country. We also describe and explain a new poisoning syndrome caused by Tricholoma equestre. This species was recently prohibited in some countries of Europe
Ki-hyun Kim - One of the best experts on this subject based on the ideXlab platform.
-
pantheric acids a c from a Poisonous Mushroom amanita pantherina promote lipid accumulation in adipocytes
Journal of Natural Products, 2019Co-Authors: Seoung Rak Lee, Rhim Ryoo, Ki Hong Nam, Jae Cheol Lee, Ki-hyun KimAbstract:Amanita pantherina is a Poisonous Mushroom that causes muscle cramps, insanity, and audiovisual disorders. As part of our systematic study on Korean Mushrooms, a chemical investigation of A. panthe...
-
macrocyclic trichothecene mycotoxins from a deadly Poisonous Mushroom podostroma cornu damae
Journal of Natural Products, 2019Co-Authors: Seoung Rak Lee, Rhim Ryoo, Soon Ja Seok, Sang Un Choi, Ki-hyun KimAbstract:Three new macrocyclic trichothecenes (1–3) and five known related compounds (4–8) were isolated from the MeOH extract of a plate culture of the fungus Podostroma cornu-damae, a deadly Poisonous Mushroom. Miophytocen D (1) is a rearranged macrocyclic type D trichothecene, featuring a bicyclo-[6.5]dodecahydrocyclopenta[b]chromene scaffold, and the structures of new compounds (1–3) were delineated by the combination of 1D and 2D NMR spectroscopic experiments and HRESIMS, modified Mosher’s esterification, and quantum chemical ECD calculations. The isolated compounds (1–8) were evaluated for cytotoxicity against four human breast cancer cell lines (Bt549, HCC70, MDA-MB-231, and MDA-MB-468). Compounds 4, 6, and 8 exhibited significant cytotoxic effects against the breast cancer cell lines, with IC50 values in the range of 0.02–80 nM, which is stronger than doxorubicin, the positive control, and a structure–activity relationship was suggested.
-
Macrocyclic Trichothecene Mycotoxins from a Deadly Poisonous Mushroom, Podostroma cornu-damae
2018Co-Authors: Seoung Rak Lee, Rhim Ryoo, Soon Ja Seok, Sang Un Choi, Ki-hyun KimAbstract:Three new macrocyclic trichothecenes (1–3) and five known related compounds (4–8) were isolated from the MeOH extract of a plate culture of the fungus Podostroma cornu-damae, a deadly Poisonous Mushroom. Miophytocen D (1) is a rearranged macrocyclic type D trichothecene, featuring a bicyclo-[6.5]dodecahydrocyclopenta[b]chromene scaffold, and the structures of new compounds (1–3) were delineated by the combination of 1D and 2D NMR spectroscopic experiments and HRESIMS, modified Mosher’s esterification, and quantum chemical ECD calculations. The isolated compounds (1–8) were evaluated for cytotoxicity against four human breast cancer cell lines (Bt549, HCC70, MDA-MB-231, and MDA-MB-468). Compounds 4, 6, and 8 exhibited significant cytotoxic effects against the breast cancer cell lines, with IC50 values in the range of 0.02–80 nM, which is stronger than doxorubicin, the positive control, and a structure–activity relationship was suggested
-
neomastoidin a a novel monoacylglycerol with an amino acid moiety from macrolepiota neomastoidea
Chemistry Letters, 2009Co-Authors: Ki-hyun Kim, Sang Un Choi, Kang Ro LeeAbstract:A novel monoacylglycerol with an amino acid moiety, neomastoidin A (1), was isolated from the fruiting bodies of the Poisonous Mushroom Macrolepiota neomastoidea. The structure of 1 was established...
-
macrolepiotin a new indole alkaloid from macrolepiota neomastoidea
The Journal of Antibiotics, 2009Co-Authors: Ki-hyun Kim, Sang Un Choi, Ki Moon Park, Kang Ro LeeAbstract:The fungi of the genus, Macrolepiota, are grouped under the family Agaricaceae (division Basidiomycota) and comprise B20 species. Various biological activities of the genus, Macrolepiota, have been reported, including anti-microbial, antioxidant and enzyme (trypsin, monophenolase) activities.1–5 However, few species have been studied with regard to their secondary metabolites. Only several free amino acids, fatty acids and sterols have been reported from Macrolepiota excoriata, Macrolepiota procera and Macrolepiota thacodes.6 Therefore, as part of a systematic study of Korean Mushrooms,7 we investigated the constituents of the fruiting bodies of the Mushroom Macrolepiota neomastoidea, widely distributed throughout Korea and other East Asian countries. This is a Poisonous Mushroom known to cause severe gastrointestinal symptoms, including intestinal irritation, vomiting and profuse diarrhea.8 Thus far, little work has been done on the chemical constituents of M. neomastoidea, except for the isolation of two compounds, lepiotins A and B.9 Recently, we reported the isolation of lepiotin C and (R)-5-hydroxypyrrolidin-2-one, as well as lepiotins A and B.10 As part of a continuing study, we have further isolated a new indole alkaloid named macrolepiotin (1), together with four known ergosterols, (22E,24R)-5a,8a-epidioxyergosta-6,9,22-triene-3b-ol (2),11 (22E,24R)-5a,8a-epidioxyergosta-6,22-dien-3b-ol (3),12 (24S)-ergost-7-en-3b-ol (4)13 and (22E,24R)-5a,6a-epoxyergosta-9(14),22-diene-3b,7a-diol (5).14 In this study, we describe the isolation and structural elucidation of 1 and the cytotoxic activities of compounds 1–5.
Rhim Ryoo - One of the best experts on this subject based on the ideXlab platform.
-
Trichothecene and tremulane sesquiterpenes from a hallucinogenic Mushroom Gymnopilus junonius and their cytotoxicity
Archives of Pharmacal Research, 2020Co-Authors: Rhim Ryoo, Jin Hee ChoiAbstract:Gymnopilus junonius (Fr.) P. D. Orton (Cortinariaceae) is a hallucinogenic Mushroom, a well-known Poisonous Mushroom that is widely known as "big laughter Mushroom" because it causes excessive laughter in those who consume it. Chemical investigation of G. junonius fruiting bodies was performed, resulting in the isolation and structural identification of three sesquiterpenes ( 1−3 ), including a new trichothecene sesquiterpene ( 2 ) and a new tremulane sesquiterpene ( 3 ). Compound 1 was identified from G. junonius for the first time. The chemical structures of the new compounds were established by detailed analysis of 1D and 2D (^1H–^1H correlated spectroscopy [COSY], heteronuclear single quantum coherence [HSQC], and heteronuclear multiple-bond coherence [HMBC]) nuclear magnetic resonance (NMR) spectra, and high-resolution mass spectrometry (HRMS). In particular, the absolute configurations of compounds 2 and 3 were unambiguously determined by quantum chemical electronic circular dichroism (ECD) calculations. The isolated compounds ( 1−3 ) were evaluated for their cytotoxic effects on human lung and prostate cancer cell lines where trichothecene sesquiterpenes ( 1 and 2 ) showed remarkable cytotoxicity similar to that of the control drug, i.e., doxorubicin. Our findings provide experimental evidence suggesting the potential anti-cancer effects of trichothecene sesquiterpenes from a Poisonous Mushroom.
-
pantheric acids a c from a Poisonous Mushroom amanita pantherina promote lipid accumulation in adipocytes
Journal of Natural Products, 2019Co-Authors: Seoung Rak Lee, Rhim Ryoo, Ki Hong Nam, Jae Cheol Lee, Ki-hyun KimAbstract:Amanita pantherina is a Poisonous Mushroom that causes muscle cramps, insanity, and audiovisual disorders. As part of our systematic study on Korean Mushrooms, a chemical investigation of A. panthe...
-
macrocyclic trichothecene mycotoxins from a deadly Poisonous Mushroom podostroma cornu damae
Journal of Natural Products, 2019Co-Authors: Seoung Rak Lee, Rhim Ryoo, Soon Ja Seok, Sang Un Choi, Ki-hyun KimAbstract:Three new macrocyclic trichothecenes (1–3) and five known related compounds (4–8) were isolated from the MeOH extract of a plate culture of the fungus Podostroma cornu-damae, a deadly Poisonous Mushroom. Miophytocen D (1) is a rearranged macrocyclic type D trichothecene, featuring a bicyclo-[6.5]dodecahydrocyclopenta[b]chromene scaffold, and the structures of new compounds (1–3) were delineated by the combination of 1D and 2D NMR spectroscopic experiments and HRESIMS, modified Mosher’s esterification, and quantum chemical ECD calculations. The isolated compounds (1–8) were evaluated for cytotoxicity against four human breast cancer cell lines (Bt549, HCC70, MDA-MB-231, and MDA-MB-468). Compounds 4, 6, and 8 exhibited significant cytotoxic effects against the breast cancer cell lines, with IC50 values in the range of 0.02–80 nM, which is stronger than doxorubicin, the positive control, and a structure–activity relationship was suggested.
-
Macrocyclic Trichothecene Mycotoxins from a Deadly Poisonous Mushroom, Podostroma cornu-damae
2018Co-Authors: Seoung Rak Lee, Rhim Ryoo, Soon Ja Seok, Sang Un Choi, Ki-hyun KimAbstract:Three new macrocyclic trichothecenes (1–3) and five known related compounds (4–8) were isolated from the MeOH extract of a plate culture of the fungus Podostroma cornu-damae, a deadly Poisonous Mushroom. Miophytocen D (1) is a rearranged macrocyclic type D trichothecene, featuring a bicyclo-[6.5]dodecahydrocyclopenta[b]chromene scaffold, and the structures of new compounds (1–3) were delineated by the combination of 1D and 2D NMR spectroscopic experiments and HRESIMS, modified Mosher’s esterification, and quantum chemical ECD calculations. The isolated compounds (1–8) were evaluated for cytotoxicity against four human breast cancer cell lines (Bt549, HCC70, MDA-MB-231, and MDA-MB-468). Compounds 4, 6, and 8 exhibited significant cytotoxic effects against the breast cancer cell lines, with IC50 values in the range of 0.02–80 nM, which is stronger than doxorubicin, the positive control, and a structure–activity relationship was suggested