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Polychlorinated Biphenyls
The Experts below are selected from a list of 267 Experts worldwide ranked by ideXlab platform
Sharon K. Sagiv – One of the best experts on this subject based on the ideXlab platform.
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Polychlorinated Biphenyls, organochlorine pesticides and neurodevelopment.
Current Opinion in Pediatrics, 2008Co-Authors: Susan A. Korrick, Sharon K. SagivAbstract:Purpose of reviewAlthough environmental levels of Polychlorinated Biphenyls and certain organochlorine pestpesticides – hexachlorobenzene, dichlorodiphenyl trichloroethane and its primary metabolite, dichlorodiphenyl dichloroethene – are generally on the decline, early-life exposures to these prevalent
Susan A. Korrick – One of the best experts on this subject based on the ideXlab platform.
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Polychlorinated Biphenyls, organochlorine pesticides and neurodevelopment.
Current Opinion in Pediatrics, 2008Co-Authors: Susan A. Korrick, Sharon K. SagivAbstract:Purpose of reviewAlthough environmental levels of Polychlorinated Biphenyls and certain organochlorine pesticides – hexachlorobenzene, dichlorodiphenyl trichloroethane and its primary metabolite, dichlorodiphenyl dichloroethene – are generally on the decline, early-life exposures to these prevalent
Kurt Straif – One of the best experts on this subject based on the ideXlab platform.
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Carcinogenicity of Polychlorinated Biphenyls and polybrominated Biphenyls
Lancet Oncology, 2013Co-Authors: Béatrice Lauby-secretan, Dana Loomis, Yann Grosse, Fatiha El Ghissassi, Véronique Bouvard, Lamia Benbrahim-tallaa, Neela Guha, Robert Baan, Heidi Mattock, Kurt StraifAbstract:Carcinogenicity of Polychlorinated Biphenyls and polybrominated Biphenyls
A.l. Prignano – One of the best experts on this subject based on the ideXlab platform.
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Toxic Substances Control Act Polychlorinated Biphenyls (PCB) Hanford Site Users Guide
, 2002Co-Authors: A.l. PrignanoAbstract:The U.S Department of Energy, Richland Operations Office and the Office of River Protection, requested the development of an integrated and consistent approach to management of Polychlorinated Biphenyls on the Hanford Site. Under their respective contracts, the Hanford Site contractors are required to comply with Polychlorinated biphenyl regulations under the Toxic Substances Control Act of 1976. The objective of this Toxic Substances Control Act Polychlorinated Biphenyls Hanford Site Users Guide is to establish consistent guidance for use by Hanford Site contractors for managing Polychlorinated Biphenyls. Polychlorinated Biphenyls have been identified in some Hanford Site waste, and based on the experiences of the rest of the US. Department of Energy Complex, Polychlorinated Biphenyls could be expected to be found in an even wider variety of waste. Because of the unique and often cumbersome regulatory requirements that apply to management of Polychlorinated Biphenyls and Polychlorinated biphenyl contaminated materials, the U.S. Department of Energy instructed the contractors to use a proactive approach to develop a Polychlorinated Biphenyls Hanford Site User’s Guide to ensure an integrated and consistent approach to management of Toxic Substances Control Act regulated Polychlorinated Biphenyls in the most cost-effective and compliant manner. Implementation of Toxic Substances Control Act regulated Polychlorinatedmore » biphenyl requirements on the Hanford Site is accomplished through three paths. One path is the application of the regulations as written to the management of waste contaminated with Polychlorinated Biphenyls. The U.S. Environmental Protection Agency provides clarification to the regulations through a series of technical references posted on their web site and via questions and answers for the regulated community.« less
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Toxic Substances Control Act Polychlorinated Biphenyls (PCB) Hanford Site Users Guide
, 2002Co-Authors: A.l. PrignanoAbstract:The U.S Department of Energy, Richland Operations Office and the Office of River Protection, requested the development of an integrated and consistent approach to management of Polychlorinated Biphenyls on the Hanford Site. Under their respective contracts, the Hanford Site contractors are required to comply with Polychlorinated biphenyl regulations under the Toxic Substances Control Act of 1976. The objective of this Toxic Substances Control Act Polychlorinated Biphenyls Hanford Site Users Guide is to establish consistent guidance for use by Hanford Site contractors for managing Polychlorinated Biphenyls. Polychlorinated Biphenyls have been identified in some Hanford Site waste, and based on the experiences of the rest of the US. Department of Energy Complex, Polychlorinated Biphenyls could be expected to be found in an even wider variety of waste. Because of the unique and often cumbersome regulatory requirements that apply to management of Polychlorinated Biphenyls and Polychlorinated biphenyl contaminated materials, the U.S. Department of Energy instructed the contractors to use a proactive approach to develop a Polychlorinated Biphenyls Hanford Site User’s Guide to ensure an integrated and consistent approach to management of Toxic Substances Control Act regulated Polychlorinated Biphenyls in the most cost-effective and compliant manner. Implementation of Toxic Substances Control Act regulated Polychlorinatedmore » biphenyl requirements on the Hanford Site is accomplished through three paths. One path is the application of the regulations as written to the management of waste contaminated with Polychlorinated Biphenyls. The U.S. Environmental Protection Agency provides clarification to the regulations through a series of technical references posted on their web site and via questions and answers for the regulated community.« less
Sandra W. Jacobson – One of the best experts on this subject based on the ideXlab platform.
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Intellectual Impairment in Children Exposed to Polychlorinated Biphenyls in Utero
The New England Journal of Medicine, 1996Co-Authors: Joseph L. Jacobson, Sandra W. JacobsonAbstract:Background In utero exposure to Polychlorinated Biphenyls, a ubiquitous environmental contaminant, has been linked to adverse effects on neurologic and intellectual function in infants and young children. We assessed whether these effects persist through school age and examined their importance in the acquisition of reading and arithmetic skills. Methods We tested 212 children, recruited as newborns to overrepresent infants born to women who had eaten Lake Michigan fish contaminated with Polychlorinated Biphenyls. A battery of IQ and achievement tests was administered when the children were 11 years of age. Concentrations of Polychlorinated Biphenyls in maternal serum and milk at delivery were slightly higher than in the general population. A composite measure of prenatal exposure was derived from concentrations in umbilical-cord serum and maternal serum and milk. Results Prenatal exposure to Polychlorinated Biphenyls was associated with lower full-scale and verbal IQ scores after control for potential co…
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intellectual impairment in children exposed to Polychlorinated Biphenyls in utero
The New England Journal of Medicine, 1996Co-Authors: Joseph L. Jacobson, Sandra W. JacobsonAbstract:BACKGROUND: In utero exposure to Polychlorinated Biphenyls, a ubiquitous environmental contaminant, has been linked to adverse effects on neurologic and intellectual function in infants and young children. We assessed whether these effects persist through school age and examined their importance in the acquisition of reading and arithmetic skills. METHODS: We tested 212 children, recruited as newborns to overrepresent infants born to women who had eaten Lake Michigan fish contaminated with Polychlorinated Biphenyls. A battery of IQ and achievement tests was administered when the children were 11 years of age. Concentrations of Polychlorinated Biphenyls in maternal serum and milk at delivery were slightly higher than in the general population. A composite measure of prenatal exposure was derived from concentrations in umbilical-cord serum and maternal serum and milk. RESULTS: Prenatal exposure to Polychlorinated Biphenyls was associated with lower full-scale and verbal IQ scores after control for potential confounding variables such as socioeconomic status (P = 0.02). The strongest effects related to memory and attention. The most highly exposed children were three times as likely to have low average IQ scores (P <0.001) and twice as likely to be at least two years behind in reading comprehension (P = 0.03). Although larger quantities of Polychlorinated Biphenyls are transferred by breast-feeding than in utero, there were deficits only in associated with transplacental exposure, suggesting that the developing fetal brain is particularly sensitive to these compounds. CONCLUSIONS: In utero exposure to Polychlorinated Biphenyls in concentrations slightly higher than those in the general population can have a long-term impact on intellectual function.