The Experts below are selected from a list of 7194 Experts worldwide ranked by ideXlab platform

Yi Deng - One of the best experts on this subject based on the ideXlab platform.

  • graphene oxide decorated microporous Polyetheretherketone with superior antibacterial capability and in vitro osteogenesis for orthopedic implant
    Macromolecular Bioscience, 2018
    Co-Authors: Ling Ouyang, Yi Deng, Lei Yang, Weizhong Yang, Zhigang Chen, Taosheng Dong
    Abstract:

    Due to its similar elastic modulus of human bones, Polyetheretherketone (PEEK) has been considered as an excellent cytocompatible material. However, the bioinertness, poor osteoconduction, and weak antibacterial activity of PEEK limit its wide applications in clinics. In this study, a facile strategy is developed to prepare graphene oxide (GO) modified sulfonated Polyetheretherketone (SPEEK) (GO-SPEEK) through a simple dip-coating method. After detailed characterization, it is found that the GO closely deposits on the surface of PEEK, which is attributed to the π-π stacking interaction between PEEK and GO. Antibacterial tests reveal that the GO-SPEEK exhibits excellent suppression toward Escherichia coli. In vitro cell attachment, growth, differentiation, alkaline phosphatase activity, quantitative real-time polymerase chain reaction analyses, and calcium mineral deposition all illustrate that the GO-SPEEK substrate can significantly accelerate the proliferation and osteogenic differentiation of osteoblast-like MG-63 cells compared with those on PEEK and SPEEK groups. These results suggest that the GO-SPEEK has an improved antibacterial activity and cytocompatibility in vitro, showing that the developed GO-SPEEK has a great potential as the bioactive implant material in bone tissue engineering.

  • Dual Ag/ZnO-Decorated Micro-/Nanoporous Sulfonated Polyetheretherketone with Superior Antibacterial Capability and Biocompatibility via Layer-by-Layer Self-Assembly Strategy.
    Macromolecular Bioscience, 2018
    Co-Authors: Yi Deng, Lei Yang, Xiaobing Huang, Junhong Chen, Xiuyuan Shi, Weizhong Yang, Min Hong, Yuan Wang, Matthew S. Dargusch, Zhigang Chen
    Abstract:

    Polyetheretherketone is attractive for dental and orthopedic applications due to its mechanical attributes close to that of human bone; however, the lack of antibacterial capability and bioactivity of Polyetheretherketone has substantially impeded its clinical applications. Here, a dual therapy implant coating is developed on the 3D micro-/nanoporous sulfonated Polyetheretherketone via layer-by-layer self-assembly of Ag ions and Zn ions. Material characterization studies have indicated that nanoparticles consisting of elemental Ag and ZnO are uniformly incorporated on the porous sulfonated Polyetheretherketone surface. The antibacterial assays demonstrate that Ag-decorated sulfonated Polyetheretherketone and Ag/ZnO-codecorated sulfonated Polyetheretherketone effectively inhibit the reproduction of Gram-negative and Gram-positive bacteria. Owing to the coordination of micro-/nanoscale topological cues and Zn induction, the Ag/ZnO-codecorated sulfonated Polyetheretherketone substrates are found to enhance biocompatibility (cell viability, spreading, and proliferation), and hasten osteodifferentiation and -maturation (alkaline phosphate activity (ALP) production, and osteogenesis-related genetic expression), compared with the Ag-decorated sulfonated Polyetheretherketone and the ZnO-decorated sulfonated Polyetheretherketone counterparts. The dual therapy Ag/ZnO-codecorated sulfonated Polyetheretherketone has an appealing bacteriostatic performance and osteogenic differentiation potential, showing great potential for dental and orthopedic implants.

  • preparation characterization cellular response and in vivo osseointegration of Polyetheretherketone nano hydroxyapatite carbon fiber ternary biocomposite
    Colloids and Surfaces B: Biointerfaces, 2015
    Co-Authors: Yi Deng, Xiaochen Liu, Ping Zhou, Lixin Wang, Xiaoling Xiong, Zhihui Tang, Jie Wei, Shicheng Wei
    Abstract:

    As FDA-approved implantable material, Polyetheretherketone (PEEK) is becoming a prime candidate to replace traditional surgical metallic implants made of titanium (Ti) and its alloys, since it has a lower elastic modulus than Ti. The bioinertness and defective osteointegration of PEEK, however, limit its clinical adoption as load-bearing dental/orthopedic material. The present work aimed at developing a PEEK bioactive ternary composite, Polyetheretherketone/nano-hydroxyapatite/carbon fiber (PEEK/n-HA/CF), and evaluating it as a potential bone-repairing material by assessment of growth and differentiation of osteoblast-like MG63 cells and by estimation of osteointegration in vivo. Our results indicated that the adhesion, proliferation and osteogenic differentiation of cells, as well as the mechanical properties were greatly promoted for the PEEK/n-HA/CF biocomposite compared with pure PEEK matrix. More importantly, the ternary composite implant boosted in vivo bioactivity and osseointegration in canine tooth defect model. Thus, the PEEK/n-HA/CF ternary biocomposite with enhanced mechanics and biological performances hold great potential as bioactive implant material in dental and orthopedic applications.

  • enhancement of osteogenesis on micro nano topographical carbon fiber reinforced Polyetheretherketone nanohydroxyapatite biocomposite
    Materials Science and Engineering: C, 2015
    Co-Authors: Xiaochen Liu, Yi Deng, Xiang Gao, Feng Deng, Shicheng Wei
    Abstract:

    As an FDA-approved implantable material, carbon fiber-reinforced Polyetheretherketone (CFRPEEK) possesses excellent mechanical properties similar to those of human cortical bone and is a prime candidate to replace conventional metallic implants. The bioinertness and inferior osteogenic properties of CFRPEEK, however, limit its clinical application as orthopedic/dental implants. The present work aimed at developing a novel carbon fiber-reinforced Polyetheretherketone-nanohydroxyapatite (PEEK/CF/n-HA) ternary biocomposite with micro/nano-topographical surface for the enhancement of the osteogenesis as a potential bioactive material for bone grafting and bone tissue-engineering applications. The combined modification of oxygen plasma and sand-blasting could improve the hydrophily and generate micro/nano-topographical structures on the surface of the CFRPEEK-based ternary biocomposite. The results clearly showcased that the micro-/nano-topographical PEEK/n-HA/CF ternary biocomposite demonstrated the outstanding ability to promote the proliferation and differentiation of MG-63 cells in vitro as well as to boost the osseointegration between implant and bone in vivo, thereby boding well application to bone tissue engineering.

  • Polyetheretherketone nano fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties
    Biomaterials, 2014
    Co-Authors: Lixin Wang, Yi Deng, Feng Deng, Shicheng Wei, Jie Wei, Shanshan Liang
    Abstract:

    Lack of antibacterial activity and binding ability to natural bone tissue has significantly limited Polyetheretherketone (PEEK) for many challenging dental implant applications. Here, we have developed a Polyetheretherketone/nano-fluorohydroxyapatite (PEEK/nano-FHA) biocomposite with enhanced antibacterial activity and osseointegration through blending method. Smooth and rough surfaces of PEEK/nano-FHA biocomposites were also prepared. Our results showed that in vitro initial cell adhesion and proliferation on the nano-FHA reinforced PEEK composite were improved. In addition, higher alkaline phosphatase activity and cell mineralization were also detected in cells cultured on PEEK/nano-FHA biocomposites, especially for rough PEEK/nano-FHA surfaces. More importantly, the as-prepared PEEK/nano-FHA biocomposite could effectively prevent the proliferation and biofilm formation of bacterial. For in vivo test, the newly formed bone volume of PEEK/nano-FHA group was higher than that of bare PEEK group based on 3D microcomputed tomography and 2D histomorphometric analysis. These reports demonstrate that the developed PEEK/nano-FHA biocomposite has increased biocompatibility and antibacterial activity in vitro, and promoted osseointegration in vivo, which suggests that it holds potential to be applied as dental implant material in dental tissue engineering applications.

Zhigang Chen - One of the best experts on this subject based on the ideXlab platform.

  • graphene oxide decorated microporous Polyetheretherketone with superior antibacterial capability and in vitro osteogenesis for orthopedic implant
    Macromolecular Bioscience, 2018
    Co-Authors: Ling Ouyang, Yi Deng, Lei Yang, Weizhong Yang, Zhigang Chen, Taosheng Dong
    Abstract:

    Due to its similar elastic modulus of human bones, Polyetheretherketone (PEEK) has been considered as an excellent cytocompatible material. However, the bioinertness, poor osteoconduction, and weak antibacterial activity of PEEK limit its wide applications in clinics. In this study, a facile strategy is developed to prepare graphene oxide (GO) modified sulfonated Polyetheretherketone (SPEEK) (GO-SPEEK) through a simple dip-coating method. After detailed characterization, it is found that the GO closely deposits on the surface of PEEK, which is attributed to the π-π stacking interaction between PEEK and GO. Antibacterial tests reveal that the GO-SPEEK exhibits excellent suppression toward Escherichia coli. In vitro cell attachment, growth, differentiation, alkaline phosphatase activity, quantitative real-time polymerase chain reaction analyses, and calcium mineral deposition all illustrate that the GO-SPEEK substrate can significantly accelerate the proliferation and osteogenic differentiation of osteoblast-like MG-63 cells compared with those on PEEK and SPEEK groups. These results suggest that the GO-SPEEK has an improved antibacterial activity and cytocompatibility in vitro, showing that the developed GO-SPEEK has a great potential as the bioactive implant material in bone tissue engineering.

  • Dual Ag/ZnO-Decorated Micro-/Nanoporous Sulfonated Polyetheretherketone with Superior Antibacterial Capability and Biocompatibility via Layer-by-Layer Self-Assembly Strategy.
    Macromolecular Bioscience, 2018
    Co-Authors: Yi Deng, Lei Yang, Xiaobing Huang, Junhong Chen, Xiuyuan Shi, Weizhong Yang, Min Hong, Yuan Wang, Matthew S. Dargusch, Zhigang Chen
    Abstract:

    Polyetheretherketone is attractive for dental and orthopedic applications due to its mechanical attributes close to that of human bone; however, the lack of antibacterial capability and bioactivity of Polyetheretherketone has substantially impeded its clinical applications. Here, a dual therapy implant coating is developed on the 3D micro-/nanoporous sulfonated Polyetheretherketone via layer-by-layer self-assembly of Ag ions and Zn ions. Material characterization studies have indicated that nanoparticles consisting of elemental Ag and ZnO are uniformly incorporated on the porous sulfonated Polyetheretherketone surface. The antibacterial assays demonstrate that Ag-decorated sulfonated Polyetheretherketone and Ag/ZnO-codecorated sulfonated Polyetheretherketone effectively inhibit the reproduction of Gram-negative and Gram-positive bacteria. Owing to the coordination of micro-/nanoscale topological cues and Zn induction, the Ag/ZnO-codecorated sulfonated Polyetheretherketone substrates are found to enhance biocompatibility (cell viability, spreading, and proliferation), and hasten osteodifferentiation and -maturation (alkaline phosphate activity (ALP) production, and osteogenesis-related genetic expression), compared with the Ag-decorated sulfonated Polyetheretherketone and the ZnO-decorated sulfonated Polyetheretherketone counterparts. The dual therapy Ag/ZnO-codecorated sulfonated Polyetheretherketone has an appealing bacteriostatic performance and osteogenic differentiation potential, showing great potential for dental and orthopedic implants.

Shicheng Wei - One of the best experts on this subject based on the ideXlab platform.

  • preparation characterization cellular response and in vivo osseointegration of Polyetheretherketone nano hydroxyapatite carbon fiber ternary biocomposite
    Colloids and Surfaces B: Biointerfaces, 2015
    Co-Authors: Yi Deng, Xiaochen Liu, Ping Zhou, Lixin Wang, Xiaoling Xiong, Zhihui Tang, Jie Wei, Shicheng Wei
    Abstract:

    As FDA-approved implantable material, Polyetheretherketone (PEEK) is becoming a prime candidate to replace traditional surgical metallic implants made of titanium (Ti) and its alloys, since it has a lower elastic modulus than Ti. The bioinertness and defective osteointegration of PEEK, however, limit its clinical adoption as load-bearing dental/orthopedic material. The present work aimed at developing a PEEK bioactive ternary composite, Polyetheretherketone/nano-hydroxyapatite/carbon fiber (PEEK/n-HA/CF), and evaluating it as a potential bone-repairing material by assessment of growth and differentiation of osteoblast-like MG63 cells and by estimation of osteointegration in vivo. Our results indicated that the adhesion, proliferation and osteogenic differentiation of cells, as well as the mechanical properties were greatly promoted for the PEEK/n-HA/CF biocomposite compared with pure PEEK matrix. More importantly, the ternary composite implant boosted in vivo bioactivity and osseointegration in canine tooth defect model. Thus, the PEEK/n-HA/CF ternary biocomposite with enhanced mechanics and biological performances hold great potential as bioactive implant material in dental and orthopedic applications.

  • enhancement of osteogenesis on micro nano topographical carbon fiber reinforced Polyetheretherketone nanohydroxyapatite biocomposite
    Materials Science and Engineering: C, 2015
    Co-Authors: Xiaochen Liu, Yi Deng, Xiang Gao, Feng Deng, Shicheng Wei
    Abstract:

    As an FDA-approved implantable material, carbon fiber-reinforced Polyetheretherketone (CFRPEEK) possesses excellent mechanical properties similar to those of human cortical bone and is a prime candidate to replace conventional metallic implants. The bioinertness and inferior osteogenic properties of CFRPEEK, however, limit its clinical application as orthopedic/dental implants. The present work aimed at developing a novel carbon fiber-reinforced Polyetheretherketone-nanohydroxyapatite (PEEK/CF/n-HA) ternary biocomposite with micro/nano-topographical surface for the enhancement of the osteogenesis as a potential bioactive material for bone grafting and bone tissue-engineering applications. The combined modification of oxygen plasma and sand-blasting could improve the hydrophily and generate micro/nano-topographical structures on the surface of the CFRPEEK-based ternary biocomposite. The results clearly showcased that the micro-/nano-topographical PEEK/n-HA/CF ternary biocomposite demonstrated the outstanding ability to promote the proliferation and differentiation of MG-63 cells in vitro as well as to boost the osseointegration between implant and bone in vivo, thereby boding well application to bone tissue engineering.

  • Polyetheretherketone nano fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties
    Biomaterials, 2014
    Co-Authors: Lixin Wang, Yi Deng, Feng Deng, Shicheng Wei, Jie Wei, Shanshan Liang
    Abstract:

    Lack of antibacterial activity and binding ability to natural bone tissue has significantly limited Polyetheretherketone (PEEK) for many challenging dental implant applications. Here, we have developed a Polyetheretherketone/nano-fluorohydroxyapatite (PEEK/nano-FHA) biocomposite with enhanced antibacterial activity and osseointegration through blending method. Smooth and rough surfaces of PEEK/nano-FHA biocomposites were also prepared. Our results showed that in vitro initial cell adhesion and proliferation on the nano-FHA reinforced PEEK composite were improved. In addition, higher alkaline phosphatase activity and cell mineralization were also detected in cells cultured on PEEK/nano-FHA biocomposites, especially for rough PEEK/nano-FHA surfaces. More importantly, the as-prepared PEEK/nano-FHA biocomposite could effectively prevent the proliferation and biofilm formation of bacterial. For in vivo test, the newly formed bone volume of PEEK/nano-FHA group was higher than that of bare PEEK group based on 3D microcomputed tomography and 2D histomorphometric analysis. These reports demonstrate that the developed PEEK/nano-FHA biocomposite has increased biocompatibility and antibacterial activity in vitro, and promoted osseointegration in vivo, which suggests that it holds potential to be applied as dental implant material in dental tissue engineering applications.

  • Polyetheretherketone/nano-fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties.
    Biomaterials, 2014
    Co-Authors: Lixin Wang, Yi Deng, Feng Deng, Jie Wei, Shanshan Liang, Shicheng Wei
    Abstract:

    Lack of antibacterial activity and binding ability to natural bone tissue has significantly limited Polyetheretherketone (PEEK) for many challenging dental implant applications. Here, we have developed a Polyetheretherketone/nano-fluorohydroxyapatite (PEEK/nano-FHA) biocomposite with enhanced antibacterial activity and osseointegration through blending method. Smooth and rough surfaces of PEEK/nano-FHA biocomposites were also prepared. Our results showed that in vitro initial cell adhesion and proliferation on the nano-FHA reinforced PEEK composite were improved. In addition, higher alkaline phosphatase activity and cell mineralization were also detected in cells cultured on PEEK/nano-FHA biocomposites, especially for rough PEEK/nano-FHA surfaces. More importantly, the as-prepared PEEK/nano-FHA biocomposite could effectively prevent the proliferation and biofilm formation of bacterial. For in vivo test, the newly formed bone volume of PEEK/nano-FHA group was higher than that of bare PEEK group based on 3D microcomputed tomography and 2D histomorphometric analysis. These reports demonstrate that the developed PEEK/nano-FHA biocomposite has increased biocompatibility and antibacterial activity in vitro, and promoted osseointegration in vivo, which suggests that it holds potential to be applied as dental implant material in dental tissue engineering applications.

Zhiqiang Wang - One of the best experts on this subject based on the ideXlab platform.

Alois K Schlarb - One of the best experts on this subject based on the ideXlab platform.

  • Mechanical and thermal behaviours of Polyetheretherketone-based multi-scale composites
    Journal of Composite Materials, 2012
    Co-Authors: Ly Lin, H Tlatlik, R Gralla, Ma Igartua, P. De Baets, Alois K Schlarb
    Abstract:

    In this study, Polyetheretherketone composites were compounded using a two-screw extruder followed by injection moulding. The effects of multi-fillers on the mechanical properties and crystallizati...

  • morphologies of the wear debris of Polyetheretherketone produced under dry sliding conditions correlation with wear mechanisms
    Wear, 2009
    Co-Authors: Ga Zhang, Alois K Schlarb
    Abstract:

    Abstract Wear debris contains extensive information on the tribological behaviours of materials [M.Q. Zhang, Z.P. Lu, K. Friedrich, On the wear debris of Polyetheretherketone: fractal dimensions in relation to wear mechanisms, Tribol. Int. 30 (1997) 87–102]. Investigations on wear debris morphology will be helpful for understanding materials’ friction and wear processes. In this work, the wear debris obtained from block-on-ring (BOR) tests of three Polyetheretherketones (PEEKs) with different molecular weights was studied. The mechanical properties of the three PEEKs were characterized in a previous work [G. Zhang, A.K. Schlarb, Correlation of the tribological behaviors with the mechanical properties of poly-ether-ether-ketones (PEEKs) with different molecular weights and their fiber filled composites, Wear, 2008, in press]. In this work, the influences of the mechanical properties of PEEKs and apparent pressure on wear debris morphology were studied. Based on analyzing wear debris morphologies, possibly involved tribological mechanisms were discussed. The results indicate that the tribological mechanisms have a close relationship with the morphology of the wear debris. Under low pressures, particle-like wear debris suggests that the micro-cutting effect exerted by the protruding regions of the counterpart dominates the tribological behaviour. Under high pressures, rod-like, bamboo-raft-like and film-like debris were noticed. This fact suggests that the transferring of PEEK to the counterpart and the plastic flow occurring in the PEEK surface layer play important roles on material loss.