The Experts below are selected from a list of 693 Experts worldwide ranked by ideXlab platform
Choul Yong Park - One of the best experts on this subject based on the ideXlab platform.
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Low recurrence rate of anchored conjunctival rotation flap technique in pterygium surgery.
BMC Ophthalmology, 2017Co-Authors: Dong Ju Kim, Roy S Chuck, Jimmy K. Lee, Choul Yong ParkAbstract:To report the recurrence rate for an anchored conjunctival rotation flap technique in primary pterygium surgery. Primary pterygium surgeries performed using anchored conjunctival rotation flap techniques (110 eyes in 110 patients) with a minimum follow-up of 12 months were reviewed. In this technique, a conjunctival flap is rotated to cover the bare sclera and Suture-fixated with either 8–0 Polyglactin (41 eyes) or 10–0 nylon (69 eyes). The recurrence rate was determined, and the two Suture materials utilized were compared. The recurrence rate was 2.71% (3 cases in 110 eyes) when an anchored conjunctival rotation flap technique was used and patients were monitored for 26.40 ± 17.09 months. Interestingly, the recurrences were only observed in Polyglactin-Sutured eyes. No recurrence was detected in nylon-Sutured eyes. No other complications were observed in either group. The anchored conjunctival rotation flap technique for pterygium surgery has a relatively low recurrence rate. Nylon Suture-fixation of the flap was found to be superior to Polyglactin Suture-fixation in preventing recurrence.
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Low recurrence rate of anchored conjunctival rotation flap technique in pterygium surgery
BMC, 2017Co-Authors: Dong Ju Kim, Roy S Chuck, Jimmy K. Lee, Choul Yong ParkAbstract:Abstract Background To report the recurrence rate for an anchored conjunctival rotation flap technique in primary pterygium surgery. Methods Primary pterygium surgeries performed using anchored conjunctival rotation flap techniques (110 eyes in 110 patients) with a minimum follow-up of 12 months were reviewed. In this technique, a conjunctival flap is rotated to cover the bare sclera and Suture-fixated with either 8–0 Polyglactin (41 eyes) or 10–0 nylon (69 eyes). The recurrence rate was determined, and the two Suture materials utilized were compared. Results The recurrence rate was 2.71% (3 cases in 110 eyes) when an anchored conjunctival rotation flap technique was used and patients were monitored for 26.40 ± 17.09 months. Interestingly, the recurrences were only observed in Polyglactin-Sutured eyes. No recurrence was detected in nylon-Sutured eyes. No other complications were observed in either group. Conclusions The anchored conjunctival rotation flap technique for pterygium surgery has a relatively low recurrence rate. Nylon Suture-fixation of the flap was found to be superior to Polyglactin Suture-fixation in preventing recurrence
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the role of macrophage migration inhibitory factor in ocular surface disease pathogenesis after chemical burn in the murine eye
Molecular Vision, 2010Co-Authors: Sei Yeul Oh, Roy S Chuck, Jong-sun Choi, Choul Yong ParkAbstract:PURPOSE: To evaluate the role of macrophage migration inhibitory factor (MIF) in the wound healing process following severe chemical burns to the ocular surface. METHODS: Chemical burning of the ocular surface was induced in mice (C57BL/6) via the application of 0.1 M NaOH. Macrophage migration inhibitory factor (MIF), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) mRNA expression in the ocular surface and lacrimal gland was evaluated via real-time reverse transcription PCR on days 2, 7, and 30 after induction of the chemical burn. The expression of MIF protein in the ocular surface and lacrimal gland was evaluated via western blot analysis. Immunohistochemical staining was conducted to detect MIF and vasculoendothelial growth factor in the cornea during the wound healing process. The angiogenic role of MIF was further evaluated using an 8-0 Polyglactin Suture technique to induce corneal neovascularization. RESULTS: MIF, TNF-α, and IL-1β mRNA expression were elevated significantly in the ocular surface up to day 30 after chemical burn induction. TNF-α alone was elevated in the lacrimal gland. MIF protein elevation was confirmed via western blot analysis, and the spatial similarity of MIF and VEGF expression in the cornea was noted during the wound healing process. 8-0 Polyglactin Sutures soaked in MIF induced significantly higher numbers of new vessels on the mouse cornea after 7 days (p=0.003, Mann-Whitney test). CONCLUSIONS: These findings indicate that MIF performs a crucial role in wound healing on the ocular surface after the induction of chemical burns.
Lisa A. Rivera - One of the best experts on this subject based on the ideXlab platform.
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Predicting Stricture in Morbidly Obese Patients Undergoing Laparoscopic Roux-en-Y Gastric Bypass: A Logistic Regression Analysis
Journal of Gastrointestinal Surgery, 2007Co-Authors: Robin P. Blackstone, Lisa A. RiveraAbstract:Gastrojejunostomy stricture after Roux-en-Y gastric bypass occurs in 3 to 27% of morbidly obese patients in the USA. We questioned whether preoperative patient characteristics, including demographic attributes and comorbid disease, might be significant factors in the etiology of stricture. In this study from November 2001 to February 2006 (51 months), at a high-volume bariatric center, of the 1,351 patients who underwent laparoscopic gastric bypass, 92 developed stricture (6.8%). All but two were treated successfully by endoscopic dilation. All patients stopped nonsteroidal anti-inflammatory medications 2 weeks prior to surgery and did not restart them. The operative procedure included the use of a 21-mm transoral circular stapler to create the gastrojejunostomy; the Roux limb was brought retrogastric, retrocolic. In an effort to reduce our center’s stricture rate, late in the study, U-clips used at the gastrojejunostomy were replaced by absorbable Sutures, and postoperative H_2 antagonists were added to the treatment protocol. The change to absorbable Polyglactin Suture proved to be significant, resulting in a lower stricture rate. The addition of H_2 antagonists showed no significant effect. Following the retrospective review of the prospective database, univariate and multivariate logistic regression analyses identified factors associated with the development of stricture. Gastroesophageal reflux disease and age were each shown to be statistically significant independent predictors of stricture following laparoscopic gastric bypass.
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Predicting Stricture in Morbidly Obese Patients Undergoing Laparoscopic Roux-en-Y Gastric Bypass: A Logistic Regression Analysis
2007Co-Authors: Robin P. Blackstone, Lisa A. RiveraAbstract:stricture after Roux-en-Y gastric bypass occurs in 3 to 27 % of morbidly obese patients in the USA. We questioned whether preoperative patient characteristics, including demographic attributes and comorbid disease, might be significant factors in the etiology of stricture. In this study from November 2001 to February 2006 (51 months), at a high-volume bariatric center, of the 1,351 patients who underwent laparoscopic gastric bypass, 92 developed stricture (6.8%). All but two were treated successfully by endoscopic dilation. All patients stopped nonsteroidal anti-inflammatory medications 2 weeks prior to surgery and did not restart them. The operative procedure included the use of a 21-mm transoral circular stapler to create the gastrojejunostomy; the Roux limb was brought retrogastric, retrocolic. In an effort to reduce our center’s stricture rate, late in the study, U-clips used at the gastrojejunostomy were replaced by absorbable Sutures, and postoperative H2 antagonists were added to the treatment protocol. The change to absorbable Polyglactin Suture proved to be significant, resulting in a lower stricture rate. The addition of H 2 antagonists showed no significant effect. Following the retrospective review of the prospective database, univariate and multivariate logistic regression analyses identified factors associated with the development of stricture. Gastroesophageal reflux disease and age were each shown to be statistically significant independent predictors of stricture following laparoscopic gastric bypass
Jim C Hu - One of the best experts on this subject based on the ideXlab platform.
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randomized controlled trial of barbed polyglyconate versus Polyglactin Suture for robot assisted laparoscopic prostatectomy anastomosis technique and outcomes
European Urology, 2010Co-Authors: Stephen B Williams, Mehrdad Alemozaffar, Blakely A Plaster, Nathanael D Hevelone, Stuart R. Lipsitz, Jim C HuAbstract:Abstract Background Transperitoneal robot-assisted laparoscopic prostatectomy (RALP) urethrovesical anastomosis is a critical step. Although the prevalence of urine leaks ranges from 4.5% to 7.5% at high-volume RALP centers, urine leaks prolong catheterization and may lead to ileus, peritonitis, and require intervention. Barbed polyglyconate Sutures maintain running Suture line tension and may be advantageous in RALP anastomosis for reducing this complication. Objective To compare barbed polyglyconate and Polyglactin 910 (Vicryl, Ethicon, Somerville, NJ, USA) running Sutures for RALP anastomosis. Design, setting, and participants This was a prospective, randomized, controlled, single-surgeon study comparing RALP anastomosis using either barbed polyglyconate ( n =45) or Polyglactin 910 ( n =36) Sutures. Surgical procedure RALP anastomosis using either barbed polyglyconate or Polyglactin 910 Sutures was studied. Measurements Operative time, cost differential, perioperative complications, and cystogram contrast extravasation by anastomosis Suture type were measured. Results and limitations Although baseline characteristics and overall operative times were similar, barbed polyglyconate Sutures were associated with shorter mean anastomosis times of 9.7min versus 9.8min ( p =0.014). In addition, anastomosis with barbed polyglyconate rather than Polyglactin 910 Sutures was associated with more frequent cystogram extravasation 8 d postoperatively (20.0% vs 2.8%; p =0.019), longer mean catheterization times (11.1 d vs 8.3 d; p =0.048), and greater Suture costs per case ($51.52 vs $8.44; p Conclusions Compared to traditional Sutures, barbed polyglyconate is more costly and requires technical modification to avoid overtightening, delayed healing, and longer catheterization time following RALP.
Chunfeng Zhao - One of the best experts on this subject based on the ideXlab platform.
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a canine non weight bearing model with radial neurectomy for rotator cuff repair
PLOS ONE, 2015Co-Authors: Nirong Bao, Peter C Amadio, Scott P Steinmann, Chunfeng ZhaoAbstract:Background The major concern of using a large animal model to study rotator cuff repair is the high rate of repair retears. The purpose of this study was to test a non-weight-bearing (NWB) canine model for rotator cuff repair research. Methods First, in the in vitro study, 18 shoulders were randomized to 3 groups. 1) Full-width transections repaired with modified Mason-Allen Sutures using 3-0 Polyglactin Suture, 2) Group 1 repaired using number 2 (#2) polyester braid and long-chain polyethylene Suture, and 3) Partial-width transections leaving the superior 2 mm infraspinatus tendon intact without repair. In the in vivo study of 6 dogs, the infraspinatus tendon was partially transected as the same as the in vitro group 3. A radial neurectomy was performed to prevent weight bearing. The operated limb was slung in a custom-made jacket for 6 weeks. Results In the in vitro study, mean ultimate tensile load and stiffness in Group 2 were significantly higher than Group 1 and 3 (p<0.05). In the in vivo study, gross inspection and histology showed that the preserved superior 2-mm portion of the infraspinatus tendon remained intact with normal structure. Conclusions Based on the biomechanical and histological findings, this canine NWB model may be an appropriate and useful model for studies of rotator cuff repair.
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A Canine Non-Weight-Bearing Model with Radial Neurectomy for Rotator Cuff Repair.
Public Library of Science (PLoS), 2026Co-Authors: Nirong Bao, Peter C Amadio, Scott P Steinmann, Chunfeng ZhaoAbstract:The major concern of using a large animal model to study rotator cuff repair is the high rate of repair retears. The purpose of this study was to test a non-weight-bearing (NWB) canine model for rotator cuff repair research.First, in the in vitro study, 18 shoulders were randomized to 3 groups. 1) Full-width transections repaired with modified Mason-Allen Sutures using 3-0 Polyglactin Suture, 2) Group 1 repaired using number 2 (#2) polyester braid and long-chain polyethylene Suture, and 3) Partial-width transections leaving the superior 2 mm infraspinatus tendon intact without repair. In the in vivo study of 6 dogs, the infraspinatus tendon was partially transected as the same as the in vitro group 3. A radial neurectomy was performed to prevent weight bearing. The operated limb was slung in a custom-made jacket for 6 weeks.In the in vitro study, mean ultimate tensile load and stiffness in Group 2 were significantly higher than Group 1 and 3 (p
Robin P. Blackstone - One of the best experts on this subject based on the ideXlab platform.
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Predicting Stricture in Morbidly Obese Patients Undergoing Laparoscopic Roux-en-Y Gastric Bypass: A Logistic Regression Analysis
Journal of Gastrointestinal Surgery, 2007Co-Authors: Robin P. Blackstone, Lisa A. RiveraAbstract:Gastrojejunostomy stricture after Roux-en-Y gastric bypass occurs in 3 to 27% of morbidly obese patients in the USA. We questioned whether preoperative patient characteristics, including demographic attributes and comorbid disease, might be significant factors in the etiology of stricture. In this study from November 2001 to February 2006 (51 months), at a high-volume bariatric center, of the 1,351 patients who underwent laparoscopic gastric bypass, 92 developed stricture (6.8%). All but two were treated successfully by endoscopic dilation. All patients stopped nonsteroidal anti-inflammatory medications 2 weeks prior to surgery and did not restart them. The operative procedure included the use of a 21-mm transoral circular stapler to create the gastrojejunostomy; the Roux limb was brought retrogastric, retrocolic. In an effort to reduce our center’s stricture rate, late in the study, U-clips used at the gastrojejunostomy were replaced by absorbable Sutures, and postoperative H_2 antagonists were added to the treatment protocol. The change to absorbable Polyglactin Suture proved to be significant, resulting in a lower stricture rate. The addition of H_2 antagonists showed no significant effect. Following the retrospective review of the prospective database, univariate and multivariate logistic regression analyses identified factors associated with the development of stricture. Gastroesophageal reflux disease and age were each shown to be statistically significant independent predictors of stricture following laparoscopic gastric bypass.
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Predicting Stricture in Morbidly Obese Patients Undergoing Laparoscopic Roux-en-Y Gastric Bypass: A Logistic Regression Analysis
2007Co-Authors: Robin P. Blackstone, Lisa A. RiveraAbstract:stricture after Roux-en-Y gastric bypass occurs in 3 to 27 % of morbidly obese patients in the USA. We questioned whether preoperative patient characteristics, including demographic attributes and comorbid disease, might be significant factors in the etiology of stricture. In this study from November 2001 to February 2006 (51 months), at a high-volume bariatric center, of the 1,351 patients who underwent laparoscopic gastric bypass, 92 developed stricture (6.8%). All but two were treated successfully by endoscopic dilation. All patients stopped nonsteroidal anti-inflammatory medications 2 weeks prior to surgery and did not restart them. The operative procedure included the use of a 21-mm transoral circular stapler to create the gastrojejunostomy; the Roux limb was brought retrogastric, retrocolic. In an effort to reduce our center’s stricture rate, late in the study, U-clips used at the gastrojejunostomy were replaced by absorbable Sutures, and postoperative H2 antagonists were added to the treatment protocol. The change to absorbable Polyglactin Suture proved to be significant, resulting in a lower stricture rate. The addition of H 2 antagonists showed no significant effect. Following the retrospective review of the prospective database, univariate and multivariate logistic regression analyses identified factors associated with the development of stricture. Gastroesophageal reflux disease and age were each shown to be statistically significant independent predictors of stricture following laparoscopic gastric bypass