The Experts below are selected from a list of 18633 Experts worldwide ranked by ideXlab platform
Shi Cong - One of the best experts on this subject based on the ideXlab platform.
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The Chemical Composition and Identification of Processing Polygonum Multiflorum
Journal of Kunming Medical University, 2011Co-Authors: Shi CongAbstract:Objective To discuss the material basis for the pharmacological effects changes of Polygonum multiflorum after microbial fermentation,and study the chemical compositions of Polygonum multiflorum after microbial fermentation.Method After a microbial fermentation,Polygonum multiflorum was extracted and separated by ethyl acetate and n-butyl alcohol,and six chemical constituents was isolated.Result By comparison with the standard preparation analysis and pope analysis,the six chemical constituents were indentified as: citreorosein(1),emodin(2),physcion(3),n-butyl-β-D-fructopyranoside(4),physcion(5),orachrysone-8-O-β-D-glucopyranoside(6).Conclusions Emodin and physcion are main chemical compositions in Polygonum multiflorum after microbial fermentation,the chemical composition has no significantly changes compared with Polygonum multiflorum.
Xingbin Yin - One of the best experts on this subject based on the ideXlab platform.
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traditional usages botany phytochemistry pharmacology and toxicology of Polygonum multiflorum thunb a review
Journal of Ethnopharmacology, 2015Co-Authors: Longfei Lin, Hongmei Lin, Miao Zhang, Xingbin YinAbstract:Abstract Ethnopharmacological relevance Polygonum multiflorum Thunb., which is known as Heshouwu (何首乌 in Chinese) in China. It is traditionally valued and reported for hair-blacking, liver and kidney-tonifying and anti-aging effects as well as low toxicity. The aim of this review is to provide comprehensive information on the botany, traditional uses, phytochemistry, pharmacological research and toxicology of Polygonum multiflorum , based on the scientific literature. Moreover, trends and perspectives for future investigation of this plant are discussed. It will build up a new foundation for further study on Polygonum multiflorum . Materials and methods A systematic review of the literature on Polygonum multiflorum was performed using several resources, including classic books on Chinese herbal medicine and various scientific databases, such as PubMed, SciFinder, the Web of Science, Science Direct, China Knowledge Resource Integrated (CNKI). Results Polygonum multiflorum is widely distributed throughout the world and has been used as a traditional medicine for centuries in China. The ethnomedical uses of Polygonum multiflorum have been recorded in many provinces of China and Japan for nine species of adulterants in six families. More than 100 chemical compounds have been isolated from this plant, and the major components have been determined to be stilbenes, quinones, flavonoids and others. Crude extracts and pure compounds of this plant are used as effective agents in pre-clinical and clinical practice due to their anti-aging, anti-hyperlipidaemia, anti-cancer and anti-inflammatory effects and to promote immunomodulation, neuroprotection, and the curing of other diseases. However, these extracts can also lead to hepatotoxicity, nephrotoxicity and embryonic toxicity. Pharmacokinetic studies have demonstrated that the main components of Polygonum multiflorum , such as 2,3,5,4′-tetrahydroxystilbene-2-O-β- d -glucopyranoside and emodin are distributed among many organs and tissues. Conclusion Therapeutic potential of Polygonum multiflorum has been demonstrated in the conditions like Alzheimer׳s disease, Parkinson׳s disease, hyperlipidaemia, inflammation and cancer, which is attributed to the presence of various stilbenes, quinones, flavonoids, phospholipids and other compounds in the drug. On the other hand, the adverse effects (hepatotoxicity, nephrotoxicity, and embryonic toxicity) of this plant were caused by the quinones, such as emodin and rhein. Thus more pharmacological and toxicological mechanisms on main active compounds are necessary to be explored, especially the combined anthraquinones (Emodin-8-O-β- d -glucopyranoside, Physcion-8-O-β- d -glucopyranoside, etc. ) and the variety of stilbenes.
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Pharmacological and other Bioactivities of the Genus Polygonum - A Review
2014Co-Authors: Xiaoxv Dong, Xingbin Yin, Bo Wang, Sali Cao, Hui Zhang, Yang ZhaoAbstract:The genus Polygonum encompasses approximately 300 species widely distributed around the world, among which 120 Polygonum species grow in China. Among the rich species, 81 of them are widely used in traditional Chinese and folk medicines. In recent years, several studies have found that the genus Polygonum posseses a variety of biological activities including antioxidation, antimicrobial, antitumor, anti-obesity, etc. However, there are still not enough systemic data on the chemical constituents and their pharmacological effects; hence, it would be useful to review current literature for available pharmacological activites of the genus and as well as its active ingredients. Both in-vitro and in-vivo studies have provided strong evidence for the therapeutic potential of the genus Polygonum. This review collates and examines information on the pharmacological effects of the genus Polygonum as well as its chemical constituents.
Hong Zhou - One of the best experts on this subject based on the ideXlab platform.
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botany phytochemistry pharmacology and potential application of Polygonum cuspidatum sieb et zucc a review
Journal of Ethnopharmacology, 2013Co-Authors: Wei Peng, Rongxin Qin, Hong ZhouAbstract:Abstract Ethnopharmacological relevance Polygonum cuspidatum Sieb. et Zucc. (Polygonum cuspidatum), also known as Reynoutria japonica Houtt and Huzhang in China, is a traditional and popular Chinese medicinal herb. Polygonum cuspidatum with a wide spectrum of pharmacological effects has been used for treatment of inflammation, favus, jaundice, scald, and hyperlipemia, etc. Aim of the review The present paper reviews the traditional applications as well as advances in botany, phytochemistry, pharmacodynamics, pharmacokinetics and toxicology of this plant. Finally, the tendency and perspective for future investigation of this plant are discussed, too. Materials and methods A systematic review of literature about Polygonum cuspidatum is carried out using resources including classic books about Chinese herbal medicine, and scientific databases including Pubmed, SciFinder, Scopus, the Web of Science and others. Results Polygonum cuspidatum is widely distributed in the world and has been used as a traditional medicine for a long history in China. Over 67 compounds including quinones, stilbenes, flavonoids, counmarins and ligans have been isolated and identified from this plant. The root of this plant is used as the effective agent in pre-clinical and clinical practice for regulating lipids, anti-endotoxic shock, anti-infection and anti-inflammation, anti-cancer and other diseases in China and Japan. Conclusion As an important traditional Chinese medicine, Polygonum cuspidatum has been used for treatment of hyperlipemia, inflammation, infection and cancer, etc. Because there is no enough systemic data about the chemical constituents and their pharmacological effects or toxicities, it is important to investigate the pharmacological effects and molecular mechanisms of this plant based on modern realization of diseases’ pathophysiology. Drug target-guided and bioactivity-guided isolation and purification of the chemical constituents from this plant and subsequent evaluation of their pharmacologic effects will promote the development of new drug and make sure which chemical constituent or multiple ingredients contributes its pharmacological effects. Additionally, chemicals and their pharmacological effects of the other parts such as the aerial part of this plant should be exploited in order to avoid resource waste and find new chemical constituents.
Dong Ki Park - One of the best experts on this subject based on the ideXlab platform.
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topical application of Polygonum multiflorum extract induces hair growth of resting hair follicles through upregulating shh and β catenin expression in c57bl 6 mice
Journal of Ethnopharmacology, 2011Co-Authors: Hyejin Park, Nannan Zhang, Dong Ki ParkAbstract:Ethnopharmacological relevance Polygonum multiflorum has traditionally been used for treating patients suffering from baldness and hair loss in East Asia. Aim of the study The present study sought to investigate the hair growth promoting activities of Polygonum multiflorum and its mechanism of action. Materials and methods The Polygonum multiflorum extract was topically applied to the shaved dorsal skin of telogenic C57BL6/N mice. To determine the effect of Polygonum multiflorum extract in telogen to anagen transition, the expression of β-catenin and Sonic hedgehog (Shh) was determined by immunohistochemistry analysis. Results Polygonum multiflorum extract promoted hair growth by inducing anagen phase in telogenic C57BL6/N mice. In Polygonum multiflorum extract treated group, we observed increase in the number and the size of hair follicles that are considered as evidence for anagen phase induction. Immunohistochemical analysis revealed that earlier induction of β-catenin and Shh were observed in Polygonum multiflorum extract treated group compared to that in control group. Conclusion These results suggest that Polygonum multiflorum extract promotes hair growth by inducing anagen phase in resting hair follicles.
Dongyan Xu - One of the best experts on this subject based on the ideXlab platform.
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effects of extract of Polygonum multiflorum on cell cycle arrest and apoptosis of human liver cell line l02
Journal of Chinese Integrative Medicine, 2010Co-Authors: Ruichen Zhang, Dongyan XuAbstract:OBJECTIVE: To analyze the chemical constituents of Polygonum multiflorum extract which may cause human liver cell damage and to explore the mechanism. METHODS: Raw and processed Polygonum multiflorum were extracted by 70% ethanol, then raw and processed Polygonum multiflorum water-eluted material (RW and PW), 50% ethanol-eluted material (R50 and P50) and 95% ethanol-eluted material (R95 and P95) were obtained by absorbing through AB-8 macroporous resin, followed by water, 50% ethanol and 95% ethanol elution in order. The water extracts of raw and processed Polygonum multiflorum (RWE or PWE) were obtained by boiling them in water as usual. Normal human liver L02 cells were treated by different concentrations of eluted Polygonum multiflorum materials for different time, and the cell growth inhibition of each group was determined by methylthiazolyldiphenyl-tetrazolium bromide method. The chemical constituents which had a significant cytotoxicity to L02 cells were analyzed by high-performance liquid chromatography (HPLC). Morphological changes of L02 cells were observed by Giemsa staining and cell cycle distribution was observed by flow cytometry. RESULTS: It was found that 95% ethanol-eluted extracts of raw and processed Polygonum multiflorum showed significant growth inhibition on normal human liver L02 cells, while the other components showed no significant inhibition on cell growth. HPLC analysis showed that the main component in 95% ethanol-eluted extract of raw and processed Polygonum multiflorum was emodin at content of (18.53+/-2.96)% and (10.28+/-1.34)% respectively. Cell cycle analysis showed that 95% ethanol-eluted material of Polygonum multiflorum and emodin had a similar significant effect of S phase arrest and all could induce L02 cell apoptosis. CONCLUSION: The main part of Polygonum multiflorum causing liver cell damage is the 95% ethanol-eluted extract, and emodin is one of the important chemical constituents leading to liver cell damage.
