The Experts below are selected from a list of 243 Experts worldwide ranked by ideXlab platform
Alan J Russell - One of the best experts on this subject based on the ideXlab platform.
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charge preserving atom transfer radical Polymerization Initiator rescues the lost function of negatively charged protein polymer conjugates
Biomacromolecules, 2019Co-Authors: Stefanie L Baker, Hironobu Murata, Bibifatima Kaupbayeva, Adina Tasbolat, Krzysztof Matyjaszewski, Alan J RussellAbstract:When grown from the surface of proteins, negatively charged polymers cause irreversible inactivation, thereby limiting the breadth of the synthetic space that negatively charged protein–polymer conjugates can be applied to. More broadly speaking, independent of polymer and synthetic approach, almost all protein–polymer conjugates are less active than their precursors. After more than a decade without major advances in understanding why the attachment of some polymers so sharply deactivates enzymes, we focused our attention on a technique to protect enzymes from the growth of a deactivating polymer by restoring the charge at the protein surface during polymer attachment. We synthesized an amino-reactive positively charged atom transfer radical Polymerization Initiator that inserted a permanent positive charge at the site of bio-macroInitiator attachment. Preserving the surface charge through attachment of the permanent positively charged Initiator led to the first observation of activity of enzymes that we...
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charge preserving atom transfer radical Polymerization Initiator rescues the lost function of negatively charged protein polymer conjugates
Biomacromolecules, 2019Co-Authors: Stefanie L Baker, Hironobu Murata, Bibifatima Kaupbayeva, Adina Tasbolat, Krzysztof Matyjaszewski, Alan J RussellAbstract:When grown from the surface of proteins, negatively charged polymers cause irreversible inactivation, thereby limiting the breadth of the synthetic space that negatively charged protein-polymer conjugates can be applied to. More broadly speaking, independent of polymer and synthetic approach, almost all protein-polymer conjugates are less active than their precursors. After more than a decade without major advances in understanding why the attachment of some polymers so sharply deactivates enzymes, we focused our attention on a technique to protect enzymes from the growth of a deactivating polymer by restoring the charge at the protein surface during polymer attachment. We synthesized an amino-reactive positively charged atom transfer radical Polymerization Initiator that inserted a permanent positive charge at the site of bio-macroInitiator attachment. Preserving the surface charge through attachment of the permanent positively charged Initiator led to the first observation of activity of enzymes that were coupled to negatively charged homopolymers.
Fabienne Barrosobujans - One of the best experts on this subject based on the ideXlab platform.
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an insight into the anionic ring opening Polymerization with tetrabutylammonium azide for the generation of pure cyclic poly glycidyl phenyl ether
Macromolecules, 2018Co-Authors: Jordan Ochs, Antonio Veloso, Daniel E Martineztong, Angel Alegria, Fabienne BarrosobujansAbstract:We evaluate the use of tetrabutylammonium azide (N3NBu4) as an anionic ring-opening Polymerization Initiator for synthesizing azide-terminated linear poly(glycidyl phenyl ether) and then generating monocyclic structures with high purity. In particular, we perform a detailed study on the end-group fidelity of polymers obtained by initiation with N3NBu4 in the presence and absence of trisisobutylaluminum (iBu3Al) and evaluate the purity of the cyclic structures obtained via copper-catalyzed alkyne–azide cycloaddition “click” reaction. We demonstrate that in contrast to the Polymerization initiated by N3NBu4 alone, the Polymerization performed in the presence of iBu3Al allows the formation of polymers with high end-group fidelity (azide groups at the α-position) for Mn < 20 kDa. The cyclic purity is evaluated by SEC with triple detection and dielectric spectroscopy. The latter technique, although not conventional for such a purpose, is shown to be very convenient to ensure cyclic purity in polymers showing a...
Krzysztof Matyjaszewski - One of the best experts on this subject based on the ideXlab platform.
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solution processable liquid metal nanodroplets by surface initiated atom transfer radical Polymerization
Nature Nanotechnology, 2019Co-Authors: Jiajun Yan, Mohammad H Malakooti, Zongyu Wang, Navid Kazem, Chengfeng Pan, Michael R Bockstaller, Carmel Majidi, Krzysztof MatyjaszewskiAbstract:Eutectic gallium indium (EGaIn) is a liquid metal alloy at room temperature. EGaIn microdroplets can be incorporated into elastomers to fabricate highly stretchable, mechanically robust, soft multifunctional composites with high thermal stability1 and electrical conductivity2–4 that are suitable for applications in soft robotics and self-healing electronics5–7. However, the current methods of preparation rely on mechanical mixing, which may lead to irregularly shaped micrometre-sized droplets and an anisotropic distribution of properties8. Therefore, procedures for the stabilization of sub-micrometre-sized droplets of EGaIn and compatibilization in polymer matrices and solvents have attracted significant attention9–12. Here we report the synthesis of EGaIn nanodroplets stabilized by polymeric ligand encapsulation. We use a surface-initiated atom transfer radical Polymerization Initiator to covalently functionalize the oxide layer on the surface of the EGaIn nanodroplets13 with poly(methyl methacrylate) (PMMA), poly(n-butyl acrylate) (PBMA), poly(2-dimethylamino)ethyl methacrylate) (PDMAEMA) and poly(n-butyl acrylate-block-methyl methacrylate) (PBA-b-PMMA). These nanodroplets are stable in organic solvents, in water or in polymer matrices up to 50 wt% concentration, enabling direct solution-casting into flexible hybrid materials. The liquid metal can be recovered from dispersion by acid treatment. The nanodroplets show good mechanical, thermal and optical properties, with a remarkable suppression of crystallization and melting temperatures (down to −80 °C from 15 °C). Eutectic Ga-In droplets can be functionalized with various polymers and co-polymers using atom transfer radical Polymerization. The droplets are ready for direct solution processing to form liquid-metal nanocomposites for potential applications in soft robotics.
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charge preserving atom transfer radical Polymerization Initiator rescues the lost function of negatively charged protein polymer conjugates
Biomacromolecules, 2019Co-Authors: Stefanie L Baker, Hironobu Murata, Bibifatima Kaupbayeva, Adina Tasbolat, Krzysztof Matyjaszewski, Alan J RussellAbstract:When grown from the surface of proteins, negatively charged polymers cause irreversible inactivation, thereby limiting the breadth of the synthetic space that negatively charged protein–polymer conjugates can be applied to. More broadly speaking, independent of polymer and synthetic approach, almost all protein–polymer conjugates are less active than their precursors. After more than a decade without major advances in understanding why the attachment of some polymers so sharply deactivates enzymes, we focused our attention on a technique to protect enzymes from the growth of a deactivating polymer by restoring the charge at the protein surface during polymer attachment. We synthesized an amino-reactive positively charged atom transfer radical Polymerization Initiator that inserted a permanent positive charge at the site of bio-macroInitiator attachment. Preserving the surface charge through attachment of the permanent positively charged Initiator led to the first observation of activity of enzymes that we...
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charge preserving atom transfer radical Polymerization Initiator rescues the lost function of negatively charged protein polymer conjugates
Biomacromolecules, 2019Co-Authors: Stefanie L Baker, Hironobu Murata, Bibifatima Kaupbayeva, Adina Tasbolat, Krzysztof Matyjaszewski, Alan J RussellAbstract:When grown from the surface of proteins, negatively charged polymers cause irreversible inactivation, thereby limiting the breadth of the synthetic space that negatively charged protein-polymer conjugates can be applied to. More broadly speaking, independent of polymer and synthetic approach, almost all protein-polymer conjugates are less active than their precursors. After more than a decade without major advances in understanding why the attachment of some polymers so sharply deactivates enzymes, we focused our attention on a technique to protect enzymes from the growth of a deactivating polymer by restoring the charge at the protein surface during polymer attachment. We synthesized an amino-reactive positively charged atom transfer radical Polymerization Initiator that inserted a permanent positive charge at the site of bio-macroInitiator attachment. Preserving the surface charge through attachment of the permanent positively charged Initiator led to the first observation of activity of enzymes that were coupled to negatively charged homopolymers.
Stefanie L Baker - One of the best experts on this subject based on the ideXlab platform.
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charge preserving atom transfer radical Polymerization Initiator rescues the lost function of negatively charged protein polymer conjugates
Biomacromolecules, 2019Co-Authors: Stefanie L Baker, Hironobu Murata, Bibifatima Kaupbayeva, Adina Tasbolat, Krzysztof Matyjaszewski, Alan J RussellAbstract:When grown from the surface of proteins, negatively charged polymers cause irreversible inactivation, thereby limiting the breadth of the synthetic space that negatively charged protein–polymer conjugates can be applied to. More broadly speaking, independent of polymer and synthetic approach, almost all protein–polymer conjugates are less active than their precursors. After more than a decade without major advances in understanding why the attachment of some polymers so sharply deactivates enzymes, we focused our attention on a technique to protect enzymes from the growth of a deactivating polymer by restoring the charge at the protein surface during polymer attachment. We synthesized an amino-reactive positively charged atom transfer radical Polymerization Initiator that inserted a permanent positive charge at the site of bio-macroInitiator attachment. Preserving the surface charge through attachment of the permanent positively charged Initiator led to the first observation of activity of enzymes that we...
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charge preserving atom transfer radical Polymerization Initiator rescues the lost function of negatively charged protein polymer conjugates
Biomacromolecules, 2019Co-Authors: Stefanie L Baker, Hironobu Murata, Bibifatima Kaupbayeva, Adina Tasbolat, Krzysztof Matyjaszewski, Alan J RussellAbstract:When grown from the surface of proteins, negatively charged polymers cause irreversible inactivation, thereby limiting the breadth of the synthetic space that negatively charged protein-polymer conjugates can be applied to. More broadly speaking, independent of polymer and synthetic approach, almost all protein-polymer conjugates are less active than their precursors. After more than a decade without major advances in understanding why the attachment of some polymers so sharply deactivates enzymes, we focused our attention on a technique to protect enzymes from the growth of a deactivating polymer by restoring the charge at the protein surface during polymer attachment. We synthesized an amino-reactive positively charged atom transfer radical Polymerization Initiator that inserted a permanent positive charge at the site of bio-macroInitiator attachment. Preserving the surface charge through attachment of the permanent positively charged Initiator led to the first observation of activity of enzymes that were coupled to negatively charged homopolymers.
Adina Tasbolat - One of the best experts on this subject based on the ideXlab platform.
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charge preserving atom transfer radical Polymerization Initiator rescues the lost function of negatively charged protein polymer conjugates
Biomacromolecules, 2019Co-Authors: Stefanie L Baker, Hironobu Murata, Bibifatima Kaupbayeva, Adina Tasbolat, Krzysztof Matyjaszewski, Alan J RussellAbstract:When grown from the surface of proteins, negatively charged polymers cause irreversible inactivation, thereby limiting the breadth of the synthetic space that negatively charged protein–polymer conjugates can be applied to. More broadly speaking, independent of polymer and synthetic approach, almost all protein–polymer conjugates are less active than their precursors. After more than a decade without major advances in understanding why the attachment of some polymers so sharply deactivates enzymes, we focused our attention on a technique to protect enzymes from the growth of a deactivating polymer by restoring the charge at the protein surface during polymer attachment. We synthesized an amino-reactive positively charged atom transfer radical Polymerization Initiator that inserted a permanent positive charge at the site of bio-macroInitiator attachment. Preserving the surface charge through attachment of the permanent positively charged Initiator led to the first observation of activity of enzymes that we...
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charge preserving atom transfer radical Polymerization Initiator rescues the lost function of negatively charged protein polymer conjugates
Biomacromolecules, 2019Co-Authors: Stefanie L Baker, Hironobu Murata, Bibifatima Kaupbayeva, Adina Tasbolat, Krzysztof Matyjaszewski, Alan J RussellAbstract:When grown from the surface of proteins, negatively charged polymers cause irreversible inactivation, thereby limiting the breadth of the synthetic space that negatively charged protein-polymer conjugates can be applied to. More broadly speaking, independent of polymer and synthetic approach, almost all protein-polymer conjugates are less active than their precursors. After more than a decade without major advances in understanding why the attachment of some polymers so sharply deactivates enzymes, we focused our attention on a technique to protect enzymes from the growth of a deactivating polymer by restoring the charge at the protein surface during polymer attachment. We synthesized an amino-reactive positively charged atom transfer radical Polymerization Initiator that inserted a permanent positive charge at the site of bio-macroInitiator attachment. Preserving the surface charge through attachment of the permanent positively charged Initiator led to the first observation of activity of enzymes that were coupled to negatively charged homopolymers.