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Attila Dobozy - One of the best experts on this subject based on the ideXlab platform.
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The occurrence of antinuclear, anti-SSA/Ro and anti-SSB/La antibodies in patients with Polymorphous Light Eruption.
Acta dermato-venereologica, 1991Co-Authors: Mária Kiss, Sándor Husz, Attila DobozyAbstract:Serological features were investigated in 22 patients with Polymorphous Light Eruption. The diagnosis was made from the history and clinical patterns and confirmed by phototesting and histological examinations. In 4 patients with Polymorphous Light Eruption, anti-RNP antibodies were detected in the serum despite the fact that the antinuclear antibody tests were negative in all cases. The serum levels of anti-SSA/Ro antibodies in the patients were mildly but significantly elevated (p less than 0.001) as compared with healthy controls. No difference was found between the patients and controls regarding the serum concentrations of anti-SSB/La antibodies. The conclusion is drawn that it is necessary to examine patients with Polymorphous Light Eruption with regard to a 'late autoimmune course' and it is worthwhile to study the relationship between the photosensitivity and the occurrence of anti-SSA/Ro antibodies.
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the occurrence of antinuclear anti ssa ro and anti ssb la antibodies in patients with Polymorphous Light Eruption
Acta Dermato-venereologica, 1991Co-Authors: Mária Kiss, Sándor Husz, Attila DobozyAbstract:Serological features were investigated in 22 patients with Polymorphous Light Eruption. The diagnosis was made from the history and clinical patterns and confirmed by phototesting and histological examinations. In 4 patients with Polymorphous Light Eruption, anti-RNP antibodies were detected in the serum despite the fact that the antinuclear antibody tests were negative in all cases. The serum levels of anti-SSA/Ro antibodies in the patients were mildly but significantly elevated (p less than 0.001) as compared with healthy controls. No difference was found between the patients and controls regarding the serum concentrations of anti-SSB/La antibodies. The conclusion is drawn that it is necessary to examine patients with Polymorphous Light Eruption with regard to a 'late autoimmune course' and it is worthwhile to study the relationship between the photosensitivity and the occurrence of anti-SSA/Ro antibodies.
Mária Kiss - One of the best experts on this subject based on the ideXlab platform.
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The occurrence of antinuclear, anti-SSA/Ro and anti-SSB/La antibodies in patients with Polymorphous Light Eruption.
Acta dermato-venereologica, 1991Co-Authors: Mária Kiss, Sándor Husz, Attila DobozyAbstract:Serological features were investigated in 22 patients with Polymorphous Light Eruption. The diagnosis was made from the history and clinical patterns and confirmed by phototesting and histological examinations. In 4 patients with Polymorphous Light Eruption, anti-RNP antibodies were detected in the serum despite the fact that the antinuclear antibody tests were negative in all cases. The serum levels of anti-SSA/Ro antibodies in the patients were mildly but significantly elevated (p less than 0.001) as compared with healthy controls. No difference was found between the patients and controls regarding the serum concentrations of anti-SSB/La antibodies. The conclusion is drawn that it is necessary to examine patients with Polymorphous Light Eruption with regard to a 'late autoimmune course' and it is worthwhile to study the relationship between the photosensitivity and the occurrence of anti-SSA/Ro antibodies.
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the occurrence of antinuclear anti ssa ro and anti ssb la antibodies in patients with Polymorphous Light Eruption
Acta Dermato-venereologica, 1991Co-Authors: Mária Kiss, Sándor Husz, Attila DobozyAbstract:Serological features were investigated in 22 patients with Polymorphous Light Eruption. The diagnosis was made from the history and clinical patterns and confirmed by phototesting and histological examinations. In 4 patients with Polymorphous Light Eruption, anti-RNP antibodies were detected in the serum despite the fact that the antinuclear antibody tests were negative in all cases. The serum levels of anti-SSA/Ro antibodies in the patients were mildly but significantly elevated (p less than 0.001) as compared with healthy controls. No difference was found between the patients and controls regarding the serum concentrations of anti-SSB/La antibodies. The conclusion is drawn that it is necessary to examine patients with Polymorphous Light Eruption with regard to a 'late autoimmune course' and it is worthwhile to study the relationship between the photosensitivity and the occurrence of anti-SSA/Ro antibodies.
Marcella Guarrera - One of the best experts on this subject based on the ideXlab platform.
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Polymorphous Light Eruption.
Advances in experimental medicine and biology, 2017Co-Authors: Marcella GuarreraAbstract:Polymorphous Light Eruption (PLE) is the commonest immuno-mediated photodermatosis. It occurs after solar or artificial UV-Light exposure and affects only the sun-exposed areas with preference of the V-area of the chest, of arms and forearms, legs, upper part of the back, and rarely the face. The lesions are itching or burning, and vary morphologically from erythema to papules, vesico-papules and occasionally blisters, plaques, sometimes erythema multiforme-like, insect bite-like wheals and purpura. The clinical manifestations befall within a few hours to days from Light exposure, last a few days, and subside in about a week without sequelae. Its diagnosis is based on history, morphology and phototests. PLE is considered as a delayed hypersensitivity response to newly UV induced, but still unidentified, antigen(s). Usually, MED is normal, but the provocative phototests with UVA or UVB reproduce the spontaneous lesions in about 50% of the patients. Broad spectrum sunscreens and antioxidants, photohardening with PUVA or narrow band UVB may be beneficial to prevent the disease. Therapy is based mainly on topical or systemic corticosteroids.
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Polymorphous Light Eruption and benign summer Light Eruption in Italy
Photodermatology photoimmunology & photomedicine, 2011Co-Authors: Marcella Guarrera, Marina Venturini, Alfredo Rebora, P. Cardo, Donatella Schena, Piergiacomo Calzavara-pinton, Giuseppe Monfrecola, Antonello Baldo, Giovanni Leone, Alessia PacificoAbstract:Background/purpose: Polymorphous Light Eruption (PLE) heterogeneity has been postulated, but the existence of benign summer Light Eruption (BSLE) is controversial. We studied the prevalence of the clinical patterns, criteria distinguishing BSLE from PLE, and diagnostic usefulness of phototest. Methods: Five Italian Photodermatology Centres recruited retrospectively 346 patients with typical clinical history and/or presentation of PLE. Age, gender, skin type, family history and presence of atopy were considered. UVA and UVB MEDs and provocative phototests with UVA and UVB were obtained with a standardized procedure. Photopatch tests were applied according to the IRCDG rules. ANA were assessed by indirect immunofluorescence. Results: Four criteria (predominance of women, shorter latency, uninvolvement of the face and absence of relapse during summer) identified BSLE in only 6.1% of cases. All had positive phototests, mostly with UVA. Uninvolvement of face, short latency and no seasonal relapses identified 11.7% patients, mostly with positive phototests to UVA. Short latency and no seasonal relapses in women identified 11.2% patients. Uninvolvement of face and no seasonal relapses in women identified 8.1% of patients. Uninvolvement of face and short latency in women identified 17.6% of patients. Conclusion: Criteria diagnosed BSLE in only a minority of patients, who were positive at phototesting, mostly with UVA.
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Epidemiologic data about Polymorphous Light Eruption in Italy
'Edizioni Minerva Medica', 2006Co-Authors: E.m. Procaccini, Marcella Guarrera, G. Fabbrocini, V. Affaticati, D. Assalve, Calzavara P. Pinton, I. Caputi, A. Ciambellotti, M.l. Flori, P. IacovelliAbstract:Aim. Polymorphous Light Eruption (PLE) is the most common idiopathic photodermatosis. It describes a broad clinical spectrum with chronic recurrences. It is often characterized by non scarring pruritic erythematous papules, vesicles or plaques. UV exposure is the main pathogenetic factor. The aim of this study was to evaluate the prevalence of PLE in Italy, the main clinical features and the clinical course and recurrences in a Mediterranean population. Methods. The study was carried out on 4 416 subjects in 8 Dermatological Units in Italy, distributed over the whole country. Subjects were required to fill a simple questionnaire (43 questions) exploring the following topics: phototype and phenotype, and modalities of solar exposure. In the subjects with a previous PLE another questionnaire was submitted to investigate the clinical features of PLE, number of recurrences, familiar, pathological and pharmacological anamnesis. The study was carried out in healthy volunteers, not affected by any dermatological disease. Results. Among the 4 416 apparently healthy subjects who filled out the survey, 212 gave a history consistent with a diagnosis of PLE. The PLE prevalence was 5.89% without significant differences among the Dermatological Units distributed at different latitudes in our Country. The coalescent papules type of PLE was the most common clinical picture (36.4%); the body site most frequently affected was the trunk (61.1%). On the contrary, chronically sun exposed body site (i.e. the face) is affected just in few cases. Also people chronically sun exposed developed PLE less frequently than occasionally sun exposed people. Sometimes, PLE developed after a particularly intense sun exposure (37.7% of PLE). Conclusion. No correlations with drug assumption or environmental chemical compound have been underlined
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Heterogeneity of Polymorphous Light Eruption: A Study of 105 Patients
Archives of dermatology, 1993Co-Authors: Marcella Guarrera, C. Micalizzi, Alfredo ReboraAbstract:Polymorphous Light Eruption (PLE) has ill-defined diagnostic borderlines. It possibly includes actinic prurigo and juvenile spring Eruption and could be a presenting sign of lupus erythematous. 1,2 In addition, benign summer Light Eruption (BSLE) is a condition that needs to be distinguished from PLE. 3,4 To verify such heterogeneity, we examined 105 patients whose signs and history were consistent with the diagnosis of PLE. Patients, Materials, and Methods. Solar urticaria was excluded on clinical grounds or when phototests elicited wheals. Patients with antinuclear antibodies at titers higher than 1:160 or with anti-Ro/SSA antibodies were also excluded. The patients were examined for skin type, duration of disease, family history, interval between sun exposure and skin Eruption (latency), duration, and fading of the lesions over the summer. The minimal erythema dose (MED) was determined with 25% incremental doses of UV-A, UV-B, and solar simulator radiation (UV-AB) on untanned skin on the lower
Sándor Husz - One of the best experts on this subject based on the ideXlab platform.
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The occurrence of antinuclear, anti-SSA/Ro and anti-SSB/La antibodies in patients with Polymorphous Light Eruption.
Acta dermato-venereologica, 1991Co-Authors: Mária Kiss, Sándor Husz, Attila DobozyAbstract:Serological features were investigated in 22 patients with Polymorphous Light Eruption. The diagnosis was made from the history and clinical patterns and confirmed by phototesting and histological examinations. In 4 patients with Polymorphous Light Eruption, anti-RNP antibodies were detected in the serum despite the fact that the antinuclear antibody tests were negative in all cases. The serum levels of anti-SSA/Ro antibodies in the patients were mildly but significantly elevated (p less than 0.001) as compared with healthy controls. No difference was found between the patients and controls regarding the serum concentrations of anti-SSB/La antibodies. The conclusion is drawn that it is necessary to examine patients with Polymorphous Light Eruption with regard to a 'late autoimmune course' and it is worthwhile to study the relationship between the photosensitivity and the occurrence of anti-SSA/Ro antibodies.
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the occurrence of antinuclear anti ssa ro and anti ssb la antibodies in patients with Polymorphous Light Eruption
Acta Dermato-venereologica, 1991Co-Authors: Mária Kiss, Sándor Husz, Attila DobozyAbstract:Serological features were investigated in 22 patients with Polymorphous Light Eruption. The diagnosis was made from the history and clinical patterns and confirmed by phototesting and histological examinations. In 4 patients with Polymorphous Light Eruption, anti-RNP antibodies were detected in the serum despite the fact that the antinuclear antibody tests were negative in all cases. The serum levels of anti-SSA/Ro antibodies in the patients were mildly but significantly elevated (p less than 0.001) as compared with healthy controls. No difference was found between the patients and controls regarding the serum concentrations of anti-SSB/La antibodies. The conclusion is drawn that it is necessary to examine patients with Polymorphous Light Eruption with regard to a 'late autoimmune course' and it is worthwhile to study the relationship between the photosensitivity and the occurrence of anti-SSA/Ro antibodies.
Edward F. Knol - One of the best experts on this subject based on the ideXlab platform.
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Diagnostic phototesting in Polymorphous Light Eruption: the optimal number of irradiations.
The British journal of dermatology, 2005Co-Authors: I.j. Schornagel, Edward F. Knol, Carla A.f.m. Bruijnzeel-koomen, H. Van Weelden, C.l.h. Guikers, Vigfús SigurdssonAbstract:Diagnostic phototesting in patients with Polymorphous Light Eruption (PLE) is performed to confirm the diagnosis and to determine the action spectrum of the disease. No universally accepted protocol for diagnostic phototesting has been established. The aim of this study was to determine the optimal number of irradiations necessary to elicit skin reactions in diagnostic phototesting of PLE patients. In total, 134 PLE patients which were phototested were studied. The cumulative number of irradiations necessary to elicit skin lesions was determined retrospectively in 94 patients. Furthermore, in a successive prospective study, another 40 patients were studied more detailed with an adjusted protocol. In the retrospective as well as the prospective study it was shown that the number of patients testing positive to UVA and/or UVB irradiation increased steadily with each exposure during the first four irradiations. Continuing exposures, the number of patients testing positive after 5 or 6 irradiations decreased steadily. Furthermore, all new visible skin reactions after 5 or 6 irradiations were already initiated during the preceding 4 irradiations. In diagnostic photoprovocation for patients with PLE, a maximum of 4 daily irradiations is optimal to elicit typical skin lesions. More extensive test protocols have no clinical implications. However, fewer exposures may lead to substantial loss of positive test results.
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decreased neutrophil skin infiltration after uvb exposure in patients with Polymorphous Light Eruption
Journal of Investigative Dermatology, 2004Co-Authors: Ines J Schornagel, Vigfús Sigurdsson, Evert Nijhuis, Carla A F M Bruijnzeelkoomen, Edward F. KnolAbstract:UV radiation, in particular UVB, suppresses the skin immune response. In patients with Polymorphous Light Eruption (PLE) the skin immune response seems activated after UV exposure. Typical PLE skin lesions can occur as early as several hours after UV exposure. In healthy volunteers, neutrophils infiltrate the skin shortly after UV exposure. The kinetics and mechanisms of neutrophil infiltration in the skin of PLE patients after UVB exposure was studied. Skin biopsies at 0, 3, 6, and 18 h were taken from five PLE patients and six healthy controls after irradiation with three minimal erythema dose UVB. Furthermore, neutrophils were isolated from blood of five PLE patients and six healthy controls to test their chemotactic activity. Immunohistochemical analysis showed a significant decreased neutrophil infiltration in PLE skin after UVB irradiation compared with healthy controls (p<0.05). In both healthy controls and PLE patients, after UVB irradiation, ICAM-1 and E-selectin expression on endothelial cells increased at 6 h after irradiation. Blood neutrophil chemotactic response towards IL-8 and C5a, as well as the expression of cell surface markers involved in adhesion and chemotaxis, was not different between PLE patients and healthy controls. In conclusion, PLE is marked by a decreased skin infiltration of neutrophils after UVB irradiation, possibly leading to a diminished neutrophil-induced suppression.
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CD11b+ Cells and Ultraviolet-B-Resistant CD1a+ Cells in Skin of Patients with Polymorphous Light Eruption
The Journal of investigative dermatology, 1999Co-Authors: Wendy Kölgen, Huib Van Weelden, Sarah Den Hengst, Kees Guikers, Rebecca C.m. Kiekens, Edward F. Knol, Carla A.f.m. Bruijnzeel-koomen, Willem A. Van Vloten, Frank R. De GruijlAbstract:After ultraviolet exposure Langerhans cells (epidermal CD1a+ cells) disappear from the healthy skin, and CD11b+ macrophage-like cells, which are reported to produce interleukin-10, appear in a matter of days. These phenomena are related to the ultraviolet-induced local suppression of contact hypersensitivity reactions. A defect in this suppression might allow inadvertent immune reactions to develop after ultraviolet (over)exposure; i.e., it could cause ultraviolet-B-induced Polymorphous Light Eruption. In order to test this we first exposed buttock skin of eight healthy volunteers to six minimal erythema doses from Philips TL12 lamps, and indeed observed a dramatic disappearance of CD1a+ cells 48 and 72 h later, at which time the number of CD11b+ cells increased in the dermis, and some occurred in the epidermis. The epidermis thickened and showed large defects, filled by CD11b+ cells, just below the stratum corneum. In 10 patients with Polymorphous Light Eruption (five with a normal minimal erythema dose and five with a low minimal erythema dose) CD1a+ cells were present in the epidermis as well as in the dermis before exposure. Strikingly, these cells were still present in considerable number at 48 and 72 h after exposure to six minimal erythema doses. CD11b+ cells already present in the dermis before ultraviolet exposure, increased after ultraviolet exposure, and subsequently also invaded the epidermis. Despite the six minimal erythema doses, there were no apparent defects in the epidermis of the Polymorphous Light Eruption patients. This deviant early response to ultraviolet radiation is likely to be of direct relevance to the Polymorphous Light Eruption and is perhaps useful as a diagnostic criterion.