The Experts below are selected from a list of 24756 Experts worldwide ranked by ideXlab platform
Bernold Hasenknopf - One of the best experts on this subject based on the ideXlab platform.
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Generation of Photocurrent by Visible-Light Irradiation of Conjugated Dawson Polyoxophosphovanadotungstate-Porphyrin Copolymers
Chemistry - A European Journal, 2015Co-Authors: Iban Azcarate, Zhaohui Huo, Rana Farha, Michel Goldmann, Bernold Hasenknopf, Emmanuel Lacote, Laurent RuhlmannAbstract:Four hybrid Polyoxometalate-porphyrin copolymer films were obtained by the electrooxidation of zinc octaethylporphyrin in the presence of four different Dawson-type Polyoxometalates bearing two pyridyl groups (POM(py)(2)) with various spacers. The POM monomers were designed around 1,3,5-trisubstituted benzene rings. Two of the substituents of the benzene ring are linked to the pyridyl groups, and the third is connected to the POM subunit. The four monomers vary in the relative positions of the nitrogen atoms of the pyridine rings or in the distance from the carbonyl group. The monomers were fully characterized by H-1, P-31, and (CNMR)-C-13 spectroscopy, electrospray mass spectrometry, IR and UV/Vis spectroscopy, and electrochemistry. The copolymers were characterized by UV/Vis spectroscopy, X-ray photoelectron spectroscopy, electrochemistry, and AFM. Their photovoltaic performance under visible light irradiation was investigated by photocurrent transient measurements under visible illumination.
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Exploring the utility of organo-Polyoxometalate hybrids to inhibit SOX transcription factors
Cell regeneration (London England), 2014Co-Authors: Kamesh Narasimhan, Bernold Hasenknopf, Emmanuel Lacote, Kévin Micoine, Serge Thorimbert, Edwin Cheung, Ralf JauchAbstract:SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology. However, rationally engineering specific inhibitors that interfere with transcription factor DNA interfaces continues to be a monumental challenge in the field of transcription factor chemical biology. Polyoxometalates (POMs) are inorganic compounds that were previously shown to target the high-mobility group (HMG) of SOX proteins at nanomolar concentrations. In continuation of this work, we carried out an assessment of the selectivity of a panel of newly synthesized organo-Polyoxometalate hybrids in targeting different transcription factor families to enable the usage of Polyoxometalates as specific SOX transcription factor drugs. The residual DNA-binding activities of 15 different transcription factors were measured after treatment with a panel of diverse Polyoxometalates. Polyoxometalates belonging to the Dawson structural class were found to be more potent inhibitors than the Keggin class. Further, organically modified Dawson Polyoxometalates were found to be the most potent in inhibiting transcription factor DNA binding activity. The size of the Polyoxometalates and its derivitization were found to be the key determinants of their potency. Polyoxometalates are highly potent, nanomolar range inhibitors of the DNA binding activity of the Sox-HMG family. However, binding assays involving a limited subset of structurally diverse Polyoxometalates revealed a low selectivity profile against different transcription factor families. Further progress in achieving selectivity and deciphering structure-activity relationship of POMs require the identification of POM binding sites on transcription factors using elaborate approaches like X-ray crystallography and multidimensional NMR. In summary, our report reaffirms that transcription factors are challenging molecular architectures and that future Polyoxometalate chemistry must consider further modification strategies, to address the substantial challenges involved in achieving target selectivity.
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Exploring the utility of organo-Polyoxometalate hybrids to inhibit SOX transcription factors
Cell Regeneration, 2014Co-Authors: Kamesh Narasimhan, Bernold Hasenknopf, Emmanuel Lacote, Kévin Micoine, Serge Thorimbert, Edwin Cheung, Ralf JauchAbstract:SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology. However, rationally engineering specific inhibitors that interfere with transcription factor DNA interfaces continues to be a monumental challenge in the field of transcription factor chemical biology. Polyoxometalates (POMs) are inorganic compounds that were previously shown to target the high-mobility group (HMG) of SOX proteins at nanomolar concentrations. In continuation of this work, we carried out an assessment of the selectivity of a panel of newly synthesized organo-Polyoxometalate hybrids in targeting different transcription factor families to enable the usage of Polyoxometalates as specific SOX transcription factor drugs.
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Regioselective Double Organic Functionalization of Polyoxotungstates through Electrophilic Addition of Aromatic Isocyanates to [P2W17O61(SnR)](7-)
European Journal of Inorganic Chemistry, 2013Co-Authors: Kévin Micoine, Emmanuel Lacote, Serge Thorimbert, Max Malacria, Bernold HasenknopfAbstract:The direct attachment of several different organic molecules to a single Polyoxometalate remains a challenge in the field of functionalized Polyoxometalates. In this paper, we show that an organotin-functionalized Dawson-type polyoxotungstate [P2W17O61(SnR)]7 reacts with aromatic isocyanates ArNCO to yield new doubly functionalized compounds [P2W17O61(SnR)(CONHAr)]6. Both organic moieties, Ar and R, can be varied independently; we have tested nine Ar and three R groups. Therefore, this synthetic methodology represents a way to graft two distinct functional molecules directly onto a Polyoxometalate.
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Chirality in Polyoxometalate Chemistry
European Journal of Inorganic Chemistry, 2008Co-Authors: Bernold Hasenknopf, Emmanuel Lacote, Kévin Micoine, Serge Thorimbert, Max Malacria, René ThouvenotAbstract:The increasing use of Polyoxometalates in the fields of material sciences, catalysis, and biology has raised the interest in chirality of such systems. This review provides a summary of the different strategies followed: i) chirality in solid-state arrangements, ii) chiral Polyoxometalate frameworks, and iii) chiral Polyoxometalate–organic hybrids. Through the discussion of selected examples, an outline for future work is drawn. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Emmanuel Lacote - One of the best experts on this subject based on the ideXlab platform.
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Generation of Photocurrent by Visible-Light Irradiation of Conjugated Dawson Polyoxophosphovanadotungstate-Porphyrin Copolymers
Chemistry - A European Journal, 2015Co-Authors: Iban Azcarate, Zhaohui Huo, Rana Farha, Michel Goldmann, Bernold Hasenknopf, Emmanuel Lacote, Laurent RuhlmannAbstract:Four hybrid Polyoxometalate-porphyrin copolymer films were obtained by the electrooxidation of zinc octaethylporphyrin in the presence of four different Dawson-type Polyoxometalates bearing two pyridyl groups (POM(py)(2)) with various spacers. The POM monomers were designed around 1,3,5-trisubstituted benzene rings. Two of the substituents of the benzene ring are linked to the pyridyl groups, and the third is connected to the POM subunit. The four monomers vary in the relative positions of the nitrogen atoms of the pyridine rings or in the distance from the carbonyl group. The monomers were fully characterized by H-1, P-31, and (CNMR)-C-13 spectroscopy, electrospray mass spectrometry, IR and UV/Vis spectroscopy, and electrochemistry. The copolymers were characterized by UV/Vis spectroscopy, X-ray photoelectron spectroscopy, electrochemistry, and AFM. Their photovoltaic performance under visible light irradiation was investigated by photocurrent transient measurements under visible illumination.
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Exploring the utility of organo-Polyoxometalate hybrids to inhibit SOX transcription factors
Cell regeneration (London England), 2014Co-Authors: Kamesh Narasimhan, Bernold Hasenknopf, Emmanuel Lacote, Kévin Micoine, Serge Thorimbert, Edwin Cheung, Ralf JauchAbstract:SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology. However, rationally engineering specific inhibitors that interfere with transcription factor DNA interfaces continues to be a monumental challenge in the field of transcription factor chemical biology. Polyoxometalates (POMs) are inorganic compounds that were previously shown to target the high-mobility group (HMG) of SOX proteins at nanomolar concentrations. In continuation of this work, we carried out an assessment of the selectivity of a panel of newly synthesized organo-Polyoxometalate hybrids in targeting different transcription factor families to enable the usage of Polyoxometalates as specific SOX transcription factor drugs. The residual DNA-binding activities of 15 different transcription factors were measured after treatment with a panel of diverse Polyoxometalates. Polyoxometalates belonging to the Dawson structural class were found to be more potent inhibitors than the Keggin class. Further, organically modified Dawson Polyoxometalates were found to be the most potent in inhibiting transcription factor DNA binding activity. The size of the Polyoxometalates and its derivitization were found to be the key determinants of their potency. Polyoxometalates are highly potent, nanomolar range inhibitors of the DNA binding activity of the Sox-HMG family. However, binding assays involving a limited subset of structurally diverse Polyoxometalates revealed a low selectivity profile against different transcription factor families. Further progress in achieving selectivity and deciphering structure-activity relationship of POMs require the identification of POM binding sites on transcription factors using elaborate approaches like X-ray crystallography and multidimensional NMR. In summary, our report reaffirms that transcription factors are challenging molecular architectures and that future Polyoxometalate chemistry must consider further modification strategies, to address the substantial challenges involved in achieving target selectivity.
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Exploring the utility of organo-Polyoxometalate hybrids to inhibit SOX transcription factors
Cell Regeneration, 2014Co-Authors: Kamesh Narasimhan, Bernold Hasenknopf, Emmanuel Lacote, Kévin Micoine, Serge Thorimbert, Edwin Cheung, Ralf JauchAbstract:SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology. However, rationally engineering specific inhibitors that interfere with transcription factor DNA interfaces continues to be a monumental challenge in the field of transcription factor chemical biology. Polyoxometalates (POMs) are inorganic compounds that were previously shown to target the high-mobility group (HMG) of SOX proteins at nanomolar concentrations. In continuation of this work, we carried out an assessment of the selectivity of a panel of newly synthesized organo-Polyoxometalate hybrids in targeting different transcription factor families to enable the usage of Polyoxometalates as specific SOX transcription factor drugs.
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Regioselective Double Organic Functionalization of Polyoxotungstates through Electrophilic Addition of Aromatic Isocyanates to [P2W17O61(SnR)](7-)
European Journal of Inorganic Chemistry, 2013Co-Authors: Kévin Micoine, Emmanuel Lacote, Serge Thorimbert, Max Malacria, Bernold HasenknopfAbstract:The direct attachment of several different organic molecules to a single Polyoxometalate remains a challenge in the field of functionalized Polyoxometalates. In this paper, we show that an organotin-functionalized Dawson-type polyoxotungstate [P2W17O61(SnR)]7 reacts with aromatic isocyanates ArNCO to yield new doubly functionalized compounds [P2W17O61(SnR)(CONHAr)]6. Both organic moieties, Ar and R, can be varied independently; we have tested nine Ar and three R groups. Therefore, this synthetic methodology represents a way to graft two distinct functional molecules directly onto a Polyoxometalate.
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Chirality in Polyoxometalate Chemistry
European Journal of Inorganic Chemistry, 2008Co-Authors: Bernold Hasenknopf, Emmanuel Lacote, Kévin Micoine, Serge Thorimbert, Max Malacria, René ThouvenotAbstract:The increasing use of Polyoxometalates in the fields of material sciences, catalysis, and biology has raised the interest in chirality of such systems. This review provides a summary of the different strategies followed: i) chirality in solid-state arrangements, ii) chiral Polyoxometalate frameworks, and iii) chiral Polyoxometalate–organic hybrids. Through the discussion of selected examples, an outline for future work is drawn. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Kévin Micoine - One of the best experts on this subject based on the ideXlab platform.
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Exploring the utility of organo-Polyoxometalate hybrids to inhibit SOX transcription factors
Cell regeneration (London England), 2014Co-Authors: Kamesh Narasimhan, Bernold Hasenknopf, Emmanuel Lacote, Kévin Micoine, Serge Thorimbert, Edwin Cheung, Ralf JauchAbstract:SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology. However, rationally engineering specific inhibitors that interfere with transcription factor DNA interfaces continues to be a monumental challenge in the field of transcription factor chemical biology. Polyoxometalates (POMs) are inorganic compounds that were previously shown to target the high-mobility group (HMG) of SOX proteins at nanomolar concentrations. In continuation of this work, we carried out an assessment of the selectivity of a panel of newly synthesized organo-Polyoxometalate hybrids in targeting different transcription factor families to enable the usage of Polyoxometalates as specific SOX transcription factor drugs. The residual DNA-binding activities of 15 different transcription factors were measured after treatment with a panel of diverse Polyoxometalates. Polyoxometalates belonging to the Dawson structural class were found to be more potent inhibitors than the Keggin class. Further, organically modified Dawson Polyoxometalates were found to be the most potent in inhibiting transcription factor DNA binding activity. The size of the Polyoxometalates and its derivitization were found to be the key determinants of their potency. Polyoxometalates are highly potent, nanomolar range inhibitors of the DNA binding activity of the Sox-HMG family. However, binding assays involving a limited subset of structurally diverse Polyoxometalates revealed a low selectivity profile against different transcription factor families. Further progress in achieving selectivity and deciphering structure-activity relationship of POMs require the identification of POM binding sites on transcription factors using elaborate approaches like X-ray crystallography and multidimensional NMR. In summary, our report reaffirms that transcription factors are challenging molecular architectures and that future Polyoxometalate chemistry must consider further modification strategies, to address the substantial challenges involved in achieving target selectivity.
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Exploring the utility of organo-Polyoxometalate hybrids to inhibit SOX transcription factors
Cell Regeneration, 2014Co-Authors: Kamesh Narasimhan, Bernold Hasenknopf, Emmanuel Lacote, Kévin Micoine, Serge Thorimbert, Edwin Cheung, Ralf JauchAbstract:SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology. However, rationally engineering specific inhibitors that interfere with transcription factor DNA interfaces continues to be a monumental challenge in the field of transcription factor chemical biology. Polyoxometalates (POMs) are inorganic compounds that were previously shown to target the high-mobility group (HMG) of SOX proteins at nanomolar concentrations. In continuation of this work, we carried out an assessment of the selectivity of a panel of newly synthesized organo-Polyoxometalate hybrids in targeting different transcription factor families to enable the usage of Polyoxometalates as specific SOX transcription factor drugs.
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Regioselective Double Organic Functionalization of Polyoxotungstates through Electrophilic Addition of Aromatic Isocyanates to [P2W17O61(SnR)](7-)
European Journal of Inorganic Chemistry, 2013Co-Authors: Kévin Micoine, Emmanuel Lacote, Serge Thorimbert, Max Malacria, Bernold HasenknopfAbstract:The direct attachment of several different organic molecules to a single Polyoxometalate remains a challenge in the field of functionalized Polyoxometalates. In this paper, we show that an organotin-functionalized Dawson-type polyoxotungstate [P2W17O61(SnR)]7 reacts with aromatic isocyanates ArNCO to yield new doubly functionalized compounds [P2W17O61(SnR)(CONHAr)]6. Both organic moieties, Ar and R, can be varied independently; we have tested nine Ar and three R groups. Therefore, this synthetic methodology represents a way to graft two distinct functional molecules directly onto a Polyoxometalate.
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Chirality in Polyoxometalate Chemistry
European Journal of Inorganic Chemistry, 2008Co-Authors: Bernold Hasenknopf, Emmanuel Lacote, Kévin Micoine, Serge Thorimbert, Max Malacria, René ThouvenotAbstract:The increasing use of Polyoxometalates in the fields of material sciences, catalysis, and biology has raised the interest in chirality of such systems. This review provides a summary of the different strategies followed: i) chirality in solid-state arrangements, ii) chiral Polyoxometalate frameworks, and iii) chiral Polyoxometalate–organic hybrids. Through the discussion of selected examples, an outline for future work is drawn. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Ralf Jauch - One of the best experts on this subject based on the ideXlab platform.
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Exploring the utility of organo-Polyoxometalate hybrids to inhibit SOX transcription factors
Cell regeneration (London England), 2014Co-Authors: Kamesh Narasimhan, Bernold Hasenknopf, Emmanuel Lacote, Kévin Micoine, Serge Thorimbert, Edwin Cheung, Ralf JauchAbstract:SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology. However, rationally engineering specific inhibitors that interfere with transcription factor DNA interfaces continues to be a monumental challenge in the field of transcription factor chemical biology. Polyoxometalates (POMs) are inorganic compounds that were previously shown to target the high-mobility group (HMG) of SOX proteins at nanomolar concentrations. In continuation of this work, we carried out an assessment of the selectivity of a panel of newly synthesized organo-Polyoxometalate hybrids in targeting different transcription factor families to enable the usage of Polyoxometalates as specific SOX transcription factor drugs. The residual DNA-binding activities of 15 different transcription factors were measured after treatment with a panel of diverse Polyoxometalates. Polyoxometalates belonging to the Dawson structural class were found to be more potent inhibitors than the Keggin class. Further, organically modified Dawson Polyoxometalates were found to be the most potent in inhibiting transcription factor DNA binding activity. The size of the Polyoxometalates and its derivitization were found to be the key determinants of their potency. Polyoxometalates are highly potent, nanomolar range inhibitors of the DNA binding activity of the Sox-HMG family. However, binding assays involving a limited subset of structurally diverse Polyoxometalates revealed a low selectivity profile against different transcription factor families. Further progress in achieving selectivity and deciphering structure-activity relationship of POMs require the identification of POM binding sites on transcription factors using elaborate approaches like X-ray crystallography and multidimensional NMR. In summary, our report reaffirms that transcription factors are challenging molecular architectures and that future Polyoxometalate chemistry must consider further modification strategies, to address the substantial challenges involved in achieving target selectivity.
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Exploring the utility of organo-Polyoxometalate hybrids to inhibit SOX transcription factors
Cell Regeneration, 2014Co-Authors: Kamesh Narasimhan, Bernold Hasenknopf, Emmanuel Lacote, Kévin Micoine, Serge Thorimbert, Edwin Cheung, Ralf JauchAbstract:SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology. However, rationally engineering specific inhibitors that interfere with transcription factor DNA interfaces continues to be a monumental challenge in the field of transcription factor chemical biology. Polyoxometalates (POMs) are inorganic compounds that were previously shown to target the high-mobility group (HMG) of SOX proteins at nanomolar concentrations. In continuation of this work, we carried out an assessment of the selectivity of a panel of newly synthesized organo-Polyoxometalate hybrids in targeting different transcription factor families to enable the usage of Polyoxometalates as specific SOX transcription factor drugs.
Serge Thorimbert - One of the best experts on this subject based on the ideXlab platform.
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Exploring the utility of organo-Polyoxometalate hybrids to inhibit SOX transcription factors
Cell regeneration (London England), 2014Co-Authors: Kamesh Narasimhan, Bernold Hasenknopf, Emmanuel Lacote, Kévin Micoine, Serge Thorimbert, Edwin Cheung, Ralf JauchAbstract:SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology. However, rationally engineering specific inhibitors that interfere with transcription factor DNA interfaces continues to be a monumental challenge in the field of transcription factor chemical biology. Polyoxometalates (POMs) are inorganic compounds that were previously shown to target the high-mobility group (HMG) of SOX proteins at nanomolar concentrations. In continuation of this work, we carried out an assessment of the selectivity of a panel of newly synthesized organo-Polyoxometalate hybrids in targeting different transcription factor families to enable the usage of Polyoxometalates as specific SOX transcription factor drugs. The residual DNA-binding activities of 15 different transcription factors were measured after treatment with a panel of diverse Polyoxometalates. Polyoxometalates belonging to the Dawson structural class were found to be more potent inhibitors than the Keggin class. Further, organically modified Dawson Polyoxometalates were found to be the most potent in inhibiting transcription factor DNA binding activity. The size of the Polyoxometalates and its derivitization were found to be the key determinants of their potency. Polyoxometalates are highly potent, nanomolar range inhibitors of the DNA binding activity of the Sox-HMG family. However, binding assays involving a limited subset of structurally diverse Polyoxometalates revealed a low selectivity profile against different transcription factor families. Further progress in achieving selectivity and deciphering structure-activity relationship of POMs require the identification of POM binding sites on transcription factors using elaborate approaches like X-ray crystallography and multidimensional NMR. In summary, our report reaffirms that transcription factors are challenging molecular architectures and that future Polyoxometalate chemistry must consider further modification strategies, to address the substantial challenges involved in achieving target selectivity.
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Exploring the utility of organo-Polyoxometalate hybrids to inhibit SOX transcription factors
Cell Regeneration, 2014Co-Authors: Kamesh Narasimhan, Bernold Hasenknopf, Emmanuel Lacote, Kévin Micoine, Serge Thorimbert, Edwin Cheung, Ralf JauchAbstract:SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology. However, rationally engineering specific inhibitors that interfere with transcription factor DNA interfaces continues to be a monumental challenge in the field of transcription factor chemical biology. Polyoxometalates (POMs) are inorganic compounds that were previously shown to target the high-mobility group (HMG) of SOX proteins at nanomolar concentrations. In continuation of this work, we carried out an assessment of the selectivity of a panel of newly synthesized organo-Polyoxometalate hybrids in targeting different transcription factor families to enable the usage of Polyoxometalates as specific SOX transcription factor drugs.
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Regioselective Double Organic Functionalization of Polyoxotungstates through Electrophilic Addition of Aromatic Isocyanates to [P2W17O61(SnR)](7-)
European Journal of Inorganic Chemistry, 2013Co-Authors: Kévin Micoine, Emmanuel Lacote, Serge Thorimbert, Max Malacria, Bernold HasenknopfAbstract:The direct attachment of several different organic molecules to a single Polyoxometalate remains a challenge in the field of functionalized Polyoxometalates. In this paper, we show that an organotin-functionalized Dawson-type polyoxotungstate [P2W17O61(SnR)]7 reacts with aromatic isocyanates ArNCO to yield new doubly functionalized compounds [P2W17O61(SnR)(CONHAr)]6. Both organic moieties, Ar and R, can be varied independently; we have tested nine Ar and three R groups. Therefore, this synthetic methodology represents a way to graft two distinct functional molecules directly onto a Polyoxometalate.
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Chirality in Polyoxometalate Chemistry
European Journal of Inorganic Chemistry, 2008Co-Authors: Bernold Hasenknopf, Emmanuel Lacote, Kévin Micoine, Serge Thorimbert, Max Malacria, René ThouvenotAbstract:The increasing use of Polyoxometalates in the fields of material sciences, catalysis, and biology has raised the interest in chirality of such systems. This review provides a summary of the different strategies followed: i) chirality in solid-state arrangements, ii) chiral Polyoxometalate frameworks, and iii) chiral Polyoxometalate–organic hybrids. Through the discussion of selected examples, an outline for future work is drawn. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
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Identification of Polyoxometalates as nanomolar noncompetitive inhibitors of protein kinase CK2.
Chemistry & Biology Chemistry and Biology; CHEMISTRY & BIOLOGY, 2008Co-Authors: Renaud Prudent, Bernold Hasenknopf, Emmanuel Lacote, Serge Thorimbert, Virginie Moucadel, Béatrice Laudet, Caroline Barette, Laurence Lafanechère, Sébastian Bareyt, Max MalacriaAbstract:Protein kinase CK2 is a multifunctional kinase of medical importance that is dysregulated in many cancers. In this study, Polyoxometalates were identified as original CK2 inhibitors. [P2Mo18O62](6-) has the most potent activity. It inhibits the kinase in the nanomolar range by targeting key structural elements located outside the ATP- and peptide substrate-binding sites. Several Polyoxometalate derivatives exhibit strong inhibitory efficiency, with IC50 values < or = 10 nM. Furthermore, these inorganic compounds show a striking specificity for CK2 when tested in a panel of 29 kinases. Therefore, Polyoxometalates are effective CK2 inhibitors in terms of both efficiency and selectivity and represent nonclassical kinase inhibitors that interact with CK2 in a unique way. This binding mode may provide an exploitable mechanism for developing potent drugs with desirable properties, such as enhanced selectivity relative to ATP-mimetic inhibitors.
