The Experts below are selected from a list of 234 Experts worldwide ranked by ideXlab platform

Michael J Mustari - One of the best experts on this subject based on the ideXlab platform.

Seiji Ono - One of the best experts on this subject based on the ideXlab platform.

Vallabh E Das - One of the best experts on this subject based on the ideXlab platform.

  • Modeling of smooth pursuit-related neuronal responses in the DLPN and NRTP of the rhesus macaque.
    Journal of neurophysiology, 2004
    Co-Authors: Seiji Ono, Vallabh E Das, John R. Economides, Michael J Mustari
    Abstract:

    The dorsolateral Pontine Nucleus (DLPN) and Nucleus reticularis tegmenti pontis (NRTP) comprise obligatory links in the cortico-ponto-cerebellar system supporting smooth pursuit eye movements. We e...

  • Gaze-related response properties of DLPN and NRTP neurons in the rhesus macaque.
    Journal of neurophysiology, 2004
    Co-Authors: Seiji Ono, Vallabh E Das, Michael J Mustari
    Abstract:

    The dorsolateral Pontine Nucleus (DLPN) and Nucleus reticularis tegmenti pontis (NRTP) are basilar Pontine nuclei important for control of eye movements. The aim of this study was to compare the re...

  • role of the dorsolateral Pontine Nucleus in short term adaptation of the horizontal vestibuloocular reflex
    Journal of Neurophysiology, 2003
    Co-Authors: Seiji Ono, Vallabh E Das, Michael J Mustari
    Abstract:

    The dorsolateral Pontine Nucleus (DLPN) is a major component of the cortico-ponto-cerebellar pathway that carries signals essential for smooth pursuit. This pathway also carries visual signals that...

  • Role of the Dorsolateral Pontine Nucleus in Visual-Vestibular Behavior
    Annals of the New York Academy of Sciences, 2003
    Co-Authors: Michael J Mustari, Seiji Ono, Vallabh E Das, Ronald J. Tusa
    Abstract:

    Visual-vestibular behavior depends on signals traveling in climbing and mossy fiber pathways. Our study examined the role of the dorsolateral Pontine Nucleus (DLPN), a major component of the cortico-ponto-cerebellar mossy fiber pathway. DLPN neurons discharge in relation to smooth pursuit and during visual stimulation, indicating a potential role in visually guided motor learning in the vestibulo-ocular reflex (VOR). We used unilateral muscimol injections to determine the potential role of the DLPN in short-term VOR gain adaptation. Preinjection adaptation of VOR gain was achieved by sinusoidal rotation (0.2 Hz, 30 degrees /s) for 2 h while the monkey viewed a stationary visual surround through either magnifying (x2) or minifying (x0.5) lenses. VOR gain increases (23-32%) or decreases (22-48%) as measured in complete darkness (VORd) were achieved. Following DLPN inactivation, initial acceleration of ipsilateral smooth-pursuit was reduced by 35-68%, and steady state gain was reduced by 32-61%. Furthermore, the monkey's ability to cancel the VOR was impaired. In contrast to these significant deficits in ipsilesional smooth pursuit, the VOR during lens viewing was similar to that measured in preinjection control experiments. Similarly, following 2 h of adaptation, VORd gain adaptation was indistinguishable from control adaptation values for either ipsilesional or contralesional directions of head rotation. Our results suggest that visual error signals for short-term adaptation of the VOR are derived from sources other than the DLPN, such as those from the accessory optic system.

Klaus-peter Hoffmann - One of the best experts on this subject based on the ideXlab platform.

  • Visual response properties of neurons in cortical areas MT and MST projecting to the dorsolateral Pontine Nucleus or the Nucleus of the optic tract in macaque monkeys.
    The European journal of neuroscience, 2009
    Co-Authors: Klaus-peter Hoffmann, Frank Bremmer, Claudia Distler
    Abstract:

    Neurons in cortical medial temporal area (MT) and medial superior temporal area (MST) projecting to the dorsolateral Pontine Nucleus (DLPN) and/or to the Nucleus of the optic tract and dorsal terminal Nucleus (NOT-DTN) were identified by antidromic electrical stimulation in five macaque monkeys. Neurons projecting to either target were located in close proximity to each other, and in all subregions of MT and MST sampled. Only a small percentage of the antidromically identified projection neurons (4.4%) sent branches to both the NOT-DTN and the DLPN. Antidromic latencies of neurons projecting to the NOT-DTN (0.9-6 ms, median 2.1 ms) and to the DLPN (0.8-5 ms, median 2.0 ms) did not differ significantly. Visual response properties of the neurons antidromically activated from either site did not differ significantly from those of cells that were not so activated. On the population level only neurons activated from the NOT-DTN had a clear preference for ipsiversive stimulus movement, whereas the neurons activated from the DLPN and neurons not antidromically activated from either target had no common directional preference. These results are discussed in terms of specification of cortico-subcortical connections and with regard to pathways underlying slow eye movements in different visuomotor behaviours.

  • Private lines of cortical visual information to the Nucleus of the optic tract and dorsolateral Pontine Nucleus.
    Progress in brain research, 2008
    Co-Authors: Claudia Distler, Klaus-peter Hoffmann
    Abstract:

    Abstract: The subcortical Nucleus of the optic tract and dorsal terminal Nucleus of the accessory optic system (NOT-DTN), along with the dorsolateral Pontine Nucleus (DLPN), has been shown to play a pivotal role in controlling slow eye movements. Both nuclei are known to receive cortical input from striate and extrastriate cortex. To determine to what degree this cortical input arises from the same areas, and potentially from the same individual neurons, in one set of experiments we placed different retrograde tracers into the NOT-DTN and the DLPN. In the ipsilateral cortical hemisphere the two projections mainly overlapped in the middle temporal (MT) area, the middle superior temporal (MST) area, and the visual area in the fundus of the STS (FST) and the surrounding cortex. In these areas, neurons projecting to the NOT-DTN or the DLPN were closely intermingled. Nevertheless, only 3–11% of the labelled neurons in MT and MST were double-labelled in our various cases. In a second set of experiments, we identified neurons in areas MT and MST projecting to the DLPN and/or to the NOT-DTN by antidromic electrical stimulation. Again, neurons projecting to either target were located in close proximity to each other and in all subregions of MT and MST sampled. Only a small percentage of the antidromically identified projection neurons (4.4%) sent branches to both the NOT-DTN and the DLPN. On the population level, only neurons activated from the NOT-DTN had a clear preference for ipsiversive stimulus movement whereas the neurons activated from the DLPN, and neurons not antidromically activated from either target, had no common directional preference. These results indicate that the cortical input to the NOT-DTN and DLPN arises from largely separate neuronal subpopulations in the motion sensitive areas in the posterior STS. Only a small percentage of the projection neurons bifurcate to supply both targets. These findings are discussed in relation to the effects of cortical lesions on the optokinetic and smooth pursuit system.

  • cortical projections to the Nucleus of the optic tract and dorsal terminal Nucleus and to the dorsolateral Pontine Nucleus in macaques a dual retrograde tracing study
    The Journal of Comparative Neurology, 2002
    Co-Authors: Claudia Distler, Michael J Mustari, Klaus-peter Hoffmann
    Abstract:

    The Nucleus of the optic tract and dorsal terminal Nucleus of the accessory optic system (NOT-DTN) along with the dorsolateral Pontine Nucleus (DLPN) have been shown to play a role in controlling slow eye movements and in maintaining stable vision during head movements. Both nuclei are known to receive cortical input from striate and extrastriate cortex. To determine to what degree this cortical input arises from the same areas and potentially from the same individual neurons, we placed different retrograde tracers into the NOT-DTN and the DLPN. In the ipsilateral cortical hemisphere the two projections mainly overlapped in the posterior part of the superior temporal sulcus (STS) comprising the middle temporal area (MT), the middle superior temporal area (MST), and the visual area in the fundus of the STS (FST) and the surrounding cortex. In these areas, neurons projecting to the NOT-DTN or the DLPN were closely intermingled. Nevertheless, only 3–11% of the labeled neurons in MT and MST were double-labeled in our various cases. These results indicate that the cortical input to the NOT-DTN and DLPN arises from largely separate neuronal subpopulations in the motion sensitive areas in the posterior STS. Only a small percentage of the projection neurons bifurcate to supply both targets. These findings are discussed in relation to the optokinetic and the smooth pursuit system. J. Comp. Neurol. 444:144–158, 2002. © 2002 Wiley-Liss, Inc.

Claudia Distler - One of the best experts on this subject based on the ideXlab platform.

  • Visual response properties of neurons in cortical areas MT and MST projecting to the dorsolateral Pontine Nucleus or the Nucleus of the optic tract in macaque monkeys.
    The European journal of neuroscience, 2009
    Co-Authors: Klaus-peter Hoffmann, Frank Bremmer, Claudia Distler
    Abstract:

    Neurons in cortical medial temporal area (MT) and medial superior temporal area (MST) projecting to the dorsolateral Pontine Nucleus (DLPN) and/or to the Nucleus of the optic tract and dorsal terminal Nucleus (NOT-DTN) were identified by antidromic electrical stimulation in five macaque monkeys. Neurons projecting to either target were located in close proximity to each other, and in all subregions of MT and MST sampled. Only a small percentage of the antidromically identified projection neurons (4.4%) sent branches to both the NOT-DTN and the DLPN. Antidromic latencies of neurons projecting to the NOT-DTN (0.9-6 ms, median 2.1 ms) and to the DLPN (0.8-5 ms, median 2.0 ms) did not differ significantly. Visual response properties of the neurons antidromically activated from either site did not differ significantly from those of cells that were not so activated. On the population level only neurons activated from the NOT-DTN had a clear preference for ipsiversive stimulus movement, whereas the neurons activated from the DLPN and neurons not antidromically activated from either target had no common directional preference. These results are discussed in terms of specification of cortico-subcortical connections and with regard to pathways underlying slow eye movements in different visuomotor behaviours.

  • Private lines of cortical visual information to the Nucleus of the optic tract and dorsolateral Pontine Nucleus.
    Progress in brain research, 2008
    Co-Authors: Claudia Distler, Klaus-peter Hoffmann
    Abstract:

    Abstract: The subcortical Nucleus of the optic tract and dorsal terminal Nucleus of the accessory optic system (NOT-DTN), along with the dorsolateral Pontine Nucleus (DLPN), has been shown to play a pivotal role in controlling slow eye movements. Both nuclei are known to receive cortical input from striate and extrastriate cortex. To determine to what degree this cortical input arises from the same areas, and potentially from the same individual neurons, in one set of experiments we placed different retrograde tracers into the NOT-DTN and the DLPN. In the ipsilateral cortical hemisphere the two projections mainly overlapped in the middle temporal (MT) area, the middle superior temporal (MST) area, and the visual area in the fundus of the STS (FST) and the surrounding cortex. In these areas, neurons projecting to the NOT-DTN or the DLPN were closely intermingled. Nevertheless, only 3–11% of the labelled neurons in MT and MST were double-labelled in our various cases. In a second set of experiments, we identified neurons in areas MT and MST projecting to the DLPN and/or to the NOT-DTN by antidromic electrical stimulation. Again, neurons projecting to either target were located in close proximity to each other and in all subregions of MT and MST sampled. Only a small percentage of the antidromically identified projection neurons (4.4%) sent branches to both the NOT-DTN and the DLPN. On the population level, only neurons activated from the NOT-DTN had a clear preference for ipsiversive stimulus movement whereas the neurons activated from the DLPN, and neurons not antidromically activated from either target, had no common directional preference. These results indicate that the cortical input to the NOT-DTN and DLPN arises from largely separate neuronal subpopulations in the motion sensitive areas in the posterior STS. Only a small percentage of the projection neurons bifurcate to supply both targets. These findings are discussed in relation to the effects of cortical lesions on the optokinetic and smooth pursuit system.

  • cortical projections to the Nucleus of the optic tract and dorsal terminal Nucleus and to the dorsolateral Pontine Nucleus in macaques a dual retrograde tracing study
    The Journal of Comparative Neurology, 2002
    Co-Authors: Claudia Distler, Michael J Mustari, Klaus-peter Hoffmann
    Abstract:

    The Nucleus of the optic tract and dorsal terminal Nucleus of the accessory optic system (NOT-DTN) along with the dorsolateral Pontine Nucleus (DLPN) have been shown to play a role in controlling slow eye movements and in maintaining stable vision during head movements. Both nuclei are known to receive cortical input from striate and extrastriate cortex. To determine to what degree this cortical input arises from the same areas and potentially from the same individual neurons, we placed different retrograde tracers into the NOT-DTN and the DLPN. In the ipsilateral cortical hemisphere the two projections mainly overlapped in the posterior part of the superior temporal sulcus (STS) comprising the middle temporal area (MT), the middle superior temporal area (MST), and the visual area in the fundus of the STS (FST) and the surrounding cortex. In these areas, neurons projecting to the NOT-DTN or the DLPN were closely intermingled. Nevertheless, only 3–11% of the labeled neurons in MT and MST were double-labeled in our various cases. These results indicate that the cortical input to the NOT-DTN and DLPN arises from largely separate neuronal subpopulations in the motion sensitive areas in the posterior STS. Only a small percentage of the projection neurons bifurcate to supply both targets. These findings are discussed in relation to the optokinetic and the smooth pursuit system. J. Comp. Neurol. 444:144–158, 2002. © 2002 Wiley-Liss, Inc.