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B O Yang - One of the best experts on this subject based on the ideXlab platform.
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Incidence of Port Site Metastasis in Laparoscopic Radical Nephroureterectomy: Single-institution Experience
Urology, 2019Co-Authors: Qianyu Kang, B O YangAbstract:Abstract Objective To address the incidence and potential risk factors of Port Site Metastasis (PSM) in patients who underwent laparoscopic radical nephroureterectomy (RNU) for upper tract urothelial carcinoma. Materials and Methods Between January 2013 and December 2018 laparoscopic RNU were performed in 240 patients at our institution, including 145 with renal pelvic tumor and 135 with ureteral tumor (40 patients have both tumor). Laparoscopies were performed through the transperitoneal approach in 28 patients, and retroperitoneal in 212 patients. Clinical data are retrospectively collected. Results Perioperative and pathologic data are available in all 240 cases. After a mean follow-up of 12.6 months (range 3-45 months), 4 patients (1.7%) developed PSM following retroperitoneal RNU at an average of 4.3 months. Tumor stage is T2N0M0 in one, T3N0M0 in two, and T3N1M0 in one, respectively. Tumor grade are high-grade urothelial carcinoma in all. The incidence of PSM is 2.8% (4/145) and 0.7% (1/135) in renal pelvic and ureteral tumor, respectively. Conclusion We rePort a 1.7% incidence of PSM in upper tract urothelial carcinoma after laparoscopic RNU. We suggest that air leakage during retroperitoneal approach, high tumor stage (pT3) and grade, and advanced renal pelvic tumor with micrometastases could increase the potential risks of PSM.
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Port Site Metastasis as a primary complication following retroperitoneal laparoscopic radical resection of renal pelvis carcinoma or nephron sparing surgery a rePort of three cases and review of the literature
Oncology Letters, 2016Co-Authors: Ning Wang, Kai Wang, Dachuan Zhong, Xia Liu, Ji Sun, Lianxiang Lin, B O YangAbstract:The present study rePorts the clinical data of two patients with renal pelvis carcinoma and one patient with renal carcinoma who developed Port-Site Metastasis following retroperitoneal laparoscopic surgery. The current study aimed to identify the cause and prognosis of the occurrence of Port-Site Metastasis subsequent to laparoscopic radical resection of renal pelvis carcinoma and nephron-sparing surgery. Post-operative pathology confirmed the presence of high-grade urothelial cell carcinoma in two patients and Fuhrman grade 3 renal clear cell carcinoma in one patient. Port-Site Metastasis was initially detected 1-7 months post-surgery. The two patients with renal pelvis carcinoma succumbed to the disease 2 and 4 months following the identification of the Port-Site Metastasis, respectively, whereas the patient with renal carcinoma survived with no disease progression during the targeted therapy period. The occurrence of Port-Site Metastasis may be attributed to systemic and local factors. Measures to reduce the development of this complication include strict compliance with the operating guidelines for tumor surgery, avoidance of air leakage at the Port-Site, complete removal of the specimen with an impermeable bag, irrigation of the laparoscopic instruments and incisional wound with povidone-iodine when necessary, and enhancement of the body's immunity. Close post-operative follow-up observation for signs of recurrence or Metastasis is essential, and systemic chemotherapy may be required in patients with high-grade renal pelvis carcinoma and renal carcinoma in order to prolong life expectancy.
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Port‑Site Metastasis as a primary complication following retroperitoneal laparoscopic radical resection of renal pelvis carcinoma or nephron‑sparing surgery: A rePort of three cases and review of the literature
Oncology letters, 2016Co-Authors: Ning Wang, Kai Wang, Dachuan Zhong, Xia Liu, Ji Sun, Lianxiang Lin, B O YangAbstract:The present study rePorts the clinical data of two patients with renal pelvis carcinoma and one patient with renal carcinoma who developed Port-Site Metastasis following retroperitoneal laparoscopic surgery. The current study aimed to identify the cause and prognosis of the occurrence of Port-Site Metastasis subsequent to laparoscopic radical resection of renal pelvis carcinoma and nephron-sparing surgery. Post-operative pathology confirmed the presence of high-grade urothelial cell carcinoma in two patients and Fuhrman grade 3 renal clear cell carcinoma in one patient. Port-Site Metastasis was initially detected 1-7 months post-surgery. The two patients with renal pelvis carcinoma succumbed to the disease 2 and 4 months following the identification of the Port-Site Metastasis, respectively, whereas the patient with renal carcinoma survived with no disease progression during the targeted therapy period. The occurrence of Port-Site Metastasis may be attributed to systemic and local factors. Measures to reduce the development of this complication include strict compliance with the operating guidelines for tumor surgery, avoidance of air leakage at the Port-Site, complete removal of the specimen with an impermeable bag, irrigation of the laparoscopic instruments and incisional wound with povidone-iodine when necessary, and enhancement of the body's immunity. Close post-operative follow-up observation for signs of recurrence or Metastasis is essential, and systemic chemotherapy may be required in patients with high-grade renal pelvis carcinoma and renal carcinoma in order to prolong life expectancy.
Seigo Kitano - One of the best experts on this subject based on the ideXlab platform.
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Port-Site Metastasis after CO2 pneumoperitoneum: role of adhesion molecules and prevention with antiadhesion molecules.
Surgical endoscopy, 2004Co-Authors: Y. Hirabayashi, K. Yamaguchi, Norio Shiraishi, Yosuke Adachi, Ikuo Saiki, Seigo KitanoAbstract:Background Port-Site Metastasis is a continuing problem in laparoscopic cancer surgery. To clarify the role of adhesion molecules in the development of Port-Site Metastasis, particularly with regard to prevention, we performed experiments in which Port-Site Metastasis was inhibited using antibodies against extracellular matrix proteins or the active Arg–Gly–Asp (RGD) peptide after CO2 pneumoperitoneum in a murine model.
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Development of Port-Site Metastasis after pneumoperitoneum.
Surgical endoscopy, 2002Co-Authors: Y. Hirabayashi, K. Yamaguchi, Norio Shiraishi, Yosuke Adachi, H. Kitamura, Seigo KitanoAbstract:Background Port-Site Metastasis is a critical problem in laparoscopic cancer surgery; the pathogenesis and means of prevention are still unclear. The aim of this study was to clarify by scanning electron microscopy the initial morphologic changes in the development of PortSite Metastasis.
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Development of Port-Site Metastasis after pneumoperitoneum: A scanning electron microscopy study
Surgical Endoscopy and Other Interventional Techniques, 2002Co-Authors: Y. Hirabayashi, K. Yamaguchi, Norio Shiraishi, Yosuke Adachi, H. Kitamura, Seigo KitanoAbstract:Background: Port-Site Metastasis is a critical problem in laparoscopic cancer surgery; the pathogenesis and means of prevention are still unclear. The aim of this study was to clarify by scanning electron microscopy the initial morphologic changes in the development of Port-Site Metastasis. Methods: Fifteen nude mice were injected with human gastric cancer (MKN 45) cells. Mice were killed on days 0, 3, and 8 (n = 5 each day) after intraperitoneal injection of 5 x 10 5 cancer cells and carbon dioxide (CO 2 ) pneumoperitoneum at 4-6 mmHg for 20 min. The abdominal wall with the Port Sites was harvested and examined under both light and scanning electron microscopy. Results: Immediately after CO 2 pneumoperitoneum (day 0), the abdominal peritoneum was peeled away and the muscular layer was destroyed at the Port Site in all mice. Several cancer cells were attached to the injured Port Sites. On day 3, the subperitoneal tissue and muscular layer defects were replaced by granulation tissue, and several cancer cells were observed in the subperitoneal tissue. On day 8, a small nodule was macroscopically visible at the Port Site; it was completely covered by mesothelial cells and consisted of numerous cancer cells. Conclusions: Free cancer cells appear to attach to the injured Port Sites immediately after CO 2 pneumoperitoneum, and these are associated with the development of Port-Site Metastasis after laparoscopic cancer surgery.
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Development of Port-Site Metastasis after pneumoperitoneum : A scanning electron microscopy study (Original Articles)
Surgical Endoscopy and Other Interventional Techniques, 2002Co-Authors: Y. Hirabayashi, K. Yamaguchi, Norio Shiraishi, Yosuke Adachi, H. Kitamura, Seigo KitanoAbstract:BackgroundPort-Site Metastasis is a critical problem in laparoscopic cancer surgery; the pathogenesis and means of prevention are still unclear. The aim of this study was to clarify by scanning electron microscopy the initial morphologic changes in the development of PortSite Metastasis.MethodsFifteen nude mice were injected with human gastric cancer (MKN 45) cells. Mice were killed on days 0, 3, and 8 (n=5 each day) after intraperitoneal injection of 5 × 10 5 cancer cells and carbon dioxide (CO 2 ) pneumoperitoneum at 4-6 mmHg for 20 min. The abdominal wall with the Port Sites was harvested and examined under both light and scanning electron microscopy.ResultsImmediately after CO 2 pneumoperitoneum (day 0), the abdominal peritoneum was peeled away and the muscular layer was destroyed at the Port Site in all mice. Several cancer cells were attached to the injured Port Sites. On day 3, the subperitoneal tissue and muscular layer defects were replaced by granulation tissue, and several cancer cells were observed in the subperitoneal tissue. On day 8, a small nodule was macroscopically visible at the Port Site; it was completely covered by mesothelial cells and consisted of numerous cancer cells.ConclusionsFree cancer cells appear to attach to the injured Port Sites immediately after CO 2 pneumoperitoneum, and these are associated with the development of Port-Site Metastasis after laparoscopic cancer surgery.
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Enhancement of Port Site Metastasis by hyaluronic acid under CO2 pneumoperitoneum in a murine model.
Surgical endoscopy, 2001Co-Authors: K. Yamaguchi, Y. Hirabayashi, Yosuke Adachi, Akio Shiromizu, N. Shirashi, Seigo KitanoAbstract:Background The mechanism underlying the development and progression of Port Site Metastasis after laparoscopic surgery for cancer is still not understood. Hyaluronic acid secreted from mesothelial cells is thought to be a key factor that causes adhesion between cancer cells and mesothelial cells. Using a murine model of carbon dioxide (CO2) pneumoperitoneum, we evaluated the effect of exogenous hyaluronic acid on Port Site Metastasis.
Joseph B. Song - One of the best experts on this subject based on the ideXlab platform.
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Port Site Metastasis after Surgery for Renal Cell Carcinoma: Harbinger of Future Metastasis
The Journal of urology, 2014Co-Authors: Joseph B. Song, Eric H. Kim, Jonathan M. Mobley, Goutham Vemana, Youssef S. Tanagho, Joel Vetter, Sam B. Bhayani, Paul Russo, Oscar Eduardo Hidetoshi Fugita, Stephen Shei-dei YangAbstract:Purpose: Port Site Metastasis is a rare occurrence after minimally invasive treatment for renal cell carcinoma. However, its prognostic implications are unclear because rePorts in the literature are heterogeneous in detail and followup. We clarify the significance of Port Site Metastasis in cancer specific survival and broaden our understanding of this phenomenon.Materials and Methods: A MEDLINE® search for published studies of renal cell carcinoma Port Site Metastasis was performed. Contributing factors to Port Site Metastasis, stage, Fuhrman grade, pathology, Port Site Metastasis treatment method, followup protocol and long-term outcomes were collected. The corresponding authors of each publication were contacted to fill in details and provide long-term outcomes. We added 1 case from our recent experience.Results: A total of 16 cases from 12 authors (including ourselves) were found. Of the 12 authors 8 were available for correspondence and 9 cases were updated. Eventual outcomes were available for 11 of...
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Camera-Port Site Metastasis of a renal-cell carcinoma after robot-assisted partial nephrectomy.
Journal of endourology, 2013Co-Authors: Joseph B. Song, Eric H. Kim, Goutham Vemana, Youssef S. Tanagho, Phillip H. Abbosh, R. Sherburne FigenshauAbstract:Abstract Background and Purpose: Port-Site Metastasis (PSM) is a rare complication of laparoscopic intervention in urologic malignancies. Of the greater than 50 rePorted cases of PSM in the urologic oncology literature, only 9 have occurred after surgery for renal-cell carcinoma (RCC). We rePort a 10th instance of RCC Metastasis—in this case to the camera-Port Site after robot-assisted partial nephrectomy (RAPN). To our knowledge, this case is the first rePorted PSM of RCC after RAPN. Patient and Methods: A 68-year-old man underwent an uncomplicated right RAPN for a 4-cm right renal mass (stage T1aN0M0). Five months later, he was found to have metastatic disease with an isolated peritoneal recurrence at the camera-Port Site. Biopsy of the lesion confirmed RCC, and the lesion was surgically resected. A comprehensive MEDLINE search for all published studies of Port-Site recurrences after laparoscopic renal surgery for RCC was performed. Results: Nine cases of PSM after successful laparoscopic radical or par...
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Camera-Port Site Metastasis of a Renal-Cell Carcinoma
2013Co-Authors: Joseph B. Song, Eric H. Kim, Youssef S. Tanagho, Phillip H. AbboshAbstract:Camera-Port Site Metastasis of a renal-cell carcinoma after robot-assisted partial nephrectom
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Port-Site Metastasis After Robot-Assisted Partial Nephrectomy
Videourology, 2013Co-Authors: Eric H. Kim, Joseph B. Song, Youssef S. Tanagho, Phillip H. Abbosh, Robert S. FigenshauAbstract:Abstract Introduction: With the increasing use of minimally invasive techniques in the management of urologic malignancies, rePorts of Port-Site Metastasis (PSM) have raised concerns regarding the ...
Stephen Shei-dei Yang - One of the best experts on this subject based on the ideXlab platform.
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Port Site Metastasis after Surgery for Renal Cell Carcinoma: Harbinger of Future Metastasis
The Journal of urology, 2014Co-Authors: Joseph B. Song, Eric H. Kim, Jonathan M. Mobley, Goutham Vemana, Youssef S. Tanagho, Joel Vetter, Sam B. Bhayani, Paul Russo, Oscar Eduardo Hidetoshi Fugita, Stephen Shei-dei YangAbstract:Purpose: Port Site Metastasis is a rare occurrence after minimally invasive treatment for renal cell carcinoma. However, its prognostic implications are unclear because rePorts in the literature are heterogeneous in detail and followup. We clarify the significance of Port Site Metastasis in cancer specific survival and broaden our understanding of this phenomenon.Materials and Methods: A MEDLINE® search for published studies of renal cell carcinoma Port Site Metastasis was performed. Contributing factors to Port Site Metastasis, stage, Fuhrman grade, pathology, Port Site Metastasis treatment method, followup protocol and long-term outcomes were collected. The corresponding authors of each publication were contacted to fill in details and provide long-term outcomes. We added 1 case from our recent experience.Results: A total of 16 cases from 12 authors (including ourselves) were found. Of the 12 authors 8 were available for correspondence and 9 cases were updated. Eventual outcomes were available for 11 of...
Gonzalo Vitagliano - One of the best experts on this subject based on the ideXlab platform.
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Port Site Metastasis and Tumor Seeding in Oncologic Laparoscopic Urology
Urology, 2008Co-Authors: Octavio A. Castillo, Gonzalo VitaglianoAbstract:Tumor seeding and Port Site Metastasis remain a valid concern during laparoscopic procedures for urologic malignancies. A systematic review of all cases rePorted in published studies was performed. A MEDLINE search identified 17 English studies rePorting a total of 29 cases of Port Site Metastasis or tumor seeding secondary to urologic laparoscopic procedures in the past 20 years. Many factors contribute to Port Site metastases and tumor seeding. Nevertheless, we believe that only proper preoperative criteria, along with cautious intraoperative judgment, will keep Port Site Metastasis to a minimum in the future.
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Port-Site Metastasis after laparoscopic partial nephrectomy: Case rePort and literature review.
Journal of endourology, 2007Co-Authors: Octavio A. Castillo, Gonzalo Vitagliano, Manuel O. Diaz, Rafael Sanchez-salasAbstract:Local recurrence and Port-Site Metastasis remain a concern in urologic laparoscopic oncologic surgery. PortSite recurrence of renal-cell carcinoma after retroperitoneal and transperitoneal radical nephrectomy has been well documented. We rePort the first case of a Port-Site Metastasis secondary to a partial nephrectomy and perform a literature review of this subject.