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Paul K. Whelton - One of the best experts on this subject based on the ideXlab platform.

  • Potassium Intake and Blood Pressure: A Dose-Response Meta-Analysis of Randomized Controlled Trials.
    Journal of the American Heart Association, 2020
    Co-Authors: Tommaso Filippini, Nicola Orsini, Androniki Naska, Maria-iosifina Kasdagli, Duarte Torres, Carla Lopes, Catarina Carvalho, Pedro Moreira, Marcella Malavolti, Paul K. Whelton
    Abstract:

    Background Epidemiologic studies, including trials, suggest an association between Potassium Intake and blood pressure (BP). However, the strength and shape of this relationship is uncertain. Metho...

  • Sodium and Potassium Intake in US Adults.
    Circulation, 2018
    Co-Authors: Paul K. Whelton
    Abstract:

    Article, see p 237 Quantitative estimates of sodium Intake in the general population provide a basis for clinical and public health decision making. For many years, National Health and Nutrition Examination Survey (NHANES) results have provided estimates for sodium and Potassium Intake in the US general noninstitutionalized population. However, these reports have been based on 24-hour dietary recalls, a method that is subject to a variety of systematic errors in the estimation of electrolyte Intake and is known to underestimate dietary sodium Intake and overestimate dietary Potassium Intake. In this issue of Circulation , Jackson et al1 provide the first nationally representative estimates for sodium and Potassium Intake in US adults based on carefully collected 24-hour urine collections. All of the 765 adults surveyed had at least one 24-hour urine collection, and a second collection was obtained in more than half (436) of the participants, allowing for a between-visit random error correction in estimation. The availability of national estimates based on 24-hour urine collections represents an important step forward for NHANES and a new norm for reporting dietary electrolyte Intake in US adults. As one would expect, the Intake of dietary sodium was higher, and of Potassium was lower, in the current report in comparison with previous NHANES estimates. The average Intake of sodium was well above the current federal Dietary Guidelines for Americans recommendations of

  • sodium and Potassium Intake in us adults
    Circulation, 2018
    Co-Authors: Paul K. Whelton
    Abstract:

    Article, see p 237 Quantitative estimates of sodium Intake in the general population provide a basis for clinical and public health decision making. For many years, National Health and Nutrition Examination Survey (NHANES) results have provided estimates for sodium and Potassium Intake in the US general noninstitutionalized population. However, these reports have been based on 24-hour dietary recalls, a method that is subject to a variety of systematic errors in the estimation of electrolyte Intake and is known to underestimate dietary sodium Intake and overestimate dietary Potassium Intake. In this issue of Circulation , Jackson et al1 provide the first nationally representative estimates for sodium and Potassium Intake in US adults based on carefully collected 24-hour urine collections. All of the 765 adults surveyed had at least one 24-hour urine collection, and a second collection was obtained in more than half (436) of the participants, allowing for a between-visit random error correction in estimation. The availability of national estimates based on 24-hour urine collections represents an important step forward for NHANES and a new norm for reporting dietary electrolyte Intake in US adults. As one would expect, the Intake of dietary sodium was higher, and of Potassium was lower, in the current report in comparison with previous NHANES estimates. The average Intake of sodium was well above the current federal Dietary Guidelines for Americans recommendations of <2300 mg/d for all adults and <1500 mg/d for those ≥51 years, and those of any age who are African American, or have hypertension, diabetes mellitus, or chronic kidney disease.2 For example, the average Intake of 3746 mg/d …

  • dietary Potassium Intake and risk of stroke in us men and women national health and nutrition examination survey i epidemiologic follow up study
    Stroke, 2001
    Co-Authors: Lydia A Bazzano, Lorraine G Ogden, Catherine Loria, Suma Vupputuri, Leann Myers, Paul K. Whelton
    Abstract:

    Background and Purpose —The few prospective studies that have explored the association between dietary Intake of Potassium and risk of stroke have reported inconsistent findings. This study examines the relationship between dietary Potassium Intake and the risk of stroke in a representative sample of the US general population. Methods —Study participants included 9805 US men and women who participated in the first National Health and Nutrition Examination Survey (NHANES I) Epidemiologic Follow-Up Study. Dietary Potassium and total energy Intake were estimated at baseline by using a 24-hour dietary recall. Incidence data for stroke and coronary heart disease were obtained from medical records and death certificates. Results —Over an average of 19 years of follow up, 927 stroke events and 1847 coronary heart disease events were documented. Overall, stroke hazard was significantly different among quartiles of Potassium Intake (likelihood ratio P =0.03); however, a test of linear trend across quartiles did not reach a customary level of statistical significance ( P =0.14). Participants consuming a low Potassium diet at baseline ( P Conclusions —These findings suggest that low dietary Potassium Intake is associated with an increased risk of stroke. However, the possibility that the association is due to residual confounding cannot be entirely ruled out in this observational study.

Nicola Orsini - One of the best experts on this subject based on the ideXlab platform.

  • Potassium Intake and Blood Pressure: A Dose-Response Meta-Analysis of Randomized Controlled Trials.
    Journal of the American Heart Association, 2020
    Co-Authors: Tommaso Filippini, Nicola Orsini, Androniki Naska, Maria-iosifina Kasdagli, Duarte Torres, Carla Lopes, Catarina Carvalho, Pedro Moreira, Marcella Malavolti, Paul K. Whelton
    Abstract:

    Background Epidemiologic studies, including trials, suggest an association between Potassium Intake and blood pressure (BP). However, the strength and shape of this relationship is uncertain. Metho...

  • Meta‐Analysis of Potassium Intake and the Risk of Stroke
    Journal of the American Heart Association, 2016
    Co-Authors: Marco Vinceti, Tommaso Filippini, Alessio Crippa, Agnès De Sesmaisons, Lauren A. Wise, Nicola Orsini
    Abstract:

    BackgroundThe possibility that lifestyle factors such as diet, specifically Potassium Intake, may modify the risk of stroke has been suggested by several observational cohort studies, including som...

  • meta analysis of Potassium Intake and the risk of stroke
    Journal of the American Heart Association, 2016
    Co-Authors: Marco Vinceti, Tommaso Filippini, Alessio Crippa, Agnès De Sesmaisons, Lauren A. Wise, Nicola Orsini
    Abstract:

    BackgroundThe possibility that lifestyle factors such as diet, specifically Potassium Intake, may modify the risk of stroke has been suggested by several observational cohort studies, including som...

  • dietary Potassium Intake and risk of stroke a dose response meta analysis of prospective studies
    Stroke, 2011
    Co-Authors: Susanna C. Larsson, Nicola Orsini, Alicja Wolk
    Abstract:

    Background and Purpose—Potassium Intake has been inconsistently associated with risk of stroke. Our aim was to conduct a meta-analysis of prospective studies to assess the relation between Potassium Intake and stroke risk. Methods—Pertinent studies were identified by a search of PubMed from January 1966 through March 2011 and by reviewing the reference lists of retrieved articles. We included prospective studies that reported relative risks with 95% CIs of stroke for ≥3 categories of Potassium Intake or for Potassium Intake analyzed as a continuous variable. Study-specific results were pooled using a random-effects model. Results—Ten independent prospective studies, with a total of 8695 stroke cases and 268 276 participants, were included in the meta-analysis. We observed a statistically significant inverse association between Potassium Intake and risk of stroke. For every 1000-mg/day increase in Potassium Intake, the risk of stroke decreased by 11% (pooled relative risk, 0.89; 95% CI, 0.83 to 0.97). In t...

  • Dietary Potassium Intake and Risk of Stroke A Dose–Response Meta-Analysis of Prospective Studies
    Stroke, 2011
    Co-Authors: Susanna C. Larsson, Nicola Orsini, Alicja Wolk
    Abstract:

    Background and Purpose—Potassium Intake has been inconsistently associated with risk of stroke. Our aim was to conduct a meta-analysis of prospective studies to assess the relation between Potassium Intake and stroke risk. Methods—Pertinent studies were identified by a search of PubMed from January 1966 through March 2011 and by reviewing the reference lists of retrieved articles. We included prospective studies that reported relative risks with 95% CIs of stroke for ≥3 categories of Potassium Intake or for Potassium Intake analyzed as a continuous variable. Study-specific results were pooled using a random-effects model. Results—Ten independent prospective studies, with a total of 8695 stroke cases and 268 276 participants, were included in the meta-analysis. We observed a statistically significant inverse association between Potassium Intake and risk of stroke. For every 1000-mg/day increase in Potassium Intake, the risk of stroke decreased by 11% (pooled relative risk, 0.89; 95% CI, 0.83 to 0.97). In t...

Majid Sheykhzade - One of the best experts on this subject based on the ideXlab platform.

  • effect of increased Potassium Intake on the renin angiotensin aldosterone system and subcutaneous resistance arteries a randomized crossover study
    Nephrology Dialysis Transplantation, 2020
    Co-Authors: Rasmus Dreier, Bahareh Abdolalizadeh, Camilla Asferg, Lisbet Rosenkrantz Holmich, Niels H Buus, Julie Lyng Forman, Ulrik B Andersen, Martin Egfjord, Majid Sheykhzade
    Abstract:

    BACKGROUND Increased Potassium Intake lowers blood pressure (BP) in hypertensive patients. The underlying mechanism is not fully understood but must be complex because increased Potassium Intake elevates circulating concentrations of the BP-raising hormone aldosterone. METHODS In a randomized placebo-controlled crossover study in 25 normotensive men, we investigated the effect of 4 weeks of Potassium supplement (90 mmol/day) compared with 4 weeks of placebo on the renin-angiotensin-aldosterone system (RAAS), urine composition and 24-h ambulatory BP. Vascular function was also assessed through wire myograph experiments on subcutaneous resistance arteries from gluteal fat biopsies. RESULTS Higher Potassium Intake increased urinary Potassium excretion (144.7 ± 28.7 versus 67.5 ± 25.5 mmol/24-h; P < 0.0001) and plasma concentrations of Potassium (4.3 ± 0.2 versus 4.0 ± 0.2 mmol/L; P = 0.0002), renin {mean 16 [95% confidence interval (CI) 12-23] versus 11 [5-16] mIU/L; P = 0.0047}, angiotensin II [mean 10.0 (95% CI 6.2-13.0) versus 6.1 (4.0-10.0) pmol/L; P = 0.0025] and aldosterone [mean 440 (95% CI 336-521) versus 237 (173-386) pmol/L; P < 0.0001]. Despite RAAS activation, systolic BP (117.6 ± 5.8 versus 118.2 ± 5.2 mmHg; P = 0.48) and diastolic BP (70.8 ± 6.2 versus 70.8 ± 6.3 mmHg; P = 0.97) were unchanged. In the wire myograph experiments, higher Potassium Intake did not affect endothelial function as assessed by acetylcholine [logarithmically transformed half maximal effective concentration (pEC50): 7.66 ± 0.95 versus 7.59 ± 0.85; P = 0.86] and substance P (pEC50: 8.42 ± 0.77 versus 8.41 ± 0.89; P = 0.97) or vascular smooth muscle cell reactivity as assessed by angiotensin II (pEC50: 9.01 ± 0.86 versus 9.02 ± 0.59; P = 0.93) and sodium nitroprusside (pEC50: 7.85 ± 1.07 versus 8.25 ± 1.32; P = 0.25) but attenuated the vasodilatory response of retigabine (pEC50: 7.47 ± 1.16 versus 8.14 ± 0.90; P = 0.0084), an activator of Kv7 channels. CONCLUSIONS Four weeks of increased Potassium Intake activates the RAAS in normotensive men without changing BP and this is not explained by improved vasodilatory responses ex vivo.

  • Effect of increased Potassium Intake on the renin-angiotensin-aldosterone system and subcutaneous resistance arteries: a randomized crossover study.
    Nephrology dialysis transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2020
    Co-Authors: Rasmus Dreier, Bahareh Abdolalizadeh, Camilla Asferg, Lisbet Rosenkrantz Holmich, Niels H Buus, Julie Lyng Forman, Ulrik B Andersen, Martin Egfjord, Majid Sheykhzade, Jørgen Jeppesen
    Abstract:

    BACKGROUND Increased Potassium Intake lowers blood pressure (BP) in hypertensive patients. The underlying mechanism is not fully understood but must be complex because increased Potassium Intake elevates circulating concentrations of the BP-raising hormone aldosterone. METHODS In a randomized placebo-controlled crossover study in 25 normotensive men, we investigated the effect of 4 weeks of Potassium supplement (90 mmol/day) compared with 4 weeks of placebo on the renin-angiotensin-aldosterone system (RAAS), urine composition and 24-h ambulatory BP. Vascular function was also assessed through wire myograph experiments on subcutaneous resistance arteries from gluteal fat biopsies. RESULTS Higher Potassium Intake increased urinary Potassium excretion (144.7 ± 28.7 versus 67.5 ± 25.5 mmol/24-h; P < 0.0001) and plasma concentrations of Potassium (4.3 ± 0.2 versus 4.0 ± 0.2 mmol/L; P = 0.0002), renin {mean 16 [95% confidence interval (CI) 12-23] versus 11 [5-16] mIU/L; P = 0.0047}, angiotensin II [mean 10.0 (95% CI 6.2-13.0) versus 6.1 (4.0-10.0) pmol/L; P = 0.0025] and aldosterone [mean 440 (95% CI 336-521) versus 237 (173-386) pmol/L; P 

Niels H Buus - One of the best experts on this subject based on the ideXlab platform.

  • effect of increased Potassium Intake on the renin angiotensin aldosterone system and subcutaneous resistance arteries a randomized crossover study
    Nephrology Dialysis Transplantation, 2020
    Co-Authors: Rasmus Dreier, Bahareh Abdolalizadeh, Camilla Asferg, Lisbet Rosenkrantz Holmich, Niels H Buus, Julie Lyng Forman, Ulrik B Andersen, Martin Egfjord, Majid Sheykhzade
    Abstract:

    BACKGROUND Increased Potassium Intake lowers blood pressure (BP) in hypertensive patients. The underlying mechanism is not fully understood but must be complex because increased Potassium Intake elevates circulating concentrations of the BP-raising hormone aldosterone. METHODS In a randomized placebo-controlled crossover study in 25 normotensive men, we investigated the effect of 4 weeks of Potassium supplement (90 mmol/day) compared with 4 weeks of placebo on the renin-angiotensin-aldosterone system (RAAS), urine composition and 24-h ambulatory BP. Vascular function was also assessed through wire myograph experiments on subcutaneous resistance arteries from gluteal fat biopsies. RESULTS Higher Potassium Intake increased urinary Potassium excretion (144.7 ± 28.7 versus 67.5 ± 25.5 mmol/24-h; P < 0.0001) and plasma concentrations of Potassium (4.3 ± 0.2 versus 4.0 ± 0.2 mmol/L; P = 0.0002), renin {mean 16 [95% confidence interval (CI) 12-23] versus 11 [5-16] mIU/L; P = 0.0047}, angiotensin II [mean 10.0 (95% CI 6.2-13.0) versus 6.1 (4.0-10.0) pmol/L; P = 0.0025] and aldosterone [mean 440 (95% CI 336-521) versus 237 (173-386) pmol/L; P < 0.0001]. Despite RAAS activation, systolic BP (117.6 ± 5.8 versus 118.2 ± 5.2 mmHg; P = 0.48) and diastolic BP (70.8 ± 6.2 versus 70.8 ± 6.3 mmHg; P = 0.97) were unchanged. In the wire myograph experiments, higher Potassium Intake did not affect endothelial function as assessed by acetylcholine [logarithmically transformed half maximal effective concentration (pEC50): 7.66 ± 0.95 versus 7.59 ± 0.85; P = 0.86] and substance P (pEC50: 8.42 ± 0.77 versus 8.41 ± 0.89; P = 0.97) or vascular smooth muscle cell reactivity as assessed by angiotensin II (pEC50: 9.01 ± 0.86 versus 9.02 ± 0.59; P = 0.93) and sodium nitroprusside (pEC50: 7.85 ± 1.07 versus 8.25 ± 1.32; P = 0.25) but attenuated the vasodilatory response of retigabine (pEC50: 7.47 ± 1.16 versus 8.14 ± 0.90; P = 0.0084), an activator of Kv7 channels. CONCLUSIONS Four weeks of increased Potassium Intake activates the RAAS in normotensive men without changing BP and this is not explained by improved vasodilatory responses ex vivo.

  • Effect of increased Potassium Intake on the renin-angiotensin-aldosterone system and subcutaneous resistance arteries: a randomized crossover study.
    Nephrology dialysis transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2020
    Co-Authors: Rasmus Dreier, Bahareh Abdolalizadeh, Camilla Asferg, Lisbet Rosenkrantz Holmich, Niels H Buus, Julie Lyng Forman, Ulrik B Andersen, Martin Egfjord, Majid Sheykhzade, Jørgen Jeppesen
    Abstract:

    BACKGROUND Increased Potassium Intake lowers blood pressure (BP) in hypertensive patients. The underlying mechanism is not fully understood but must be complex because increased Potassium Intake elevates circulating concentrations of the BP-raising hormone aldosterone. METHODS In a randomized placebo-controlled crossover study in 25 normotensive men, we investigated the effect of 4 weeks of Potassium supplement (90 mmol/day) compared with 4 weeks of placebo on the renin-angiotensin-aldosterone system (RAAS), urine composition and 24-h ambulatory BP. Vascular function was also assessed through wire myograph experiments on subcutaneous resistance arteries from gluteal fat biopsies. RESULTS Higher Potassium Intake increased urinary Potassium excretion (144.7 ± 28.7 versus 67.5 ± 25.5 mmol/24-h; P < 0.0001) and plasma concentrations of Potassium (4.3 ± 0.2 versus 4.0 ± 0.2 mmol/L; P = 0.0002), renin {mean 16 [95% confidence interval (CI) 12-23] versus 11 [5-16] mIU/L; P = 0.0047}, angiotensin II [mean 10.0 (95% CI 6.2-13.0) versus 6.1 (4.0-10.0) pmol/L; P = 0.0025] and aldosterone [mean 440 (95% CI 336-521) versus 237 (173-386) pmol/L; P 

Jianfeng Huang - One of the best experts on this subject based on the ideXlab platform.