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Saad Shousha - One of the best experts on this subject based on the ideXlab platform.
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Role of Insulin and/or Fasting in a Protocol for Inducing Pregnancy Toxemia in Twin-Bearing Zaraibi Goats
2011Co-Authors: Abd Elghany Hefnawy, Saad ShoushaAbstract:In this study we determined the effect of insulin injection and /or short fasting on the induction of Pregnancy Toxemia in Zariabi goats. Eighteen twin-bearing Zaraibi goats (around 130 days of gestation) were divided into control group (Group C, n = 6) fed ad labtium, feed deprived only group (Group A, n = 6) and feed deprived with insulin injection group (Group B, n = 6). Clinical signs of Pregnancy Toxemia appeared after 24 and 72 h in group B and A, respectively. Refeeding and 50 ml of 500 gm dextrose /l were injected after appearance of the clinical signs every 12 h for two successive doses. Plasma concentrations of glucose and β-hydroxybutyrate were significantly (p 0.1) at 48 h of refeeding and injection of dextrose in both experimentally induced groups. There was significant (P < 0.05) decrease in the length of gestation in both experimental groups (A & B) than that of control one. The lengths of gestation were 140.3 ± 1.1, 139.2 ± 0.8 and 149.1 ± 1.4 days in group A, B and C, respectively. Simple protocol of short fasting combined with insulin injection can induce Pregnancy Toxemia and this protocol might be used for valuable studies for Pregnancy Toxemia in twin-bearing Zaraibi goats.
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role of insulin and or fasting in a protocol for inducing Pregnancy Toxemia in twin bearing zaraibi goats
2011Co-Authors: Abd Elghany Hefnawy, Saad Shousha, S A YoussefAbstract:In this study we determined the effect of insulin injection and /or short fasting on the induction of Pregnancy Toxemia in Zariabi goats. Eighteen twin-bearing Zaraibi goats (around 130 days of gestation) were divided into control group (Group C, n = 6) fed ad labtium, feed deprived only group (Group A, n = 6) and feed deprived with insulin injection group (Group B, n = 6). Clinical signs of Pregnancy Toxemia appeared after 24 and 72 h in group B and A, respectively. Refeeding and 50 ml of 500 gm dextrose /l were injected after appearance of the clinical signs every 12 h for two successive doses. Plasma concentrations of glucose and β-hydroxybutyrate were significantly (p 0.1) at 48 h of refeeding and injection of dextrose in both experimentally induced groups. There was significant (P < 0.05) decrease in the length of gestation in both experimental groups (A & B) than that of control one. The lengths of gestation were 140.3 ± 1.1, 139.2 ± 0.8 and 149.1 ± 1.4 days in group A, B and C, respectively. Simple protocol of short fasting combined with insulin injection can induce Pregnancy Toxemia and this protocol might be used for valuable studies for Pregnancy Toxemia in twin-bearing Zaraibi goats.
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Hematobiochemical Profile of Pregnant and Experimentally Pregnancy Toxemic Goats
2011Co-Authors: Abd Elghany Hefnawy, Saad ShoushaAbstract:Hyperketonemia and hypoglycemia are more common obvious biochemical features of Pregnancy Toxemia as well as liver and kidney may be involved in the pathogenesis of Toxemia. Fifteen pregnant goats with twins (3-4 years, 20-27 kg body weight and 120-130 days of gestation) were classified into two groups, control one consists of six goats and experimental group consists of nine goats for induction of Pregnancy Toxemia by the stress of fasting with access of water until the symptoms of Pregnancy Toxemia were appeared within 72 hours. Serum samples were obtained and analyzed for βhydroxybutyrate, glucose, total protein, albumin, globulin, urea, creatinine, AST, ALT, total lipids, cholesterol, calcium, magnesium, phosphorus, sodium and potassium using kits, while insulin, cortisol, T3, T4, growth hormone were measured by radioimmunoassay. Hematological profile was investigated on whole blood samples. β-hydroxybutyrate, AST, ALT, urea, creatinine, cortisol and insulin hormones were significantly higher in toxemic goats than those of control ones while glucose, sodium, potassium, calcium, magnesium, T4, total protein, globulin, albumin, cholesterol and total lipids values were significantly lower in toxemic goats than those of control ones while, there were no significant changes in phosphorous, T3 and growth hormone. A significant increase in leucocytes, hemoglobin, packed cell volume and neutrophils and a significant decrease in lymphocytes were observed in Pregnancy toxemic goats than those of control ones. Clinical chemistry of Pregnancy Toxemia can affect hormonal, electrolytes and mineral balance as well as immune and hematological picture in goats.
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Some Immunohormonal Changes in Experimentally Pregnant Toxemic Goats
Veterinary medicine international, 2010Co-Authors: Abd Elghany Hefnawy, Seham Youssef, Saad ShoushaAbstract:Pregnancy Toxemia was induced in nine pregnant goat does with twins by the stress of fasting with access to water in late Pregnancy to investigate the effect of Pregnancy Toxemia on immunoglobulins (IgA, IgM, and IgG), cortisol, insulin, thyroid, and growth hormones and their correlations with the plasma levels of glucose and β-Hydroxybutyrate. Plasma samples were collected at 0, 12, 24, 36, 48, and 72 hours after induction of Pregnancy Toxemia. The result revealed that experimental animals developed neurological findings with convulsions and acetone odor from the mouth with recumbency after 72 hours. Laboratory findings showed a significant increase in β-Hydroxybutyrate, cortisol, and insulin while there were significant decreases in glucose, thyroid, and immunoglobulins (IgA, IgM, and IgG). Plasma glucose concentrations had significant negative correlations with β-hydroxybutyrate, cortisol, and insulin while the correlations were significantly positive with immunoglobulins and thyroid hormone. Plasma β-hydroxybutyrate concentration was significantly positively correlated with cortisol and negatively correlated with immunoglobulins, insulin, and thyroid hormone. From this study we can conclude that Pregnancy Toxemia might affect humoral immune responses as well as insulin, cortisol, and thyroid hormones. Moreover, insulin might have a compensatory role to increase suppressive effect on ketogenesis in experimentally pregnant toxemic goats.
Jared D. Taylor - One of the best experts on this subject based on the ideXlab platform.
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characterization of short and long term morbidity and mortality of goat kids born to does with Pregnancy Toxemia
Journal of Veterinary Internal Medicine, 2021Co-Authors: Leslie F. Weaver, Melanie J. Boileau, Lyndi L. Gilliam, Jared D. TaylorAbstract:BACKGROUND Pregnancy Toxemia is a common metabolic disease of periparturient small ruminants. Information on its effects on metabolism and perinatal adaptation of newborn lambs and kids is lacking. OBJECTIVES Evaluate differences in morbidity, mortality, and common biochemical and hematologic variables between Pregnancy Toxemia kids (PT) and control kids (CON). ANIMALS Sixteen kids born to does being treated at the hospital for Pregnancy Toxemia (blood beta-hydroxybutyrate concentration [BHB] > 1.2 mmol/L) and 12 kids from healthy dams (dam BHB < 1.2 mmol/L) that kidded at the hospital. METHODS In this cohort study, serial measurements of blood L-lactate, glucose, and BHB concentrations, arterial blood gases, hematocrit, total protein concentrations, nonesterified fatty acids (NEFAs) concentrations, and body weight were compared between groups over the first 72 hours of life. Long-term follow-up was performed after 3 months. RESULTS Pregnancy Toxemia kids were more likely to require tube feeding at 0 and 12 hours (relative risk 7.7 [1.13, 52.45] and 2.8 [1.39, 5.65]). Pregnancy Toxemia kids were more acidemic (7.26 ± 0.069 vs 7.34 ± 0.079, P = .003) and hyperlactatemic (8.17 ± 2.57 vs 5.48 ± 2.71, P = .003) at birth than CON kids. Control kids were 1.1 [1.01, 1.77] times more likely to survive to discharge and 2.2 [1.15, 4.20] times more likely to survive to 3 months than PT kids. CONCLUSIONS AND CLINICAL IMPORTANCE Pregnancy Toxemia kids had higher short- and long-term mortality and were more likely to require perinatal intervention. Weight loss in the first few days could be a useful predictor of nonsurvival.
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Characterization of short‐ and long‐term morbidity and mortality of goat kids born to does with Pregnancy Toxemia
Journal of veterinary internal medicine, 2021Co-Authors: Leslie F. Weaver, Melanie J. Boileau, Lyndi L. Gilliam, Jared D. TaylorAbstract:BACKGROUND Pregnancy Toxemia is a common metabolic disease of periparturient small ruminants. Information on its effects on metabolism and perinatal adaptation of newborn lambs and kids is lacking. OBJECTIVES Evaluate differences in morbidity, mortality, and common biochemical and hematologic variables between Pregnancy Toxemia kids (PT) and control kids (CON). ANIMALS Sixteen kids born to does being treated at the hospital for Pregnancy Toxemia (blood beta-hydroxybutyrate concentration [BHB] > 1.2 mmol/L) and 12 kids from healthy dams (dam BHB
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Evaluation of prognostic indicators for goats with Pregnancy Toxemia.
Journal of the American Veterinary Medical Association, 2019Co-Authors: Katharine M. Simpson, Jared D. Taylor, Robert N. StreeterAbstract:Objective To evaluate potential prognostic indicators for does with Pregnancy Toxemia (PT) and their offspring. DESIGN Retrospective cohort study. ANIMALS 56 does. PROCEDURES Medical records were s...
Abd Elghany Hefnawy - One of the best experts on this subject based on the ideXlab platform.
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Role of Insulin and/or Fasting in a Protocol for Inducing Pregnancy Toxemia in Twin-Bearing Zaraibi Goats
2011Co-Authors: Abd Elghany Hefnawy, Saad ShoushaAbstract:In this study we determined the effect of insulin injection and /or short fasting on the induction of Pregnancy Toxemia in Zariabi goats. Eighteen twin-bearing Zaraibi goats (around 130 days of gestation) were divided into control group (Group C, n = 6) fed ad labtium, feed deprived only group (Group A, n = 6) and feed deprived with insulin injection group (Group B, n = 6). Clinical signs of Pregnancy Toxemia appeared after 24 and 72 h in group B and A, respectively. Refeeding and 50 ml of 500 gm dextrose /l were injected after appearance of the clinical signs every 12 h for two successive doses. Plasma concentrations of glucose and β-hydroxybutyrate were significantly (p 0.1) at 48 h of refeeding and injection of dextrose in both experimentally induced groups. There was significant (P < 0.05) decrease in the length of gestation in both experimental groups (A & B) than that of control one. The lengths of gestation were 140.3 ± 1.1, 139.2 ± 0.8 and 149.1 ± 1.4 days in group A, B and C, respectively. Simple protocol of short fasting combined with insulin injection can induce Pregnancy Toxemia and this protocol might be used for valuable studies for Pregnancy Toxemia in twin-bearing Zaraibi goats.
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role of insulin and or fasting in a protocol for inducing Pregnancy Toxemia in twin bearing zaraibi goats
2011Co-Authors: Abd Elghany Hefnawy, Saad Shousha, S A YoussefAbstract:In this study we determined the effect of insulin injection and /or short fasting on the induction of Pregnancy Toxemia in Zariabi goats. Eighteen twin-bearing Zaraibi goats (around 130 days of gestation) were divided into control group (Group C, n = 6) fed ad labtium, feed deprived only group (Group A, n = 6) and feed deprived with insulin injection group (Group B, n = 6). Clinical signs of Pregnancy Toxemia appeared after 24 and 72 h in group B and A, respectively. Refeeding and 50 ml of 500 gm dextrose /l were injected after appearance of the clinical signs every 12 h for two successive doses. Plasma concentrations of glucose and β-hydroxybutyrate were significantly (p 0.1) at 48 h of refeeding and injection of dextrose in both experimentally induced groups. There was significant (P < 0.05) decrease in the length of gestation in both experimental groups (A & B) than that of control one. The lengths of gestation were 140.3 ± 1.1, 139.2 ± 0.8 and 149.1 ± 1.4 days in group A, B and C, respectively. Simple protocol of short fasting combined with insulin injection can induce Pregnancy Toxemia and this protocol might be used for valuable studies for Pregnancy Toxemia in twin-bearing Zaraibi goats.
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Hematobiochemical Profile of Pregnant and Experimentally Pregnancy Toxemic Goats
2011Co-Authors: Abd Elghany Hefnawy, Saad ShoushaAbstract:Hyperketonemia and hypoglycemia are more common obvious biochemical features of Pregnancy Toxemia as well as liver and kidney may be involved in the pathogenesis of Toxemia. Fifteen pregnant goats with twins (3-4 years, 20-27 kg body weight and 120-130 days of gestation) were classified into two groups, control one consists of six goats and experimental group consists of nine goats for induction of Pregnancy Toxemia by the stress of fasting with access of water until the symptoms of Pregnancy Toxemia were appeared within 72 hours. Serum samples were obtained and analyzed for βhydroxybutyrate, glucose, total protein, albumin, globulin, urea, creatinine, AST, ALT, total lipids, cholesterol, calcium, magnesium, phosphorus, sodium and potassium using kits, while insulin, cortisol, T3, T4, growth hormone were measured by radioimmunoassay. Hematological profile was investigated on whole blood samples. β-hydroxybutyrate, AST, ALT, urea, creatinine, cortisol and insulin hormones were significantly higher in toxemic goats than those of control ones while glucose, sodium, potassium, calcium, magnesium, T4, total protein, globulin, albumin, cholesterol and total lipids values were significantly lower in toxemic goats than those of control ones while, there were no significant changes in phosphorous, T3 and growth hormone. A significant increase in leucocytes, hemoglobin, packed cell volume and neutrophils and a significant decrease in lymphocytes were observed in Pregnancy toxemic goats than those of control ones. Clinical chemistry of Pregnancy Toxemia can affect hormonal, electrolytes and mineral balance as well as immune and hematological picture in goats.
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Some Immunohormonal Changes in Experimentally Pregnant Toxemic Goats
Veterinary medicine international, 2010Co-Authors: Abd Elghany Hefnawy, Seham Youssef, Saad ShoushaAbstract:Pregnancy Toxemia was induced in nine pregnant goat does with twins by the stress of fasting with access to water in late Pregnancy to investigate the effect of Pregnancy Toxemia on immunoglobulins (IgA, IgM, and IgG), cortisol, insulin, thyroid, and growth hormones and their correlations with the plasma levels of glucose and β-Hydroxybutyrate. Plasma samples were collected at 0, 12, 24, 36, 48, and 72 hours after induction of Pregnancy Toxemia. The result revealed that experimental animals developed neurological findings with convulsions and acetone odor from the mouth with recumbency after 72 hours. Laboratory findings showed a significant increase in β-Hydroxybutyrate, cortisol, and insulin while there were significant decreases in glucose, thyroid, and immunoglobulins (IgA, IgM, and IgG). Plasma glucose concentrations had significant negative correlations with β-hydroxybutyrate, cortisol, and insulin while the correlations were significantly positive with immunoglobulins and thyroid hormone. Plasma β-hydroxybutyrate concentration was significantly positively correlated with cortisol and negatively correlated with immunoglobulins, insulin, and thyroid hormone. From this study we can conclude that Pregnancy Toxemia might affect humoral immune responses as well as insulin, cortisol, and thyroid hormones. Moreover, insulin might have a compensatory role to increase suppressive effect on ketogenesis in experimentally pregnant toxemic goats.
Rodolfo José Cavalcanti Souto - One of the best experts on this subject based on the ideXlab platform.
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Changes in cardiac biomarkers in goats naturally affected by Pregnancy Toxemia.
Research in veterinary science, 2020Co-Authors: Leonardo Magno De Souza, Carla Lopes De Mendonça, Regina Nóbrega De Assis, E.f. Oliveira Filho, Gliére Silmara Leite Soares, Rodolfo José Cavalcanti Souto, P. C. Soares, José Augusto Bastos AfonsoAbstract:Pregnancy Toxemia (PT) is considered one of the most common metabolic diseases with high impact on the production of small ruminants. The objective of this study was investigate possible myocardial damage in goats affected with PT by the determination of serum myocardial biomarkers CK-MB and cTnI. A total of 44 goats affected with PT, and 10 apparently healthy goats (control group or CG) were used in the study. In goats with PT, the serum concentrations of cTnI (0.43 ng/mL) were significantly higher than that in CG goats (0.06 ng/mL). Although CK-MB showed no significant difference, it was approximately three times higher in animals with PT. The serum concentrations of insulin were significantly lower in PT goats (5.03 ppmol/L) compared to CG goats (10.66 pmol/L). The serum concentrations of cortisol in PT goats (155.41 nmol/L) were significantly higher than that in CG goats (36.58 nmol/L). Results of this study indicate that a clinically significant myocardial damage might occur in goats affected with PT leading to significant elevations in values of cTnI and CK-MB. Therefore, these parameters could be used as a potential prognostic indicator in goats affected with this important disease.
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Biochemical, endocrine, and histopathological profile of liver and kidneys of sheep with Pregnancy Toxemia
Pesquisa Veterinária Brasileira, 2019Co-Authors: Rodolfo José Cavalcanti Souto, Carla Lopes De Mendonça, José Augusto Bastos Afonso, Daniel Nunes De Araújo Gonçalves, Antônio Flávio Medeiros Dantas, Jobson Filipe De Paula Cajueiro, Emanuel F. Olivera Filho, P. C. SoaresAbstract:ABSTRACT: The objective of the present study was to characterize the biochemical, hormonal, and mineral profile, and histopathology of the liver and kidneys, related to the severity of natural cases of Pregnancy Toxemia (PT) in sheep. A total of 45 sheep with PT were analyzed at the “Clínica de Bovinos”, Campus Garanhuns-UFRPE. The animals were submitted to clinical examination, followed by the collection of blood and urine. A necropsy was performed on thirteen animals that died and a histopathological examination was performed on samples of liver and kidneys. Increased creatinine, urea, glucose, fructosamine, non-esterified fatty acids, β-hydroxybutyrate, cortisol, chlorine, amylase, aspartate aminotransferase, gamma-glutamyltransferase, and folic acid were found, whereas insulin, potassium, and total and ionizable calcium presented low values for the species. Total protein, albumin, globulin, sodium, magnesium, and vitamin B12 remained within the normal range. In the macroscopic analysis of the liver, it was possible to observe an increase in organ and border size, yellowish coloration and parenchyma that varied from firm to friable. Vacuolation of the hepatocytes and renal tubular cells was observed. Metabolic disorders in sheep associated with hepatic and renal lesions are more apparent in overweight animals. With the greater impairment in hepatic and renal function, the clinical prognosis of animals with a high body score should be considered reserved.
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NÍVEIS SÉRICOS DE TRIIODOTIRONINA (T3) E TIROXINA (T4) EM OVELHAS COM Toxemia DA PRENHEZ (SERUM LEVELS OF TRIIODOTHYRONINE (T3) AND THYROXINE (T4) IN EWES DIAGNOSED WITH Pregnancy Toxemia)
2015Co-Authors: Alexandre Tadeu Mota, Carla Lopes De Mendonça, Rodolfo José Cavalcanti Souto, Liliane Bezerra, José Augusto, Bastos AfonsoAbstract:The aims of the present study were to determine serum levels of triiodothyronine (T3) and thyroxine (T4) in ewes diagnosed with Pregnancy Toxemia (PT) and evaluate the participation of these hormones in this type of metabolic disorder. Analyses were performed of the clinical cases of 24 ewes diagnosed with PT and treated at the Bovine Clinic of the University Federal Rural of Pernambuco, Campus Garanhuns, from 2007 to 2012. The animals were submitted to clinical and ultrasound exams. Blood and urine were collected for the laboratory exams. The main abnormalities were apathy, elevated body temperature, congested mucosa, dehydration, edema in the limbs, amaurosis, tachycardia, inappetence or anorexia and diminished ruminal motility. The mortality rate was 50%. Among the animals that died, 58.33% were hyperglycemic. The study of ketone bodies revealed ketonuria. Three conditions of glycemia were found in the ewes with PT. The laboratory findings revealed high levels of non-esterified fatty acids and β-hydroxybutyric acid. Serum levels of T3 (3.21 nmol/L) and T4 (69.16 nmol/L) were low. In conclusion, Pregnancy Toxemia in ewes is characterized by endocrine alterations that reflect a negative energy balance..
Mehdi Sakha - One of the best experts on this subject based on the ideXlab platform.
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Metabolic adaptation after experimental clinical Pregnancy Toxemia in ewes
Comparative Clinical Pathology, 2016Co-Authors: Mehdi SakhaAbstract:This study was performed to evaluate the effect of induction of clinical ketosis or Pregnancy Toxemia (PT) and subsequent effects on serum biochemical factors. Seven native pregnant ewes aged 3–4 years, 45–50 kg weight with BCS of 3.5–4 on a 0–5 scale were selected. The Pregnancy of ewes was confirmed by ultrasound examination. Blood samples were harvested from the jugular vein before and after the induction of PT by food deprivation. Serum β-hydroxybutyrate (BHBA), Nonesterified fatty acids (NEFA), BUN, glucose, calcium, total protein, and cortisol concentrations were measured. Serum BHBA, NEFA, BUN, and cortisol concentrations after induction of PT were significantly higher ( P
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The comparison of some biochemical parameters in hyperketonemic and normal ewes
European Journal of Experimental Biology, 2014Co-Authors: Amin Anoushepour, Parham Mottaghian, Mehdi SakhaAbstract:The objective of this study is to assess and compare the alterations in some biochemical parameters in normal and ewes affected by subclinical Pregnancy Toxemia. Pregnancy Toxemia in sheep and goats is a multifactor disorder of metabolism usually occurs in the last month of Pregnancy. Hypoglycemia and hyperketonemia are the primary metabolic disturbances in Pregnancy Toxemia. Pregnant ewes in their last month of gestation were classified based on their BHBA levels in two groups of normoketonemic and hyperketonemic ewes. Serum concentrations of NEFA, BUN, ALT, AST, Cortisol, Calcium, Glucose, total Protein and Ceruloplasmin were determined and compared between these two groups. Serum levels of NEFA, Cortisol and Ceruloplasmin were significantly (p
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Liver copper and serum ceruloplasmin concentrations in hyperketonemic pregnant ewes
European Journal of Experimental Biology, 2013Co-Authors: Mehdi Sakha, Amin Anoushepour, Mohammad Gholi Nadalian, Zohreh KhakiAbstract:This study has accomplished due to evaluate the effect of induction of subclinical Pregnancy Toxemia (PT) and subsequent hyperketonemia in ewes on serum ceruloplasmin and liver copper concentrations. The experiment was performed on five pregnant native ewes aged 3-4 years, 45-50 kg weight with BCS of 3.5-4 on a 0-5 scale. The Pregnancy of these ewes were confirmed with ultrasound examination. Blood and biopsy samples were taken from the jugular vein and 12th ICS, respectively before the induction of subclinical Pregnancy Toxemia by food deprivation and after that (serum β-hydroxybutyrate concentrations>0.8mmol/l) when ewes suffering subclinical PT. Serum BHBA concentrations of ewes after induction of subclinical PT were significantly higher than before the induction (P