The Experts below are selected from a list of 2064 Experts worldwide ranked by ideXlab platform
Carl Counts - One of the best experts on this subject based on the ideXlab platform.
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Comparison of prenate advance™ with other prescription Prenatal Vitamins: a folic acid dissolution study
Advances in Therapy, 2000Co-Authors: Ken Giebe, Carl CountsAbstract:Folic acid is important in the prevention of neural tube defects. This study assessed the folic acid dissolution performance of Prenate Advance and six other commonly prescribed Prenatal Vitamins and compared the results with the United States Pharmacopeia (USP) standards. Of the seven products tested, only three met the USP standard for folic acid dissolution. At 110% of the labeled amount, the Prenate Advance product had the highest folic acid dissolution level. Average dissolution for the four products failing to meet the USP standard ranged from 0% to 38% of labeled amount. These results corroborate findings from other studies suggesting marked differences in dissolution of prescription Prenatal Vitamins. These findings raise concerns of whether some women could fail to achieve the recommended folate levels needed in early pregnancy to prevent neural tube defects. Prenate Advance met the USP requirement for folic acid dissolution.
Rebecca J. Schmidt - One of the best experts on this subject based on the ideXlab platform.
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Association of Maternal Prenatal Vitamin Use With Risk for Autism Spectrum Disorder Recurrence in Young Siblings.
JAMA Psychiatry, 2019Co-Authors: Rebecca J. Schmidt, Ana-maria Iosif, Elizabeth Guerrero Angel, Sally J OzonoffAbstract:Importance Maternal use of folic acid supplements has been inconsistently associated with reduced risk for autism spectrum disorder (ASD) in the child. No study to date has examined this association in the context of ASD recurrence in high-risk families. Objective To examine the association between maternal Prenatal vitamin use and ASD recurrence risk in younger siblings of children with ASD. Design, Setting, and Participants This prospective cohort study analyzed data from a sample of children (n = 332) and their mothers (n = 305) enrolled in the MARBLES (Markers of Autism Risk in Babies: Learning Early Signs) study. Participants in the MARBLES study were recruited at the MIND Institute of the University of California, Davis and were primarily from families receiving services for children with ASD in the California Department of Developmental Services. In this sample, the younger siblings at high risk for ASD were born between December 1, 2006, and June 30, 2015, and completed a final clinical assessment within 6 months of their third birthday. Prenatal vitamin use during pregnancy was reported by mothers during telephone interviews. Data analysis for this study was conducted from January 1, 2017, to December 3, 2018. Main Outcomes and Measures Autism spectrum disorder, other nontypical development (non-TD), and typical development (TD) were algorithmically defined according to Autism Diagnostic Observation Schedule and Mullen Scales of Early Learning subscale scores. Results After exclusions, the final sample comprised 241 younger siblings, of which 140 (58.1%) were male and 101 (41.9%) were female, with a mean (SD) age of 36.5 (1.6) months. Most mothers (231 [95.9%]) reported taking Prenatal Vitamins during pregnancy, but only 87 mothers (36.1%) met the recommendations to take Prenatal Vitamins in the 6 months before pregnancy. The prevalence of ASD was 14.1% (18) in children whose mothers took Prenatal Vitamins in the first month of pregnancy compared with 32.7% (37) in children whose mothers did not take Prenatal Vitamins during that time. Children whose mothers reported taking Prenatal Vitamins during the first month of pregnancy were less likely to receive an ASD diagnosis (adjusted relative risk [RR], 0.50; 95% CI, 0.30-0.81) but not a non-TD 36-month outcome (adjusted RR, 1.14; 95% CI, 0.75-1.75) compared with children whose mothers reported not taking Prenatal Vitamins. Children in the former maternal Prenatal vitamin group also had statistically significantly lower autism symptom severity (adjusted estimated difference, –0.60; 95% CI, –0.97 to –0.23) and higher cognitive scores (adjusted estimated difference, 7.1; 95% CI, 1.2-13.1). Conclusions and Relevance Maternal Prenatal vitamin intake during the first month of pregnancy may reduce ASD recurrence in siblings of children with ASD in high-risk families. Additional research is needed to confirm these results; to investigate dose thresholds, contributing nutrients, and biologic mechanisms of Prenatal Vitamins; and to inform public health recommendations for ASD prevention in affected families.
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Prenatal Vitamins one carbon metabolism gene variants and risk for autism
Epidemiology, 2011Co-Authors: Rebecca J. Schmidt, Robin L Hansen, Jaana Hartiala, Hooman Allayee, Linda C Schmidt, Daniel J Tancredi, Flora Tassone, Irva HertzpicciottoAbstract:Background Causes of autism are unknown. Associations with maternal nutritional factors and their interactions with gene variants have not been reported.
Ken Giebe - One of the best experts on this subject based on the ideXlab platform.
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Comparison of prenate advance™ with other prescription Prenatal Vitamins: a folic acid dissolution study
Advances in Therapy, 2000Co-Authors: Ken Giebe, Carl CountsAbstract:Folic acid is important in the prevention of neural tube defects. This study assessed the folic acid dissolution performance of Prenate Advance and six other commonly prescribed Prenatal Vitamins and compared the results with the United States Pharmacopeia (USP) standards. Of the seven products tested, only three met the USP standard for folic acid dissolution. At 110% of the labeled amount, the Prenate Advance product had the highest folic acid dissolution level. Average dissolution for the four products failing to meet the USP standard ranged from 0% to 38% of labeled amount. These results corroborate findings from other studies suggesting marked differences in dissolution of prescription Prenatal Vitamins. These findings raise concerns of whether some women could fail to achieve the recommended folate levels needed in early pregnancy to prevent neural tube defects. Prenate Advance met the USP requirement for folic acid dissolution.
Lee S. Cohen - One of the best experts on this subject based on the ideXlab platform.
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Supplement use by women during pregnancy: data from the Massachusetts General Hospital National Pregnancy Registry for Atypical Antipsychotics
Archives of Women's Mental Health, 2016Co-Authors: Marlene P. Freeman, Alexandra Z. Sosinsky, Danna Moustafa, Adele C. Viguera, Lee S. CohenAbstract:Women of reproductive age commonly use integrative treatments. However, the reproductive safety for most complementary products lacks systematic study. We aimed to study the use of supplements by women in a prospective pregnancy registry. The Massachusetts General Hospital National Pregnancy Registry for Atypical Antipsychotics was established to evaluate the reproductive safety of atypical antipsychotics. Exposed and control participants were systematically queried about the use of Vitamins and supplements. Slightly greater than half (53.2 %) of the participants eligible for analysis ( N = 534) were using at least one vitamin or supplement at the time of enrollment, not including Prenatal Vitamins or folic acid. The most common supplements used were omega-3 fatty acids (38.0 %), vitamin D (11.0 %), calcium (8.2 %), and iron (4.7 %). Probiotics and melatonin were used by 2.6 and 0.9 %, respectively. In this prospective pregnancy registry, we found that over half of the participants were taking supplements or Vitamins other than Prenatal Vitamins and folic acid. These findings underscore the need for active query on the part of health care providers about the use of supplements during pregnancy, and the need to obtain rigorous reproductive safety and efficacy data for supplements used by pregnant women and reproductive aged women.
Karin B. Michels - One of the best experts on this subject based on the ideXlab platform.
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Prenatal vitamin intake during pregnancy and offspring obesity
2016Co-Authors: Marcelle M. Dougan, Walter C. Willett, Karin B. MichelsAbstract:Background/Objectives—In animal studies, exposure to multi-Vitamins may be associated with obesity in the offspring; however, data in humans is sparse. We therefore examined the association between Prenatal vitamin intake during pregnancy and offspring obesity. Subjects/Methods—We investigated the association between Prenatal vitamin intake and obesity among 29 160 mother-daughter dyads in the Nurses ’ Health Study II. Mothers of participants provided information on Prenatal vitamin use during pregnancy with the nurse daughter. Information on body fatness at ages 5 and 10, body mass index (BMI) at age 18, weight in 1989 and 2009, waist circumference, and height was obtained from the daughter. Polytomous logistic regression was used to predict BMI in early adulthood and adulthood, and body fatness in childhood. Linear regression was used to predict waist circumference in adulthood. Results—In utero exposure to Prenatal Vitamins was not associated with body fatness, either in childhood or adulthood. Women whose mothers took Prenatal Vitamins during pregnancy had a covariate-adjusted odds ratio of being obese in adulthood of 0.99 (95 % CI 0.92 – 1.05, P-value = 0.68) compared to women whose mothers did not take Prenatal Vitamins. Women whose mother
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Prenatal vitamin intake during pregnancy and offspring obesity
International Journal of Obesity, 2013Co-Authors: Marcelle M. Dougan, Walter C. Willett, Karin B. MichelsAbstract:In animal studies, exposure to multiVitamins may be associated with obesity in the offspring; however, data in humans are sparse. We therefore examined the association between Prenatal vitamin intake during pregnancy and offspring obesity. We investigated the association between Prenatal vitamin intake and obesity among 29 160 mother–daughter dyads in the Nurses’ Health Study II. Mothers of participants provided information on Prenatal vitamin use during pregnancy with the nurse daughter. Information on body fatness at ages 5 and 10, body mass index (BMI) at age 18, weight in 1989 and 2009, waist circumference, and height was obtained from the daughter. Polytomous logistic regression was used to predict BMI in early adulthood and adulthood, and body fatness in childhood. Linear regression was used to predict waist circumference in adulthood. In utero exposure to Prenatal Vitamins was not associated with body fatness, either in childhood or in adulthood. Women whose mothers took Prenatal Vitamins during pregnancy had a covariate-adjusted odds ratio (OR) of being obese in adulthood of 0.99 (95% confidence interval (CI) 0.92–1.05, P-value=0.68) compared with women whose mothers did not take Prenatal Vitamins. Women whose mothers took Prenatal Vitamins during pregnancy had a covariate-adjusted OR of having the largest body shape at age 5 of 1.02 (95% CI 0.90–1.15, P-value=0.78). In additional analyses, in utero exposure to Prenatal Vitamins was also unrelated to adult abdominal adiposity. Exposure to Prenatal Vitamins was not associated with body fatness either in childhood or in adulthood.