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Diana Borges Dock-nascimento - One of the best experts on this subject based on the ideXlab platform.
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Metabolic and Inflammatory Benefits of Reducing Preoperative Fasting Time in Pediatric Surgery.
Revista do Colegio Brasileiro de Cirurgioes, 2020Co-Authors: Carlos Augusto Leite De Barros Carvalho, Diana Borges Dock-nascimento, Augusto Aurélio De Carvalho, Antônio D'oliveira Gonçalves Preza, Paulo Luiz Batista Nogueira, Katia Bezerra Veloso Mendes, José Eduardo De Aguilar-nascimentoAbstract:OBJECTIVE To investigate the metabolic/inflammatory impact of reducing the Preoperative Fasting time in preschool children. METHODS Forty children were randomly assigned to a Fasting group (absolute Fasting after 00:00) and a carbohydrate (CHO) group (allowed to ingest, two hours before surgery, a carbohydrate-rich beverage). Blood samples were collected right before and after surgery to quantify the levels of albumin, interleukin-6, glucose, insulin, C-reactive protein and to calculate insulin resistance by the HOMA-IR index. RESULTS Preoperative Fasting time in the CHO group were shorter than in the Fasting group (2.49h vs. 11.24h, p
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Actual Preoperative Fasting time in Brazilian hospitals: the BIGFAST multicenter study.
Therapeutics and clinical risk management, 2014Co-Authors: José Eduardo De Aguilar-nascimento, Diana Borges Dock-nascimento, Ana L De Almeida Dias, Maria Isabel Td Correia, Antonio Cl Campos, Pedro Eder Portari-filho, Sergio De Souza OliveiraAbstract:BACKGROUND Prolonged Fasting increases organic response to trauma. This multicenter study investigated the gap between the prescribed and the actual Preoperative Fasting times in Brazilian hospitals and factors associated with this gap. METHODS Patients (18-90-years-old) who underwent elective operations between August 2011 and September 2012 were included in the study. The actual and prescribed times for Fasting were collected and correlated with sex, age, surgical disease (malignancies or benign disease), operation type, American Society of Anesthesiologists score, type of hospital (public or private), and nutritional status. RESULTS A total of 3,715 patients (58.1% females) with a median age of 49 (18-94) years from 16 Brazilian hospitals entered the study. The median (range) Preoperative Fasting time was 12 (2-216) hours, and Fasting time was longer (P
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Reducing Preoperative Fasting time: A trend based on evidence.
World journal of gastrointestinal surgery, 2010Co-Authors: José Eduardo De Aguilar-nascimento, Diana Borges Dock-nascimentoAbstract:Preoperative Fasting is mandatory before anesthesia to reduce the risk of aspiration. However, the prescribed 6-8 h of Fasting is usually prolonged to 12-16 h for various reasons. Prolonged Fasting triggers a metabolic response that precipitates gluconeogenesis and increases the organic response to trauma. Various randomized trials and meta-analyses have consistently shown that is safe to reduce the Preoperative Fasting time with a carbohydrate-rich drink up to 2 h before surgery. Benefits related to this shorter Preoperative Fasting include the reduction of postoperative gastrointestinal discomfort and insulin resistance. New formulas containing amino acids such as glutamine and other peptides are being studied and are promising candidates to be used to reduce Preoperative Fasting time.
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Preoperative Fasting of 2 hours minimizes insulin resistance and organic response to trauma after video-cholecystectomy: a randomized, controlled, clinical trial.
World journal of surgery, 2009Co-Authors: Marcelo Sepulveda Magalhaes Faria, José Eduardo De Aguilar-nascimento, Diana Borges Dock-nascimento, Osvânio S. Pimenta, Luis C. Alvarenga, Natasha SlhessarenkoAbstract:Background Studies showing the improvement of insulin sensitivity by reducing the term of Preoperative Fasting are mostly done in patients undergoing major operations. More information about the role of shortened Preoperative Fasting in perioperative metabolism is needed for such elective minor/moderate abdominal procedures as laparoscopic cholecystectomy. We investigated the influence of a carbohydrate-rich drink given 2 h before laparoscopic cholecystectomy on insulin resistance and the metabolic response to trauma.
José Eduardo De Aguilar-nascimento - One of the best experts on this subject based on the ideXlab platform.
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Metabolic and Inflammatory Benefits of Reducing Preoperative Fasting Time in Pediatric Surgery.
Revista do Colegio Brasileiro de Cirurgioes, 2020Co-Authors: Carlos Augusto Leite De Barros Carvalho, Diana Borges Dock-nascimento, Augusto Aurélio De Carvalho, Antônio D'oliveira Gonçalves Preza, Paulo Luiz Batista Nogueira, Katia Bezerra Veloso Mendes, José Eduardo De Aguilar-nascimentoAbstract:OBJECTIVE To investigate the metabolic/inflammatory impact of reducing the Preoperative Fasting time in preschool children. METHODS Forty children were randomly assigned to a Fasting group (absolute Fasting after 00:00) and a carbohydrate (CHO) group (allowed to ingest, two hours before surgery, a carbohydrate-rich beverage). Blood samples were collected right before and after surgery to quantify the levels of albumin, interleukin-6, glucose, insulin, C-reactive protein and to calculate insulin resistance by the HOMA-IR index. RESULTS Preoperative Fasting time in the CHO group were shorter than in the Fasting group (2.49h vs. 11.24h, p
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Actual Preoperative Fasting time in Brazilian hospitals: the BIGFAST multicenter study.
Therapeutics and clinical risk management, 2014Co-Authors: José Eduardo De Aguilar-nascimento, Diana Borges Dock-nascimento, Ana L De Almeida Dias, Maria Isabel Td Correia, Antonio Cl Campos, Pedro Eder Portari-filho, Sergio De Souza OliveiraAbstract:BACKGROUND Prolonged Fasting increases organic response to trauma. This multicenter study investigated the gap between the prescribed and the actual Preoperative Fasting times in Brazilian hospitals and factors associated with this gap. METHODS Patients (18-90-years-old) who underwent elective operations between August 2011 and September 2012 were included in the study. The actual and prescribed times for Fasting were collected and correlated with sex, age, surgical disease (malignancies or benign disease), operation type, American Society of Anesthesiologists score, type of hospital (public or private), and nutritional status. RESULTS A total of 3,715 patients (58.1% females) with a median age of 49 (18-94) years from 16 Brazilian hospitals entered the study. The median (range) Preoperative Fasting time was 12 (2-216) hours, and Fasting time was longer (P
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Reducing Preoperative Fasting time: A trend based on evidence.
World journal of gastrointestinal surgery, 2010Co-Authors: José Eduardo De Aguilar-nascimento, Diana Borges Dock-nascimentoAbstract:Preoperative Fasting is mandatory before anesthesia to reduce the risk of aspiration. However, the prescribed 6-8 h of Fasting is usually prolonged to 12-16 h for various reasons. Prolonged Fasting triggers a metabolic response that precipitates gluconeogenesis and increases the organic response to trauma. Various randomized trials and meta-analyses have consistently shown that is safe to reduce the Preoperative Fasting time with a carbohydrate-rich drink up to 2 h before surgery. Benefits related to this shorter Preoperative Fasting include the reduction of postoperative gastrointestinal discomfort and insulin resistance. New formulas containing amino acids such as glutamine and other peptides are being studied and are promising candidates to be used to reduce Preoperative Fasting time.
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Preoperative Fasting of 2 hours minimizes insulin resistance and organic response to trauma after video-cholecystectomy: a randomized, controlled, clinical trial.
World journal of surgery, 2009Co-Authors: Marcelo Sepulveda Magalhaes Faria, José Eduardo De Aguilar-nascimento, Diana Borges Dock-nascimento, Osvânio S. Pimenta, Luis C. Alvarenga, Natasha SlhessarenkoAbstract:Background Studies showing the improvement of insulin sensitivity by reducing the term of Preoperative Fasting are mostly done in patients undergoing major operations. More information about the role of shortened Preoperative Fasting in perioperative metabolism is needed for such elective minor/moderate abdominal procedures as laparoscopic cholecystectomy. We investigated the influence of a carbohydrate-rich drink given 2 h before laparoscopic cholecystectomy on insulin resistance and the metabolic response to trauma.
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Preoperative Fasting of 8 hours or 2 hours: what does evidence reveal?
Revista do Colegio Brasileiro de Cirurgioes, 2009Co-Authors: José Eduardo De Aguilar-nascimento, Francine Perrone, Leicia Iris De Assunção PradoAbstract:Insulin resistance is a transitory phenomenon of the metabolic response to trauma. In uncomplicated operations it lasts for 2-4 weeks postoperatively, and is directly related to the magnitude of the injury. The Fasting status caused by conventional Fasting protocols aggravates this resistance and may induce hyperglycemia. Conventional Preoperative Fasting time may aggravate this resistance and increment the elevation of glycemia especially because it is frequently longer than the expected 6-8h and may reach 10-16 hs. Additionally, overnight Fasting may cause variable degrees of dehydration depending on the extension of the Fasting period. Recently, various societies of anesthesia and nutrition have changed their guidelines to propose a reduction of Preoperative Fasting to 2h with clear fluids containing carbohydrates. These new protocols (ACERTO, ERAS) are based on the safety of this routine as consistently demonstrated by various randomized trials and a meta-analysis.
Jie Jia - One of the best experts on this subject based on the ideXlab platform.
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Influence of different Preoperative Fasting times on women and neonates in cesarean section: a retrospective analysis
BMC pregnancy and childbirth, 2019Co-Authors: Yijuan Sun, Zaomei Wei, Jie JiaAbstract:This study was to evaluate the impact of different Preoperative Fasting conditions on women and neonates through a retrospective analysis. A total of 1599 women were divided into 5 groups according to different Preoperative Fasting times: group A: solid food ≥8 h; clear fluids ≥6 h; B: solid food ≥8 h; clear fluids ≥2 h 8 h and clear fluids > 2 h at least), the incidence rate of hypoglycemia and acidosis of neonates in group C displayed a certain decrease (P
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influence of different Preoperative Fasting times on women and neonates in cesarean section a retrospective analysis
BMC Pregnancy and Childbirth, 2019Co-Authors: Yijuan Sun, Zaomei Wei, Jie JiaAbstract:This study was to evaluate the impact of different Preoperative Fasting conditions on women and neonates through a retrospective analysis. A total of 1599 women were divided into 5 groups according to different Preoperative Fasting times: group A: solid food ≥8 h; clear fluids ≥6 h; B: solid food ≥8 h; clear fluids ≥2 h 8 h and clear fluids > 2 h at least), the incidence rate of hypoglycemia and acidosis of neonates in group C displayed a certain decrease (P < 0.05). Although shorter Fasting times (solid food < 6 h at least) reduced the incidence of hypoglycemia and acidosis in neonates, it increased the risk of vomiting of women. The Preoperative Fasting of solid food ≥6 h < 8 h and clear fluids < 2 h reduces the incidence of vomiting in women’s anesthesia and the risk of hypoglycemia and acidosis in neonates.
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Influence of different Preoperative Fasting times on women and neonates in cesarean section: a retrospective analysis
BMC, 2019Co-Authors: Yijuan Sun, Zaomei Wei, Jie JiaAbstract:Abstract Background This study was to evaluate the impact of different Preoperative Fasting conditions on women and neonates through a retrospective analysis. Methods A total of 1599 women were divided into 5 groups according to different Preoperative Fasting times: group A: solid food ≥8 h; clear fluids ≥6 h; B: solid food ≥8 h; clear fluids ≥2 h
Ron W. F. De Bruin - One of the best experts on this subject based on the ideXlab platform.
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Preoperative Fasting protects against renal ischemia-reperfusion injury in aged and overweight mice.
PloS one, 2014Co-Authors: F. Jongbloed, Sandra Van Den Engel, Harry Van Steeg, Ron W. F. De Bruin, Jeroen L. A. Pennings, César Payán-gómez, Conny T. M. Van Oostrom, Alain De Bruin, Jan H.j. Hoeijmakers, Jan N.m. IjzermansAbstract:Ischemia-reperfusion injury (IRI) is inevitable during kidney transplantation leading to oxidative stress and inflammation. We previously reported that Preoperative Fasting in young-lean male mice protects against IRI. Since patients are generally of older age with morbidities possibly leading to a different response to Fasting, we investigated the effects of Preoperative Fasting on renal IRI in aged-overweight male and female mice. Male and female F1-FVB/C57BL6-hybrid mice, average age 73 weeks weighing 47.2 grams, were randomized to Preoperative ad libitum feeding or 3 days Fasting, followed by renal IRI. Body weight, kidney function and survival of the animals were monitored until day 28 postoperatively. Kidney histopathology was scored for all animals and gene expression profiles after Fasting were analyzed in kidneys of young and aged male mice. Preoperative Fasting significantly improved survival after renal IRI in both sexes compared with normal fed mice. Fasted groups had a better kidney function shown by lower serum urea levels after renal IRI. Histopathology showed less acute tubular necrosis and more regeneration in kidneys from fasted mice. A mRNA analysis indicated the involvement of metabolic processes including fatty acid oxidation and retinol metabolism, and the NRF2-mediated stress response. Similar to young-lean, healthy male mice, Preoperative Fasting protects against renal IRI in aged-overweight mice of both genders. These findings suggest a general protective response of Fasting against renal IRI regardless of age, gender, body weight and genetic background. Therefore, Fasting could be a non-invasive intervention inducing increased oxidative stress resistance in older and overweight patients as well.
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Preoperative Fasting protects aged-corpulent mice against renal ischemia-reperfusion injury.
BMC Proceedings, 2012Co-Authors: F. Jongbloed, Jan Nm Uzermans, Sandra Van Den Engel, Harry Van Steeg, Martijn E.t. Dollé, Ron W. F. De BruinAbstract:Background Oxidative stress (OS), the production of free oxygen radicals caused by for instance renal ischemia/reperfusion injury (IRI), results in age associated diseases and accelerated aging. We have shown that Preoperative Fasting in young-lean C57BL6 male mice protects against renal IRI [1]. Since human patients are usually older and suffer from (co)morbidities, we investigated the effects of Preoperative Fasting on OS induced by renal IRI in both female and male aged-corpulent mice in a F1 -FVB/C57BL6hybrid background.
F. Jongbloed - One of the best experts on this subject based on the ideXlab platform.
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Preoperative Fasting protects against renal ischemia-reperfusion injury in aged and overweight mice.
PloS one, 2014Co-Authors: F. Jongbloed, Sandra Van Den Engel, Harry Van Steeg, Ron W. F. De Bruin, Jeroen L. A. Pennings, César Payán-gómez, Conny T. M. Van Oostrom, Alain De Bruin, Jan H.j. Hoeijmakers, Jan N.m. IjzermansAbstract:Ischemia-reperfusion injury (IRI) is inevitable during kidney transplantation leading to oxidative stress and inflammation. We previously reported that Preoperative Fasting in young-lean male mice protects against IRI. Since patients are generally of older age with morbidities possibly leading to a different response to Fasting, we investigated the effects of Preoperative Fasting on renal IRI in aged-overweight male and female mice. Male and female F1-FVB/C57BL6-hybrid mice, average age 73 weeks weighing 47.2 grams, were randomized to Preoperative ad libitum feeding or 3 days Fasting, followed by renal IRI. Body weight, kidney function and survival of the animals were monitored until day 28 postoperatively. Kidney histopathology was scored for all animals and gene expression profiles after Fasting were analyzed in kidneys of young and aged male mice. Preoperative Fasting significantly improved survival after renal IRI in both sexes compared with normal fed mice. Fasted groups had a better kidney function shown by lower serum urea levels after renal IRI. Histopathology showed less acute tubular necrosis and more regeneration in kidneys from fasted mice. A mRNA analysis indicated the involvement of metabolic processes including fatty acid oxidation and retinol metabolism, and the NRF2-mediated stress response. Similar to young-lean, healthy male mice, Preoperative Fasting protects against renal IRI in aged-overweight mice of both genders. These findings suggest a general protective response of Fasting against renal IRI regardless of age, gender, body weight and genetic background. Therefore, Fasting could be a non-invasive intervention inducing increased oxidative stress resistance in older and overweight patients as well.
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Preoperative Fasting protects aged-corpulent mice against renal ischemia-reperfusion injury.
BMC Proceedings, 2012Co-Authors: F. Jongbloed, Jan Nm Uzermans, Sandra Van Den Engel, Harry Van Steeg, Martijn E.t. Dollé, Ron W. F. De BruinAbstract:Background Oxidative stress (OS), the production of free oxygen radicals caused by for instance renal ischemia/reperfusion injury (IRI), results in age associated diseases and accelerated aging. We have shown that Preoperative Fasting in young-lean C57BL6 male mice protects against renal IRI [1]. Since human patients are usually older and suffer from (co)morbidities, we investigated the effects of Preoperative Fasting on OS induced by renal IRI in both female and male aged-corpulent mice in a F1 -FVB/C57BL6hybrid background.
