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Diederick E Grobbee - One of the best experts on this subject based on the ideXlab platform.
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Blood Pressure Response to changes in sodium and potassium intake: a metaregression analysis of randomised trials
Journal of human hypertension, 2003Co-Authors: Johanna M. Geleijnse, F. J. Kok, Diederick E GrobbeeAbstract:Blood Pressure Response to changes in sodium and potassium intake: a metaregression analysis of randomised trials
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Blood Pressure Response to changes in sodium and potassium intake: A metaregression analysis of randomised trials
Journal of Human Hypertension, 2003Co-Authors: Johanna M. Geleijnse, F. J. Kok, Diederick E GrobbeeAbstract:The objective of the study was to assess the blood Pressure Response to changes in sodium and potassium intake and examine effect modification by age, gender, blood Pressure, body weight and habitual sodium and potassium intake. Randomised trials of sodium reduction or potassium supplementation and blood Pressure were identified through reference lists of systematic reviews and an additional MEDLINE search (January 1995-March 2001). A total of 40 sodium trials and 27 potassium trials in adults with a minimum duration of 2 weeks were selected for analysis. Data on changes in electrolyte intake and blood Pressure during intervention were collected, as well as data on mean age, gender, body weight, initial electrolyte intake and initial blood Pressure of the trial populations. Blood Pressure effects of changes in electrolyte intake were assessed by weighted metaregression analysis, overall and in strata of trial population characteristics. Analyses were repeated with adjustment for potential confounders. Sodium reduction (median: -77 mmol/24 h) was associated with a change of -2.54 mmHg (95% CI: -3.16, -1.92) in systolic blood Pressure and -1.96 mmHg (-2.41, -1.51) in diastolic blood Pressure. Corresponding values for increased potassium intake (median: 44 mmol/24 h) were -2.42 mmHg (-3.75, -1.08) and -1.57 mmHg (-2.65, -0.50). Blood Pressure Response was larger in hypertensives than normotensives, both for sodium (systolic: -5.24 vs -1.26 mmHg, P < 0.001; diastolic: -3.69 vs -1.14 mmHg, P < 0.001) and potassium (systolic: -3.51 vs -0.97 mmHg, P=0.089; diastolic: -2.51 vs -0.34 mmHg, P=0.074). In conclusion, reduced intake of sodium and increased intake of potassium could make an important contribution to the prevention of hypertension, especially in populations with elevated blood Pressure.
Johanna M. Geleijnse - One of the best experts on this subject based on the ideXlab platform.
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Blood Pressure Response to changes in sodium and potassium intake: a metaregression analysis of randomised trials
Journal of human hypertension, 2003Co-Authors: Johanna M. Geleijnse, F. J. Kok, Diederick E GrobbeeAbstract:Blood Pressure Response to changes in sodium and potassium intake: a metaregression analysis of randomised trials
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Blood Pressure Response to changes in sodium and potassium intake: A metaregression analysis of randomised trials
Journal of Human Hypertension, 2003Co-Authors: Johanna M. Geleijnse, F. J. Kok, Diederick E GrobbeeAbstract:The objective of the study was to assess the blood Pressure Response to changes in sodium and potassium intake and examine effect modification by age, gender, blood Pressure, body weight and habitual sodium and potassium intake. Randomised trials of sodium reduction or potassium supplementation and blood Pressure were identified through reference lists of systematic reviews and an additional MEDLINE search (January 1995-March 2001). A total of 40 sodium trials and 27 potassium trials in adults with a minimum duration of 2 weeks were selected for analysis. Data on changes in electrolyte intake and blood Pressure during intervention were collected, as well as data on mean age, gender, body weight, initial electrolyte intake and initial blood Pressure of the trial populations. Blood Pressure effects of changes in electrolyte intake were assessed by weighted metaregression analysis, overall and in strata of trial population characteristics. Analyses were repeated with adjustment for potential confounders. Sodium reduction (median: -77 mmol/24 h) was associated with a change of -2.54 mmHg (95% CI: -3.16, -1.92) in systolic blood Pressure and -1.96 mmHg (-2.41, -1.51) in diastolic blood Pressure. Corresponding values for increased potassium intake (median: 44 mmol/24 h) were -2.42 mmHg (-3.75, -1.08) and -1.57 mmHg (-2.65, -0.50). Blood Pressure Response was larger in hypertensives than normotensives, both for sodium (systolic: -5.24 vs -1.26 mmHg, P < 0.001; diastolic: -3.69 vs -1.14 mmHg, P < 0.001) and potassium (systolic: -3.51 vs -0.97 mmHg, P=0.089; diastolic: -2.51 vs -0.34 mmHg, P=0.074). In conclusion, reduced intake of sodium and increased intake of potassium could make an important contribution to the prevention of hypertension, especially in populations with elevated blood Pressure.
Byung Il Choi - One of the best experts on this subject based on the ideXlab platform.
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endothelial dysfunction in patients with exaggerated blood Pressure Response during treadmill test
Clinical Cardiology, 2004Co-Authors: Hyukjae Chang, Jaehoon Chung, Soyeon Choi, Myeongho Yoon, Gyoseung Hwang, Joonhan Shin, Seungjea Tahk, Byung Il ChoiAbstract:Background: The diagnostic and prognostic importance of exaggerated blood Pressure Response to exercise is controversial. Endothelial dysfunction has been demonstrated in patients with atherosclerosis and risk factors for coronary artery disease, but there is a paucity of information on patients with exercise-induced hypertension. Hypothesis: We designed the study to evaluate endothelial function in patients with exaggerated blood Pressure Response during exercise. Methods: Exercise-induced hypertension was defined as systolic blood Pressure ≥ 210 mmHg in men and ≥ 190 mmHg in women during the treadmill test. Using a high-resolution ultrasound technique, endothelial function of the brachial artery in patients with exercise-induced hypertension (n = 25) and control subjects (n= 25) was investigated. Results: Endothelium-dependent vasodilation was impaired in patients with exercise-induced hypertension compared with controls (7.77 ± 5.14 vs. 2.81 ± 2.29%, p < 0.05). Onunivariate analysis, the extent of vasodilation correlated negatively with age (r = -0.43, p<0.05) and Δ systolic blood Pressure (r = -0.39, p < 0.05). Even after adjustment for factors known to affect endothelial function, endothelium-dependent vasodilation was decreased in patients with exercise-induced hypertension (β = 5.375, p = 0.02). Conclusion: Patients with exercise-induced hypertension have impaired endothelium-dependent vasodilation. This study also supports the concept that endothelial dysfunction may play an important role in exercise-induced hypertension.
Steven N Blair - One of the best experts on this subject based on the ideXlab platform.
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exaggerated blood Pressure Response to dynamic exercise and risk of future hypertension
Journal of Clinical Epidemiology, 1998Co-Authors: Charles E Matthews, Russell R Pate, Kirby L Jackson, Dianne S Ward, Caroline A Macera, Harold W Kohl, Steven N BlairAbstract:Abstract This study examined the association between an exaggerated blood Pressure Response to treadmill exercise and the risk of developing hypertension. Subjects were healthy normotensive men ( n = 5386) who had a baseline graded maximal exercise test between 1971 and 1982, and completed a mailed follow-up questionnaire. At follow-up in 1986, cases ( n = 151) reported physician diagnosed hypertension and controls ( n = 201) reported normotension. Those who had developed hypertension at follow-up were more likely to have had an exaggerated blood Pressure Response to exercise (OR = 2.4, 1.4–4.3) In multiple logistic regression analysis an exaggerated Response was significantly associated (OR = 3.0, 1.5–6.1) with future hypertension after controlling for sitting systolic and diastolic blood Pressure, weight change from age 21 to follow-up, entry age, family history of hypertension, body mass index, treadmill time, alcohol consumption, and years of follow-up. These results suggest that an exaggerated blood Pressure Response to exercise is independently associated with increased risk of future hypertension, and therefore, may be an important factor in determining hypertension risk.
F. J. Kok - One of the best experts on this subject based on the ideXlab platform.
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Blood Pressure Response to changes in sodium and potassium intake: a metaregression analysis of randomised trials
Journal of human hypertension, 2003Co-Authors: Johanna M. Geleijnse, F. J. Kok, Diederick E GrobbeeAbstract:Blood Pressure Response to changes in sodium and potassium intake: a metaregression analysis of randomised trials
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Blood Pressure Response to changes in sodium and potassium intake: A metaregression analysis of randomised trials
Journal of Human Hypertension, 2003Co-Authors: Johanna M. Geleijnse, F. J. Kok, Diederick E GrobbeeAbstract:The objective of the study was to assess the blood Pressure Response to changes in sodium and potassium intake and examine effect modification by age, gender, blood Pressure, body weight and habitual sodium and potassium intake. Randomised trials of sodium reduction or potassium supplementation and blood Pressure were identified through reference lists of systematic reviews and an additional MEDLINE search (January 1995-March 2001). A total of 40 sodium trials and 27 potassium trials in adults with a minimum duration of 2 weeks were selected for analysis. Data on changes in electrolyte intake and blood Pressure during intervention were collected, as well as data on mean age, gender, body weight, initial electrolyte intake and initial blood Pressure of the trial populations. Blood Pressure effects of changes in electrolyte intake were assessed by weighted metaregression analysis, overall and in strata of trial population characteristics. Analyses were repeated with adjustment for potential confounders. Sodium reduction (median: -77 mmol/24 h) was associated with a change of -2.54 mmHg (95% CI: -3.16, -1.92) in systolic blood Pressure and -1.96 mmHg (-2.41, -1.51) in diastolic blood Pressure. Corresponding values for increased potassium intake (median: 44 mmol/24 h) were -2.42 mmHg (-3.75, -1.08) and -1.57 mmHg (-2.65, -0.50). Blood Pressure Response was larger in hypertensives than normotensives, both for sodium (systolic: -5.24 vs -1.26 mmHg, P < 0.001; diastolic: -3.69 vs -1.14 mmHg, P < 0.001) and potassium (systolic: -3.51 vs -0.97 mmHg, P=0.089; diastolic: -2.51 vs -0.34 mmHg, P=0.074). In conclusion, reduced intake of sodium and increased intake of potassium could make an important contribution to the prevention of hypertension, especially in populations with elevated blood Pressure.
