The Experts below are selected from a list of 45 Experts worldwide ranked by ideXlab platform
Zihfen Wang - One of the best experts on this subject based on the ideXlab platform.
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hydrodynamic properties in a hydrogen Production Fermenter using sugary wastewater
International Journal of Hydrogen Energy, 2016Co-Authors: Hsin Lo, Zihfen WangAbstract:Abstract The biohydrogen Production performance was investigated in both of the continuously stirred anaerobic bioreactor (CSABR) and the egg-shaped external circulation hydrogen Production bioreactor (EEC-HPBR) in this study. It was found that the biohydrogen Production rate in EEC-HPBR was higher than that in the CSABR when the hydraulic retention time (HRT) was varied from 8 to 2 h. The hydrodynamic properties such as the bubble diameter, bubble rising velocity and phase holdups were carried out in a 2-D bioreactor to simulate the real 3-D bioreactor. The seed sludge in the 2-D bioreactor was taken from the CSABR at the same operational condition with a substrate concentration of 20 g total sugar/L. It was found that the average bubble diameter was 0.33 mm with a mild change during the HRT from 8 to 1 h. The bubble rising velocity against the substrate feeding rate increased linearly. The gas (e g ) and solid (e s ) phase-holdups increased with a decrease of the liquid (e l ) phase-holdup when HRT was shortened. The flow regime and mass transfer effects will change according to the bubble formation in the bioreactor. Finally, the study demonstrates that the parameters such as bubble diameter, bubble rising velocity and phase-holdups support bioreactor scale-up. Also this applies to the conditions for steady-state operations of the hydrogen Production bioreactor from sugary wastewater.
Meng‑hua Chiang - One of the best experts on this subject based on the ideXlab platform.
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Using the mycelium-covered cereals as an efficient inoculation method for rapamycin fermentation in a 15-L Fermenter using Streptomyces hygroscopicus
Bioresources and Bioprocessing, 2015Co-Authors: Meng‑hua ChiangAbstract:Rapamycin is produced from Streptomyces hygroscopicus, and was initially identified as an antifungal antibiotic. More recently, rapamycin has been found to have various medical applications, including in relation to immunosuppression and anti-aging. Due to its complex structure, biological Production is the major route for commercialized rapamycin Production. The conventional fermentation process requires a large seed Fermenter for the inoculation process (in general, the volume of the seed Fermenter is equal to 5–10 % that of the Production Fermenter), which presents challenges with regard to scaling up Production, due to the high investment costs of seed Fermenters. This study explored different inoculation strategies for rapamycin Production in a 15-L agitation Fermenter. The results indicated that solid-state fermentation (SSF) using barley as the substrate is a suitable method for the inoculation. The highest rapamycin concentration measured in the batch with SSF (barley) inoculated was about 520 mg/L, which was significantly higher than that of 400 mg/L obtained in the batch inoculated with 5 % liquid seed medium. Besides the higher rapamycin Production, using SSF of barley as the inoculation method can greatly reduce both the labor and cost requirements. The usage of mycelium-covered barley as the solid substrate for the inoculation of 15-L Fermenter leading to a higher rapamycin Production compared to that of conventional liquid seed medium. The solid-state inoculation method can avoid both the intensive labor requirement and costly seed Fermenter needed with the latter approach. This inoculation method thus has the potential to be applied to the large-scale Production of rapamycin.
Meng-hua Chiang - One of the best experts on this subject based on the ideXlab platform.
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Using the mycelium-covered cereals as an efficient inoculation method for rapamycin fermentation in a 15-L Fermenter using Streptomyces hygroscopicus
Bioresources and Bioprocessing, 2015Co-Authors: Meng-hua ChiangAbstract:Background Rapamycin is produced from Streptomyces hygroscopicus , and was initially identified as an antifungal antibiotic. More recently, rapamycin has been found to have various medical applications, including in relation to immunosuppression and anti-aging. Due to its complex structure, biological Production is the major route for commercialized rapamycin Production. The conventional fermentation process requires a large seed Fermenter for the inoculation process (in general, the volume of the seed Fermenter is equal to 5–10 % that of the Production Fermenter), which presents challenges with regard to scaling up Production, due to the high investment costs of seed Fermenters. This study explored different inoculation strategies for rapamycin Production in a 15-L agitation Fermenter. Results The results indicated that solid-state fermentation (SSF) using barley as the substrate is a suitable method for the inoculation. The highest rapamycin concentration measured in the batch with SSF (barley) inoculated was about 520 mg/L, which was significantly higher than that of 400 mg/L obtained in the batch inoculated with 5 % liquid seed medium. Besides the higher rapamycin Production, using SSF of barley as the inoculation method can greatly reduce both the labor and cost requirements. Conclusions The usage of mycelium-covered barley as the solid substrate for the inoculation of 15-L Fermenter leading to a higher rapamycin Production compared to that of conventional liquid seed medium. The solid-state inoculation method can avoid both the intensive labor requirement and costly seed Fermenter needed with the latter approach. This inoculation method thus has the potential to be applied to the large-scale Production of rapamycin.
Hsin Lo - One of the best experts on this subject based on the ideXlab platform.
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hydrodynamic properties in a hydrogen Production Fermenter using sugary wastewater
International Journal of Hydrogen Energy, 2016Co-Authors: Hsin Lo, Zihfen WangAbstract:Abstract The biohydrogen Production performance was investigated in both of the continuously stirred anaerobic bioreactor (CSABR) and the egg-shaped external circulation hydrogen Production bioreactor (EEC-HPBR) in this study. It was found that the biohydrogen Production rate in EEC-HPBR was higher than that in the CSABR when the hydraulic retention time (HRT) was varied from 8 to 2 h. The hydrodynamic properties such as the bubble diameter, bubble rising velocity and phase holdups were carried out in a 2-D bioreactor to simulate the real 3-D bioreactor. The seed sludge in the 2-D bioreactor was taken from the CSABR at the same operational condition with a substrate concentration of 20 g total sugar/L. It was found that the average bubble diameter was 0.33 mm with a mild change during the HRT from 8 to 1 h. The bubble rising velocity against the substrate feeding rate increased linearly. The gas (e g ) and solid (e s ) phase-holdups increased with a decrease of the liquid (e l ) phase-holdup when HRT was shortened. The flow regime and mass transfer effects will change according to the bubble formation in the bioreactor. Finally, the study demonstrates that the parameters such as bubble diameter, bubble rising velocity and phase-holdups support bioreactor scale-up. Also this applies to the conditions for steady-state operations of the hydrogen Production bioreactor from sugary wastewater.
M Ignova - One of the best experts on this subject based on the ideXlab platform.
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Multivariate statistical methods in bioprocess fault detection and performance forecasting
Transactions of the Institute of Measurement and Control, 1997Co-Authors: M Ignova, Alan C Ward, Jarka Glassey, Gary MontagueAbstract:This paper demonstrates how multivariante statistical data analysis procedures used as feature extraction methods can assist in the operation of an industrial fermentation process. The quality of the Production Fermenter seed and the subsequent forecasting of productivity are the two examples considered, with results presented from industrial plant. The feature extraction methodologies utilised are based around principal component analysis (PCA) and the extension to batch systems through the use of multi-way PCA.
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seed data analysis for Production Fermenter performance estimation
IFAC Proceedings Volumes, 1995Co-Authors: M Ignova, J Glassey, G A Montague, Alan C Ward, T S IrvineAbstract:Abstract The ability to supervise highly non-linear and time variant bioprocesses is of considerable importance to the bio-industries which are continually striving to obtain improved productivity and to reduce process variability. In this contribution the seed stage (a batch process) of an industrial antibiotic fermentation is considered to correlate the performance of the main Production fermentations with the quality of the seed. Four pattern recognition techniques were applied to the seed data: Artificial Neural Networics (ANNs), Principal Component Analysis (PCA), Non-Linear Principal Component Analysis (NLPCA) and Kohonen Self Organising Feature Map (SOFM). It is shown that high and low performing fermentations can be distinguished using information from only the seed stage. Data from industrial penicillin G Fermenters is used to demonstrate the procedures.
