The Experts below are selected from a list of 102 Experts worldwide ranked by ideXlab platform
Edward J Cone - One of the best experts on this subject based on the ideXlab platform.
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urine drug testing of chronic pain patients v prevalence of Propoxyphene following its withdrawal from the united states market
Journal of Analytical Toxicology, 2013Co-Authors: Brandi L Puet, Anne Z Depriest, Julie Knight, Rebecca Heltsley, David L Black, Yale H Caplan, Edward J ConeAbstract:Propoxyphene is an opioid analgesic that was surrounded by controversy concerning its safety and efficacy during its lifespan in the US market. Propoxyphene was withdrawn in November of 2010 from the US market and is still being detected one year post-withdrawal in urine specimens from the pain management population. In this study, the prevalence of Propoxyphene was determined in a total of 417,914 urine specimens collected from 630 clinics involved in pain management located in 24 states during the period of January 1, 2010, through December 31, 2011. Propoxyphene and norPropoxyphene were measured in urine by a validated liquid chromatography‐tandem mass spectrometry procedure with a lower limit of quantitation of 50 ng/mL. The positivity rate for Propoxyphene prevalence declined sharply between November and December of 2010 and further declined at a gradual rate, ending in a prevalence of 0.27% (one out of every 370 specimens, n 5 25,658) for the month of December 2011. The presented data provide evidence of the dramatic decline in the use of Propoxyphene products since their removal from the medical market, and may be beneficial to US urine drug testing programs determining the need for continual monitoring of Propoxyphene levels.
Robert S Hoffman - One of the best experts on this subject based on the ideXlab platform.
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Propoxyphene induced wide qrs complex dysrhythmia responsive to sodium bicarbonate a case report
Clinical Toxicology, 1995Co-Authors: Christine M Stork, John T Redd, Kenneth Fine, Robert S HoffmanAbstract:Propoxyphene overdose is known to cause widening of the QRS complex on ECG. We report a case of a 54-year-old female who ingested approximately 100 Propoxyphene hydrochloride tablets in a suicide attempt. She developed a wide complex dysrhythmia which responded to sodium bicarbonate therapy. Propoxyphene-induced wide complex dysrhythmia responsive to sodium bicarbonate therapy has not been previously reported in the literature.
Bruce A Goldberger - One of the best experts on this subject based on the ideXlab platform.
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fatal poisonings involving Propoxyphene before and after voluntary withdrawal from the united states market an analysis from the state of florida
Forensic Science International, 2017Co-Authors: Chris Delcher, Guanming Chen, Yanning Wang, Svetla Slavova, Bruce A GoldbergerAbstract:Abstract The synthetic opioid Propoxyphene was a schedule IV controlled substance with multiple reported health risks before the US Food and Drug Administration issued a request for voluntary market withdrawal in November 2010. The purpose of this study is to investigate the characteristics and occurrences of Propoxyphene-related deaths in Florida before and after voluntary market removal. Decedent-level toxicology data from Florida’s Medical Examiners Commission was used to compare the temporal, polysubstance use, sociodemographic, and geographic profiles associated with Propoxyphene-involved deaths for a pre-withdrawal (November 2008–November 2010) and post-withdrawal (December 2010–December 2012) period. Sensitivity analyses using multiple data sources, including Florida’s Prescription Drug Monitoring Program and other states’ data, were conducted to examine potential reporting bias. Results showed that the number of Propoxyphene-involved deaths declined by 84% from 580 deaths to 92 deaths after market withdrawal. The co-occurrence of other prevalent drugs, such as oxycodone (17.2% to 26.1%, p = 0.0422) increased significantly in the post-withdrawal study period. A larger proportion of the Propoxyphene-related deaths were reported from South Florida after the withdrawal (28.4% to 56.5%, p
Brandi L Puet - One of the best experts on this subject based on the ideXlab platform.
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urine drug testing of chronic pain patients v prevalence of Propoxyphene following its withdrawal from the united states market
Journal of Analytical Toxicology, 2013Co-Authors: Brandi L Puet, Anne Z Depriest, Julie Knight, Rebecca Heltsley, David L Black, Yale H Caplan, Edward J ConeAbstract:Propoxyphene is an opioid analgesic that was surrounded by controversy concerning its safety and efficacy during its lifespan in the US market. Propoxyphene was withdrawn in November of 2010 from the US market and is still being detected one year post-withdrawal in urine specimens from the pain management population. In this study, the prevalence of Propoxyphene was determined in a total of 417,914 urine specimens collected from 630 clinics involved in pain management located in 24 states during the period of January 1, 2010, through December 31, 2011. Propoxyphene and norPropoxyphene were measured in urine by a validated liquid chromatography‐tandem mass spectrometry procedure with a lower limit of quantitation of 50 ng/mL. The positivity rate for Propoxyphene prevalence declined sharply between November and December of 2010 and further declined at a gradual rate, ending in a prevalence of 0.27% (one out of every 370 specimens, n 5 25,658) for the month of December 2011. The presented data provide evidence of the dramatic decline in the use of Propoxyphene products since their removal from the medical market, and may be beneficial to US urine drug testing programs determining the need for continual monitoring of Propoxyphene levels.
Christine M Stork - One of the best experts on this subject based on the ideXlab platform.
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Propoxyphene induced wide qrs complex dysrhythmia responsive to sodium bicarbonate a case report
Clinical Toxicology, 1995Co-Authors: Christine M Stork, John T Redd, Kenneth Fine, Robert S HoffmanAbstract:Propoxyphene overdose is known to cause widening of the QRS complex on ECG. We report a case of a 54-year-old female who ingested approximately 100 Propoxyphene hydrochloride tablets in a suicide attempt. She developed a wide complex dysrhythmia which responded to sodium bicarbonate therapy. Propoxyphene-induced wide complex dysrhythmia responsive to sodium bicarbonate therapy has not been previously reported in the literature.
