The Experts below are selected from a list of 22386 Experts worldwide ranked by ideXlab platform
Anthony P. Sclafani - One of the best experts on this subject based on the ideXlab platform.
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induction of dermal collagenesis angiogenesis and adipogenesis in human skin by injection of platelet rich fibrin matrix
Archives of Facial Plastic Surgery, 2012Co-Authors: Anthony P. Sclafani, Steven A. MccormickAbstract:Objective To evaluate the histological changes induced in human skin by injection of autologous platelet-rich fibrin matrix (PRFM). Methods Four healthy adult volunteers were included in the study. Platelet-rich fibrin matrix was prepared from 9 mL of autologous blood using a Proprietary System (Selphyl; Aesthetic Factors, Wayne, New Jersey) and injected into the deep dermis and immediate subdermis of the upper arms of subjects. Full-thickness skin biopsy specimens were taken from the treated areas over a 10-week period, and the specimens were processed for histological evaluation. Results Findings from histological examination supported the clinical observation of soft-tissue augmentation. As early as 7 days after treatment, activated fibroblasts and new collagen deposition were noted and continued to be evident throughout the course of the study. Development of new blood vessels was noted by 19 days; also at this time, intradermal collections of adipocytes and stimulation of subdermal adipocytes were noted. These findings became more pronounced over the duration of the study, although the fibroblastic response became much less pronounced. No abnormal mitotic figures were observed at any point, and a very mild chronic inflammatory response was noted only at the earliest time points of the study. Conclusions Injection of PRFM into the deep dermis and subdermis of the skin stimulates a number of cellular changes that can be harnessed for use. Coupled with prior in vitro and in vivo studies, we now have a much clearer picture of the cellular effects of PRFM and its potential uses in facial plastic surgery. Further work is planned to more clearly elucidate the potential role of PRFM in aesthetic and reconstructive surgery. Trial Registration clinicaltrials.gov Identifier: NCT00956020
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Platelet-rich fibrin matrix for improvement of deep nasolabial folds
Journal of Cosmetic Dermatology, 2010Co-Authors: Anthony P. SclafaniAbstract:Background Dermal augmentation continues to grow as an aesthetic facial procedure. Many exogenous filler materials rely on an autologous fibrotic response for volume augmentation. Aims To evaluate the efficacy of a single injection of autologous platelet-rich fibrin matrix (PRFM) for the correction of deep nasolabial folds (NLFs). Patients/methods Whole blood was obtained from 15 adults, and an activated autologous PRFM produced using a Proprietary System (Selphyl®; Aesthetic Factors, Inc., Wayne, NJ, USA) was then injected into the dermis and immediate subdermis below the NLFs. Subjects were photographed before and after treatment; NLFs were rated by the treating physician before and after treatment using the Wrinkle Assessment Scale (WAS) and patients rated their appearance at each post-treatment visit using the Global Aesthetic Improvement Scale. Patients were evaluated at 1, 2, 6, and 12 weeks after treatment. Results All patients were treated to maximal (no over-) correction, with a mean reduction in WAS score of 2.12 ± 0.56. At 1 week after treatment, this difference was 0.65 ± 0.68, but rose to 0.97 ± 0.75, 1.08 ± 0.59, and 1.13 ± 0.72 at 2, 6, and 12 weeks after treatment, respectively (P
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platelet rich fibrin matrix for improvement of deep nasolabial folds
Journal of Cosmetic Dermatology, 2010Co-Authors: Anthony P. SclafaniAbstract:Background Dermal augmentation continues to grow as an aesthetic facial procedure. Many exogenous filler materials rely on an autologous fibrotic response for volume augmentation. Aims To evaluate the efficacy of a single injection of autologous platelet-rich fibrin matrix (PRFM) for the correction of deep nasolabial folds (NLFs). Patients/methods Whole blood was obtained from 15 adults, and an activated autologous PRFM produced using a Proprietary System (Selphyl®; Aesthetic Factors, Inc., Wayne, NJ, USA) was then injected into the dermis and immediate subdermis below the NLFs. Subjects were photographed before and after treatment; NLFs were rated by the treating physician before and after treatment using the Wrinkle Assessment Scale (WAS) and patients rated their appearance at each post-treatment visit using the Global Aesthetic Improvement Scale. Patients were evaluated at 1, 2, 6, and 12 weeks after treatment. Results All patients were treated to maximal (no over-) correction, with a mean reduction in WAS score of 2.12 ± 0.56. At 1 week after treatment, this difference was 0.65 ± 0.68, but rose to 0.97 ± 0.75, 1.08 ± 0.59, and 1.13 ± 0.72 at 2, 6, and 12 weeks after treatment, respectively (P < 0.001). No patient noted any fibrosis, irregularity, hardness, restricted movement, or lumpiness. Conclusions PRFM can provide significant long-term diminution of deep NLFs without the use of foreign materials. PRFM holds significant potential for stimulated dermal augmentation.
Michel R V Chaudron - One of the best experts on this subject based on the ideXlab platform.
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The impact of UML modeling on defect density and defect resolution time in a Proprietary System
Empirical Software Engineering, 2014Co-Authors: Ariadi Nugroho, Michel R V ChaudronAbstract:Background : The contribution of modeling in software development has been a subject of debates. The proponents of model-driven development argue that a big upfront modeling requires substantial investment, but it will payoff later in the implementation phase in terms of increased productivity and quality. Other software engineers perceive modeling activity as a waste of time and money without any real contribution to the final software product. Considering present advancement of model-based software development in software industry, we are challenged to investigate the real contribution of modeling in software development. Objective : We analyze the impacts of UML modeling, specifically the production of class and sequence diagrams, on the quality of the code, as measured by defect density, and on defect resolution time. Method : Using data of a Proprietary System, we conduct post-mortem analyses to test the difference in defect density between software modules that are modeled and not modeled. Similarly, we test the difference in resolution time between defects that are related to modeled and not modeled functionality. Result : We have found that the production of UML class diagrams and sequence diagrams reduces defect density in the code and the time required to fix defects. These results are obtained after controlling for the effects of co-factors such as code coupling and complexity. Conclusion : The results confirm that not only does the production of UML class diagrams and sequence diagrams possibly help improve the quality of software, but also it possibly help increase the productivity in software maintenance.
Kai Beckmann - One of the best experts on this subject based on the ideXlab platform.
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Integrating existing Proprietary System models into a model-driven test process for an industrial automation scenario
2015 3rd International Conference on Model-Driven Engineering and Software Development (MODELSWARD), 2015Co-Authors: Kai BeckmannAbstract:The introduction of modern model-driven software development methodologies into the industrial practise still proves to be a challenge. Especially small or medium-sized enterprises (SMEs) need an incremental and continuous modernisation process, which incorporates existing projects, is customised and cost-effective. Particularly, suitable solutions for model-based or -driven testing with test automation to increase the efficiency are in demand. This paper presents an approach for integrating existing Proprietary System models of an SME partner for describing industrial automation processes into a model-driven test process, utilising a domain-specific language for the test specification. The test objectives focuses on the correct implementation of the communication and synchronisation of distributed state machines. The presented approach is integrated into a test framework, which is based on the Eclipse Modelling Framework (EMF) and the Eclipse Test and Performance Tools Platform Project (TPTP) framework. To separate the possibly changeable System and DSL-specific models from the implementation of the test framework, a stable and more generic test meta model was defined.
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MODELSWARD - Integrating existing Proprietary System models into a model-driven test process for an industrial automation scenario
Proceedings of the 3rd International Conference on Model-Driven Engineering and Software Development, 2015Co-Authors: Kai BeckmannAbstract:The introduction of modern model-driven software development methodologies into the industrial practise still proves to be a challenge. Especially small or medium-sized enterprises (SMEs) need an incremental and continuous modernisation process, which incorporates existing projects, is customised and cost-effective. Particularly, suitable solutions for model-based or -driven testing with test automation to increase the efficiency are in demand. This paper presents an approach for integrating existing Proprietary System models of an SME partner for describing industrial automation processes into a model-driven test process, utilising a domain-specific language for the test specification. The test objectives focuses on the correct implementation of the communication and synchronisation of distributed state machines. The presented approach is integrated into a test framework, which is based on the Eclipse Modelling Framework (EMF) and the Eclipse Test and Performance Tools Platform Project (TPTP) framework. To separate the possibly changeable System and DSL-specific models from the implementation of the test framework, a stable and more generic test meta model was defined.
Rodney John Allam - One of the best experts on this subject based on the ideXlab platform.
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demonstration of the allam cycle an update on the development status of a high efficiency supercritical carbon dioxide power process employing full carbon capture
Energy Procedia, 2017Co-Authors: Rodney John Allam, Scott Thomas Martin, Brock Alan Forrest, Jeremy Eron Fetvedt, Xijia LuAbstract:Abstract The Allam cycle is a novel CO2, oxy-fuel power cycle that utilizes hydrocarbon fuels while inherently capturing approximately 100% of atmospheric emissions, including nearly all CO2 emissions at a cost of electricity that is highly competitive with the best available energy production Systems that do not employ CO2 capture. The Proprietary System achieves these results through a semi-closed-loop, high-pressure, low-pressure-ratio recuperated Brayton cycle that uses supercritical CO2 as the working fluid, dramatically reducing energy losses compared to steam- and air-based cycles. In conventional cycles, the separation and removal of low concentration combustion derived impurities such as CO2 results in a large additional capital cost and increased parasitic power. As a result, removal in conventional cycles can increase the cost of electricity by 50% to 70% [1] . The compelling economics of the Allam Cycle are driven by high target efficiencies, 59% net for natural gas and 51% net for coal (LHV basis) while inherently capturing nearly 100% CO2 at pipeline pressure with low projected capital and OM for the demonstration plant, the construction and commissioning status, schedule, key components, layout, and detailed design; turbine design, manufacturing status; development of a novel dynamic control System and control simulator for the demonstration plant; and other key aspects of the cycle. It will provide an update on the progress of the gasified solid fuel Allam Cycle and then address the overall Allam Cycle commercialization program, benefits and applications, and the expected design of the natural gas 300 MWe commercial NET Power plant projected for 2020.
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high efficiency and low cost of electricity generation from fossil fuels while eliminating atmospheric emissions including carbon dioxide
Energy Procedia, 2013Co-Authors: Rodney John Allam, Jeremy Eron Fetvedt, Miles R Palmer, William G Brown, David Freed, Hideo Nomoto, Masao Itoh, Nobuo Okita, Charles JonesAbstract:Abstract NET Power has developed a novel, oxy-fuel thermodynamic power cycle [1] that uses hydrocarbon fuels, captures 100% of atmospheric emissions, including all carbon dioxide, and has a cost of electricity that is highly competitive with the best current Systems that do not have CO2 capture. The Proprietary System achieves these results through a closed-loop, high-pressure, low-pressure-ratio recuperated Brayton cycle that uses supercritical CO2 as the working fluid. The cycle exploits the special thermodynamic properties of carbon dioxide as a working fluid by eliminating the energy losses that steam-based cycles encounter due to the heat of vaporization and condensation. The compelling economics of the System are driven by high target efficiencies – 59% net LHV for natural gas and 51% net LHV for coal – and low projected capital and O&M costs, which are the result of utilizing only a single turbine, having a smaller plant footprint, and requiring fewer, smaller components than comparable fossil-fuel Systems. NET Power, Toshiba Corporation, Exelon Corporation, and the Shaw Power Group are partnering to commercialize this System by developing a 50MWt facility that is scheduled to begin testing in 2014. This facility will generate electricity from natural gas and capture 100% of emissions, including all CO2. The initial design for a commercial System with an electrical output in the range of 200MWt to 500MWt is also under development. The turbine for the 50MWt plant is being designed at the 500MWt level and then scaled down for the demonstration plant to facilitate rapid development of the large-scale turbine in the future. The demonstration plant will test all components and control Systems and the operability of the cycle, including 100% capture of carbon dioxide and other impurities, using a range of fuel gas compositions. The NET Power cycle will have an important impact on the power industry's ability to control and limit greenhouse gas emissions. Driven by its competitive cost when compared to state-of-the-art technologies without CO2 capture, the authors believe the NET Power cycle will remove economic barriers to the deployment of 100%-carbon-capture, fossil-fuel-based electricity generation technology. This will enable both the developed and developing world to produce cheap electricity that does not contribute to CO2-based climate change.
Ariadi Nugroho - One of the best experts on this subject based on the ideXlab platform.
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The impact of UML modeling on defect density and defect resolution time in a Proprietary System
Empirical Software Engineering, 2014Co-Authors: Ariadi Nugroho, Michel R V ChaudronAbstract:Background : The contribution of modeling in software development has been a subject of debates. The proponents of model-driven development argue that a big upfront modeling requires substantial investment, but it will payoff later in the implementation phase in terms of increased productivity and quality. Other software engineers perceive modeling activity as a waste of time and money without any real contribution to the final software product. Considering present advancement of model-based software development in software industry, we are challenged to investigate the real contribution of modeling in software development. Objective : We analyze the impacts of UML modeling, specifically the production of class and sequence diagrams, on the quality of the code, as measured by defect density, and on defect resolution time. Method : Using data of a Proprietary System, we conduct post-mortem analyses to test the difference in defect density between software modules that are modeled and not modeled. Similarly, we test the difference in resolution time between defects that are related to modeled and not modeled functionality. Result : We have found that the production of UML class diagrams and sequence diagrams reduces defect density in the code and the time required to fix defects. These results are obtained after controlling for the effects of co-factors such as code coupling and complexity. Conclusion : The results confirm that not only does the production of UML class diagrams and sequence diagrams possibly help improve the quality of software, but also it possibly help increase the productivity in software maintenance.
