The Experts below are selected from a list of 65193 Experts worldwide ranked by ideXlab platform
Tonya M Palermo - One of the best experts on this subject based on the ideXlab platform.
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web based cognitive behavioral intervention for Pain in pediatric acute recurrent and chronic pancreatitis protocol of a multicenter randomized controlled trial from the study of chronic pancreatitis diabetes and pancreatic cancer cpdpc
Contemporary Clinical Trials, 2020Co-Authors: Tonya M Palermo, Caitlin B Murray, Homer Aalfs, Maisam Abuelhaija, Bradley A Barth, Melena D Bellin, Kate M Ellery, Douglas S Fishman, Cheryl E GariepyAbstract:Abstract Introduction Abdominal Pain is common and is associated with high disease burden and health care costs in pediatric acute recurrent and chronic pancreatitis (ARP/CP). Despite the strong central component of Pain in ARP/CP and the efficacy of Psychological therapies for other centralized Pain syndromes, no studies have evaluated Psychological Pain interventions in children with ARP/CP. The current trial seeks to 1) evaluate the efficacy of a Psychological Pain intervention for pediatric ARP/CP, and 2) examine baseline patient-specific genetic, clinical, and psychosocial characteristics that may predict or moderate treatment response. Methods This single-blinded randomized placebo-controlled multicenter trial aims to enroll 260 youth (ages 10–18) with ARP/CP and their parents from twenty-one INSPPIRE ( IN ternational S tudy Group of P ediatric P ancreatitis: I n search for a cu RE) centers. Participants will be randomly assigned to either a web-based cognitive behavioral Pain management intervention (Web-based Management of Adolescent Pain Chronic Pancreatitis; WebMAP; N = 130) or to a web-based Pain education program (WebED; N = 130). Assessments will be completed at baseline (T1), immediately after completion of the intervention (T2) and at 6 months post-intervention (T3). The primary study outcome is abdominal Pain severity. Secondary outcomes include Pain-related disability, Pain interference, health-related quality of life, emotional distress, impact of Pain, opioid use, and healthcare utilization. Conclusions This is the first clinical trial to evaluate the efficacy of a Psychological Pain intervention for children with CP for reduction of abdominal Pain and improvement of health-related quality of life. Findings will inform delivery of web-based Pain management and potentially identify patient-specific biological and psychosocial factors associated with favorable response to therapy. Clinical Trial Registration #: NCT03707431.
Fabrice Jollant - One of the best experts on this subject based on the ideXlab platform.
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a visual analog scale to measure Psychological and physical Pain a preliminary validation of the ppp vas in two independent samples of depressed patients
Progress in Neuro-psychopharmacology & Biological Psychiatry, 2019Co-Authors: Fabrice Jollant, Geraldine Voegeli, Nolan C Kordsmeier, Jessica M Carbajal, Stephane Richarddevantoy, Gustavo Turecki, Ricardo CacedaAbstract:Abstract Objective Psychological Pain lies at the heart of human experience. However, it may also be abnormally intense and/or prolonged in pathological states, with negative outcomes. A simple and reliable measure of Psychological Pain for clinical use would be useful. In this study, we present a preliminary validation of a simple visual analog scale jointly measuring Psychological and physical Pain. Methods Two samples of adult (non elderly) depressed patients and healthy controls were independently recruited in two locations in Canada and the USA (N = 46/48 and 200/20, respectively). Six dimensions were successively scored on a paper visual analog scale measuring current, mean and worst Pain over the last 15 days, for physical then Psychological Pain. Results All physical and Psychological Pain dimensions discriminated depressed from non-depressed subjects. Among depressed patients, Psychological Pain scores were higher than physical Pain scores for a given period of assessment. Moreover, correlations between dimensions from the same Pain category (physical or Psychological) were higher than between different Pain categories. Psychological Pain was mainly correlated with depression and hopelessness scales while physical Pain was mainly correlated with anxiety scales. Secondary analyses showed that Psychological (and some physical) Pain measures were correlated with suicidal ideas in one location, but no difference in Pain scores was found between patients with vs. without a history of suicidal acts in both samples. Childhood trauma positively correlated with several Pain dimensions. Conclusion The PPP-VAS appears to be a valid tool in terms of discriminative capacities and convergent-divergent validities. Validation in different samples, including adolescents and elderly, and in various psychiatric and medical conditions will have to be conducted, in addition to the assessment of concurrent and predictive validities, and the confirmation of sensitivity to change. The role of Psychological Pain in the suicidal process needs to be further elucidated.
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cognitive inhibition in depression and suicidal behavior a neuroimaging study
Psychological Medicine, 2016Co-Authors: Stephane Richarddevantoy, Gustavo Turecki, Yang Ding, Martin Lepage, Fabrice JollantAbstract:BACKGROUND: Cognitive inhibition deficits have previously been found in suicide attempters. This study examined the neural basis for these deficits in depressed patients with and without a history of suicidal behavior. METHOD: Functional magnetic resonance imaging was used to measure brain activation during the Go/No-Go response inhibition task in 25 unmedicated and depressed middle-aged suicide attempters, 22 unmedicated depressed patient controls with no personal or family history of suicidal behavior, and 27 healthy controls. Whole-brain analyses were conducted with SPM12. RESULTS: Suicide attempters exhibited an elevated number of commission errors relative to both control groups. However, suicide attempters did not differ from patient controls in terms of brain activation for any contrast. Analyses showed a significant association between depression and brain activation in the left inferior frontal gyrus and medial thalamus during Go v. No-Go, and in the bilateral parietal cortex and left orbitofrontal cortex during No-Go v. baseline. These regions were correlated with Psychological Pain, suicidal ideation and global functioning. There was no association between brain activation and personal histories of suicidal act. CONCLUSIONS: Our study suggests that deficits in cognitive inhibition, in relation to the inferior frontal gyrus, thalamus, orbitofrontal cortex and parietal cortex, are related to the depressive state and not specifically to suicide vulnerability. We hypothesize that state-related deficits may add to trait-like cognitive impairments to facilitate suicidal acts. These different types of cognitive impairments may necessitate different therapeutic strategies for the prevention of suicide. Language: en
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higher Psychological Pain during a major depressive episode may be a factor of vulnerability to suicidal ideation and act
Journal of Affective Disorders, 2010Co-Authors: Emilie Olie, Fabrice Jollant, Philippe Courtet, Sebastien Guillaume, Isabelle JaussentAbstract:Abstract Background It has been suggested that Psychological Pain (“psychache”) is a key factor in the suicidal process. In addition, suicidal acts may be best understood within a stress-vulnerability model. We hypothesized that more intense psychache during a major depressive episode would be a factor of vulnerability to suicidal behavior. Methods Patients hospitalized for a major depressive episode, including 87 individuals with a recent history of suicidal acts, 61 individuals with a past history of suicidal acts, and 62 individuals without any suicidal history, were assessed at admission using several Visual Analog scales to measure levels of psychache, physical Pain and suicidal ideation. Results Patients with a recent or past history of suicide attempts expressed significantly higher levels of current Psychological Pain, and a higher intensity and frequency of current suicidal ideation than patients without any history of suicidal acts. The level of current psychache was significantly and positively associated with intensity and frequency of suicidal ideation. There were no between-group differences for physical Pain. Limitations Medication status was not controlled. A lack of statistical power may have masked an association between physical Pain and suicidal ideation. Conclusions Higher Psychological Pain during a major depressive episode may be a factor of vulnerability to suicidal behavior, by increasing the propensity to suicidal ideation. Measuring and taking care of psychache during a depressive episode should be a major therapeutic target during crisis intervention.
Philippe Courtet - One of the best experts on this subject based on the ideXlab platform.
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nothing hurts less than being dead Psychological Pain in case descriptions of psychiatric euthanasia and assisted suicide from the netherlands rien ne fait moins mal qu etre mort la douleur psychologique dans les descriptions de cas d euthanasie et de suicide assiste psychiatrique aux pays bas
The Canadian Journal of Psychiatry, 2020Co-Authors: Philippe Courtet, Aiste Lengvenyte, Robertas Strumila, Scott Y H Kim, Emilie OlieAbstract:Objectives:Euthanasia and assisted suicide (EAS) of individuals with mental disorders is a growing practice in several countries, including the Netherlands. Here, we aimed to identify the most freq...
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Cognitive, Emotional, Temperament, and Personality Trait Correlates of Suicidal Behavior
Current Psychiatry Reports, 2016Co-Authors: Lucas Giner, Hilario Blasco-fontecilla, Diego De La Vega, Philippe CourtetAbstract:Suicide is one of the leading causes of violent death in many countries and its prevention is included in worldwide health objectives. Currently, the DSM-5 considers suicidal behavior as an entity that requires further study. Among the three validators required for considering a psychiatric disorder, there is one based on Psychological correlates, biological markers, and patterns of comorbidity. This review includes the most important and recent studies on Psychological factors: cognitive, emotional, temperament, and personality correlates (unrelated to diagnostic criteria). We included classic factors related to suicidal behavior such as cognitive, inflexibility, problem-solving, coping, rumination, thought suppression, decision-making, autobiographical memory, working memory, language fluency, burdensomeness, belongingness, fearless, Pain insensitivity, impulsiveness, aggressiveness, and hopelessness. The personality correlates reported are mainly based on the personality theories of Cloninger, Costa and McCrae, and Eysenck. Moreover, it explores conceptual links to other new pathways in Psychological factors, emptiness, and Psychological Pain as a possible origin and common end path for a portion of suicidal behaviors.
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higher Psychological Pain during a major depressive episode may be a factor of vulnerability to suicidal ideation and act
Journal of Affective Disorders, 2010Co-Authors: Emilie Olie, Fabrice Jollant, Philippe Courtet, Sebastien Guillaume, Isabelle JaussentAbstract:Abstract Background It has been suggested that Psychological Pain (“psychache”) is a key factor in the suicidal process. In addition, suicidal acts may be best understood within a stress-vulnerability model. We hypothesized that more intense psychache during a major depressive episode would be a factor of vulnerability to suicidal behavior. Methods Patients hospitalized for a major depressive episode, including 87 individuals with a recent history of suicidal acts, 61 individuals with a past history of suicidal acts, and 62 individuals without any suicidal history, were assessed at admission using several Visual Analog scales to measure levels of psychache, physical Pain and suicidal ideation. Results Patients with a recent or past history of suicide attempts expressed significantly higher levels of current Psychological Pain, and a higher intensity and frequency of current suicidal ideation than patients without any history of suicidal acts. The level of current psychache was significantly and positively associated with intensity and frequency of suicidal ideation. There were no between-group differences for physical Pain. Limitations Medication status was not controlled. A lack of statistical power may have masked an association between physical Pain and suicidal ideation. Conclusions Higher Psychological Pain during a major depressive episode may be a factor of vulnerability to suicidal behavior, by increasing the propensity to suicidal ideation. Measuring and taking care of psychache during a depressive episode should be a major therapeutic target during crisis intervention.
Cheryl E Gariepy - One of the best experts on this subject based on the ideXlab platform.
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web based cognitive behavioral intervention for Pain in pediatric acute recurrent and chronic pancreatitis protocol of a multicenter randomized controlled trial from the study of chronic pancreatitis diabetes and pancreatic cancer cpdpc
Contemporary Clinical Trials, 2020Co-Authors: Tonya M Palermo, Caitlin B Murray, Homer Aalfs, Maisam Abuelhaija, Bradley A Barth, Melena D Bellin, Kate M Ellery, Douglas S Fishman, Cheryl E GariepyAbstract:Abstract Introduction Abdominal Pain is common and is associated with high disease burden and health care costs in pediatric acute recurrent and chronic pancreatitis (ARP/CP). Despite the strong central component of Pain in ARP/CP and the efficacy of Psychological therapies for other centralized Pain syndromes, no studies have evaluated Psychological Pain interventions in children with ARP/CP. The current trial seeks to 1) evaluate the efficacy of a Psychological Pain intervention for pediatric ARP/CP, and 2) examine baseline patient-specific genetic, clinical, and psychosocial characteristics that may predict or moderate treatment response. Methods This single-blinded randomized placebo-controlled multicenter trial aims to enroll 260 youth (ages 10–18) with ARP/CP and their parents from twenty-one INSPPIRE ( IN ternational S tudy Group of P ediatric P ancreatitis: I n search for a cu RE) centers. Participants will be randomly assigned to either a web-based cognitive behavioral Pain management intervention (Web-based Management of Adolescent Pain Chronic Pancreatitis; WebMAP; N = 130) or to a web-based Pain education program (WebED; N = 130). Assessments will be completed at baseline (T1), immediately after completion of the intervention (T2) and at 6 months post-intervention (T3). The primary study outcome is abdominal Pain severity. Secondary outcomes include Pain-related disability, Pain interference, health-related quality of life, emotional distress, impact of Pain, opioid use, and healthcare utilization. Conclusions This is the first clinical trial to evaluate the efficacy of a Psychological Pain intervention for children with CP for reduction of abdominal Pain and improvement of health-related quality of life. Findings will inform delivery of web-based Pain management and potentially identify patient-specific biological and psychosocial factors associated with favorable response to therapy. Clinical Trial Registration #: NCT03707431.
Sandra J Weiss - One of the best experts on this subject based on the ideXlab platform.
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resting state eeg delta power is associated with Psychological Pain in adults with a history of depression
Biological Psychology, 2015Co-Authors: Esther L Meerwijk, Judith M Ford, Sandra J WeissAbstract:Psychological Pain is a prominent symptom of clinical depression. We asked if frontal alpha asymmetry, frontal EEG power, and frontal fractal dimension asymmetry predicted Psychological Pain in adults with a history of depression. Resting-state frontal EEG (F3/F4) was recorded while participants (N=35) sat upright with their eyes closed. Frontal delta power predicted Psychological Pain while controlling for depressive symptoms, with participants who exhibited less power experiencing greater Psychological Pain. Frontal fractal dimension asymmetry, a nonlinear measure of complexity, also predicted Psychological Pain, such that greater left than right complexity was associated with greater Psychological Pain. Frontal alpha asymmetry did not contribute unique variance to any regression model of Psychological Pain. As resting-state delta power is associated with the brain's default mode network, results suggest that the default mode network was less activated during high Psychological Pain. Findings are consistent with a state of arousal associated with Psychological Pain.
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Psychological Pain and reduced resting state heart rate variability in adults with a history of depression
Psychophysiology, 2014Co-Authors: Esther L Meerwijk, Catherine A Chesla, Sandra J WeissAbstract:Psychological Pain is a prominent symptom in people who experience depression, but its relation with physiological measures has not been explored. This study compared two measures of Psychological Pain, the Orbach & Mikulincer Mental Pain (OMMP) questionnaire and the Psychache Scale, for their relationship with resting-state heart rate variability (HRV) in 35 adults with a history of depression. Low-frequency HRV decreased significantly with increasing Psychological Pain, particularly in participants who did not use antidepressants, while the beat-to-beat fractal dimension decreased in participants who did use antidepressants. Neither heart rate nor high-frequency HRV was associated with Psychological Pain. These results suggest a state of arousal characterized by increased sympathetic activity. Results also indicate that the OMMP may be a more accurate measure of autonomic arousal associated with current Psychological Pain than the Psychache Scale.