The Experts below are selected from a list of 2328 Experts worldwide ranked by ideXlab platform
Carlos Schonfeldtlecuona - One of the best experts on this subject based on the ideXlab platform.
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drug induced liver injury associated with antidepressive Psychopharmacotherapy an explorative assessment based on quantitative signal detection using different meddra terms
The Journal of Clinical Pharmacology, 2016Co-Authors: Maximilian Gahr, Rene Zeiss, Dirk Lang, Bernhard J Connemann, Christoph Hiemke, Carlos SchonfeldtlecuonaAbstract:: Drug-induced liver injury is a major problem of pharmacotherapy and is also frequent with antidepressive Psychopharmacotherapy. However, there are only few studies using a consistent methodologic approach to study hepatotoxicity of a larger group of antidepress ants. We performed a quantitative signal detection analysis using data from the Uppsala Monitoring Centre from the WHO that records adverse drug reaction (ADR) data from worldwide sources; we retrieved substance- and country-specific (Australia, France, Germany, Italy, Spain, the United Kingdom, and the United States) ADR data and calculated reporting odds ratios as measures for disproportionality within a case/noncase approach. To allow for identification of agents that cause severe forms of hepatotoxic ADRs, we used 2 terms of the MedDRA ("drug-related hepatic disorders-comprehensive search" [DRHD-CS] and "… -severe events only" [DRHD-SEO]). Distribution of signals was heterogeneous throughout the different data sets, and consistent findings were present for only a few substances: agomelatine (AGM) and tianeptine as well as both positive control agents (amineptine, nefazodone) generated signals related to DRHD-CS and DRHD-SEO in all analyzed data sets. Tri- and tetracyclic antidepressants (here amitriptyline, clomipramine, mianserin, mirtazapine, trimipramine) were associated with hepatotoxicity in several data sets. Using 2 MedDRA terms did not allow for detection of agents that cause severe hepatotoxic ADR. Our results support the findings of previous, primarily literature-based, systematic analyses of hepatotoxicity related to antidepressive Psychopharmacotherapy. No new safety information could be generated. Application of 2 MedDRA terms did not increase the substance-specific safety information.
Philip G. Janicak - One of the best experts on this subject based on the ideXlab platform.
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Comprar PRINCIPLES AND PRACTICE OF Psychopharmacotherapy | Philip G. Janicak | 9780781727945 | Lippincott Williams & Wilkins
2011Co-Authors: Philip G. JanicakAbstract:Tienda online donde Comprar PRINCIPLES AND PRACTICE OF Psychopharmacotherapy al precio 174,60 € de Philip G. Janicak, tienda de Libros de Medicina, Libros de Psicologia - Psicofarmacologia
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Principles and Practice of Psychopharmacotherapy 5th Edition
2010Co-Authors: Philip G. JanicakAbstract:Principles and Practice of Psychopharmacotherapy 5th Edition - Libros de Medicina - Psicofarmacologia - 152,00
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Comprar Principles and Practice of Psychopharmacotherapy 5th Edition | Philip G. Janicak | 9781605475653 | Lippincott Williams & Wilkins
2010Co-Authors: Philip G. JanicakAbstract:Tienda online donde Comprar Principles and Practice of Psychopharmacotherapy 5th Edition al precio 152,00 € de Philip G. Janicak, tienda de Libros de Medicina, Libros de Psicologia - Psicofarmacologia
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handbook of Psychopharmacotherapy
2008Co-Authors: Philip G. JanicakAbstract:General principles - principles of Psychopharmacotherapy, role of neuroscience, diagnostic assessment, role of the laboratory assessment of drug efficacy and relevant clinical issues - evaluation of drug study designs, statistical summarization of drug studies, patient issues, drug management, role of the food and drug administration, cost of treatment pharmacokinetics - general principles, role of pharmacokinetics, alteration in pharmacokinetics, the four primary pharmacokinetic phases, therapeutic drug monitoring indications for antipsychotics - schizophrenia, other psychotic disorders, nonpsychotic disorders treatment with antipsychotics -mechanism of action, effects on cognition and behaviour, management of acute psychosis, maintenance/prophylaxis, long-acting antipsychotics, pharmacokinetics/plasma levels, alternative treatment strategies, role of psychosocial therapies, adverse effects indications for antidepressant therapy - mechanism of action, treatment planning, management of an acute depressive episode, maintenance/prophylaxis, pharmacokinetics, therapeutic drug monitoring, alternative treatment strategies, role of psychosocial therapies, herbal therapies, adverse effects treatment with electroconvulsive therapy and other somatic therapies - electroconvulsive therapy, experimental somatic therapies indications for mood stabilizers - bipolar disorder treatment with mood stabilizers - mechanism of action, management of an acute manic episode, maintenance/prophylaxis, alternative treatment strategies, pharmacokinetics of mood stabilizers, adverse effects of mood stabilizers, adverse effects of other drugs indications for antianxiety and sedative-hypnotic agents - generalized anxiety disorder, phobic disorders, psychological factors affecting medical condition, sleep disorders treatment with antianxiety and sedative-hypnotic agents - mechanism of action, treatment of generalized anxiety disorder, treatment of phobic disorders, treatment of sleep disorders, pharmacokinetics, adverse effects of anxiolytics, adverse effects of sedative-hypnotic assessment and treatment of other disorders - panic disorders, obsessive-compulsive disorder, trichotillomania, post-traumatic stress disorder assessment and treatment of special populations - the pregnant patient, the child and the adolescent patient, the personality-disordered patient, the elderly patient, the dying patient, the alcoholic patient, the human immunodeficiency virus-infected patient, the eating-disordered patient, conclusion.
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Comprar Handbook of Psychopharmacotherapy 2/e (A Life Span Approach) | Mani L. Pavuluri MD, PhD, FRANZCP | 9780781771962 | Lippincott Williams & Wilkins
2008Co-Authors: Franzcp Mani L. Pavuluri, Philip G. JanicakAbstract:Tienda online donde Comprar Handbook of Psychopharmacotherapy 2/e (A Life Span Approach) al precio 51,45 € de Mani L. Pavuluri MD, PhD, FRANZCP | Philip G. Janicak MD, tienda de Libros de Medicina, Libros de Psiquiatria - Psiquiatria General
Maximilian Gahr - One of the best experts on this subject based on the ideXlab platform.
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drug induced liver injury associated with antidepressive Psychopharmacotherapy an explorative assessment based on quantitative signal detection using different meddra terms
The Journal of Clinical Pharmacology, 2016Co-Authors: Maximilian Gahr, Rene Zeiss, Dirk Lang, Bernhard J Connemann, Christoph Hiemke, Carlos SchonfeldtlecuonaAbstract:: Drug-induced liver injury is a major problem of pharmacotherapy and is also frequent with antidepressive Psychopharmacotherapy. However, there are only few studies using a consistent methodologic approach to study hepatotoxicity of a larger group of antidepress ants. We performed a quantitative signal detection analysis using data from the Uppsala Monitoring Centre from the WHO that records adverse drug reaction (ADR) data from worldwide sources; we retrieved substance- and country-specific (Australia, France, Germany, Italy, Spain, the United Kingdom, and the United States) ADR data and calculated reporting odds ratios as measures for disproportionality within a case/noncase approach. To allow for identification of agents that cause severe forms of hepatotoxic ADRs, we used 2 terms of the MedDRA ("drug-related hepatic disorders-comprehensive search" [DRHD-CS] and "… -severe events only" [DRHD-SEO]). Distribution of signals was heterogeneous throughout the different data sets, and consistent findings were present for only a few substances: agomelatine (AGM) and tianeptine as well as both positive control agents (amineptine, nefazodone) generated signals related to DRHD-CS and DRHD-SEO in all analyzed data sets. Tri- and tetracyclic antidepressants (here amitriptyline, clomipramine, mianserin, mirtazapine, trimipramine) were associated with hepatotoxicity in several data sets. Using 2 MedDRA terms did not allow for detection of agents that cause severe hepatotoxic ADR. Our results support the findings of previous, primarily literature-based, systematic analyses of hepatotoxicity related to antidepressive Psychopharmacotherapy. No new safety information could be generated. Application of 2 MedDRA terms did not increase the substance-specific safety information.
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Drug‐Induced Liver Injury Associated With Antidepressive Psychopharmacotherapy: An Explorative Assessment Based on Quantitative Signal Detection Using Different MedDRA Terms
The Journal of Clinical Pharmacology, 2015Co-Authors: Maximilian Gahr, Rene Zeiss, Dirk Lang, Bernhard J Connemann, Christoph Hiemke, Carlos Schönfeldt-lecuonaAbstract:Drug-induced liver injury is a major problem of pharmacotherapy and is also frequent with antidepressive Psychopharmacotherapy. However, there are only few studies using a consistent methodologic approach to study hepatotoxicity of a larger group of antidepress ants. We performed a quantitative signal detection analysis using data from the Uppsala Monitoring Centre from the WHO that records adverse drug reaction (ADR) data from worldwide sources; we retrieved substance- and country-specific (Australia, France, Germany, Italy, Spain, the United Kingdom, and the United States) ADR data and calculated reporting odds ratios as measures for disproportionality within a case/noncase approach. To allow for identification of agents that cause severe forms of hepatotoxic ADRs, we used 2 terms of the MedDRA ("drug-related hepatic disorders-comprehensive search" [DRHD-CS] and "… -severe events only" [DRHD-SEO]). Distribution of signals was heterogeneous throughout the different data sets, and consistent findings were present for only a few substances: agomelatine (AGM) and tianeptine as well as both positive control agents (amineptine, nefazodone) generated signals related to DRHD-CS and DRHD-SEO in all analyzed data sets. Tri- and tetracyclic antidepressants (here amitriptyline, clomipramine, mianserin, mirtazapine, trimipramine) were associated with hepatotoxicity in several data sets. Using 2 MedDRA terms did not allow for detection of agents that cause severe hepatotoxic ADR. Our results support the findings of previous, primarily literature-based, systematic analyses of hepatotoxicity related to antidepressive Psychopharmacotherapy. No new safety information could be generated. Application of 2 MedDRA terms did not increase the substance-specific safety information.
Miro Jakovljević - One of the best experts on this subject based on the ideXlab platform.
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Person-Centered Psychopharmacotherapy
Person Centered Psychiatry, 2016Co-Authors: Miro Jakovljević, Mohammed T. Abou-salehAbstract:Modern Psychopharmacotherapy is currently in contention both outside and within the field of psychiatry. There is a huge gap between possibilities for achieving high treatment effectiveness and poor results in clinical practice. Conventional psychopharmacology paradigms focusing just on a disease perspective, biological narrative and a “one fits all” treatment are often regarded as inadequate and disjunctive. A significant proportion of psychiatric patients achieve no improvement or only partial improvement in their symptoms and other outcome indicators, while many of them suffer adverse and even toxic effects of medications. Patients are commonly treated just as biological organisms that respond neurochemically to medications, but not as persons who respond to the meaning that those medications and mental disorders have. Psychopharmacotherapy as a sole form of treatment may carry the wrong message that patients do not have to change their life style and do not have to learn any new skills, and that they just have to receive the right medication and take it on time because the only problem is in brain chemistry. Evidence-based Psychopharmacotherapy and person-centered Psychopharmacotherapy are not competitors but a complementary duality, as intimately connected as brain and soul. Narrative preserves individuality, distinctiveness, and therapeutic context, whereas quantitative methods and evidence-based guidelines offer a solid partial foundation for what may be in general terms reliable and helpful. The purpose of person-centered Psychopharmacotherapy is to marshall the benefits of medication and to empower patients to control their diseases, to reauthor their problematic life story, to obtain full personal recovery and to obtain as high as possible well-being.
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Person-centred Psychopharmacotherapy: what is it? Each patient is a unique, responsive and responsible subject.
Psychiatria Danubina, 2015Co-Authors: Miro JakovljevićAbstract:Modern Psychopharmacotherapy is currently in contention both outside and within the field of psychiatry. Conventional psychopharmacology paradigms focusing just on a disease perspective, biological narrative and a "one fits all" treatment are often regarded as inadequate and disjunctive. A significant proportion of psychiatric patients achieve no improvement or only partial improvement in their symptoms, while many of them suffer adverse and even toxic effects of medications. Psychopharmacotherapy as a sole form of treatment may carry the wrong message that patients don't have to change their life style and don't have to learn any new skills, they just have to receive their medication on time because the only problem is in brain chemistry. Evidence-based Psychopharmacotherapy and person-centered narrative Psychopharmacotherapy are not competitors but a complementuary duality, as intimately connected as brain and soul. Narrative preserves individuality, distinctivenesss and therapeutic context, whereas quantitative methods and evidence-based guidelines offer a solid foundation for what is reliably and generally correct. The purpose of person-centered Psychopharmacotherapy is to empower the patients to control their disease, to re-author their problematic life story, to obtain full personal recovery and to regain control over their life.
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Creative, person-centered and narrative Psychopharmacotherapy or how to prevent and overcome treatment resistance in psychiatry.
Psychiatria Danubina, 2015Co-Authors: Miro JakovljevićAbstract:Despite of the huge progress in clinical psychopharmacology and recent introduction of many new mental health medicines, a significant proportion of psychiatric patients do not respond satisfactory to pharmacological treatment. Such patients are commonly labeled "treatment resistant" although there is no full agreement about definition of the term. The precise prevalence of treatment resistance is hard to determine due to the lack of consensus regarding the term definition and too many cases of pseudo-resistance. Resistant and refractory mental disorders have significant economic, social, physical, and psychological consequences. The suffering and disability associated with chronic, unremitting mental disorders is profound. Changing treatment philosophy may be a critical step towards overcoming what some view as "therapeutic stagnation in psychiatry" and providing better treatment effectiveness and efficiency for patients benefit. A "paradigm shift" is needed from the mechanistic, formistic and reducionistic way of thinking of technical and impersonal psychopharmacology to contextual and systemic thinking with new treatment holodigm individualizing and personalizing Psychopharmacotherapy in a more creative manner. Treatment resistance as a construct should be reconsidered as well as "monotherapy before polytherapy" treatment strategy. The best treatments are those that utilize and integrate multiple therapeutic modalities. The concept of creative, person-centered narrative Psychopharmacotherapy gives a hope for increasing treatment effectiveness and efficiency in psychiatry.
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How to increase treatment effectiveness and efficiency in psychiatry: creative Psychopharmacotherapy - part 1: definition, fundamental principles and higher effectiveness polypharmacy.
Psychiatria Danubina, 2013Co-Authors: Miro JakovljevićAbstract:Psychopharmacotherapy is a fascinating field that can be understood in many different ways. It is both a science and an art of communication with a heavily subjective dimension. The advent of a significant number of the effective and well tolerated mental health medicines during and after 1990s decade of the brain has increased our possibilities to treat major mental disorders in more successful ways with much better treatment outcome including full recovery. However, there is a huge gap between our possibilities for achieving high treatment effectiveness and not satisfying results in day-to-day clinical practice. Creative approach to Psychopharmacotherapy could advance everyday clinical practice and bridge the gap. Creative Psychopharmacotherapy is a concept that incorporates creativity as its fundamental tool. Creativity involves the intention and ability to transcend limiting traditional ideas, rules, patterns and relationships and to create meaningful new ideas, interpretations, contexts and methods in clinical psychopharmacology.
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Creativity, mental disorders and their treatment: recovery-oriented Psychopharmacotherapy.
Psychiatria Danubina, 2013Co-Authors: Miro JakovljevićAbstract:This paper discusses interrelations between creativity, mental disorders and their treatment. The psychology of creativity is very important for successful Psychopharmacotherapy, but our knowledge about creativity is still insufficient. Even that which is known is not within the armamentarium of most practicing psychiatrists. In the first part of this article creativity and possible associations between creativity, mental health, and well-being are described. The second part deals with the intriguing relationship between creativity and mental disorders. The third part emphasizes the role of creativity in the treatment of mental disorders. This paper ends by underlining the importance of a creativity-enhancing oriented, and personal recovery-focused Psychopharmacotherapy in helping psychiatric patients achieve fulfilled and purposeful lives.
Bernhard J Connemann - One of the best experts on this subject based on the ideXlab platform.
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drug induced liver injury associated with antidepressive Psychopharmacotherapy an explorative assessment based on quantitative signal detection using different meddra terms
The Journal of Clinical Pharmacology, 2016Co-Authors: Maximilian Gahr, Rene Zeiss, Dirk Lang, Bernhard J Connemann, Christoph Hiemke, Carlos SchonfeldtlecuonaAbstract:: Drug-induced liver injury is a major problem of pharmacotherapy and is also frequent with antidepressive Psychopharmacotherapy. However, there are only few studies using a consistent methodologic approach to study hepatotoxicity of a larger group of antidepress ants. We performed a quantitative signal detection analysis using data from the Uppsala Monitoring Centre from the WHO that records adverse drug reaction (ADR) data from worldwide sources; we retrieved substance- and country-specific (Australia, France, Germany, Italy, Spain, the United Kingdom, and the United States) ADR data and calculated reporting odds ratios as measures for disproportionality within a case/noncase approach. To allow for identification of agents that cause severe forms of hepatotoxic ADRs, we used 2 terms of the MedDRA ("drug-related hepatic disorders-comprehensive search" [DRHD-CS] and "… -severe events only" [DRHD-SEO]). Distribution of signals was heterogeneous throughout the different data sets, and consistent findings were present for only a few substances: agomelatine (AGM) and tianeptine as well as both positive control agents (amineptine, nefazodone) generated signals related to DRHD-CS and DRHD-SEO in all analyzed data sets. Tri- and tetracyclic antidepressants (here amitriptyline, clomipramine, mianserin, mirtazapine, trimipramine) were associated with hepatotoxicity in several data sets. Using 2 MedDRA terms did not allow for detection of agents that cause severe hepatotoxic ADR. Our results support the findings of previous, primarily literature-based, systematic analyses of hepatotoxicity related to antidepressive Psychopharmacotherapy. No new safety information could be generated. Application of 2 MedDRA terms did not increase the substance-specific safety information.
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Drug‐Induced Liver Injury Associated With Antidepressive Psychopharmacotherapy: An Explorative Assessment Based on Quantitative Signal Detection Using Different MedDRA Terms
The Journal of Clinical Pharmacology, 2015Co-Authors: Maximilian Gahr, Rene Zeiss, Dirk Lang, Bernhard J Connemann, Christoph Hiemke, Carlos Schönfeldt-lecuonaAbstract:Drug-induced liver injury is a major problem of pharmacotherapy and is also frequent with antidepressive Psychopharmacotherapy. However, there are only few studies using a consistent methodologic approach to study hepatotoxicity of a larger group of antidepress ants. We performed a quantitative signal detection analysis using data from the Uppsala Monitoring Centre from the WHO that records adverse drug reaction (ADR) data from worldwide sources; we retrieved substance- and country-specific (Australia, France, Germany, Italy, Spain, the United Kingdom, and the United States) ADR data and calculated reporting odds ratios as measures for disproportionality within a case/noncase approach. To allow for identification of agents that cause severe forms of hepatotoxic ADRs, we used 2 terms of the MedDRA ("drug-related hepatic disorders-comprehensive search" [DRHD-CS] and "… -severe events only" [DRHD-SEO]). Distribution of signals was heterogeneous throughout the different data sets, and consistent findings were present for only a few substances: agomelatine (AGM) and tianeptine as well as both positive control agents (amineptine, nefazodone) generated signals related to DRHD-CS and DRHD-SEO in all analyzed data sets. Tri- and tetracyclic antidepressants (here amitriptyline, clomipramine, mianserin, mirtazapine, trimipramine) were associated with hepatotoxicity in several data sets. Using 2 MedDRA terms did not allow for detection of agents that cause severe hepatotoxic ADR. Our results support the findings of previous, primarily literature-based, systematic analyses of hepatotoxicity related to antidepressive Psychopharmacotherapy. No new safety information could be generated. Application of 2 MedDRA terms did not increase the substance-specific safety information.
