The Experts below are selected from a list of 82392 Experts worldwide ranked by ideXlab platform
Jung O Kwon - One of the best experts on this subject based on the ideXlab platform.
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bilateral bronchiectasis and bronchiolitis at thin section ct diagnostic implications in nontuberculous mycobacterial Pulmonary Infection
Radiology, 2005Co-Authors: Wonjung Koh, Yeon Joo Jeong, Kyung Soo Lee, Jung O Kwon, Seohyun Kwak, Taesung KimAbstract:PURPOSE: To determine frequency of nontuberculous mycobacterial (NTM) Pulmonary Infection in patients with bilateral bronchiectasis and bronchiolitis at chest computed tomography (CT) and whether CT findings are indicative of Mycobacterium avium-intracellulare complex (MAC) Infection. MATERIALS AND METHODS: Institutional review board approved this research study; patient informed consent (not required) was obtained from all patients to perform CT. From July 2000 to December 2002, 126 consecutive patients, who were suspected of having NTM Pulmonary Infection at helical CT (120 kVp, 70 mA, 2.5-mm collimation, pitch of 6) with findings of bilateral bronchiectasis and bronchiolitis, were included. Of these, 105 patients underwent study for diagnosis of NTM disease. Medical records and CT scans were reviewed for final diagnoses. Clinical and chest CT findings in patients with NTM disease and those with other airway diseases were compared (unpaired t test, χ2 test, or Fisher exact test). RESULTS: NTM Pulmonary ...
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nontuberculous mycobacterial Pulmonary Infection in immunocompetent patients comparison of thin section ct and histopathologic findings
Radiology, 2004Co-Authors: Yeon Joo Jeong, Kyung Soo Lee, Wonjung Koh, Joungho Han, Taesung Kim, Jung O KwonAbstract:PURPOSE: To identify and describe the thin-section computed tomographic (CT) findings of nontuberculous mycobacterial (NTM) Pulmonary Infection in immunocompetent patients and to compare these findings with histopathologic findings. MATERIALS AND METHODS: Between April 2002 and March 2003, the thin-section chest CT findings in and histopathologic lung tissue specimens from 22 patients who fulfilled the American Thoracic Society diagnostic criteria for NTM Pulmonary Infection were retrospectively reviewed. The lung lesion patterns (ie, small nodules, branching centrilobular nodules [ie, tree-in-bud pattern], consolidation, cavities, bronchiectasis, and volume loss) seen at CT at the sites of transbronchial lung biopsy (n = 22) or lobectomy (n = 1) were compared with the histopathologic findings. RESULTS: Thirteen of the 22 patients were found to have Mycobacterium abscessus Pulmonary Infection; seven, to have Mycobacterium avium-intracellulare complex Infection; and two, to have Mycobacterium fortuitum inf...
Ting Zhang - One of the best experts on this subject based on the ideXlab platform.
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genetically engineered distal airway stem cell transplantation protects mice from Pulmonary Infection
Embo Molecular Medicine, 2020Co-Authors: Yueqing Zhou, Yun Shi, Ling Yang, Yufen Sun, Yufei Han, Zixian Zhao, Yujia Wang, Ying Liu, Ting ZhangAbstract:Severe Pulmonary Infection is a major threat to human health accompanied by substantial medical costs, prolonged inpatient requirements, and high mortality rates. New antimicrobial therapeutic strategies are urgently required to address the emergence of antibiotic resistance and persistent bacterial Infections. In this study, we show that the constitutive expression of a native antimicrobial peptide LL-37 in transgenic mice aids in clearing Pseudomonas aeruginosa (PAO1), a major pathogen of clinical Pulmonary Infection. Orthotopic transplantation of adult mouse distal airway stem cells (DASCs), genetically engineered to express LL-37, into injured mouse lung foci enabled large-scale incorporation of cells and long-term release of the host defense peptide, protecting the mice from bacterial pneumonia and hypoxemia. Further, correlates of DASCs in adult humans were isolated, expanded, and genetically engineered to demonstrate successful construction of an anti-infective artificial lung. Together, our stem cell-based gene delivery therapeutic platform proposes a new strategy for addressing recurrent Pulmonary Infections with future translational opportunities.
Zhang T - One of the best experts on this subject based on the ideXlab platform.
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Genetically engineered distal airway stem cell transplantation protects mice from Pulmonary Infection
'EMBO', 2020Co-Authors: Yq Shou, Shi Y, Yang L, Yf Sun, Yf Han, Zx Zhao, Yj Wang, Liu Y, Ma Y, Zhang TAbstract:Severe Pulmonary Infection is a major threat to human health accompanied by substantial, which increases medical costs, prolonged inpatient requirements, and high mortality rates. New anti-microbial therapeutic strategies are urgently required to address with the emergence of antibiotic resistance and persistent bacterial Infections. In this study, we show that constitutive expression of a native anti-microbial peptide hCAP-18/LL-37 (LL9 37) in transgenic mice aids in clearing Pseudomonas aeruginosa (PAO1), a major pathogen of clinical Pulmonary Infection. Orthotopic transplantation of adult mouse distal airway stem cells (DASCs), genetically engineered to express LL-37, into injured mouse lung foci enabled large scale incorporation of cells and long-term release of the host defense peptide, protecting the mice from bacterial pneumonia and hypoxemia. Further, adult human DASCs were isolated, expanded, and genetically engineered to demonstrate successful construction of an anti-infective artificial lung. Together, our stem cell-based gene delivery therapeutic platform proposes a new strategy for addressing recurrent Pulmonary Infections with, providing future translational opportunities
Yun Shi - One of the best experts on this subject based on the ideXlab platform.
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genetically engineered distal airway stem cell transplantation protects mice from Pulmonary Infection
Embo Molecular Medicine, 2020Co-Authors: Yueqing Zhou, Yun Shi, Ling Yang, Yufen Sun, Yufei Han, Zixian Zhao, Yujia Wang, Ying Liu, Ting ZhangAbstract:Severe Pulmonary Infection is a major threat to human health accompanied by substantial medical costs, prolonged inpatient requirements, and high mortality rates. New antimicrobial therapeutic strategies are urgently required to address the emergence of antibiotic resistance and persistent bacterial Infections. In this study, we show that the constitutive expression of a native antimicrobial peptide LL-37 in transgenic mice aids in clearing Pseudomonas aeruginosa (PAO1), a major pathogen of clinical Pulmonary Infection. Orthotopic transplantation of adult mouse distal airway stem cells (DASCs), genetically engineered to express LL-37, into injured mouse lung foci enabled large-scale incorporation of cells and long-term release of the host defense peptide, protecting the mice from bacterial pneumonia and hypoxemia. Further, correlates of DASCs in adult humans were isolated, expanded, and genetically engineered to demonstrate successful construction of an anti-infective artificial lung. Together, our stem cell-based gene delivery therapeutic platform proposes a new strategy for addressing recurrent Pulmonary Infections with future translational opportunities.
Taesung Kim - One of the best experts on this subject based on the ideXlab platform.
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bilateral bronchiectasis and bronchiolitis at thin section ct diagnostic implications in nontuberculous mycobacterial Pulmonary Infection
Radiology, 2005Co-Authors: Wonjung Koh, Yeon Joo Jeong, Kyung Soo Lee, Jung O Kwon, Seohyun Kwak, Taesung KimAbstract:PURPOSE: To determine frequency of nontuberculous mycobacterial (NTM) Pulmonary Infection in patients with bilateral bronchiectasis and bronchiolitis at chest computed tomography (CT) and whether CT findings are indicative of Mycobacterium avium-intracellulare complex (MAC) Infection. MATERIALS AND METHODS: Institutional review board approved this research study; patient informed consent (not required) was obtained from all patients to perform CT. From July 2000 to December 2002, 126 consecutive patients, who were suspected of having NTM Pulmonary Infection at helical CT (120 kVp, 70 mA, 2.5-mm collimation, pitch of 6) with findings of bilateral bronchiectasis and bronchiolitis, were included. Of these, 105 patients underwent study for diagnosis of NTM disease. Medical records and CT scans were reviewed for final diagnoses. Clinical and chest CT findings in patients with NTM disease and those with other airway diseases were compared (unpaired t test, χ2 test, or Fisher exact test). RESULTS: NTM Pulmonary ...
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nontuberculous mycobacterial Pulmonary Infection in immunocompetent patients comparison of thin section ct and histopathologic findings
Radiology, 2004Co-Authors: Yeon Joo Jeong, Kyung Soo Lee, Wonjung Koh, Joungho Han, Taesung Kim, Jung O KwonAbstract:PURPOSE: To identify and describe the thin-section computed tomographic (CT) findings of nontuberculous mycobacterial (NTM) Pulmonary Infection in immunocompetent patients and to compare these findings with histopathologic findings. MATERIALS AND METHODS: Between April 2002 and March 2003, the thin-section chest CT findings in and histopathologic lung tissue specimens from 22 patients who fulfilled the American Thoracic Society diagnostic criteria for NTM Pulmonary Infection were retrospectively reviewed. The lung lesion patterns (ie, small nodules, branching centrilobular nodules [ie, tree-in-bud pattern], consolidation, cavities, bronchiectasis, and volume loss) seen at CT at the sites of transbronchial lung biopsy (n = 22) or lobectomy (n = 1) were compared with the histopathologic findings. RESULTS: Thirteen of the 22 patients were found to have Mycobacterium abscessus Pulmonary Infection; seven, to have Mycobacterium avium-intracellulare complex Infection; and two, to have Mycobacterium fortuitum inf...
