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Fong-fu Hsu - One of the best experts on this subject based on the ideXlab platform.
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Correction to: Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry.
Journal of the American Society for Mass Spectrometry, 2018Co-Authors: Cheryl Frankfater, Xuntian Jiang, Fong-fu HsuAbstract:In the preceding article "Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry" by Frankfater et al., errors in Figs. 2 and 3 have occurred. The legend (Fig. 2).
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Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry
Journal of The American Society for Mass Spectrometry, 2018Co-Authors: Cheryl Frankfater, Xuntian Jiang, Fong-fu HsuAbstract:Charge remote fragmentation (CRF) elimination of C_nH_2n+2 residues along the aliphatic tail of long chain fatty acid is hall mark of keV high-energy CID fragmentation process. It is an important fragmentation pathway leading to structural characterization of biomolecules by CID tandem mass spectrometry. In this report, we describe MALDI LIFT TOF-TOF mass spectrometric approach to study a wide variety of fatty acids (FAs), which were derivatized to N-(4-aminomethylphenyl) Pyridinium (AMPP) Derivative, and desorbed as M^+ ions by laser with or without matrix. The high-energy MALDI LIFT TOF-TOF mass spectra of FA-AMPP contain fragment ions mainly deriving from CRF cleavages of C_nH_2n+2 residues, as expected. These ions together with ions from specific cleavages of the bond(s) involving the functional group within the molecule provide more complete structural identification than those produced by low-energy CID/HCD using a linear ion-trap instrument. However, this LIFT TOF-TOF mass spectrometric approach inherits low sensitivity, a typical feature of high-energy CID tandem mass spectrometry. Because of the lack of unit mass precursor ion selection with sufficient sensitivity of the current LIFT TOF-TOF technology, product ion spectra from same chain length fatty acids with difference in one or two double bonds in a mixture are not distinguishable. Graphical Abstract ᅟ
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Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry.
Journal of the American Society for Mass Spectrometry, 2018Co-Authors: Cheryl Frankfater, Xuntian Jiang, Fong-fu HsuAbstract:In the preceding article “Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry” by Frankfater et al., errors in Figs. 2 and 3 have occurred. The legend (Fig. 2)
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characterization of long chain fatty acid as n 4 aminomethylphenyl Pyridinium Derivative by maldi lift tof tof mass spectrometry
Journal of the American Society for Mass Spectrometry, 2018Co-Authors: Cheryl Frankfater, Xuntian Jiang, Fong-fu HsuAbstract:In the preceding article “Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry” by Frankfater et al., errors in Figs. 2 and 3 have occurred. The legend (Fig. 2)
Cheryl Frankfater - One of the best experts on this subject based on the ideXlab platform.
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Correction to: Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry.
Journal of the American Society for Mass Spectrometry, 2018Co-Authors: Cheryl Frankfater, Xuntian Jiang, Fong-fu HsuAbstract:In the preceding article "Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry" by Frankfater et al., errors in Figs. 2 and 3 have occurred. The legend (Fig. 2).
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Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry
Journal of The American Society for Mass Spectrometry, 2018Co-Authors: Cheryl Frankfater, Xuntian Jiang, Fong-fu HsuAbstract:Charge remote fragmentation (CRF) elimination of C_nH_2n+2 residues along the aliphatic tail of long chain fatty acid is hall mark of keV high-energy CID fragmentation process. It is an important fragmentation pathway leading to structural characterization of biomolecules by CID tandem mass spectrometry. In this report, we describe MALDI LIFT TOF-TOF mass spectrometric approach to study a wide variety of fatty acids (FAs), which were derivatized to N-(4-aminomethylphenyl) Pyridinium (AMPP) Derivative, and desorbed as M^+ ions by laser with or without matrix. The high-energy MALDI LIFT TOF-TOF mass spectra of FA-AMPP contain fragment ions mainly deriving from CRF cleavages of C_nH_2n+2 residues, as expected. These ions together with ions from specific cleavages of the bond(s) involving the functional group within the molecule provide more complete structural identification than those produced by low-energy CID/HCD using a linear ion-trap instrument. However, this LIFT TOF-TOF mass spectrometric approach inherits low sensitivity, a typical feature of high-energy CID tandem mass spectrometry. Because of the lack of unit mass precursor ion selection with sufficient sensitivity of the current LIFT TOF-TOF technology, product ion spectra from same chain length fatty acids with difference in one or two double bonds in a mixture are not distinguishable. Graphical Abstract ᅟ
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Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry.
Journal of the American Society for Mass Spectrometry, 2018Co-Authors: Cheryl Frankfater, Xuntian Jiang, Fong-fu HsuAbstract:In the preceding article “Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry” by Frankfater et al., errors in Figs. 2 and 3 have occurred. The legend (Fig. 2)
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characterization of long chain fatty acid as n 4 aminomethylphenyl Pyridinium Derivative by maldi lift tof tof mass spectrometry
Journal of the American Society for Mass Spectrometry, 2018Co-Authors: Cheryl Frankfater, Xuntian Jiang, Fong-fu HsuAbstract:In the preceding article “Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry” by Frankfater et al., errors in Figs. 2 and 3 have occurred. The legend (Fig. 2)
Xuntian Jiang - One of the best experts on this subject based on the ideXlab platform.
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Correction to: Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry.
Journal of the American Society for Mass Spectrometry, 2018Co-Authors: Cheryl Frankfater, Xuntian Jiang, Fong-fu HsuAbstract:In the preceding article "Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry" by Frankfater et al., errors in Figs. 2 and 3 have occurred. The legend (Fig. 2).
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Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry
Journal of The American Society for Mass Spectrometry, 2018Co-Authors: Cheryl Frankfater, Xuntian Jiang, Fong-fu HsuAbstract:Charge remote fragmentation (CRF) elimination of C_nH_2n+2 residues along the aliphatic tail of long chain fatty acid is hall mark of keV high-energy CID fragmentation process. It is an important fragmentation pathway leading to structural characterization of biomolecules by CID tandem mass spectrometry. In this report, we describe MALDI LIFT TOF-TOF mass spectrometric approach to study a wide variety of fatty acids (FAs), which were derivatized to N-(4-aminomethylphenyl) Pyridinium (AMPP) Derivative, and desorbed as M^+ ions by laser with or without matrix. The high-energy MALDI LIFT TOF-TOF mass spectra of FA-AMPP contain fragment ions mainly deriving from CRF cleavages of C_nH_2n+2 residues, as expected. These ions together with ions from specific cleavages of the bond(s) involving the functional group within the molecule provide more complete structural identification than those produced by low-energy CID/HCD using a linear ion-trap instrument. However, this LIFT TOF-TOF mass spectrometric approach inherits low sensitivity, a typical feature of high-energy CID tandem mass spectrometry. Because of the lack of unit mass precursor ion selection with sufficient sensitivity of the current LIFT TOF-TOF technology, product ion spectra from same chain length fatty acids with difference in one or two double bonds in a mixture are not distinguishable. Graphical Abstract ᅟ
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Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry.
Journal of the American Society for Mass Spectrometry, 2018Co-Authors: Cheryl Frankfater, Xuntian Jiang, Fong-fu HsuAbstract:In the preceding article “Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry” by Frankfater et al., errors in Figs. 2 and 3 have occurred. The legend (Fig. 2)
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characterization of long chain fatty acid as n 4 aminomethylphenyl Pyridinium Derivative by maldi lift tof tof mass spectrometry
Journal of the American Society for Mass Spectrometry, 2018Co-Authors: Cheryl Frankfater, Xuntian Jiang, Fong-fu HsuAbstract:In the preceding article “Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry” by Frankfater et al., errors in Figs. 2 and 3 have occurred. The legend (Fig. 2)
Roderick H Scott - One of the best experts on this subject based on the ideXlab platform.
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A Pyridinium Derivative from Red Sea soft corals inhibited voltage-activated potassium conductances and increased excitability of rat cultured sensory neurones
BMC Pharmacology, 2006Co-Authors: Tarek A Temraz, Wael E Houssen, Marcel Jaspars, David R Woolley, Kerrie N Wease, Steven N Davies, Roderick H ScottAbstract:Background Whole cell patch clamp recording and intracellular Ca^2+ imaging were carried out on rat cultured dorsal root ganglion (DRG) neurones to characterize the actions of crude extracts and purified samples from Red Sea soft corals. The aim of the project was to identify compounds that would alter the excitability of DRG neurones. Results Crude extracts of Sarcophyton glaucum and Lobophyton crassum attenuated spike frequency adaptation causing DRG neurones to switch from firing single action potentials to multiple firing. The increase in excitability was associated with enhanced KCl-evoked Ca^2+ influx. The mechanism of action of the natural products in the samples from the soft corals involved inhibition of voltage-activated K^+ currents. An active component of the crude marine samples was identified as 3-carboxy-1-methyl Pyridinium (trigonelline). Application of synthetic 3-carboxy-1-methyl Pyridinium at high concentration (0.1 mM) also induced multiple firing and reduced voltage-activated K^+ current. The changes in excitability of DRG neurones induced by 3-carboxy-1-methyl Pyridinium suggest that this compound contributes to the bioactivity produced by the crude extracts from two soft corals. Conclusion Sarcophyton glaucum and Lobophyton crassum contain natural products including 3-carboxy-1-methyl Pyridinium that increase the excitability of DRG neurones. We speculate that in addition to developmental control and osmoregulation these compounds may contribute to chemical defenses.
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a Pyridinium Derivative from red sea soft corals inhibited voltage activated potassium conductances and increased excitability of rat cultured sensory neurones
BMC Pharmacology, 2006Co-Authors: Tarek A Temraz, Wael E Houssen, Marcel Jaspars, David R Woolley, Kerrie N Wease, Steven N Davies, Roderick H ScottAbstract:Background Whole cell patch clamp recording and intracellular Ca2+ imaging were carried out on rat cultured dorsal root ganglion (DRG) neurones to characterize the actions of crude extracts and purified samples from Red Sea soft corals. The aim of the project was to identify compounds that would alter the excitability of DRG neurones.
Tarek A Temraz - One of the best experts on this subject based on the ideXlab platform.
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A Pyridinium Derivative from Red Sea soft corals inhibited voltage-activated potassium conductances and increased excitability of rat cultured sensory neurones
BMC Pharmacology, 2006Co-Authors: Tarek A Temraz, Wael E Houssen, Marcel Jaspars, David R Woolley, Kerrie N Wease, Steven N Davies, Roderick H ScottAbstract:Background Whole cell patch clamp recording and intracellular Ca^2+ imaging were carried out on rat cultured dorsal root ganglion (DRG) neurones to characterize the actions of crude extracts and purified samples from Red Sea soft corals. The aim of the project was to identify compounds that would alter the excitability of DRG neurones. Results Crude extracts of Sarcophyton glaucum and Lobophyton crassum attenuated spike frequency adaptation causing DRG neurones to switch from firing single action potentials to multiple firing. The increase in excitability was associated with enhanced KCl-evoked Ca^2+ influx. The mechanism of action of the natural products in the samples from the soft corals involved inhibition of voltage-activated K^+ currents. An active component of the crude marine samples was identified as 3-carboxy-1-methyl Pyridinium (trigonelline). Application of synthetic 3-carboxy-1-methyl Pyridinium at high concentration (0.1 mM) also induced multiple firing and reduced voltage-activated K^+ current. The changes in excitability of DRG neurones induced by 3-carboxy-1-methyl Pyridinium suggest that this compound contributes to the bioactivity produced by the crude extracts from two soft corals. Conclusion Sarcophyton glaucum and Lobophyton crassum contain natural products including 3-carboxy-1-methyl Pyridinium that increase the excitability of DRG neurones. We speculate that in addition to developmental control and osmoregulation these compounds may contribute to chemical defenses.
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a Pyridinium Derivative from red sea soft corals inhibited voltage activated potassium conductances and increased excitability of rat cultured sensory neurones
BMC Pharmacology, 2006Co-Authors: Tarek A Temraz, Wael E Houssen, Marcel Jaspars, David R Woolley, Kerrie N Wease, Steven N Davies, Roderick H ScottAbstract:Background Whole cell patch clamp recording and intracellular Ca2+ imaging were carried out on rat cultured dorsal root ganglion (DRG) neurones to characterize the actions of crude extracts and purified samples from Red Sea soft corals. The aim of the project was to identify compounds that would alter the excitability of DRG neurones.
