The Experts below are selected from a list of 234 Experts worldwide ranked by ideXlab platform
Anne M. Charrier - One of the best experts on this subject based on the ideXlab platform.
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Subpicomolar Iron Sensing Platform Based on Functional Lipid Monolayer Microarrays
Analytical Chemistry, 2016Co-Authors: Ahmad Kenaan, Tuyen D. Nguyen, Herve Dallaporta, Jean-manuel Raimundo, Anne M. CharrierAbstract:We report herein the fabrication of novel micro-arrays based on air-stable functional lipid monolayers over silicon using a combination of e-beam lithography and lift-off. We demonstrate these microarrays can be use as ultrasensitive platform for Kelvin probe force microscopy in sensing experiments. Specificity of the detection is given by the functional group grafted at the lipid headgroup. The arrays developed for the detection of ferric ions, Fe3+, using a gamma-Pyrone Derivative chelator, demonstrate subpicomolar limit of detection with high specificity. In addition, the technique takes advantage of the structure of the array with the silicon areas playing the role of reference for the measurement, and we determine critical pattern dimensions below which the probe size/shape impacts the measured results.
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Subpicomolar Iron Sensing Platform Based on Functional Lipid Monolayer Microarrays
2016Co-Authors: Ahmad Kenaan, Tuyen D. Nguyen, Herve Dallaporta, Jean-manuel Raimundo, Anne M. CharrierAbstract:We report herein the fabrication of novel microarrays based on air-stable functional lipid monolayers over silicon using a combination of e-beam lithography and lift-off. We demonstrate these microarrays can be use as ultrasensitive platform for Kelvin probe force microscopy in sensing experiments. Specificity of the detection is given by the functional group grafted at the lipid headgroup. The arrays developed for the detection of ferric ions, Fe3+, using a γ-Pyrone Derivative chelator, demonstrate subpicomolar limit of detection with high specificity. In addition, the technique takes advantage of the structure of the array with the silicon areas playing the role of reference for the measurement, and we determine critical pattern dimensions below which the probe size/shape impacts the measured results
Peter Proksch - One of the best experts on this subject based on the ideXlab platform.
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New C-methylated flavonoids and α-Pyrone Derivative from roots of Talinum triangulare growing in Nigeria.
Fitoterapia, 2016Co-Authors: Bo Umeokoli, Rini Muharini, Festus B. C. Okoye, V.i.e. Ajiwe, Mabel Ukachi Akpuaka, Wenhan Lin, Zhen Liu, Peter ProkschAbstract:The first chemical examination of roots of the traditionally used medicinal plant Talinum triangulare (Portulacaceae) from Nigeria led to the isolation of two new C-methylated flavonoids, 5,6-dimethoxy-7-hydroxy-8-methyl-flavone (1), 5,6-dimethoxy-8-methyl-2-phenyl-7H-1-benzopyran-7-one (2), and one new α-Pyrone Derivative, 4-methoxy-6-(2-hydroxy-4-phenylbutyl)-2H-pyran-2-one (3), along with thirteen known compounds, including nine amides (4-12), indole-3-carboxylic acid (13), p-hydroxy benzoic acid (14), and two steroids (15-16). Their structures were elucidated by extensive spectroscopic measurements including 1D, 2D NMR, MS, and by comparison with the literature. All isolated compounds were screened for their cytotoxic and antifungal activities. However, none of them showed significant activity.
Tuyen D. Nguyen - One of the best experts on this subject based on the ideXlab platform.
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Subpicomolar Iron Sensing Platform Based on Functional Lipid Monolayer Microarrays
Analytical Chemistry, 2016Co-Authors: Ahmad Kenaan, Tuyen D. Nguyen, Herve Dallaporta, Jean-manuel Raimundo, Anne M. CharrierAbstract:We report herein the fabrication of novel micro-arrays based on air-stable functional lipid monolayers over silicon using a combination of e-beam lithography and lift-off. We demonstrate these microarrays can be use as ultrasensitive platform for Kelvin probe force microscopy in sensing experiments. Specificity of the detection is given by the functional group grafted at the lipid headgroup. The arrays developed for the detection of ferric ions, Fe3+, using a gamma-Pyrone Derivative chelator, demonstrate subpicomolar limit of detection with high specificity. In addition, the technique takes advantage of the structure of the array with the silicon areas playing the role of reference for the measurement, and we determine critical pattern dimensions below which the probe size/shape impacts the measured results.
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Subpicomolar Iron Sensing Platform Based on Functional Lipid Monolayer Microarrays
2016Co-Authors: Ahmad Kenaan, Tuyen D. Nguyen, Herve Dallaporta, Jean-manuel Raimundo, Anne M. CharrierAbstract:We report herein the fabrication of novel microarrays based on air-stable functional lipid monolayers over silicon using a combination of e-beam lithography and lift-off. We demonstrate these microarrays can be use as ultrasensitive platform for Kelvin probe force microscopy in sensing experiments. Specificity of the detection is given by the functional group grafted at the lipid headgroup. The arrays developed for the detection of ferric ions, Fe3+, using a γ-Pyrone Derivative chelator, demonstrate subpicomolar limit of detection with high specificity. In addition, the technique takes advantage of the structure of the array with the silicon areas playing the role of reference for the measurement, and we determine critical pattern dimensions below which the probe size/shape impacts the measured results
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A field effect transistor biosensor with a γ-Pyrone Derivative engineered lipid-sensing layer for ultrasensitive Fe3+ ion detection with low pH interference.
Biosensors & bioelectronics, 2013Co-Authors: Tuyen D. Nguyen, Jean-manuel Raimundo, Abdelfettah Labed, Racha El Zein, Sebastien Lavandier, Frédéric Bedu, Igor Ozerov, Hervé Dallaporta, Anne CharrierAbstract:Field effect transistors have risen as one of the most promising techniques in the development of biomedical diagnosis and monitoring. In such devices, the sensitivity and specificity of the sensor rely on the properties of the active sensing layer (gate dielectric and probe layer). We propose here a new type of transistor developed for the detection of Fe(3+) ions in which this sensing layer is made of a monolayer of lipids, engineered in such a way that it is not sensitive to pH in the acidic range, therefore making the device perfectly suitable for biomedical diagnosis. Probes are γ-Pyrone Derivatives that have been grafted to the lipid headgroups. Affinity constants derived for the chelator/Fe(3+) complexation as well as for other ions demonstrate very high sensitivity and specificity towards ferric ions with values as high as 5.10(10) M and a detected concentration as low as 50 fM.
Proksch Peter - One of the best experts on this subject based on the ideXlab platform.
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New C-methylated flavonoids and alpha-Pyrone Derivative from roots of Talinum triangulare growing in Nigeria
FITOTERAPIA, 2016Co-Authors: Umeokoli, Blessing O., Muharini Rini, Okoye, Festus B., Ajiwe Vincent, Akpuaka, Mabel U., Lin Wenhan, Liu Zhen, Proksch PeterAbstract:The first chemical examination of roots of the traditionally used medicinal plant Talinum triangulare (Portulacaceae) from Nigeria led to the isolation of two new C-methylated flavonoids, 5,6-dimethoxy-7-hydroxy-8-methyl-flavone (1), 5,6-dimethoxy-8-methyl-2-phenyl-7H-1-benzopyran-7-one (2), and one new a-Pyrone Derivative, 4-methoxy-6-(2-hydroxy-4-phenylbutyl)-2H-pyran-2-one (3), along with thirteen known compounds, including nine amides (4-12), indole-3-carboxylic acid (13), p-hydroxy benzoic acid (14), and two steroids (15-16). Their structures were elucidated by extensive spectroscopic measurements including 1D, 2D NMR, MS, and by comparison with the literature. All isolated compounds were screened for their cytotoxic and antifungal activities. However, none of them showed significant activity. (C) 2016 Elsevier B.V. All rights reserved.Society for Medicinal Plant and Natural Product Research (GA)SCI(E)PubMedARTICLEzhenfeizi0@sina.com; proksch@uni-duesseldorf.de169-17310
Jean-manuel Raimundo - One of the best experts on this subject based on the ideXlab platform.
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Subpicomolar Iron Sensing Platform Based on Functional Lipid Monolayer Microarrays
Analytical Chemistry, 2016Co-Authors: Ahmad Kenaan, Tuyen D. Nguyen, Herve Dallaporta, Jean-manuel Raimundo, Anne M. CharrierAbstract:We report herein the fabrication of novel micro-arrays based on air-stable functional lipid monolayers over silicon using a combination of e-beam lithography and lift-off. We demonstrate these microarrays can be use as ultrasensitive platform for Kelvin probe force microscopy in sensing experiments. Specificity of the detection is given by the functional group grafted at the lipid headgroup. The arrays developed for the detection of ferric ions, Fe3+, using a gamma-Pyrone Derivative chelator, demonstrate subpicomolar limit of detection with high specificity. In addition, the technique takes advantage of the structure of the array with the silicon areas playing the role of reference for the measurement, and we determine critical pattern dimensions below which the probe size/shape impacts the measured results.
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Subpicomolar Iron Sensing Platform Based on Functional Lipid Monolayer Microarrays
2016Co-Authors: Ahmad Kenaan, Tuyen D. Nguyen, Herve Dallaporta, Jean-manuel Raimundo, Anne M. CharrierAbstract:We report herein the fabrication of novel microarrays based on air-stable functional lipid monolayers over silicon using a combination of e-beam lithography and lift-off. We demonstrate these microarrays can be use as ultrasensitive platform for Kelvin probe force microscopy in sensing experiments. Specificity of the detection is given by the functional group grafted at the lipid headgroup. The arrays developed for the detection of ferric ions, Fe3+, using a γ-Pyrone Derivative chelator, demonstrate subpicomolar limit of detection with high specificity. In addition, the technique takes advantage of the structure of the array with the silicon areas playing the role of reference for the measurement, and we determine critical pattern dimensions below which the probe size/shape impacts the measured results
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A field effect transistor biosensor with a γ-Pyrone Derivative engineered lipid-sensing layer for ultrasensitive Fe3+ ion detection with low pH interference.
Biosensors & bioelectronics, 2013Co-Authors: Tuyen D. Nguyen, Jean-manuel Raimundo, Abdelfettah Labed, Racha El Zein, Sebastien Lavandier, Frédéric Bedu, Igor Ozerov, Hervé Dallaporta, Anne CharrierAbstract:Field effect transistors have risen as one of the most promising techniques in the development of biomedical diagnosis and monitoring. In such devices, the sensitivity and specificity of the sensor rely on the properties of the active sensing layer (gate dielectric and probe layer). We propose here a new type of transistor developed for the detection of Fe(3+) ions in which this sensing layer is made of a monolayer of lipids, engineered in such a way that it is not sensitive to pH in the acidic range, therefore making the device perfectly suitable for biomedical diagnosis. Probes are γ-Pyrone Derivatives that have been grafted to the lipid headgroups. Affinity constants derived for the chelator/Fe(3+) complexation as well as for other ions demonstrate very high sensitivity and specificity towards ferric ions with values as high as 5.10(10) M and a detected concentration as low as 50 fM.
