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Harald Lund - One of the best experts on this subject based on the ideXlab platform.
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dietary Quinic Acid supplied as the nutritional supplement aio ac 11 leads to induction of micromolar levels of nicotinamide and tryptophan in the urine
Phytotherapy Research, 2011Co-Authors: Ronald W. Pero, Harald LundAbstract:Hippuric Acid is synthesized and produced primarily by the gastrointestinal (GI) microflora. However, there is no known health benefit for hippuric Acid except its catabolic conjugation of benzene-type compounds via glycine and subsequent excretion in the urine. For years the GI tract microflora were known to metabolize Quinic Acid to hippuric Acid. Recently it was also proposed that DNA repair was strongly enhanced by Quinic Acid. In order to explain these Quinic Acid effects, Pero and colleagues have examined whether tryptophan and nicotinamide were also enhanced by Quinic Acid levels in urine. They were indeed, and so another study was designed using a natural supplement source of Quinic Acid called AIO + AC-11®, and then the effects of intervention were measured after only 21 days. It was possible to show profound increases in Quinic Acid that were again paralleled by increases in tryptophan and nicotinamide urinary levels. Because the high pressure liquid chromatography (HPLC) methods differed greatly between the two studies, differences in chemical analyses probably did not contribute to the data base.
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Dietary Quinic Acid supplied as the nutritional supplement AIO + AC-11® leads to induction of micromolar levels of nicotinamide and tryptophan in the urine.
Phytotherapy research : PTR, 2010Co-Authors: Ronald W. Pero, Harald LundAbstract:Hippuric Acid is synthesized and produced primarily by the gastrointestinal (GI) microflora. However, there is no known health benefit for hippuric Acid except its catabolic conjugation of benzene-type compounds via glycine and subsequent excretion in the urine. For years the GI tract microflora were known to metabolize Quinic Acid to hippuric Acid. Recently it was also proposed that DNA repair was strongly enhanced by Quinic Acid. In order to explain these Quinic Acid effects, Pero and colleagues have examined whether tryptophan and nicotinamide were also enhanced by Quinic Acid levels in urine. They were indeed, and so another study was designed using a natural supplement source of Quinic Acid called AIO + AC-11®, and then the effects of intervention were measured after only 21 days. It was possible to show profound increases in Quinic Acid that were again paralleled by increases in tryptophan and nicotinamide urinary levels. Because the high pressure liquid chromatography (HPLC) methods differed greatly between the two studies, differences in chemical analyses probably did not contribute to the data base.
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Dietary Quinic Acid supplied as the nutritional supplement AIO + AC-11® leads to induction of micromolar levels of nicotinamide and tryptophan in the urine
Phytotherapy Research, 2010Co-Authors: Ronald William Pero, Harald LundAbstract:Hippuric Acid is synthesized and produced primarily by the gastrointestinal (GI) microflora. However, there is no known health benefit for hippuric Acid except its catabolic conjugation of benzene-type compounds via glycine and subsequent excretion in the urine as hippuric Acid. For years GI tract microflora were known to metabolize Quinic Acid to hippuric Acid. Recently it was also proposed that DNA repair was strongly enhanced by Quinic Acid. In order to explain these Quinic Acid effects, Pero and colleagues (Pero et al. Phytotherapy Res. 23: 335-346, 2009) have examined if tryptophan and nicotinamide were also enhanced by Quinic Acid levels in urine. They were indeed, and so another study was designed using a natural supplement source of Quinic Acid called AIO + AC-11®, and then measuring the effects of intervention after only 21 days. It was possible to show profound increases in Quinic Acid that were again paralleled by increases in tryptophan and nicotinamide urinary levels. Because the high pressure liquid chromatography (HPLC) methods differed greatly between the two studies differences in chemical analyses probably did not contribute to the data base.
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Antioxidant metabolism induced by Quinic Acid. Increased urinary excretion of tryptophan and nicotinamide.
Phytotherapy research : PTR, 2009Co-Authors: Ronald W. Pero, Harald Lund, Tomas LeandersonAbstract:For over 50 years, hippuric/Quinic Acids were believed to have no biological efficacy. Here data are presented to support the hypothesis that Quinic Acid is not responsible for any efficacy, but rather that Quinic Acid nutritionally supports the synthesis of tryptophan and nicotinamide in the gastrointestinal (GI) tract, and that this in turn leads to DNA repair enhancement and NF-kB inhibition via increased nicotinamide and tryptophan production.Moreover, it is shown that Quinic Acid is a normal constituent of our diet, capable of conversion to tryptophan and nicotinamide via the GI tract microflora, thus providing an in situ physiological source of these essential metabolic ingredients to humans. The concentrations of Quinic and hippuric Acids in the diet were dependent on each other when analysed in urine, as was evidenced by a significant linear regression analysis that included unsupplemented control subjects (n = 45, p < 0.001). Thus, these ingredients were identified as major dietary components, and not simply originating from environmental pollution as previously had been thought.
Ronald W. Pero - One of the best experts on this subject based on the ideXlab platform.
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dietary Quinic Acid supplied as the nutritional supplement aio ac 11 leads to induction of micromolar levels of nicotinamide and tryptophan in the urine
Phytotherapy Research, 2011Co-Authors: Ronald W. Pero, Harald LundAbstract:Hippuric Acid is synthesized and produced primarily by the gastrointestinal (GI) microflora. However, there is no known health benefit for hippuric Acid except its catabolic conjugation of benzene-type compounds via glycine and subsequent excretion in the urine. For years the GI tract microflora were known to metabolize Quinic Acid to hippuric Acid. Recently it was also proposed that DNA repair was strongly enhanced by Quinic Acid. In order to explain these Quinic Acid effects, Pero and colleagues have examined whether tryptophan and nicotinamide were also enhanced by Quinic Acid levels in urine. They were indeed, and so another study was designed using a natural supplement source of Quinic Acid called AIO + AC-11®, and then the effects of intervention were measured after only 21 days. It was possible to show profound increases in Quinic Acid that were again paralleled by increases in tryptophan and nicotinamide urinary levels. Because the high pressure liquid chromatography (HPLC) methods differed greatly between the two studies, differences in chemical analyses probably did not contribute to the data base.
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Dietary Quinic Acid supplied as the nutritional supplement AIO + AC-11® leads to induction of micromolar levels of nicotinamide and tryptophan in the urine.
Phytotherapy research : PTR, 2010Co-Authors: Ronald W. Pero, Harald LundAbstract:Hippuric Acid is synthesized and produced primarily by the gastrointestinal (GI) microflora. However, there is no known health benefit for hippuric Acid except its catabolic conjugation of benzene-type compounds via glycine and subsequent excretion in the urine. For years the GI tract microflora were known to metabolize Quinic Acid to hippuric Acid. Recently it was also proposed that DNA repair was strongly enhanced by Quinic Acid. In order to explain these Quinic Acid effects, Pero and colleagues have examined whether tryptophan and nicotinamide were also enhanced by Quinic Acid levels in urine. They were indeed, and so another study was designed using a natural supplement source of Quinic Acid called AIO + AC-11®, and then the effects of intervention were measured after only 21 days. It was possible to show profound increases in Quinic Acid that were again paralleled by increases in tryptophan and nicotinamide urinary levels. Because the high pressure liquid chromatography (HPLC) methods differed greatly between the two studies, differences in chemical analyses probably did not contribute to the data base.
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Antioxidant metabolism induced by Quinic Acid. Increased urinary excretion of tryptophan and nicotinamide.
Phytotherapy research : PTR, 2009Co-Authors: Ronald W. Pero, Harald Lund, Tomas LeandersonAbstract:For over 50 years, hippuric/Quinic Acids were believed to have no biological efficacy. Here data are presented to support the hypothesis that Quinic Acid is not responsible for any efficacy, but rather that Quinic Acid nutritionally supports the synthesis of tryptophan and nicotinamide in the gastrointestinal (GI) tract, and that this in turn leads to DNA repair enhancement and NF-kB inhibition via increased nicotinamide and tryptophan production.Moreover, it is shown that Quinic Acid is a normal constituent of our diet, capable of conversion to tryptophan and nicotinamide via the GI tract microflora, thus providing an in situ physiological source of these essential metabolic ingredients to humans. The concentrations of Quinic and hippuric Acids in the diet were dependent on each other when analysed in urine, as was evidenced by a significant linear regression analysis that included unsupplemented control subjects (n = 45, p < 0.001). Thus, these ingredients were identified as major dietary components, and not simply originating from environmental pollution as previously had been thought.
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an active ingredient of cat s claw water extracts identification and efficacy of Quinic Acid
Journal of Ethnopharmacology, 2005Co-Authors: Yezhou Sheng, Christina Akesson, Kristin Holmgren, Carl Bryngelsson, Vincent Giamapa, Ronald W. PeroAbstract:Historic medicinal practice has defined Cat's Claw, also known as Una de Gato or Uncaria tomentosa, as an effective treatment for several health disorders including chronic inflammation, gastrointestinal dysfunction such as ulcers, tumors and infections. The efficacy of Cat's Claw was originally believed, as early as the 1960s, to be due to the presence of oxindole alkaloids. However, more recently water-soluble Cat's Claw extracts were shown not to contain significant amounts of alkaloids (<0.05%), and yet still were shown to be very efficacious. Here we characterize the active ingredients of a water-soluble Cat's Claw extract called C-Med-100 as inhibiting cell growth without cell death thus providing enhanced opportunities for DNA repair, and the consequences thereof, such as immune stimulation, anti-inflammation and cancer prevention. The active ingredients were chemically defined as Quinic Acid esters and could also be shown to be bioactive in vivo as Quinic Acid.
Takayuki Shibamoto - One of the best experts on this subject based on the ideXlab platform.
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Formation of volatile chemicals from thermal degradation of less volatile coffee components: Quinic Acid, caffeic Acid, and chlorogenic Acid.
Journal of agricultural and food chemistry, 2010Co-Authors: Joon-kwan Moon, Takayuki ShibamotoAbstract:The less volatile constituents of coffee beans (Quinic Acid, caffeic Acid, and chlorogenic Acid) were roasted under a stream of nitrogen, air, or helium. The volatile degradation compounds formed were analyzed by gas chromatography and gas chromatography-mass spectrometry. Caffeic Acid produced the greatest amount of total volatiles. Quinic Acid and chlorogenic Acid produced a greater number of volatiles under the nitrogen stream than under the air stream. These results suggest that the presence of oxygen does not play an important role in the formation of volatile compounds by the heat degradation of these chemicals. 2,5-Dimethylfuran formed in relatively large amounts (59.8-2231.0 microg/g) in the samples obtained from Quinic Acid and chlorogenic Acid but was not found in the samples from caffeic Acid. Furfuryl alcohol was found in the Quinic Acid (259.9 microg/g) and caffeic Acid (174.4 microg/g) samples roasted under a nitrogen stream but not in the chlorogenic sample. The three Acids used in the present study do not contain a nitrogen atom, yet nitrogen-containing heterocyclic compounds, pyridine, pyrrole, and pyrazines, were recovered. Phenol and its derivatives were identified in the largest quantities. The amounts of total phenols ranged from 60.6 microg/g (Quinic Acid under helium) to 89893.7 microg/g (caffeic Acid under helium). It was proposed that phenol was formed mainly from Quinic Acid and that catechols were formed from caffeic Acid. Formation of catechol from caffeic Acid under anaerobic condition indicates that the reaction participating in catechol formation was not oxidative degradation.
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formation of volatile chemicals from thermal degradation of less volatile coffee components Quinic Acid caffeic Acid and chlorogenic Acid
Journal of Agricultural and Food Chemistry, 2010Co-Authors: Joon-kwan Moon, Takayuki ShibamotoAbstract:The less volatile constituents of coffee beans (Quinic Acid, caffeic Acid, and chlorogenic Acid) were roasted under a stream of nitrogen, air, or helium. The volatile degradation compounds formed were analyzed by gas chromatography and gas chromatography−mass spectrometry. Caffeic Acid produced the greatest amount of total volatiles. Quinic Acid and chlorogenic Acid produced a greater number of volatiles under the nitrogen stream than under the air stream. These results suggest that the presence of oxygen does not play an important role in the formation of volatile compounds by the heat degradation of these chemicals. 2,5-Dimethylfuran formed in relatively large amounts (59.8−2231.0 μg/g) in the samples obtained from Quinic Acid and chlorogenic Acid but was not found in the samples from caffeic Acid. Furfuryl alcohol was found in the Quinic Acid (259.9 μg/g) and caffeic Acid (174.4 μg/g) samples roasted under a nitrogen stream but not in the chlorogenic sample. The three Acids used in the present study do...
Richard R. Schmidt - One of the best experts on this subject based on the ideXlab platform.
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Sialyltransferase Inhibitors Based on CMP-Quinic Acid
European Journal of Organic Chemistry, 2000Co-Authors: Christoph Schaub, Bernd Müller, Richard R. SchmidtAbstract:Quinic Acid was transformed into phosphitamides 16, 25, and 36, which could be readily linked to 5′-O-unprotected cytidine derivative 17. Ensuing oxidation of the obtained phosphite triesters with tBuO2H and hydrogenolytic de-O-benzylation furnished the corresponding phosphate diesters 18, 26, and 38. Base catalyzed removal of acetyl protecting groups, and methyl ester hydrolysis furnished CMP-Neu5Ac analogues 1d, 1e, and 2. Quinic Acid was also transformed into 1,2-unsaturated diallyl α-hydroxymethyl-phosphate derivatives (R)- and (S)-46, which on reaction with cytidine phosphitamide 47 afforded the phosphite triesters. Subsequent oxidation with tBuO2H and then treatment with NEt3 gave phosphate diester derivatives (R)- and (S)-48. Deallylation, acetyl group removal, and methyl ester hydrolysis furnished (R)- and (S)-3, respectively. Treatment of (R)- and (S)-48 with DBU as a base led to acetic Acid elimination, thus yielding, after de-O-allylation, acetyl group cleavage, and ester hydrolysis, diene derivative (E)-4. Donor substrate analogues 1d and 1e exhibited good α(2-6)-sialyltransferase inhibition (Ki: 2.0·10−4 and 2.0·10−5M). However, transition state analogues (R)-, and particularly (S)-3 showed excellent inhibition properties (Ki: 1.6·10−6 and 2.7·10−7M).
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New sialyltransferase inhibitors based on CMP-Quinic Acid: development of a new sialyltransferase assay
Glycoconjugate journal, 1998Co-Authors: Christoph Schaub, Bernd Müller, Richard R. SchmidtAbstract:Quinic Acid (4) was transformed into phosphitamides 6, 14, and 15, which could be readily linked to 5′-O-unprotected cytidine derivative 7; ensuing oxidation of the obtained phosphite triesters with tert-butylhydroperoxide furnished the corresponding phosphate triesters 8, 16, and 17, respectively. Hydrogenolytic debenzylation of the phosphate moiety, base catalysed removal of acetyl protective groups, and basic hydrolysis of the methylester of the Quinic Acid moiety furnished CMP-Neu5Ac analogues 1-3. In order to measure their inhibition of sialyltransferases, a nonradioactive sialyltransferase assay [employed for α(2-6)-sialyltransferase from rat liver (EC 2.4.99.1)] based on reversed-phase HPLC separation of UV-abelled acceptor 20 (p-nitrophenyl glycoside of N-acetyllactosamine) from the UV-labelled product 21 (p-nitrophenyl glycoside of sialyl α(2-6′)-N-acetyllactosamine) and p-nitrophenylalanine as internal standard was developed. The assay reproduced the reported KM values for CMP-Neu5Ac and N-acetyllactosamine and the Ki values for CDP. 1 and 2 turned out to be potent sialyltransferase inhibitors. © 1998 Rapid Science Ltd
Joon-kwan Moon - One of the best experts on this subject based on the ideXlab platform.
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Formation of volatile chemicals from thermal degradation of less volatile coffee components: Quinic Acid, caffeic Acid, and chlorogenic Acid.
Journal of agricultural and food chemistry, 2010Co-Authors: Joon-kwan Moon, Takayuki ShibamotoAbstract:The less volatile constituents of coffee beans (Quinic Acid, caffeic Acid, and chlorogenic Acid) were roasted under a stream of nitrogen, air, or helium. The volatile degradation compounds formed were analyzed by gas chromatography and gas chromatography-mass spectrometry. Caffeic Acid produced the greatest amount of total volatiles. Quinic Acid and chlorogenic Acid produced a greater number of volatiles under the nitrogen stream than under the air stream. These results suggest that the presence of oxygen does not play an important role in the formation of volatile compounds by the heat degradation of these chemicals. 2,5-Dimethylfuran formed in relatively large amounts (59.8-2231.0 microg/g) in the samples obtained from Quinic Acid and chlorogenic Acid but was not found in the samples from caffeic Acid. Furfuryl alcohol was found in the Quinic Acid (259.9 microg/g) and caffeic Acid (174.4 microg/g) samples roasted under a nitrogen stream but not in the chlorogenic sample. The three Acids used in the present study do not contain a nitrogen atom, yet nitrogen-containing heterocyclic compounds, pyridine, pyrrole, and pyrazines, were recovered. Phenol and its derivatives were identified in the largest quantities. The amounts of total phenols ranged from 60.6 microg/g (Quinic Acid under helium) to 89893.7 microg/g (caffeic Acid under helium). It was proposed that phenol was formed mainly from Quinic Acid and that catechols were formed from caffeic Acid. Formation of catechol from caffeic Acid under anaerobic condition indicates that the reaction participating in catechol formation was not oxidative degradation.
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formation of volatile chemicals from thermal degradation of less volatile coffee components Quinic Acid caffeic Acid and chlorogenic Acid
Journal of Agricultural and Food Chemistry, 2010Co-Authors: Joon-kwan Moon, Takayuki ShibamotoAbstract:The less volatile constituents of coffee beans (Quinic Acid, caffeic Acid, and chlorogenic Acid) were roasted under a stream of nitrogen, air, or helium. The volatile degradation compounds formed were analyzed by gas chromatography and gas chromatography−mass spectrometry. Caffeic Acid produced the greatest amount of total volatiles. Quinic Acid and chlorogenic Acid produced a greater number of volatiles under the nitrogen stream than under the air stream. These results suggest that the presence of oxygen does not play an important role in the formation of volatile compounds by the heat degradation of these chemicals. 2,5-Dimethylfuran formed in relatively large amounts (59.8−2231.0 μg/g) in the samples obtained from Quinic Acid and chlorogenic Acid but was not found in the samples from caffeic Acid. Furfuryl alcohol was found in the Quinic Acid (259.9 μg/g) and caffeic Acid (174.4 μg/g) samples roasted under a nitrogen stream but not in the chlorogenic sample. The three Acids used in the present study do...
