The Experts below are selected from a list of 39 Experts worldwide ranked by ideXlab platform
Miquel A Pericas - One of the best experts on this subject based on the ideXlab platform.
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a polystyrene supported 9 amino 9 deoxy epi Quinine Derivative for continuous flow asymmetric michael reactions
ChemInform, 2015Co-Authors: Javier Izquierdo, Carles Ayats, Andrea H Henseler, Miquel A PericasAbstract:A polystyrene-supported Quinine Derivative is successful applied as a catalyst for the Michael addition of ethyl nitroacetate (II) to enones (I) under batch conditions leading to a diastereomeric mixture of esters (III) and (IV).
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a polystyrene supported 9 amino 9 deoxy epi Quinine Derivative for continuous flow asymmetric michael reactions
Organic and Biomolecular Chemistry, 2015Co-Authors: Javier Izquierdo, Carles Ayats, Andrea H Henseler, Miquel A PericasAbstract:A polystyrene (PS)-supported 9-amino(9-deoxy)epi Quinine Derivative catalyzes Michael reactions affording excellent levels of conversion and enantioselectivity using different nucleophiles and structurally diverse enones. The highly recyclable, immobilized catalyst has been used to implement a single-pass, continuous flow process (residence time: 40 min) that can be operated for 21 hours without significant decrease in conversion and with improved enantioselectivity with respect to batch operation. The flow process has also been used for the sequential preparation of a small library of enantioenriched Michael adducts.
Alessandra Puglisi - One of the best experts on this subject based on the ideXlab platform.
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solid supported 9 amino 9 deoxy epi Quinine as efficient organocatalyst for stereoselective reactions in batch and under continuous flow conditions
Advanced Synthesis & Catalysis, 2015Co-Authors: Riccardo Porta, Maurizio Benaglia, Francesca Coccia, Franco Cozzi, Alessandra PuglisiAbstract:Polystyrene-supported 9-amino-9-deoxy-epi-Quinine was synthesized through co-polymerization of an ad hoc-designed chiral monomer with divinylbenzene, in the presence of azobis(isobutyronitile) (AIBN) as radical initiator and toluene and 1-dodecanol as porogenic solvents. The heterogenized catalyst efficiently promoted the reaction of isobutyric aldehyde with β-nitrostyrene, in very high yield and enantioselectivity, comparable or even higher than that of the homogeneous counterpart (up to 95% ee). The recyclability of the catalyst, its general applicability and its successful application to other reactions was also demonstrated. Finally, for the first time, a 9-amino-epi-Quinine Derivative was employed to perform an enantioselective Michael reaction under continuous-flow conditions; by using a home-made, packed-bed catalytic reactor, the aldehyde addition to nitrostyrene was successfully realized in flow mode, leading to the product in up to 93% ee.
Javier Izquierdo - One of the best experts on this subject based on the ideXlab platform.
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a polystyrene supported 9 amino 9 deoxy epi Quinine Derivative for continuous flow asymmetric michael reactions
ChemInform, 2015Co-Authors: Javier Izquierdo, Carles Ayats, Andrea H Henseler, Miquel A PericasAbstract:A polystyrene-supported Quinine Derivative is successful applied as a catalyst for the Michael addition of ethyl nitroacetate (II) to enones (I) under batch conditions leading to a diastereomeric mixture of esters (III) and (IV).
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a polystyrene supported 9 amino 9 deoxy epi Quinine Derivative for continuous flow asymmetric michael reactions
Organic and Biomolecular Chemistry, 2015Co-Authors: Javier Izquierdo, Carles Ayats, Andrea H Henseler, Miquel A PericasAbstract:A polystyrene (PS)-supported 9-amino(9-deoxy)epi Quinine Derivative catalyzes Michael reactions affording excellent levels of conversion and enantioselectivity using different nucleophiles and structurally diverse enones. The highly recyclable, immobilized catalyst has been used to implement a single-pass, continuous flow process (residence time: 40 min) that can be operated for 21 hours without significant decrease in conversion and with improved enantioselectivity with respect to batch operation. The flow process has also been used for the sequential preparation of a small library of enantioenriched Michael adducts.
Carles Ayats - One of the best experts on this subject based on the ideXlab platform.
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a polystyrene supported 9 amino 9 deoxy epi Quinine Derivative for continuous flow asymmetric michael reactions
ChemInform, 2015Co-Authors: Javier Izquierdo, Carles Ayats, Andrea H Henseler, Miquel A PericasAbstract:A polystyrene-supported Quinine Derivative is successful applied as a catalyst for the Michael addition of ethyl nitroacetate (II) to enones (I) under batch conditions leading to a diastereomeric mixture of esters (III) and (IV).
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a polystyrene supported 9 amino 9 deoxy epi Quinine Derivative for continuous flow asymmetric michael reactions
Organic and Biomolecular Chemistry, 2015Co-Authors: Javier Izquierdo, Carles Ayats, Andrea H Henseler, Miquel A PericasAbstract:A polystyrene (PS)-supported 9-amino(9-deoxy)epi Quinine Derivative catalyzes Michael reactions affording excellent levels of conversion and enantioselectivity using different nucleophiles and structurally diverse enones. The highly recyclable, immobilized catalyst has been used to implement a single-pass, continuous flow process (residence time: 40 min) that can be operated for 21 hours without significant decrease in conversion and with improved enantioselectivity with respect to batch operation. The flow process has also been used for the sequential preparation of a small library of enantioenriched Michael adducts.
Andrea H Henseler - One of the best experts on this subject based on the ideXlab platform.
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a polystyrene supported 9 amino 9 deoxy epi Quinine Derivative for continuous flow asymmetric michael reactions
ChemInform, 2015Co-Authors: Javier Izquierdo, Carles Ayats, Andrea H Henseler, Miquel A PericasAbstract:A polystyrene-supported Quinine Derivative is successful applied as a catalyst for the Michael addition of ethyl nitroacetate (II) to enones (I) under batch conditions leading to a diastereomeric mixture of esters (III) and (IV).
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a polystyrene supported 9 amino 9 deoxy epi Quinine Derivative for continuous flow asymmetric michael reactions
Organic and Biomolecular Chemistry, 2015Co-Authors: Javier Izquierdo, Carles Ayats, Andrea H Henseler, Miquel A PericasAbstract:A polystyrene (PS)-supported 9-amino(9-deoxy)epi Quinine Derivative catalyzes Michael reactions affording excellent levels of conversion and enantioselectivity using different nucleophiles and structurally diverse enones. The highly recyclable, immobilized catalyst has been used to implement a single-pass, continuous flow process (residence time: 40 min) that can be operated for 21 hours without significant decrease in conversion and with improved enantioselectivity with respect to batch operation. The flow process has also been used for the sequential preparation of a small library of enantioenriched Michael adducts.
