The Experts below are selected from a list of 258 Experts worldwide ranked by ideXlab platform
Alessandra Silvani - One of the best experts on this subject based on the ideXlab platform.
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stereocontrolled reduction of an oxazepinohexahydroindolo 2 3 a Quinolizine derivative asymmetric total synthesis of tacamonine
Tetrahedron Letters, 2001Co-Authors: Bruno Danieli, Giordano Lesma, Daniele Passarella, Alessandro Sacchetti, Alessandra SilvaniAbstract:Abstract Efficient, stereocontrolled total synthesis of the title compound is described, starting from enantiopure intermediates. A key step was the diastereoselective catalytic hydrogenation of a pentacyclic oxazepinohexahydroindolo[2,3- a ]Quinolizine derivative.
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Stereocontrolled reduction of an oxazepinohexahydroindolo[2,3-a]Quinolizine derivative: asymmetric total synthesis of (+)-tacamonine
Tetrahedron Letters, 2001Co-Authors: Bruno Danieli, Giordano Lesma, Daniele Passarella, Alessandro Sacchetti, Alessandra SilvaniAbstract:Abstract Efficient, stereocontrolled total synthesis of the title compound is described, starting from enantiopure intermediates. A key step was the diastereoselective catalytic hydrogenation of a pentacyclic oxazepinohexahydroindolo[2,3- a ]Quinolizine derivative.
Bruno Danieli - One of the best experts on this subject based on the ideXlab platform.
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stereocontrolled reduction of an oxazepinohexahydroindolo 2 3 a Quinolizine derivative asymmetric total synthesis of tacamonine
Tetrahedron Letters, 2001Co-Authors: Bruno Danieli, Giordano Lesma, Daniele Passarella, Alessandro Sacchetti, Alessandra SilvaniAbstract:Abstract Efficient, stereocontrolled total synthesis of the title compound is described, starting from enantiopure intermediates. A key step was the diastereoselective catalytic hydrogenation of a pentacyclic oxazepinohexahydroindolo[2,3- a ]Quinolizine derivative.
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Stereocontrolled reduction of an oxazepinohexahydroindolo[2,3-a]Quinolizine derivative: asymmetric total synthesis of (+)-tacamonine
Tetrahedron Letters, 2001Co-Authors: Bruno Danieli, Giordano Lesma, Daniele Passarella, Alessandro Sacchetti, Alessandra SilvaniAbstract:Abstract Efficient, stereocontrolled total synthesis of the title compound is described, starting from enantiopure intermediates. A key step was the diastereoselective catalytic hydrogenation of a pentacyclic oxazepinohexahydroindolo[2,3- a ]Quinolizine derivative.
Mark R J Elsegood - One of the best experts on this subject based on the ideXlab platform.
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complementary stereoselective conjugate addition reactions on indolo 2 3 a Quinolizine templates
Tetrahedron Letters, 2006Co-Authors: Steven M Allin, Jagjit S Khera, Christopher I Thomas, Jason Witherington, Kevin J Doyle, Mark R J Elsegood, Mark EdgarAbstract:We report a new and highly stereoselective approach for the construction of a range of functionalized indolo[2,3-a]Quinolizine targets from a readily available, nonracemic chiral template. The methods developed allow us to predetermine relative product stereochemistries by judicious choice of substrate sub-structure.
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a highly stereoselective synthesis of the indolo 2 3 a Quinolizine ring system and application to natural product synthesis
European Journal of Organic Chemistry, 2005Co-Authors: Steven M Allin, Christopher I Thomas, Kevin J Doyle, James E Allard, Mark R J ElsegoodAbstract:We present a facile and highly stereoselective approach to the indolo[2,3-a]Quinolizine ring system from a readily available, non-racemic chiral template. We demonstrate the potential for application of this methodology to natural product synthesis through conversion of the template to some representative indole alkaloids with high enantiomeric purity in both enantiomeric series. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
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highly stereoselective synthesis of the indolo 2 3 a Quinolizine ring system and application to indole natural product synthesis
Tetrahedron Letters, 2004Co-Authors: Steven M Allin, Christopher I Thomas, Kevin J Doyle, James E Allard, Mark R J ElsegoodAbstract:We report a novel, facile and highly stereoselective approach to the indolo[2,3-a]Quinolizine ring system from a readily available, non-racemic chiral template. We demonstrate the potential for application of this methodology to natural product synthesis through conversion of the template to a simple indole alkaloid with high enantiomeric purity.
Yu. Yu. Morzherin - One of the best experts on this subject based on the ideXlab platform.
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Regioselective reaction of ortho-piperidinobenzaldehydes with pyrazolone
Russian Chemical Bulletin, 2011Co-Authors: A. Yu. Platonova, T. V. Glukhareva, E. V. Deeva, O. A. Zimovets, D. V. Shatunova, O. S. El’tsov, P. A. Slepukhin, Yu. Yu. MorzherinAbstract:Cyclization of 2-(4- R -piperidino)benzaldehydes with 5-methyl-2-phenyl-2,4-dihydro-3 H -pyrazol-3-one proceeding via tert -amino effect mechanism is stereoselective. Relative configuration of (3 R *,4a S *,5 R *)-2,3,4,4a,5,6-hexahydro-1 H -benzo[ c ]Quinolizine was established on the base of NMR spectroscopy data and X-ray analysis.
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Diastereoselective synthesis of spiro derivatives of 3-substituted 2,3,4,4a,5,6-hexahydro-1H-benzo[c]Quinolizines
Russian Journal of Organic Chemistry, 2009Co-Authors: T. V. Glukhareva, E. V. Deeva, A. Yu. Platonova, I. V. Geide, M. I. Kodess, Yu. Yu. MorzherinAbstract:The cyclization via the mechanism of “ tert -amino effect” of 2-(4-R-piperidino)benzaldehydes with cyclic active methylene components (Meldrum’s acid, 1,3-cyclohexanedione, and N,N-disubstituted barbituric acids) proceeded stereoselectively giving spiro-joined 2,3,4,4a,5,6-hexahydro-1 H -benzo[ c ]Quinolizines with axially oriented hydrogen atoms in the positions 3 and 4a of the benzo[c]Quinolizine ring.
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Stereoselective synthesis of new spiro-fused heterocyclic systems, 2,3,4,4a,5.6-hexahydro-6H-spiro[benzo[c]Quinolizine-5,4′-pyrazol]-5′-ones
Chemistry of Heterocyclic Compounds, 2007Co-Authors: T. V. Glukhareva, E. V. Deeva, P. E. Kropotina, M. F. Kosterina, Yu. I. Nein, Yu. Yu. MorzherinAbstract:The synthesis of 2,3,4,4a,5,6-hexahydro-6H-spiro[benzo[c]Quinolizine-5,4′-pyrazol]-5′-ones has been achieved by the reaction of 2-piperidinobenzaldehydes with 2-aryl-5-methyl-2,4-dihydropyrazol-3-one via the “tert-amino effect” mechanism.
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stereoselective synthesis of new spiro fused heterocyclic systems 2 3 4 4a 5 6 hexahydro 6h spiro benzo c Quinolizine 5 4 pyrazol 5 ones
Chemistry of Heterocyclic Compounds, 2007Co-Authors: T. V. Glukhareva, E. V. Deeva, P. E. Kropotina, M. F. Kosterina, Yu. I. Nein, Yu. Yu. MorzherinAbstract:The synthesis of 2,3,4,4a,5,6-hexahydro-6H-spiro[benzo[c]Quinolizine-5,4′-pyrazol]-5′-ones has been achieved by the reaction of 2-piperidinobenzaldehydes with 2-aryl-5-methyl-2,4-dihydropyrazol-3-one via the “tert-amino effect” mechanism.
Steven M Allin - One of the best experts on this subject based on the ideXlab platform.
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complementary stereoselective conjugate addition reactions on indolo 2 3 a Quinolizine templates
Tetrahedron Letters, 2006Co-Authors: Steven M Allin, Jagjit S Khera, Christopher I Thomas, Jason Witherington, Kevin J Doyle, Mark R J Elsegood, Mark EdgarAbstract:We report a new and highly stereoselective approach for the construction of a range of functionalized indolo[2,3-a]Quinolizine targets from a readily available, nonracemic chiral template. The methods developed allow us to predetermine relative product stereochemistries by judicious choice of substrate sub-structure.
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a highly stereoselective synthesis of the indolo 2 3 a Quinolizine ring system and application to natural product synthesis
European Journal of Organic Chemistry, 2005Co-Authors: Steven M Allin, Christopher I Thomas, Kevin J Doyle, James E Allard, Mark R J ElsegoodAbstract:We present a facile and highly stereoselective approach to the indolo[2,3-a]Quinolizine ring system from a readily available, non-racemic chiral template. We demonstrate the potential for application of this methodology to natural product synthesis through conversion of the template to some representative indole alkaloids with high enantiomeric purity in both enantiomeric series. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
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highly stereoselective synthesis of the indolo 2 3 a Quinolizine ring system and application to indole natural product synthesis
Tetrahedron Letters, 2004Co-Authors: Steven M Allin, Christopher I Thomas, Kevin J Doyle, James E Allard, Mark R J ElsegoodAbstract:We report a novel, facile and highly stereoselective approach to the indolo[2,3-a]Quinolizine ring system from a readily available, non-racemic chiral template. We demonstrate the potential for application of this methodology to natural product synthesis through conversion of the template to a simple indole alkaloid with high enantiomeric purity.
