Radioluminescence

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Guillem Pratx - One of the best experts on this subject based on the ideXlab platform.

  • pegylated β nagdf4 tb caf2 core shell nanophosphors for enhanced Radioluminescence and folate receptor targeting
    ACS Applied Nano Materials, 2019
    Co-Authors: Yufu Ren, Conroy Sun, Guillem Pratx, Hayden Winter, Justin G Rosch, Kyungoh Jung, Allison N Duross, Madeleine R Landry
    Abstract:

    Lanthanide-doped nanocrystals have been examined extensively as contrast agents for various optical molecular imaging techniques. One of the greatest strengths of these nanomaterials is their ability to enable novel imaging modalities, such as X-ray excited Radioluminescence imaging, which leverages the exceptional tissue depth penetration of X-rays and reduced tissue autofluorescence. Here, we report a uniquely engineered NaGdF4/Tb@CaF2 nanoscintillator with substantial lattice mismatch through integration of coprecipitation and thermal decomposition synthetic routes. We observed greatly enhanced Radioluminescence by the NaGdF4/15%Tb@CaF2 core/shell nanocrystals, which results from the minimized surface quenching and localized structure transformation. Polyethylene glycol coated NaGdF4/15%Tb@CaF2 nanocrystals demonstrated robust aqueous colloidal stability and were well tolerated by a panel of cell lines. The core/shell NaGdF4/15%Tb@CaF2 nanophosphors were subsequently decorated with targeting folate lig...

  • Radioluminescence in biomedicine: physics, applications, and models.
    Physics in Medicine & Biology, 2019
    Co-Authors: Justin S Klein, Conroy Sun, Guillem Pratx
    Abstract:

    The electromagnetic spectrum contains different frequency bands useful for medical imaging and therapy. Short wavelengths (ionizing radiation) are commonly used for radiological and radionuclide imaging and for cancer radiation therapy. Intermediate wavelengths (optical radiation) are useful for more localized imaging and for photodynamic therapy (PDT). Finally, longer wavelengths are the basis for magnetic resonance imaging and for hyperthermia treatments. Recently, there has been a surge of interest for new biomedical methods that synergize optical and ionizing radiation by exploiting the ability of ionizing radiation to stimulate optical emissions. These physical phenomena, together known as Radioluminescence, are being used for applications as diverse as radionuclide imaging, radiation therapy monitoring, phototherapy, and nanoparticle-based molecular imaging. This review provides a comprehensive treatment of the physics of Radioluminescence and includes simple analytical models to estimate the luminescence yield of scintillators and nanoscintillators, Cherenkov radiation, air fluorescence, and biologically endogenous Radioluminescence. Examples of methods that use Radioluminescence for diagnostic or therapeutic applications are reviewed and analyzed in light of these quantitative physical models of Radioluminescence.

  • modular low light microscope for imaging cellular bioluminescence and Radioluminescence
    Nature Protocols, 2017
    Co-Authors: Silvan Türkcan, Guillem Pratx
    Abstract:

    Bioluminescence and Radioluminescence are both dim phenomena that require a highly sensitive microscope for imaging at the cellular level. This protocol describes how to construct a modular low-light microscope for imaging these events.

  • we h 207a 01 computational evaluation of high resolution 18f positron imaging using Radioluminescence microscopy with lu2o3 eu thin film scintillator
    Medical Physics, 2016
    Co-Authors: Qian Wang, Debanti Sengupta, Guillem Pratx
    Abstract:

    Purpose: Radioluminescence microscopy, an emerging and powerful tool for high resolution beta imaging, has been applied to molecular imaging of cellular metabolism to understand tumor biology. A novel thin-film (10 µm thickness) scintillator made of Lu2O3: Eu has been developed to enhance the system performance. However the advances of Radioluminescence imaging with Lu2O3scintillator compared with that using conventional scintillator have not been explored theoretically to date. To validate the advantages of the thin-film scintillator, this study uses a novel computational simulation framework to evaluate the performance of Radioluminescence microscopy using both conventional and thin-film scintillators. Methods: Numerical models for different stages of positron imaging are established. Positron from 18F passing through the scintillator and its neighbor structures are modeled by Monte-Carlo simulation using Geant4. The propagation and focus of photons by the microscope are modeled by convolution with a depth-varying point spread function generated by the Gibson-Lanni model. Photons focused on the detector plane are then captured and converted into electronic signals by an electron multiplication (EM) CCD camera, which is described by a photosensor model considering various noises and charge amplification. Results: The performance metrics of Radioluminescence imaging with a thin-film Lu2O3 and conventional CdWO4 scintillator are compared, including spatial resolution, sensitivity, positron track area and intensity. The spatial resolution of Lu2O3 system can achieve 10 µm maximally, a 12 µm enhancement from that obtained from CdWO4 system. Meanwhile, the system with Lu2O3 scintillator can provide a higher mean sensitivity: 40% compared with that (21.5%) obtained from CdWO4 system. Moreover, the simulation results are in good agreement with previous experimental measurements. Conclusion: This study provides a new theoretical understanding of our imaging system and has the potential to promote the development of Radioluminescence microscopy for more reliable and robust application on the functional imaging of delicate biological structures. The authors acknowledge funding from NIH grant R01CA186275 and SBIR grant 1R43GM110888-01.

  • Bright Lu2O3:Eu Thin‐Film Scintillators for High‐Resolution Radioluminescence Microscopy
    Advanced Healthcare Materials, 2015
    Co-Authors: Debanti Sengupta, Stuart R. Miller, Zsolt Marton, Frederick T. Chin, Vivek V. Nagarkar, Guillem Pratx
    Abstract:

    The performance of a new thin-film Lu2O3:Eu scintillator for single-cell radionuclide imaging is investigated. Imaging the metabolic properties of heterogeneous cell populations in real time is an important challenge with clinical implications. An innovative technique called Radioluminescence microscopy has been developed to quantitatively and sensitively measure radionuclide uptake in single cells. The most important component of this technique is the scintillator, which converts the energy released during radioactive decay into luminescent signals. The sensitivity and spatial resolution of the imaging system depend critically on the characteristics of the scintillator, that is, the material used and its geometrical configuration. Scintillators fabricated using conventional methods are relatively thick and therefore do not provide optimal spatial resolution. A thin-film Lu2O3:Eu scintillator is compared to a conventional 500 μm thick CdWO4 scintillator for Radioluminescence imaging. Despite its thinness, the unique scintillation properties of the Lu2O3:Eu scintillator allow us to capture single-positron decays with fourfold higher sensitivity, which is a significant achievement. The thin-film Lu2O3:Eu scintillators also yield Radioluminescence images where individual cells appear smaller and better resolved on average than with the CdWO4 scintillators. Coupled with the thin-film scintillator technology, Radioluminescence microscopy can yield valuable and clinically relevant data on the metabolism of single cells.

Yutaka Fujimoto - One of the best experts on this subject based on the ideXlab platform.

  • photoluminescence and Radioluminescence properties of mno doped sno zno p2o5 glasses
    Optical Materials, 2015
    Co-Authors: Hirokazu Masai, Yusuke Hino, Takayuki Yanagida, Yutaka Fujimoto
    Abstract:

    Abstract In this study, the photoluminescence and Radioluminescence properties of MnO-doped SnO–ZnO–P2O5 glasses are examined. We have confirmed that linear dose-dependence and Radioluminescence emission decay depend on Mn2+ concentration. Energy transfer from donor Sn2+ center to acceptor Mn2+ center is observed in both photoluminescence and Radioluminescence processes, and the energy transfer efficiency is more than 90% when the Mn2+/Sn2+ ratio is 5. Since emission intensity of Mn2+ is higher than that of Sn2+ in Radioluminescence compared to photoluminescence, it is suggested that energy transfer from the host matrix to Mn2+ center by X-ray occurred preferentially over energy transfer to Sn2+ center. The present results suggest that the conventional parity rule for photoluminescence is not always adaptable for Radioluminescence, although emission-related energy levels are the same for both the processes.

  • Photoluminescence and Radioluminescence properties of MnO-doped SnO–ZnO–P2O5 glasses
    Optical Materials, 2015
    Co-Authors: Hirokazu Masai, Yusuke Hino, Takayuki Yanagida, Yutaka Fujimoto
    Abstract:

    Abstract In this study, the photoluminescence and Radioluminescence properties of MnO-doped SnO–ZnO–P2O5 glasses are examined. We have confirmed that linear dose-dependence and Radioluminescence emission decay depend on Mn2+ concentration. Energy transfer from donor Sn2+ center to acceptor Mn2+ center is observed in both photoluminescence and Radioluminescence processes, and the energy transfer efficiency is more than 90% when the Mn2+/Sn2+ ratio is 5. Since emission intensity of Mn2+ is higher than that of Sn2+ in Radioluminescence compared to photoluminescence, it is suggested that energy transfer from the host matrix to Mn2+ center by X-ray occurred preferentially over energy transfer to Sn2+ center. The present results suggest that the conventional parity rule for photoluminescence is not always adaptable for Radioluminescence, although emission-related energy levels are the same for both the processes.

Debanti Sengupta - One of the best experts on this subject based on the ideXlab platform.

  • we h 207a 01 computational evaluation of high resolution 18f positron imaging using Radioluminescence microscopy with lu2o3 eu thin film scintillator
    Medical Physics, 2016
    Co-Authors: Qian Wang, Debanti Sengupta, Guillem Pratx
    Abstract:

    Purpose: Radioluminescence microscopy, an emerging and powerful tool for high resolution beta imaging, has been applied to molecular imaging of cellular metabolism to understand tumor biology. A novel thin-film (10 µm thickness) scintillator made of Lu2O3: Eu has been developed to enhance the system performance. However the advances of Radioluminescence imaging with Lu2O3scintillator compared with that using conventional scintillator have not been explored theoretically to date. To validate the advantages of the thin-film scintillator, this study uses a novel computational simulation framework to evaluate the performance of Radioluminescence microscopy using both conventional and thin-film scintillators. Methods: Numerical models for different stages of positron imaging are established. Positron from 18F passing through the scintillator and its neighbor structures are modeled by Monte-Carlo simulation using Geant4. The propagation and focus of photons by the microscope are modeled by convolution with a depth-varying point spread function generated by the Gibson-Lanni model. Photons focused on the detector plane are then captured and converted into electronic signals by an electron multiplication (EM) CCD camera, which is described by a photosensor model considering various noises and charge amplification. Results: The performance metrics of Radioluminescence imaging with a thin-film Lu2O3 and conventional CdWO4 scintillator are compared, including spatial resolution, sensitivity, positron track area and intensity. The spatial resolution of Lu2O3 system can achieve 10 µm maximally, a 12 µm enhancement from that obtained from CdWO4 system. Meanwhile, the system with Lu2O3 scintillator can provide a higher mean sensitivity: 40% compared with that (21.5%) obtained from CdWO4 system. Moreover, the simulation results are in good agreement with previous experimental measurements. Conclusion: This study provides a new theoretical understanding of our imaging system and has the potential to promote the development of Radioluminescence microscopy for more reliable and robust application on the functional imaging of delicate biological structures. The authors acknowledge funding from NIH grant R01CA186275 and SBIR grant 1R43GM110888-01.

  • Bright Lu2O3:Eu Thin‐Film Scintillators for High‐Resolution Radioluminescence Microscopy
    Advanced Healthcare Materials, 2015
    Co-Authors: Debanti Sengupta, Stuart R. Miller, Zsolt Marton, Frederick T. Chin, Vivek V. Nagarkar, Guillem Pratx
    Abstract:

    The performance of a new thin-film Lu2O3:Eu scintillator for single-cell radionuclide imaging is investigated. Imaging the metabolic properties of heterogeneous cell populations in real time is an important challenge with clinical implications. An innovative technique called Radioluminescence microscopy has been developed to quantitatively and sensitively measure radionuclide uptake in single cells. The most important component of this technique is the scintillator, which converts the energy released during radioactive decay into luminescent signals. The sensitivity and spatial resolution of the imaging system depend critically on the characteristics of the scintillator, that is, the material used and its geometrical configuration. Scintillators fabricated using conventional methods are relatively thick and therefore do not provide optimal spatial resolution. A thin-film Lu2O3:Eu scintillator is compared to a conventional 500 μm thick CdWO4 scintillator for Radioluminescence imaging. Despite its thinness, the unique scintillation properties of the Lu2O3:Eu scintillator allow us to capture single-positron decays with fourfold higher sensitivity, which is a significant achievement. The thin-film Lu2O3:Eu scintillators also yield Radioluminescence images where individual cells appear smaller and better resolved on average than with the CdWO4 scintillators. Coupled with the thin-film scintillator technology, Radioluminescence microscopy can yield valuable and clinically relevant data on the metabolism of single cells.

  • bright lu2o3 eu thin film scintillators for high resolution Radioluminescence microscopy
    Advanced Healthcare Materials, 2015
    Co-Authors: Debanti Sengupta, Stuart R. Miller, Zsolt Marton, Frederick T. Chin, Vivek V. Nagarkar, Guillem Pratx
    Abstract:

    The performance of a new thin-film Lu2O3:Eu scintillator for single-cell radionuclide imaging is investigated. Imaging the metabolic properties of heterogeneous cell populations in real time is an important challenge with clinical implications. An innovative technique called Radioluminescence microscopy has been developed to quantitatively and sensitively measure radionuclide uptake in single cells. The most important component of this technique is the scintillator, which converts the energy released during radioactive decay into luminescent signals. The sensitivity and spatial resolution of the imaging system depend critically on the characteristics of the scintillator, that is, the material used and its geometrical configuration. Scintillators fabricated using conventional methods are relatively thick and therefore do not provide optimal spatial resolution. A thin-film Lu2O3:Eu scintillator is compared to a conventional 500 μm thick CdWO4 scintillator for Radioluminescence imaging. Despite its thinness, the unique scintillation properties of the Lu2O3:Eu scintillator allow us to capture single-positron decays with fourfold higher sensitivity, which is a significant achievement. The thin-film Lu2O3:Eu scintillators also yield Radioluminescence images where individual cells appear smaller and better resolved on average than with the CdWO4 scintillators. Coupled with the thin-film scintillator technology, Radioluminescence microscopy can yield valuable and clinically relevant data on the metabolism of single cells.

Yonghua Zhan - One of the best experts on this subject based on the ideXlab platform.

  • Gamma rays excited Radioluminescence tomographic imaging.
    BioMedical Engineering OnLine, 2018
    Co-Authors: Xuanxuan Zhang, Yonghua Zhan, Shouping Zhu, Xueli Chen, Fei Kang, Jing Wang, Xu Cao
    Abstract:

    Radionuclide-excited luminescence imaging is an optical radionuclide imaging strategy to reveal the distributions of radioluminescent nanophosphors (RLNPs) inside small animals, which uses Radioluminescence emitted from RLNPs when excited by high energy rays such as gamma rays generated during the decay of radiotracers used in clinical nuclear medicine imaging. Currently, there is no report of tomographic imaging based on Radioluminescence. In this paper, we proposed a gamma rays excited Radioluminescence tomography (GRLT) to reveal three-dimensional distributions of RLNPs inside a small animal using Radioluminescence through image reconstruction from surface measurements of radioluminescent photons using an inverse algorithm. The diffusion equation was employed to model propagations of radioluminescent photons in biological tissues with highly scattering and low absorption characteristics. Phantom and artificial source-implanted mouse model experiments were employed to test the feasibility of GRLT, and the results demonstrated that the ability of GRLT to reveal the distribution of RLNPs such as Gd2O2S:Tb using the radioluminescent signals when excited by gamma rays produced from 99mTc. With the emerging of targeted RLNPs, GRLT can provide new possibilities for in vivo and noninvasive examination of biological processes at cellular levels. Especially, combining with Cerenkov luminescence imaging, GRLT can achieve dual molecular information of RLNPs and nuclides using single optical imaging technology.

  • intrinsically zirconium 89 labeled gd2o2s eu nanoprobes for in vivo positron emission tomography and gamma ray induced Radioluminescence imaging
    Small, 2016
    Co-Authors: Yonghua Zhan, Hector F. Valdovinos, Hakan Orbay, Jimin Liang, Fanrong Ai, Haiyan Sun, Feng Chen, Todd E. Barnhart
    Abstract:

    The engineering of a novel dual-modality imaging probe is reported here by intrinsically labeling zirconium-89 ((89) Zr, a positron emission radioisotope with a half-life of 78.4 h) to PEGylated Gd2 O2 S:Eu nanophorphors, forming [(89) Zr]Gd2 O2 S:Eu@PEG for in vivo positron emission tomography/Radioluminescence lymph node mapping.

  • Intrinsically Zirconium‐89 Labeled Gd2O2S:Eu Nanoprobes for In Vivo Positron Emission Tomography and Gamma‐Ray‐Induced Radioluminescence Imaging
    Small, 2016
    Co-Authors: Yonghua Zhan, Hector F. Valdovinos, Hakan Orbay, Jimin Liang, Todd E. Barnhart, Fanrong Ai, Feng Chen, Jie Tian
    Abstract:

    : The engineering of a novel dual-modality imaging probe is reported here by intrinsically labeling zirconium-89 ((89) Zr, a positron emission radioisotope with a half-life of 78.4 h) to PEGylated Gd2 O2 S:Eu nanophorphors, forming [(89) Zr]Gd2 O2 S:Eu@PEG for in vivo positron emission tomography/Radioluminescence lymph node mapping.

Hirokazu Masai - One of the best experts on this subject based on the ideXlab platform.

  • Photoluminescence and Radioluminescence in Pr-doped lanthanum aluminoborate glasses
    Journal of Asian Ceramic Societies, 2017
    Co-Authors: Shunichi Kaneko, Hirokazu Masai, Go Okada, Noriaki Kawaguchi, Takayuki Yanagida
    Abstract:

    Photoluminescence (PL) and Radioluminescence properties of Pr-doped lanthanum aluminoborate glasses with the composition xPr-20La2O3-30Al2O3-50B2O3 (0 ≤ x ≤ 1.0) were studied. In the PL spectra, th...

  • photoluminescence and Radioluminescence properties of mno doped sno zno p2o5 glasses
    Optical Materials, 2015
    Co-Authors: Hirokazu Masai, Yusuke Hino, Takayuki Yanagida, Yutaka Fujimoto
    Abstract:

    Abstract In this study, the photoluminescence and Radioluminescence properties of MnO-doped SnO–ZnO–P2O5 glasses are examined. We have confirmed that linear dose-dependence and Radioluminescence emission decay depend on Mn2+ concentration. Energy transfer from donor Sn2+ center to acceptor Mn2+ center is observed in both photoluminescence and Radioluminescence processes, and the energy transfer efficiency is more than 90% when the Mn2+/Sn2+ ratio is 5. Since emission intensity of Mn2+ is higher than that of Sn2+ in Radioluminescence compared to photoluminescence, it is suggested that energy transfer from the host matrix to Mn2+ center by X-ray occurred preferentially over energy transfer to Sn2+ center. The present results suggest that the conventional parity rule for photoluminescence is not always adaptable for Radioluminescence, although emission-related energy levels are the same for both the processes.

  • Photoluminescence and Radioluminescence properties of MnO-doped SnO–ZnO–P2O5 glasses
    Optical Materials, 2015
    Co-Authors: Hirokazu Masai, Yusuke Hino, Takayuki Yanagida, Yutaka Fujimoto
    Abstract:

    Abstract In this study, the photoluminescence and Radioluminescence properties of MnO-doped SnO–ZnO–P2O5 glasses are examined. We have confirmed that linear dose-dependence and Radioluminescence emission decay depend on Mn2+ concentration. Energy transfer from donor Sn2+ center to acceptor Mn2+ center is observed in both photoluminescence and Radioluminescence processes, and the energy transfer efficiency is more than 90% when the Mn2+/Sn2+ ratio is 5. Since emission intensity of Mn2+ is higher than that of Sn2+ in Radioluminescence compared to photoluminescence, it is suggested that energy transfer from the host matrix to Mn2+ center by X-ray occurred preferentially over energy transfer to Sn2+ center. The present results suggest that the conventional parity rule for photoluminescence is not always adaptable for Radioluminescence, although emission-related energy levels are the same for both the processes.