The Experts below are selected from a list of 114 Experts worldwide ranked by ideXlab platform
J. Adam Driscoll - One of the best experts on this subject based on the ideXlab platform.
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Influence of Geometry and Architecture on the In Vivo Success of 3D-Printed Scaffolds for Spinal Fusion.
Tissue engineering. Part A, 2020Co-Authors: Mitchell Hallman, J. Adam Driscoll, Ryan Lubbe, Soyeon Jeong, Kevin Y. Chang, Meraaj S. Haleem, Adam E. Jakus, Richard R. Pahapill, Chawon Yun, Ramille N. ShahAbstract:We previously developed a Recombinant Growth Factor-free, three-dimensional (3D)-printed material comprising hydroxyapatite (HA) and demineralized bone matrix (DBM) for bone regeneration. This mate...
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3D-Printed Ceramic-Demineralized Bone Matrix Hyperelastic Bone Composite Scaffolds for Spinal Fusion
Tissue engineering. Part A, 2019Co-Authors: J. Adam Driscoll, Ryan Lubbe, Kevin Y. Chang, Meraaj S. Haleem, Adam E. Jakus, Chawon Yun, Gurmit Singh, Andrew D. Schneider, Karina M. Katchko, Carmen SorianoAbstract:Although numerous spinal biologics are commercially available, a cost-effective and safe bone graft substitute material for spine fusion has yet to be proven. In this study, "3D-Paints" containing varying volumetric ratios of hydroxyapatite (HA) and human demineralized bone matrix (DBM) in a poly(lactide-co-glycolide) elastomer were three-dimensional (3D) printed into scaffolds to promote osteointegration in rats, with an end goal of spine fusion without the need for Recombinant Growth Factor. Spine fusion was evaluated by manual palpation, and osteointegration and de novo bone formation within scaffold struts were evaluated by laboratory and synchrotron microcomputed tomography and histology. The 3:1 HA:DBM composite achieved the highest mean fusion score and fusion rate (92%), which was significantly greater than the 3D printed DBM-only scaffold (42%). New bone was identified extending from the host transverse processes into the scaffold macropores, and osteointegration scores correlated with successful fusion. Strikingly, the combination of HA and DBM resulted in the Growth of bone-like spicules within the DBM particles inside scaffold struts. These spicules were not observed in DBM-only scaffolds, suggesting that de novo spicule formation requires both HA and DBM. Collectively, our work suggests that this Recombinant Growth Factor-free composite shows promise to overcome the limitations of currently used bone graft substitutes for spine fusion. Impact Statement Currently, there exists a no safe, yet highly effective, bone graft substitute that is well accepted for use in spine fusion procedures. With this work, we show that a three-dimensional printed scaffold containing osteoconductive hydroxyapatite and osteoinductive demineralized bone matrix that promotes new bone spicule formation, osteointegration, and successful fusion (stabilization) when implemented in a preclinical model of spine fusion. Our study suggests that this material shows promise as a Recombinant Growth Factor-free bone graft substitute that could safely promote high rates of successful fusion and improve patient care.
Carmen Soriano - One of the best experts on this subject based on the ideXlab platform.
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3D-Printed Ceramic-Demineralized Bone Matrix Hyperelastic Bone Composite Scaffolds for Spinal Fusion
Tissue engineering. Part A, 2019Co-Authors: J. Adam Driscoll, Ryan Lubbe, Kevin Y. Chang, Meraaj S. Haleem, Adam E. Jakus, Chawon Yun, Gurmit Singh, Andrew D. Schneider, Karina M. Katchko, Carmen SorianoAbstract:Although numerous spinal biologics are commercially available, a cost-effective and safe bone graft substitute material for spine fusion has yet to be proven. In this study, "3D-Paints" containing varying volumetric ratios of hydroxyapatite (HA) and human demineralized bone matrix (DBM) in a poly(lactide-co-glycolide) elastomer were three-dimensional (3D) printed into scaffolds to promote osteointegration in rats, with an end goal of spine fusion without the need for Recombinant Growth Factor. Spine fusion was evaluated by manual palpation, and osteointegration and de novo bone formation within scaffold struts were evaluated by laboratory and synchrotron microcomputed tomography and histology. The 3:1 HA:DBM composite achieved the highest mean fusion score and fusion rate (92%), which was significantly greater than the 3D printed DBM-only scaffold (42%). New bone was identified extending from the host transverse processes into the scaffold macropores, and osteointegration scores correlated with successful fusion. Strikingly, the combination of HA and DBM resulted in the Growth of bone-like spicules within the DBM particles inside scaffold struts. These spicules were not observed in DBM-only scaffolds, suggesting that de novo spicule formation requires both HA and DBM. Collectively, our work suggests that this Recombinant Growth Factor-free composite shows promise to overcome the limitations of currently used bone graft substitutes for spine fusion. Impact Statement Currently, there exists a no safe, yet highly effective, bone graft substitute that is well accepted for use in spine fusion procedures. With this work, we show that a three-dimensional printed scaffold containing osteoconductive hydroxyapatite and osteoinductive demineralized bone matrix that promotes new bone spicule formation, osteointegration, and successful fusion (stabilization) when implemented in a preclinical model of spine fusion. Our study suggests that this material shows promise as a Recombinant Growth Factor-free bone graft substitute that could safely promote high rates of successful fusion and improve patient care.
Kevin Y. Chang - One of the best experts on this subject based on the ideXlab platform.
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Influence of Geometry and Architecture on the In Vivo Success of 3D-Printed Scaffolds for Spinal Fusion.
Tissue engineering. Part A, 2020Co-Authors: Mitchell Hallman, J. Adam Driscoll, Ryan Lubbe, Soyeon Jeong, Kevin Y. Chang, Meraaj S. Haleem, Adam E. Jakus, Richard R. Pahapill, Chawon Yun, Ramille N. ShahAbstract:We previously developed a Recombinant Growth Factor-free, three-dimensional (3D)-printed material comprising hydroxyapatite (HA) and demineralized bone matrix (DBM) for bone regeneration. This mate...
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3D-Printed Ceramic-Demineralized Bone Matrix Hyperelastic Bone Composite Scaffolds for Spinal Fusion
Tissue engineering. Part A, 2019Co-Authors: J. Adam Driscoll, Ryan Lubbe, Kevin Y. Chang, Meraaj S. Haleem, Adam E. Jakus, Chawon Yun, Gurmit Singh, Andrew D. Schneider, Karina M. Katchko, Carmen SorianoAbstract:Although numerous spinal biologics are commercially available, a cost-effective and safe bone graft substitute material for spine fusion has yet to be proven. In this study, "3D-Paints" containing varying volumetric ratios of hydroxyapatite (HA) and human demineralized bone matrix (DBM) in a poly(lactide-co-glycolide) elastomer were three-dimensional (3D) printed into scaffolds to promote osteointegration in rats, with an end goal of spine fusion without the need for Recombinant Growth Factor. Spine fusion was evaluated by manual palpation, and osteointegration and de novo bone formation within scaffold struts were evaluated by laboratory and synchrotron microcomputed tomography and histology. The 3:1 HA:DBM composite achieved the highest mean fusion score and fusion rate (92%), which was significantly greater than the 3D printed DBM-only scaffold (42%). New bone was identified extending from the host transverse processes into the scaffold macropores, and osteointegration scores correlated with successful fusion. Strikingly, the combination of HA and DBM resulted in the Growth of bone-like spicules within the DBM particles inside scaffold struts. These spicules were not observed in DBM-only scaffolds, suggesting that de novo spicule formation requires both HA and DBM. Collectively, our work suggests that this Recombinant Growth Factor-free composite shows promise to overcome the limitations of currently used bone graft substitutes for spine fusion. Impact Statement Currently, there exists a no safe, yet highly effective, bone graft substitute that is well accepted for use in spine fusion procedures. With this work, we show that a three-dimensional printed scaffold containing osteoconductive hydroxyapatite and osteoinductive demineralized bone matrix that promotes new bone spicule formation, osteointegration, and successful fusion (stabilization) when implemented in a preclinical model of spine fusion. Our study suggests that this material shows promise as a Recombinant Growth Factor-free bone graft substitute that could safely promote high rates of successful fusion and improve patient care.
Chawon Yun - One of the best experts on this subject based on the ideXlab platform.
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Influence of Geometry and Architecture on the In Vivo Success of 3D-Printed Scaffolds for Spinal Fusion.
Tissue engineering. Part A, 2020Co-Authors: Mitchell Hallman, J. Adam Driscoll, Ryan Lubbe, Soyeon Jeong, Kevin Y. Chang, Meraaj S. Haleem, Adam E. Jakus, Richard R. Pahapill, Chawon Yun, Ramille N. ShahAbstract:We previously developed a Recombinant Growth Factor-free, three-dimensional (3D)-printed material comprising hydroxyapatite (HA) and demineralized bone matrix (DBM) for bone regeneration. This mate...
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3D-Printed Ceramic-Demineralized Bone Matrix Hyperelastic Bone Composite Scaffolds for Spinal Fusion
Tissue engineering. Part A, 2019Co-Authors: J. Adam Driscoll, Ryan Lubbe, Kevin Y. Chang, Meraaj S. Haleem, Adam E. Jakus, Chawon Yun, Gurmit Singh, Andrew D. Schneider, Karina M. Katchko, Carmen SorianoAbstract:Although numerous spinal biologics are commercially available, a cost-effective and safe bone graft substitute material for spine fusion has yet to be proven. In this study, "3D-Paints" containing varying volumetric ratios of hydroxyapatite (HA) and human demineralized bone matrix (DBM) in a poly(lactide-co-glycolide) elastomer were three-dimensional (3D) printed into scaffolds to promote osteointegration in rats, with an end goal of spine fusion without the need for Recombinant Growth Factor. Spine fusion was evaluated by manual palpation, and osteointegration and de novo bone formation within scaffold struts were evaluated by laboratory and synchrotron microcomputed tomography and histology. The 3:1 HA:DBM composite achieved the highest mean fusion score and fusion rate (92%), which was significantly greater than the 3D printed DBM-only scaffold (42%). New bone was identified extending from the host transverse processes into the scaffold macropores, and osteointegration scores correlated with successful fusion. Strikingly, the combination of HA and DBM resulted in the Growth of bone-like spicules within the DBM particles inside scaffold struts. These spicules were not observed in DBM-only scaffolds, suggesting that de novo spicule formation requires both HA and DBM. Collectively, our work suggests that this Recombinant Growth Factor-free composite shows promise to overcome the limitations of currently used bone graft substitutes for spine fusion. Impact Statement Currently, there exists a no safe, yet highly effective, bone graft substitute that is well accepted for use in spine fusion procedures. With this work, we show that a three-dimensional printed scaffold containing osteoconductive hydroxyapatite and osteoinductive demineralized bone matrix that promotes new bone spicule formation, osteointegration, and successful fusion (stabilization) when implemented in a preclinical model of spine fusion. Our study suggests that this material shows promise as a Recombinant Growth Factor-free bone graft substitute that could safely promote high rates of successful fusion and improve patient care.
Meraaj S. Haleem - One of the best experts on this subject based on the ideXlab platform.
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Influence of Geometry and Architecture on the In Vivo Success of 3D-Printed Scaffolds for Spinal Fusion.
Tissue engineering. Part A, 2020Co-Authors: Mitchell Hallman, J. Adam Driscoll, Ryan Lubbe, Soyeon Jeong, Kevin Y. Chang, Meraaj S. Haleem, Adam E. Jakus, Richard R. Pahapill, Chawon Yun, Ramille N. ShahAbstract:We previously developed a Recombinant Growth Factor-free, three-dimensional (3D)-printed material comprising hydroxyapatite (HA) and demineralized bone matrix (DBM) for bone regeneration. This mate...
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3D-Printed Ceramic-Demineralized Bone Matrix Hyperelastic Bone Composite Scaffolds for Spinal Fusion
Tissue engineering. Part A, 2019Co-Authors: J. Adam Driscoll, Ryan Lubbe, Kevin Y. Chang, Meraaj S. Haleem, Adam E. Jakus, Chawon Yun, Gurmit Singh, Andrew D. Schneider, Karina M. Katchko, Carmen SorianoAbstract:Although numerous spinal biologics are commercially available, a cost-effective and safe bone graft substitute material for spine fusion has yet to be proven. In this study, "3D-Paints" containing varying volumetric ratios of hydroxyapatite (HA) and human demineralized bone matrix (DBM) in a poly(lactide-co-glycolide) elastomer were three-dimensional (3D) printed into scaffolds to promote osteointegration in rats, with an end goal of spine fusion without the need for Recombinant Growth Factor. Spine fusion was evaluated by manual palpation, and osteointegration and de novo bone formation within scaffold struts were evaluated by laboratory and synchrotron microcomputed tomography and histology. The 3:1 HA:DBM composite achieved the highest mean fusion score and fusion rate (92%), which was significantly greater than the 3D printed DBM-only scaffold (42%). New bone was identified extending from the host transverse processes into the scaffold macropores, and osteointegration scores correlated with successful fusion. Strikingly, the combination of HA and DBM resulted in the Growth of bone-like spicules within the DBM particles inside scaffold struts. These spicules were not observed in DBM-only scaffolds, suggesting that de novo spicule formation requires both HA and DBM. Collectively, our work suggests that this Recombinant Growth Factor-free composite shows promise to overcome the limitations of currently used bone graft substitutes for spine fusion. Impact Statement Currently, there exists a no safe, yet highly effective, bone graft substitute that is well accepted for use in spine fusion procedures. With this work, we show that a three-dimensional printed scaffold containing osteoconductive hydroxyapatite and osteoinductive demineralized bone matrix that promotes new bone spicule formation, osteointegration, and successful fusion (stabilization) when implemented in a preclinical model of spine fusion. Our study suggests that this material shows promise as a Recombinant Growth Factor-free bone graft substitute that could safely promote high rates of successful fusion and improve patient care.