The Experts below are selected from a list of 45 Experts worldwide ranked by ideXlab platform

Wendyl Dsouza - One of the best experts on this subject based on the ideXlab platform.

  • electroencephalography in the diagnosis of genetic generalized epilepsy syndromes
    Frontiers in Neurology, 2017
    Co-Authors: Udaya Seneviratne, Mark J. Cook, Wendyl Dsouza
    Abstract:

    Genetic generalized epilepsy (GGE) consists of several syndromes diagnosed and classified on the basis of clinical and electroencephalographic (EEG) features. The EEG signature of GGE is bisynchronous, symmetric and generalized spike-wave complex. Other typical EEG features include polyspikes, polyspike-wave discharges, occipital intermittent rhythmic delta activity, eye-closure sensitivity, fixation-off sensitivity and photoparoxysmal response. However, admixed with typical changes, atypical epileptiform discharges are also commonly seen in GGE. There are circadian variations of generalized epileptiform discharges. Activation procedures such as sleep, sleep deprivation, hyperventilation, intermittent photic stimulation, eye closure and fixation-off are useful techniques to increase the yield of EEG abnormalities. Specific triggers such as pattern stimulation and cognitive tasks are useful in eliciting Reflex Seizure-related EEG abnormalities in selected patients. Distinct electrographic abnormalities to help classification can be identified among different electroclinical syndromes.

  • the electroencephalogram of idiopathic generalized epilepsy
    Epilepsia, 2012
    Co-Authors: Udaya Seneviratne, Mark J. Cook, Wendyl Dsouza
    Abstract:

    Idiopathic generalized epilepsy (IGE) is classified into several subsyndromes based on clinical and electroencephalography (EEG) features. The EEG signature of IGE is bisynchronous, symmetric, and generalized spike-wave complex; although focal, irregular, and so called "fragments" of discharges are not uncommon. Other characteristic EEG features include polyspikes, polyspike-wave discharges, occipital intermittent rhythmic delta activity, and photoparoxysmal response. Both human and animal data suggest involvement of the thalamus and the cortex in the generation of spike-wave discharges in IGE. Circadian variations of generalized epileptiform discharges are well described, and these can be useful in diagnostic confirmation. Those discharges tend to occur more often after awakening and during cyclic alternating pattern phase-A of non-rapid eye movement sleep. Activation procedures such as hyperventilation, intermittent photic stimulation, eye closure, and fixation-off are useful techniques to increase the yield of both interictal and ictal EEG abnormalities. Although not in routine use, specific triggers such as pattern stimulation and cognitive tasks may also be of value in eliciting rare Reflex Seizure-related EEG abnormalities. Variations of EEG abnormalities are evident between different electroclinical syndromes. EEG is also affected by certain external as well as internal factors, which should be borne in mind when interpreting EEG studies in IGE.

Udaya Seneviratne - One of the best experts on this subject based on the ideXlab platform.

  • electroencephalography in the diagnosis of genetic generalized epilepsy syndromes
    Frontiers in Neurology, 2017
    Co-Authors: Udaya Seneviratne, Mark J. Cook, Wendyl Dsouza
    Abstract:

    Genetic generalized epilepsy (GGE) consists of several syndromes diagnosed and classified on the basis of clinical and electroencephalographic (EEG) features. The EEG signature of GGE is bisynchronous, symmetric and generalized spike-wave complex. Other typical EEG features include polyspikes, polyspike-wave discharges, occipital intermittent rhythmic delta activity, eye-closure sensitivity, fixation-off sensitivity and photoparoxysmal response. However, admixed with typical changes, atypical epileptiform discharges are also commonly seen in GGE. There are circadian variations of generalized epileptiform discharges. Activation procedures such as sleep, sleep deprivation, hyperventilation, intermittent photic stimulation, eye closure and fixation-off are useful techniques to increase the yield of EEG abnormalities. Specific triggers such as pattern stimulation and cognitive tasks are useful in eliciting Reflex Seizure-related EEG abnormalities in selected patients. Distinct electrographic abnormalities to help classification can be identified among different electroclinical syndromes.

  • Electroencephalography in the Diagnosis of Genetic Generalized Epilepsy Syndromes
    Frontiers Media S.A., 2017
    Co-Authors: Udaya Seneviratne, Mark J. Cook, Wendyl Jude D’souza
    Abstract:

    Genetic generalized epilepsy (GGE) consists of several syndromes diagnosed and classified on the basis of clinical features and electroencephalographic (EEG) abnormalities. The main EEG feature of GGE is bilateral, synchronous, symmetric, and generalized spike-wave complex. Other classic EEG abnormalities are polyspikes, epileptiform K-complexes and sleep spindles, polyspike-wave discharges, occipital intermittent rhythmic delta activity, eye-closure sensitivity, fixation-off sensitivity, and photoparoxysmal response. However, admixed with typical changes, atypical epileptiform discharges are also commonly seen in GGE. There are circadian variations of generalized epileptiform discharges. Sleep, sleep deprivation, hyperventilation, intermittent photic stimulation, eye closure, and fixation-off are often used as activation techniques to increase the diagnostic yield of EEG recordings. Reflex Seizure-related EEG abnormalities can be elicited by the use of triggers such as cognitive tasks and pattern stimulation during the EEG recording in selected patients. Distinct electrographic abnormalities to help classification can be identified among different electroclinical syndromes

  • the electroencephalogram of idiopathic generalized epilepsy
    Epilepsia, 2012
    Co-Authors: Udaya Seneviratne, Mark J. Cook, Wendyl Dsouza
    Abstract:

    Idiopathic generalized epilepsy (IGE) is classified into several subsyndromes based on clinical and electroencephalography (EEG) features. The EEG signature of IGE is bisynchronous, symmetric, and generalized spike-wave complex; although focal, irregular, and so called "fragments" of discharges are not uncommon. Other characteristic EEG features include polyspikes, polyspike-wave discharges, occipital intermittent rhythmic delta activity, and photoparoxysmal response. Both human and animal data suggest involvement of the thalamus and the cortex in the generation of spike-wave discharges in IGE. Circadian variations of generalized epileptiform discharges are well described, and these can be useful in diagnostic confirmation. Those discharges tend to occur more often after awakening and during cyclic alternating pattern phase-A of non-rapid eye movement sleep. Activation procedures such as hyperventilation, intermittent photic stimulation, eye closure, and fixation-off are useful techniques to increase the yield of both interictal and ictal EEG abnormalities. Although not in routine use, specific triggers such as pattern stimulation and cognitive tasks may also be of value in eliciting rare Reflex Seizure-related EEG abnormalities. Variations of EEG abnormalities are evident between different electroclinical syndromes. EEG is also affected by certain external as well as internal factors, which should be borne in mind when interpreting EEG studies in IGE.

Mark J. Cook - One of the best experts on this subject based on the ideXlab platform.

  • electroencephalography in the diagnosis of genetic generalized epilepsy syndromes
    Frontiers in Neurology, 2017
    Co-Authors: Udaya Seneviratne, Mark J. Cook, Wendyl Dsouza
    Abstract:

    Genetic generalized epilepsy (GGE) consists of several syndromes diagnosed and classified on the basis of clinical and electroencephalographic (EEG) features. The EEG signature of GGE is bisynchronous, symmetric and generalized spike-wave complex. Other typical EEG features include polyspikes, polyspike-wave discharges, occipital intermittent rhythmic delta activity, eye-closure sensitivity, fixation-off sensitivity and photoparoxysmal response. However, admixed with typical changes, atypical epileptiform discharges are also commonly seen in GGE. There are circadian variations of generalized epileptiform discharges. Activation procedures such as sleep, sleep deprivation, hyperventilation, intermittent photic stimulation, eye closure and fixation-off are useful techniques to increase the yield of EEG abnormalities. Specific triggers such as pattern stimulation and cognitive tasks are useful in eliciting Reflex Seizure-related EEG abnormalities in selected patients. Distinct electrographic abnormalities to help classification can be identified among different electroclinical syndromes.

  • Electroencephalography in the Diagnosis of Genetic Generalized Epilepsy Syndromes
    Frontiers Media S.A., 2017
    Co-Authors: Udaya Seneviratne, Mark J. Cook, Wendyl Jude D’souza
    Abstract:

    Genetic generalized epilepsy (GGE) consists of several syndromes diagnosed and classified on the basis of clinical features and electroencephalographic (EEG) abnormalities. The main EEG feature of GGE is bilateral, synchronous, symmetric, and generalized spike-wave complex. Other classic EEG abnormalities are polyspikes, epileptiform K-complexes and sleep spindles, polyspike-wave discharges, occipital intermittent rhythmic delta activity, eye-closure sensitivity, fixation-off sensitivity, and photoparoxysmal response. However, admixed with typical changes, atypical epileptiform discharges are also commonly seen in GGE. There are circadian variations of generalized epileptiform discharges. Sleep, sleep deprivation, hyperventilation, intermittent photic stimulation, eye closure, and fixation-off are often used as activation techniques to increase the diagnostic yield of EEG recordings. Reflex Seizure-related EEG abnormalities can be elicited by the use of triggers such as cognitive tasks and pattern stimulation during the EEG recording in selected patients. Distinct electrographic abnormalities to help classification can be identified among different electroclinical syndromes

  • the electroencephalogram of idiopathic generalized epilepsy
    Epilepsia, 2012
    Co-Authors: Udaya Seneviratne, Mark J. Cook, Wendyl Dsouza
    Abstract:

    Idiopathic generalized epilepsy (IGE) is classified into several subsyndromes based on clinical and electroencephalography (EEG) features. The EEG signature of IGE is bisynchronous, symmetric, and generalized spike-wave complex; although focal, irregular, and so called "fragments" of discharges are not uncommon. Other characteristic EEG features include polyspikes, polyspike-wave discharges, occipital intermittent rhythmic delta activity, and photoparoxysmal response. Both human and animal data suggest involvement of the thalamus and the cortex in the generation of spike-wave discharges in IGE. Circadian variations of generalized epileptiform discharges are well described, and these can be useful in diagnostic confirmation. Those discharges tend to occur more often after awakening and during cyclic alternating pattern phase-A of non-rapid eye movement sleep. Activation procedures such as hyperventilation, intermittent photic stimulation, eye closure, and fixation-off are useful techniques to increase the yield of both interictal and ictal EEG abnormalities. Although not in routine use, specific triggers such as pattern stimulation and cognitive tasks may also be of value in eliciting rare Reflex Seizure-related EEG abnormalities. Variations of EEG abnormalities are evident between different electroclinical syndromes. EEG is also affected by certain external as well as internal factors, which should be borne in mind when interpreting EEG studies in IGE.

Peter Huppke - One of the best experts on this subject based on the ideXlab platform.

  • a synaptic protein defect associated with Reflex Seizure disorder
    Neurology, 2019
    Co-Authors: Pasquale Striano, Peter Huppke
    Abstract:

    In this issue of Neurology® , Vlaskamp et al.1 report a multicenter, international (Australia, Italy, the Netherlands, Germany, the United States, and China), collaborative study analyzing the phenotypic spectrum associated with SYNGAP1 mutations with the aim of characterizing the epilepsy phenotypes and analyzing genotype-phenotype correlations. Mutations in SYNGAP1 were first identified in 2009 in patients with nonsyndromic intellectual disability and autism spectrum disorder and then recognized as an important cause of developmental delay and epileptic encephalopathy.2–4

Mike Glynn - One of the best experts on this subject based on the ideXlab platform.

  • ilae official report a practical clinical definition of epilepsy
    Epilepsia, 2014
    Co-Authors: Robert S Fisher, Carlos Acevedo, Alexis Arzimanoglou, Alicia Bogacz, Helen J Cross, Christian E Elger, Jerome Engel, Lars Forsgren, Jacqueline A French, Mike Glynn
    Abstract:

    Epilepsy was defined conceptually in 2005 as a disorder of the brain characterized by an enduring predisposition to generate epileptic Seizures. This definition is usually practically applied as having two unprovoked Seizures >24 h apart. The International League Against Epilepsy (ILAE) accepted recommendations of a task force altering the practical definition for special circumstances that do not meet the two unprovoked Seizures criteria. The task force proposed that epilepsy be considered to be a disease of the brain defined by any of the following conditions: (1) At least two unprovoked (or Reflex) Seizures occurring >24 h apart; (2) one unprovoked (or Reflex) Seizure and a probability of further Seizures similar to the general recurrence risk (at least 60%) after two unprovoked Seizures, occurring over the next 10 years; (3) diagnosis of an epilepsy syndrome. Epilepsy is considered to be resolved for individuals who either had an age-dependent epilepsy syndrome but are now past the applicable age or who have remained Seizure-free for the last 10 years and off antiSeizure medicines for at least the last 5 years. "Resolved" is not necessarily identical to the conventional view of "remission or "cure." Different practical definitions may be formed and used for various specific purposes. This revised definition of epilepsy brings the term in concordance with common use. A PowerPoint slide summarizing this article is available for download in the Supporting Information section here.