The Experts below are selected from a list of 171 Experts worldwide ranked by ideXlab platform

Alejandro Buchmann - One of the best experts on this subject based on the ideXlab platform.

  • Selective In-Place Appends for Real: Reducing Erases on Wear-prone DBMS Storage
    2017 IEEE 33rd International Conference on Data Engineering (ICDE), 2017
    Co-Authors: Sergey Hardock, Ilia Petrovy, Robert Gottstein, Alejandro Buchmann
    Abstract:

    In the present paper we demonstrate the novel technique to apply the recently proposed approach of In-Place Appends - overwrites on Flash without a prior erase operation. IPA can be applied selectively: only to DB-objects that have frequent and relatively small updates. To do so we couple IPA to the concept of NoFTL Regions, allowing the DBA to place update-intensive DB-objects into special IPA-enabled Regions. The decision about Region Configuration can be (semi-)automated by an advisor analyzing DB-log files in the background.

  • ICDE - Selective In-Place Appends for Real: Reducing Erases on Wear-prone DBMS Storage
    2017 IEEE 33rd International Conference on Data Engineering (ICDE), 2017
    Co-Authors: Sergey Hardock, Ilia Petrovy, Robert Gottstein, Alejandro Buchmann
    Abstract:

    Abstract-In the present paper we demonstrate the novel technique to apply the recently proposed approach of In-Place Appends - overwrites on Flash without a prior erase operation. IPA can be applied selectively: only to DB-objects that have frequent and relatively small updates. To do so we couple IPA to the concept of NoFTL Regions, allowing the DBA to place update-intensive DB-objects into special IPA-enabled Regions. The decision about Region Configuration can be (semi-)automated by an advisor analyzing DB-log files in the background.

Sergey Hardock - One of the best experts on this subject based on the ideXlab platform.

  • Selective In-Place Appends for Real: Reducing Erases on Wear-prone DBMS Storage
    2017 IEEE 33rd International Conference on Data Engineering (ICDE), 2017
    Co-Authors: Sergey Hardock, Ilia Petrovy, Robert Gottstein, Alejandro Buchmann
    Abstract:

    In the present paper we demonstrate the novel technique to apply the recently proposed approach of In-Place Appends - overwrites on Flash without a prior erase operation. IPA can be applied selectively: only to DB-objects that have frequent and relatively small updates. To do so we couple IPA to the concept of NoFTL Regions, allowing the DBA to place update-intensive DB-objects into special IPA-enabled Regions. The decision about Region Configuration can be (semi-)automated by an advisor analyzing DB-log files in the background.

  • ICDE - Selective In-Place Appends for Real: Reducing Erases on Wear-prone DBMS Storage
    2017 IEEE 33rd International Conference on Data Engineering (ICDE), 2017
    Co-Authors: Sergey Hardock, Ilia Petrovy, Robert Gottstein, Alejandro Buchmann
    Abstract:

    Abstract-In the present paper we demonstrate the novel technique to apply the recently proposed approach of In-Place Appends - overwrites on Flash without a prior erase operation. IPA can be applied selectively: only to DB-objects that have frequent and relatively small updates. To do so we couple IPA to the concept of NoFTL Regions, allowing the DBA to place update-intensive DB-objects into special IPA-enabled Regions. The decision about Region Configuration can be (semi-)automated by an advisor analyzing DB-log files in the background.

Ilia Petrovy - One of the best experts on this subject based on the ideXlab platform.

  • Selective In-Place Appends for Real: Reducing Erases on Wear-prone DBMS Storage
    2017 IEEE 33rd International Conference on Data Engineering (ICDE), 2017
    Co-Authors: Sergey Hardock, Ilia Petrovy, Robert Gottstein, Alejandro Buchmann
    Abstract:

    In the present paper we demonstrate the novel technique to apply the recently proposed approach of In-Place Appends - overwrites on Flash without a prior erase operation. IPA can be applied selectively: only to DB-objects that have frequent and relatively small updates. To do so we couple IPA to the concept of NoFTL Regions, allowing the DBA to place update-intensive DB-objects into special IPA-enabled Regions. The decision about Region Configuration can be (semi-)automated by an advisor analyzing DB-log files in the background.

  • ICDE - Selective In-Place Appends for Real: Reducing Erases on Wear-prone DBMS Storage
    2017 IEEE 33rd International Conference on Data Engineering (ICDE), 2017
    Co-Authors: Sergey Hardock, Ilia Petrovy, Robert Gottstein, Alejandro Buchmann
    Abstract:

    Abstract-In the present paper we demonstrate the novel technique to apply the recently proposed approach of In-Place Appends - overwrites on Flash without a prior erase operation. IPA can be applied selectively: only to DB-objects that have frequent and relatively small updates. To do so we couple IPA to the concept of NoFTL Regions, allowing the DBA to place update-intensive DB-objects into special IPA-enabled Regions. The decision about Region Configuration can be (semi-)automated by an advisor analyzing DB-log files in the background.

Robert Gottstein - One of the best experts on this subject based on the ideXlab platform.

  • Selective In-Place Appends for Real: Reducing Erases on Wear-prone DBMS Storage
    2017 IEEE 33rd International Conference on Data Engineering (ICDE), 2017
    Co-Authors: Sergey Hardock, Ilia Petrovy, Robert Gottstein, Alejandro Buchmann
    Abstract:

    In the present paper we demonstrate the novel technique to apply the recently proposed approach of In-Place Appends - overwrites on Flash without a prior erase operation. IPA can be applied selectively: only to DB-objects that have frequent and relatively small updates. To do so we couple IPA to the concept of NoFTL Regions, allowing the DBA to place update-intensive DB-objects into special IPA-enabled Regions. The decision about Region Configuration can be (semi-)automated by an advisor analyzing DB-log files in the background.

  • ICDE - Selective In-Place Appends for Real: Reducing Erases on Wear-prone DBMS Storage
    2017 IEEE 33rd International Conference on Data Engineering (ICDE), 2017
    Co-Authors: Sergey Hardock, Ilia Petrovy, Robert Gottstein, Alejandro Buchmann
    Abstract:

    Abstract-In the present paper we demonstrate the novel technique to apply the recently proposed approach of In-Place Appends - overwrites on Flash without a prior erase operation. IPA can be applied selectively: only to DB-objects that have frequent and relatively small updates. To do so we couple IPA to the concept of NoFTL Regions, allowing the DBA to place update-intensive DB-objects into special IPA-enabled Regions. The decision about Region Configuration can be (semi-)automated by an advisor analyzing DB-log files in the background.

Ronald E. Bontrop - One of the best experts on this subject based on the ideXlab platform.

  • DR haplotype diversity of the cynomolgus macaque as defined by its transcriptome
    Immunogenetics, 2012
    Co-Authors: Gaby G. M. Doxiadis, Annemiek J. M. Vos-rouweler, Nanine Groot, Nel Otting, Ronald E. Bontrop
    Abstract:

    The DR Region of particular primate species may display allelic polymorphism and gene copy number variation (Region Configuration polymorphism). The sum of these distinct types of polymorphism is defined as complexity. To date, however, the DR Region of cynomolgus macaques ( Macaca fascicularis ) has been poorly defined. Transcriptome analysis of a pedigreed colony, comprising animals from Indonesia and Indochina, revealed a total of 15 Mafa - DRA and 57 DRB alleles, specifying 28 different Region Configurations. The DRA alleles can be divided into two distinct lineages. One lineage is polymorphic, but the majority of the amino acid replacements map to the leader peptide. The second lineage is at best oligomorphic, and segregates with one specific Mafa-DRB allele. The number of Mafa-DRB genes ranges from two to five per haplotype. Due to the presence of pseudogenes, however, each haplotype encodes only one to three bona fide DRB transcripts. Depending on the Region Configuration in which the Mafa-DRB gene is embedded, identical alleles may display differential transcription levels. Region Configurations appear to have been generated by recombination-like events. When genes or gene segments are relocated, it seems plausible that they may be placed in the context of distinct transcription control elements. As such, DRB Region-related transcription level differences may add an extra layer of polymorphism to this section of the adaptive immune system.

  • Extensive DRB Region diversity in cynomolgus macaques: recombination as a driving force
    Immunogenetics, 2010
    Co-Authors: Gaby G. M. Doxiadis, Nanine Groot, Natasja G. Groot, Gabriëlle Rotmans, Annemiek J. M. Vos-rouweler, Ronald E. Bontrop
    Abstract:

    The DR Region of primate species is generally complex and displays diversity concerning the number and combination of distinct types of DRB genes present per Region Configuration. A highly variable short tandem repeat (STR) present in intron 2 of nearly all primate DRB genes can be utilized as a quick and accurate high through-put typing procedure. This approach resulted previously in the description of unique and haplotype-specific DRB-STR length patterns in humans, chimpanzees, and rhesus macaques. For the present study, a cohort of 230 cynomolgus monkeys, including self-sustaining breeding groups, has been examined. MtDNA analysis showed that most animals originated from the Indonesian islands, but some are derived from the mainland, south and north of the Isthmus of Kra. Haplotyping and subsequent sequencing resulted in the detection of 118 alleles, including 28 unreported ones. A total of 49 Mafa-DRB Region Configurations were detected, of which 28 have not yet been described. Humans and chimpanzees possess a low number of different DRB Region Configurations in concert with a high degree of allelic variation. In contrast, however, allelic heterogeneity within a given Mafa - DRB Configuration is even less frequently observed than in rhesus macaques. Several of these Region Configurations appear to have been generated by recombination-like events, most probably propagated by a retroviral element mapping within DRB6 pseudogenes, which are present on the majority of haplotypes. This undocumented high level of DRB Region Configuration-associated diversity most likely represents a species-specific strategy to cope with various pathogens.

  • Reshuffling of ancient peptide binding motifs between HLA-DRB multigene family members: old wine served in new skins.
    Molecular Immunology, 2008
    Co-Authors: Gaby G. M. Doxiadis, Nanine Groot, Natasja G. Groot, Ilias I.n. Doxiadis, Ronald E. Bontrop
    Abstract:

    In most primate species, the class II Region of the Major Histocompatibility Complex (MHC) displays diversity with regard to gene copy number and combination of DRB genes present per Region Configuration. Some of these loci exhibit extremely high levels of allelic variability, whereas others display only moderate levels of polymorphism. To understand the evolutionary history of the various HLA-DR Region genes, a large number of full-length sequences of rhesus macaques, chimpanzees and humans were determined. The exon–intron organisation of the DRA gene, displaying only low levels of polymorphism, appears to have been highly conserved during primate evolution. The physical length of various DRB genes/alleles, however, fluctuates significantly in primates due to the presence of indels (insertions/deletions), mainly mapping to intron 1. Phylogenetic evidence supports the notion that the generation of new DRB genes is a dynamic and steadily ongoing process. Indeed, most of the primate DRB alleles investigated represent relatively young entities, possessing species-unique sequences. This seems to contradict the current view that the highly similar peptide binding motifs of many HLA-, Patr- and Mamu-DR molecules, encoded by exon 2 of the DRB gene, represent old entities, which predate primate speciation. As no evidence was found for convergent evolution, the combination of these two observations indicates that ancient peptide binding motifs are frequently reshuffled among duplicated members of the HLA-DRB multigene family.

  • Impact of endogenous intronic retroviruses on major histocompatibility complex class II diversity and stability.
    Journal of Virology, 2008
    Co-Authors: Gaby G. M. Doxiadis, Nanine Groot, Ronald E. Bontrop
    Abstract:

    The major histocompatibility complex (MHC) represents a multigene family that is known to display allelic and gene copy number variations. Primate species such as humans, chimpanzees (Pan troglodytes), and rhesus macaques (Macaca mulatta) show DRB Region Configuration polymorphism at the population level, meaning that the number and content of DRB loci may vary per haplotype. Introns of primate DRB alleles differ significantly in length due to insertions of transposable elements as long endogenous retrovirus (ERV) and human ERV (HERV) sequences in the DRB2, DRB6, and DRB7 pseudogenes. Although the integration of intronic HERVs resulted sooner or later in the inactivation of the targeted genes, the fixation of these endogenous retroviral segments over long time spans seems to have provided evolutionary advantage. Intronic HERVs may have integrated in a sense or an antisense manner. On the one hand, antisense-oriented retroelements such as HERV-K14I, observed in intron 2 of the DRB7 genes in humans and chimpanzees, seem to promote stability, as Configurations/alleles containing these hits have experienced strong conservative selection during primate evolution. On the other hand, the HERVK3I present in intron 1 of all DRB2 and/or DRB6 alleles tested so far integrated in a sense orientation. The data suggest that multigenic Regions in particular may benefit from sense introgressions by HERVs, as these elements seem to promote and maintain the generation of diversity, whereas these types of integrations may be lethal in monogenic systems, since they are known to influence transcript regulation negatively.

  • A highly divergent microsatellite facilitating fast and accurate DRB haplotyping in humans and rhesus macaques.
    Proceedings of the National Academy of Sciences of the United States of America, 2007
    Co-Authors: Gaby G. M. Doxiadis, Nanine Groot, Jon J. Van Rood, Frans H.j. Claas, Ilias I.n. Doxiadis, Ronald E. Bontrop
    Abstract:

    The DRB Region of the MHC in primate species is known to display abundant Region Configuration polymorphism with regard to the number and content of genes present per haplotype. Furthermore, depending on the species studied, the different DRB genes themselves may display varying degrees of allelic polymorphism. Because of this combination of diversity (differential gene number) and polymorphism (allelic variation), molecular typing methods for the primate DRB Region are cumbersome. All intact DRB genes present in humans and rhesus macaques appear to possess, however, a complex and highly divergent microsatellite. Microsatellite analysis of a sizeable panel of outbred rhesus macaques, covering most of the known Mamu-DRB haplotypes, resulted in the definition of unique genotyping patterns that appear to be specific for a given haplotype. Subsequent examination of a representative panel of human cells illustrated that this approach also facilitates high-resolution HLA-DRB typing in an easy, quick, and reproducible fashion. The genetic composition of this complex microsatellite is shown to be in concordance with the phylogenetic relationships of various HLA-DRB and Mamu-DRB exon 2 gene/lineage sequences. Moreover, its length variability segregates with allelic variation of the respective gene. This simple protocol may find application in a variety of research avenues such as transplantation biology, disease association studies, molecular ecology, paternity testing, and forensic medicine.