The Experts below are selected from a list of 42 Experts worldwide ranked by ideXlab platform

Yuxia Zhao - One of the best experts on this subject based on the ideXlab platform.

  • Rehmannia Glutinosa Extract activates endothelial progenitor cells in a rat model of myocardial infarction through a sdf 1 α cxcr4 cascade
    PLOS ONE, 2013
    Co-Authors: Yingbin Wang, Yunfang Liu, Fangfang Yan, Bo Wang, Wenwu Bai, Yuxia Zhao
    Abstract:

    Objectives Endothelial progenitor cells (EPCs) can be used to repair tissues after myocardial infarction (MI) but EPC activators have adverse reactions. Rehmannia Glutinosa is a herb used in traditional Chinese medicine, which can promote bone-marrow proliferation and protect the ischemic myocardium. We investigated the effects of Rehmannia Glutinosa Extract (RGE) on EPCs in a rat model of MI.

  • Rehmannia Glutinosa Extract activates endothelial progenitor cells in a rat model of myocardial infarction through a sdf 1 α cxcr4 cascade
    PLOS ONE, 2013
    Co-Authors: Yingbin Wang, Bo Wang, Xiaoting Lu, Yuxia Zhao
    Abstract:

    Objectives Endothelial progenitor cells (EPCs) can be used to repair tissues after myocardial infarction (MI) but EPC activators have adverse reactions. Rehmannia Glutinosa is a herb used in traditional Chinese medicine, which can promote bone-marrow proliferation and protect the ischemic myocardium. We investigated the effects of Rehmannia Glutinosa Extract (RGE) on EPCs in a rat model of MI. Methods A total of 120 male Wistar rats were randomized to 2 groups (n = 60 each) for treatment: high-dose RGE (1.5 g·kg−1·day−1 orally) for 8 weeks, then left anterior descending coronary artery ligation, mock surgery or no treatment, then RGE orally for 4 weeks; or normal saline (NS) as the above protocol. The infarct region of the left ventricle was assessed by serial sectioning and morphology. EPCs were evaluated by number and function. Protein and mRNA levels of CD133, vascular endothelial growth factor receptor 2 (VEGFR2), chemokine C-X-C motif receptor 4 (CXCR4), stromal cell–derived factor-1α (SDF-1α) were measured by immunohistochemistry, Western blot and quantitative PCR analysis. Results RGE significantly improved left ventricular function, decreased the ischemic area and the apoptotic index in the infarct myocardium, also decreased the concentration of serum cardiac troponin T and brain natriuretic peptide at the chronic stage after MI (from week 2 to week 4). RGE increased EPC number, proliferation, migration and tube-formation capacity. It was able to up-regulate the expression of angiogenesis-associated ligand/receptor, including CD133, VEGFR2 and SDF-1α/CXCR4. In vitro, the effect of RGE on SDF-1α/CXCR4 cascade was reversed by the CXCR4 specific antagonist AMD3100. Conclusion RGE may enhance the mobilization, migration and therapeutic angiogenesis of EPCs after MI by activating the SDF-1α/CXCR4 cascade.

  • Rehmannia Glutinosa Extract Activates Endothelial Progenitor Cells in a Rat Model of Myocardial Infarction through a SDF-1 α/CXCR4 Cascade
    2013
    Co-Authors: Yingbin Wang, Yunfang Liu, Fangfang Yan, Bo Wang, Wenwu Bai, Yuxia Zhao
    Abstract:

    ObjectivesEndothelial progenitor cells (EPCs) can be used to repair tissues after myocardial infarction (MI) but EPC activators have adverse reactions. Rehmannia Glutinosa is a herb used in traditional Chinese medicine, which can promote bone-marrow proliferation and protect the ischemic myocardium. We investigated the effects of Rehmannia Glutinosa Extract (RGE) on EPCs in a rat model of MI. MethodsA total of 120 male Wistar rats were randomized to 2 groups (n = 60 each) for treatment: high-dose RGE (1.5 g·kg−1·day−1 orally) for 8 weeks, then left anterior descending coronary artery ligation, mock surgery or no treatment, then RGE orally for 4 weeks; or normal saline (NS) as the above protocol. The infarct region of the left ventricle was assessed by serial sectioning and morphology. EPCs were evaluated by number and function. Protein and mRNA levels of CD133, vascular endothelial growth factor receptor 2 (VEGFR2), chemokine C-X-C motif receptor 4 (CXCR4), stromal cell–derived factor-1α (SDF-1α) were measured by immunohistochemistry, Western blot and quantitative PCR analysis. ResultsRGE significantly improved left ventricular function, decreased the ischemic area and the apoptotic index in the infarct myocardium, also decreased the concentration of serum cardiac troponin T and brain natriuretic peptide at the chronic stage after MI (from week 2 to week 4). RGE increased EPC number, proliferation, migration and tube-formation capacity. It was able to up-regulate the expression of angiogenesis-associated ligand/receptor, including CD133, VEGFR2 and SDF-1α/CXCR4. In vitro, the effect of RGE on SDF-1α/CXCR4 cascade was reversed by the CXCR4 specific antagonist AMD3100. ConclusionRGE may enhance the mobilization, migration and therapeutic angiogenesis of EPCs after MI by activating the SDF-1α/CXCR4 cascade.

  • Heart function and serum myocardium markers level of rats.
    2013
    Co-Authors: Yingbin Wang, Yunfang Liu, Fangfang Yan, Bo Wang, Wenwu Bai, Yuxia Zhao
    Abstract:

    (A) Electrocardiography (ECG) before and after myocardial infarction (MI). Leads I, II, III, aVR, aVL and aVF of normal (N) and MI rats. (B) Ultrasonic cardiography before and after MI. Images are M-mold (m) ultrasound and hemorheologic (h) ultrasound in normal and MI rats. (C) Left ventricular ejection fraction (LVEF) after MI. NS-b, normal saline (NS)-blank; NS-m, NS-mock; RGE-b, Rehmannia Glutinosa Extract (RGE)-blank; RGE-m, RGE-mock. (D) The levels of myocardium markers: cardiac troponin T (Tn-T) and brain natriuretic peptide (BNP). Data are mean ± SD. *P

Yingbin Wang - One of the best experts on this subject based on the ideXlab platform.

  • Rehmannia Glutinosa Extract activates endothelial progenitor cells in a rat model of myocardial infarction through a sdf 1 α cxcr4 cascade
    PLOS ONE, 2013
    Co-Authors: Yingbin Wang, Yunfang Liu, Fangfang Yan, Bo Wang, Wenwu Bai, Yuxia Zhao
    Abstract:

    Objectives Endothelial progenitor cells (EPCs) can be used to repair tissues after myocardial infarction (MI) but EPC activators have adverse reactions. Rehmannia Glutinosa is a herb used in traditional Chinese medicine, which can promote bone-marrow proliferation and protect the ischemic myocardium. We investigated the effects of Rehmannia Glutinosa Extract (RGE) on EPCs in a rat model of MI.

  • Rehmannia Glutinosa Extract activates endothelial progenitor cells in a rat model of myocardial infarction through a sdf 1 α cxcr4 cascade
    PLOS ONE, 2013
    Co-Authors: Yingbin Wang, Bo Wang, Xiaoting Lu, Yuxia Zhao
    Abstract:

    Objectives Endothelial progenitor cells (EPCs) can be used to repair tissues after myocardial infarction (MI) but EPC activators have adverse reactions. Rehmannia Glutinosa is a herb used in traditional Chinese medicine, which can promote bone-marrow proliferation and protect the ischemic myocardium. We investigated the effects of Rehmannia Glutinosa Extract (RGE) on EPCs in a rat model of MI. Methods A total of 120 male Wistar rats were randomized to 2 groups (n = 60 each) for treatment: high-dose RGE (1.5 g·kg−1·day−1 orally) for 8 weeks, then left anterior descending coronary artery ligation, mock surgery or no treatment, then RGE orally for 4 weeks; or normal saline (NS) as the above protocol. The infarct region of the left ventricle was assessed by serial sectioning and morphology. EPCs were evaluated by number and function. Protein and mRNA levels of CD133, vascular endothelial growth factor receptor 2 (VEGFR2), chemokine C-X-C motif receptor 4 (CXCR4), stromal cell–derived factor-1α (SDF-1α) were measured by immunohistochemistry, Western blot and quantitative PCR analysis. Results RGE significantly improved left ventricular function, decreased the ischemic area and the apoptotic index in the infarct myocardium, also decreased the concentration of serum cardiac troponin T and brain natriuretic peptide at the chronic stage after MI (from week 2 to week 4). RGE increased EPC number, proliferation, migration and tube-formation capacity. It was able to up-regulate the expression of angiogenesis-associated ligand/receptor, including CD133, VEGFR2 and SDF-1α/CXCR4. In vitro, the effect of RGE on SDF-1α/CXCR4 cascade was reversed by the CXCR4 specific antagonist AMD3100. Conclusion RGE may enhance the mobilization, migration and therapeutic angiogenesis of EPCs after MI by activating the SDF-1α/CXCR4 cascade.

  • Rehmannia Glutinosa Extract Activates Endothelial Progenitor Cells in a Rat Model of Myocardial Infarction through a SDF-1 α/CXCR4 Cascade
    2013
    Co-Authors: Yingbin Wang, Yunfang Liu, Fangfang Yan, Bo Wang, Wenwu Bai, Yuxia Zhao
    Abstract:

    ObjectivesEndothelial progenitor cells (EPCs) can be used to repair tissues after myocardial infarction (MI) but EPC activators have adverse reactions. Rehmannia Glutinosa is a herb used in traditional Chinese medicine, which can promote bone-marrow proliferation and protect the ischemic myocardium. We investigated the effects of Rehmannia Glutinosa Extract (RGE) on EPCs in a rat model of MI. MethodsA total of 120 male Wistar rats were randomized to 2 groups (n = 60 each) for treatment: high-dose RGE (1.5 g·kg−1·day−1 orally) for 8 weeks, then left anterior descending coronary artery ligation, mock surgery or no treatment, then RGE orally for 4 weeks; or normal saline (NS) as the above protocol. The infarct region of the left ventricle was assessed by serial sectioning and morphology. EPCs were evaluated by number and function. Protein and mRNA levels of CD133, vascular endothelial growth factor receptor 2 (VEGFR2), chemokine C-X-C motif receptor 4 (CXCR4), stromal cell–derived factor-1α (SDF-1α) were measured by immunohistochemistry, Western blot and quantitative PCR analysis. ResultsRGE significantly improved left ventricular function, decreased the ischemic area and the apoptotic index in the infarct myocardium, also decreased the concentration of serum cardiac troponin T and brain natriuretic peptide at the chronic stage after MI (from week 2 to week 4). RGE increased EPC number, proliferation, migration and tube-formation capacity. It was able to up-regulate the expression of angiogenesis-associated ligand/receptor, including CD133, VEGFR2 and SDF-1α/CXCR4. In vitro, the effect of RGE on SDF-1α/CXCR4 cascade was reversed by the CXCR4 specific antagonist AMD3100. ConclusionRGE may enhance the mobilization, migration and therapeutic angiogenesis of EPCs after MI by activating the SDF-1α/CXCR4 cascade.

  • Heart function and serum myocardium markers level of rats.
    2013
    Co-Authors: Yingbin Wang, Yunfang Liu, Fangfang Yan, Bo Wang, Wenwu Bai, Yuxia Zhao
    Abstract:

    (A) Electrocardiography (ECG) before and after myocardial infarction (MI). Leads I, II, III, aVR, aVL and aVF of normal (N) and MI rats. (B) Ultrasonic cardiography before and after MI. Images are M-mold (m) ultrasound and hemorheologic (h) ultrasound in normal and MI rats. (C) Left ventricular ejection fraction (LVEF) after MI. NS-b, normal saline (NS)-blank; NS-m, NS-mock; RGE-b, Rehmannia Glutinosa Extract (RGE)-blank; RGE-m, RGE-mock. (D) The levels of myocardium markers: cardiac troponin T (Tn-T) and brain natriuretic peptide (BNP). Data are mean ± SD. *P

Bo Wang - One of the best experts on this subject based on the ideXlab platform.

  • Rehmannia Glutinosa Extract activates endothelial progenitor cells in a rat model of myocardial infarction through a sdf 1 α cxcr4 cascade
    PLOS ONE, 2013
    Co-Authors: Yingbin Wang, Yunfang Liu, Fangfang Yan, Bo Wang, Wenwu Bai, Yuxia Zhao
    Abstract:

    Objectives Endothelial progenitor cells (EPCs) can be used to repair tissues after myocardial infarction (MI) but EPC activators have adverse reactions. Rehmannia Glutinosa is a herb used in traditional Chinese medicine, which can promote bone-marrow proliferation and protect the ischemic myocardium. We investigated the effects of Rehmannia Glutinosa Extract (RGE) on EPCs in a rat model of MI.

  • Rehmannia Glutinosa Extract activates endothelial progenitor cells in a rat model of myocardial infarction through a sdf 1 α cxcr4 cascade
    PLOS ONE, 2013
    Co-Authors: Yingbin Wang, Bo Wang, Xiaoting Lu, Yuxia Zhao
    Abstract:

    Objectives Endothelial progenitor cells (EPCs) can be used to repair tissues after myocardial infarction (MI) but EPC activators have adverse reactions. Rehmannia Glutinosa is a herb used in traditional Chinese medicine, which can promote bone-marrow proliferation and protect the ischemic myocardium. We investigated the effects of Rehmannia Glutinosa Extract (RGE) on EPCs in a rat model of MI. Methods A total of 120 male Wistar rats were randomized to 2 groups (n = 60 each) for treatment: high-dose RGE (1.5 g·kg−1·day−1 orally) for 8 weeks, then left anterior descending coronary artery ligation, mock surgery or no treatment, then RGE orally for 4 weeks; or normal saline (NS) as the above protocol. The infarct region of the left ventricle was assessed by serial sectioning and morphology. EPCs were evaluated by number and function. Protein and mRNA levels of CD133, vascular endothelial growth factor receptor 2 (VEGFR2), chemokine C-X-C motif receptor 4 (CXCR4), stromal cell–derived factor-1α (SDF-1α) were measured by immunohistochemistry, Western blot and quantitative PCR analysis. Results RGE significantly improved left ventricular function, decreased the ischemic area and the apoptotic index in the infarct myocardium, also decreased the concentration of serum cardiac troponin T and brain natriuretic peptide at the chronic stage after MI (from week 2 to week 4). RGE increased EPC number, proliferation, migration and tube-formation capacity. It was able to up-regulate the expression of angiogenesis-associated ligand/receptor, including CD133, VEGFR2 and SDF-1α/CXCR4. In vitro, the effect of RGE on SDF-1α/CXCR4 cascade was reversed by the CXCR4 specific antagonist AMD3100. Conclusion RGE may enhance the mobilization, migration and therapeutic angiogenesis of EPCs after MI by activating the SDF-1α/CXCR4 cascade.

  • Rehmannia Glutinosa Extract Activates Endothelial Progenitor Cells in a Rat Model of Myocardial Infarction through a SDF-1 α/CXCR4 Cascade
    2013
    Co-Authors: Yingbin Wang, Yunfang Liu, Fangfang Yan, Bo Wang, Wenwu Bai, Yuxia Zhao
    Abstract:

    ObjectivesEndothelial progenitor cells (EPCs) can be used to repair tissues after myocardial infarction (MI) but EPC activators have adverse reactions. Rehmannia Glutinosa is a herb used in traditional Chinese medicine, which can promote bone-marrow proliferation and protect the ischemic myocardium. We investigated the effects of Rehmannia Glutinosa Extract (RGE) on EPCs in a rat model of MI. MethodsA total of 120 male Wistar rats were randomized to 2 groups (n = 60 each) for treatment: high-dose RGE (1.5 g·kg−1·day−1 orally) for 8 weeks, then left anterior descending coronary artery ligation, mock surgery or no treatment, then RGE orally for 4 weeks; or normal saline (NS) as the above protocol. The infarct region of the left ventricle was assessed by serial sectioning and morphology. EPCs were evaluated by number and function. Protein and mRNA levels of CD133, vascular endothelial growth factor receptor 2 (VEGFR2), chemokine C-X-C motif receptor 4 (CXCR4), stromal cell–derived factor-1α (SDF-1α) were measured by immunohistochemistry, Western blot and quantitative PCR analysis. ResultsRGE significantly improved left ventricular function, decreased the ischemic area and the apoptotic index in the infarct myocardium, also decreased the concentration of serum cardiac troponin T and brain natriuretic peptide at the chronic stage after MI (from week 2 to week 4). RGE increased EPC number, proliferation, migration and tube-formation capacity. It was able to up-regulate the expression of angiogenesis-associated ligand/receptor, including CD133, VEGFR2 and SDF-1α/CXCR4. In vitro, the effect of RGE on SDF-1α/CXCR4 cascade was reversed by the CXCR4 specific antagonist AMD3100. ConclusionRGE may enhance the mobilization, migration and therapeutic angiogenesis of EPCs after MI by activating the SDF-1α/CXCR4 cascade.

  • Heart function and serum myocardium markers level of rats.
    2013
    Co-Authors: Yingbin Wang, Yunfang Liu, Fangfang Yan, Bo Wang, Wenwu Bai, Yuxia Zhao
    Abstract:

    (A) Electrocardiography (ECG) before and after myocardial infarction (MI). Leads I, II, III, aVR, aVL and aVF of normal (N) and MI rats. (B) Ultrasonic cardiography before and after MI. Images are M-mold (m) ultrasound and hemorheologic (h) ultrasound in normal and MI rats. (C) Left ventricular ejection fraction (LVEF) after MI. NS-b, normal saline (NS)-blank; NS-m, NS-mock; RGE-b, Rehmannia Glutinosa Extract (RGE)-blank; RGE-m, RGE-mock. (D) The levels of myocardium markers: cardiac troponin T (Tn-T) and brain natriuretic peptide (BNP). Data are mean ± SD. *P

Wenwu Bai - One of the best experts on this subject based on the ideXlab platform.

  • Rehmannia Glutinosa Extract activates endothelial progenitor cells in a rat model of myocardial infarction through a sdf 1 α cxcr4 cascade
    PLOS ONE, 2013
    Co-Authors: Yingbin Wang, Yunfang Liu, Fangfang Yan, Bo Wang, Wenwu Bai, Yuxia Zhao
    Abstract:

    Objectives Endothelial progenitor cells (EPCs) can be used to repair tissues after myocardial infarction (MI) but EPC activators have adverse reactions. Rehmannia Glutinosa is a herb used in traditional Chinese medicine, which can promote bone-marrow proliferation and protect the ischemic myocardium. We investigated the effects of Rehmannia Glutinosa Extract (RGE) on EPCs in a rat model of MI.

  • Rehmannia Glutinosa Extract Activates Endothelial Progenitor Cells in a Rat Model of Myocardial Infarction through a SDF-1 α/CXCR4 Cascade
    2013
    Co-Authors: Yingbin Wang, Yunfang Liu, Fangfang Yan, Bo Wang, Wenwu Bai, Yuxia Zhao
    Abstract:

    ObjectivesEndothelial progenitor cells (EPCs) can be used to repair tissues after myocardial infarction (MI) but EPC activators have adverse reactions. Rehmannia Glutinosa is a herb used in traditional Chinese medicine, which can promote bone-marrow proliferation and protect the ischemic myocardium. We investigated the effects of Rehmannia Glutinosa Extract (RGE) on EPCs in a rat model of MI. MethodsA total of 120 male Wistar rats were randomized to 2 groups (n = 60 each) for treatment: high-dose RGE (1.5 g·kg−1·day−1 orally) for 8 weeks, then left anterior descending coronary artery ligation, mock surgery or no treatment, then RGE orally for 4 weeks; or normal saline (NS) as the above protocol. The infarct region of the left ventricle was assessed by serial sectioning and morphology. EPCs were evaluated by number and function. Protein and mRNA levels of CD133, vascular endothelial growth factor receptor 2 (VEGFR2), chemokine C-X-C motif receptor 4 (CXCR4), stromal cell–derived factor-1α (SDF-1α) were measured by immunohistochemistry, Western blot and quantitative PCR analysis. ResultsRGE significantly improved left ventricular function, decreased the ischemic area and the apoptotic index in the infarct myocardium, also decreased the concentration of serum cardiac troponin T and brain natriuretic peptide at the chronic stage after MI (from week 2 to week 4). RGE increased EPC number, proliferation, migration and tube-formation capacity. It was able to up-regulate the expression of angiogenesis-associated ligand/receptor, including CD133, VEGFR2 and SDF-1α/CXCR4. In vitro, the effect of RGE on SDF-1α/CXCR4 cascade was reversed by the CXCR4 specific antagonist AMD3100. ConclusionRGE may enhance the mobilization, migration and therapeutic angiogenesis of EPCs after MI by activating the SDF-1α/CXCR4 cascade.

  • Heart function and serum myocardium markers level of rats.
    2013
    Co-Authors: Yingbin Wang, Yunfang Liu, Fangfang Yan, Bo Wang, Wenwu Bai, Yuxia Zhao
    Abstract:

    (A) Electrocardiography (ECG) before and after myocardial infarction (MI). Leads I, II, III, aVR, aVL and aVF of normal (N) and MI rats. (B) Ultrasonic cardiography before and after MI. Images are M-mold (m) ultrasound and hemorheologic (h) ultrasound in normal and MI rats. (C) Left ventricular ejection fraction (LVEF) after MI. NS-b, normal saline (NS)-blank; NS-m, NS-mock; RGE-b, Rehmannia Glutinosa Extract (RGE)-blank; RGE-m, RGE-mock. (D) The levels of myocardium markers: cardiac troponin T (Tn-T) and brain natriuretic peptide (BNP). Data are mean ± SD. *P

Yunfang Liu - One of the best experts on this subject based on the ideXlab platform.

  • Rehmannia Glutinosa Extract activates endothelial progenitor cells in a rat model of myocardial infarction through a sdf 1 α cxcr4 cascade
    PLOS ONE, 2013
    Co-Authors: Yingbin Wang, Yunfang Liu, Fangfang Yan, Bo Wang, Wenwu Bai, Yuxia Zhao
    Abstract:

    Objectives Endothelial progenitor cells (EPCs) can be used to repair tissues after myocardial infarction (MI) but EPC activators have adverse reactions. Rehmannia Glutinosa is a herb used in traditional Chinese medicine, which can promote bone-marrow proliferation and protect the ischemic myocardium. We investigated the effects of Rehmannia Glutinosa Extract (RGE) on EPCs in a rat model of MI.

  • Rehmannia Glutinosa Extract Activates Endothelial Progenitor Cells in a Rat Model of Myocardial Infarction through a SDF-1 α/CXCR4 Cascade
    2013
    Co-Authors: Yingbin Wang, Yunfang Liu, Fangfang Yan, Bo Wang, Wenwu Bai, Yuxia Zhao
    Abstract:

    ObjectivesEndothelial progenitor cells (EPCs) can be used to repair tissues after myocardial infarction (MI) but EPC activators have adverse reactions. Rehmannia Glutinosa is a herb used in traditional Chinese medicine, which can promote bone-marrow proliferation and protect the ischemic myocardium. We investigated the effects of Rehmannia Glutinosa Extract (RGE) on EPCs in a rat model of MI. MethodsA total of 120 male Wistar rats were randomized to 2 groups (n = 60 each) for treatment: high-dose RGE (1.5 g·kg−1·day−1 orally) for 8 weeks, then left anterior descending coronary artery ligation, mock surgery or no treatment, then RGE orally for 4 weeks; or normal saline (NS) as the above protocol. The infarct region of the left ventricle was assessed by serial sectioning and morphology. EPCs were evaluated by number and function. Protein and mRNA levels of CD133, vascular endothelial growth factor receptor 2 (VEGFR2), chemokine C-X-C motif receptor 4 (CXCR4), stromal cell–derived factor-1α (SDF-1α) were measured by immunohistochemistry, Western blot and quantitative PCR analysis. ResultsRGE significantly improved left ventricular function, decreased the ischemic area and the apoptotic index in the infarct myocardium, also decreased the concentration of serum cardiac troponin T and brain natriuretic peptide at the chronic stage after MI (from week 2 to week 4). RGE increased EPC number, proliferation, migration and tube-formation capacity. It was able to up-regulate the expression of angiogenesis-associated ligand/receptor, including CD133, VEGFR2 and SDF-1α/CXCR4. In vitro, the effect of RGE on SDF-1α/CXCR4 cascade was reversed by the CXCR4 specific antagonist AMD3100. ConclusionRGE may enhance the mobilization, migration and therapeutic angiogenesis of EPCs after MI by activating the SDF-1α/CXCR4 cascade.

  • Heart function and serum myocardium markers level of rats.
    2013
    Co-Authors: Yingbin Wang, Yunfang Liu, Fangfang Yan, Bo Wang, Wenwu Bai, Yuxia Zhao
    Abstract:

    (A) Electrocardiography (ECG) before and after myocardial infarction (MI). Leads I, II, III, aVR, aVL and aVF of normal (N) and MI rats. (B) Ultrasonic cardiography before and after MI. Images are M-mold (m) ultrasound and hemorheologic (h) ultrasound in normal and MI rats. (C) Left ventricular ejection fraction (LVEF) after MI. NS-b, normal saline (NS)-blank; NS-m, NS-mock; RGE-b, Rehmannia Glutinosa Extract (RGE)-blank; RGE-m, RGE-mock. (D) The levels of myocardium markers: cardiac troponin T (Tn-T) and brain natriuretic peptide (BNP). Data are mean ± SD. *P