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David A Bennett - One of the best experts on this subject based on the ideXlab platform.
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epigenetic age of the pre frontal cortex is associated with neuritic plaques amyloid load and alzheimer s disease related cognitive functioning
Aging (Albany NY), 2015Co-Authors: Morgan E Levine, David A Bennett, Ake T Lu, Steve HorvathAbstract:There is an urgent need to develop molecular biomarkers of brain age in Order to advance our understanding of age related neurodegeneration. Recently, we developed a highly accurate epigenetic biomarker of tissue age (known as epigenetic clock) which is based on DNA methylation levels. Here we use n=700 dorsolateral prefrontal cortex (DLPFC) samples from Caucasian subjects of th e Religious Order Study and the Rush Memory and Aging Project to examine the association between epigenetic age and Alzheimer's disease (AD) related cognitive decline, and AD related neuropathological markers. Epigenetic age acceleration of DLPFC is correlated with several neuropathological measurements including diffuse plaques (r=0.12, p=0.0015), neuritic plaques (r=0.11, p=0.00 36), and amyloid load (r=0.091, p=0.016). Further, it is associated with a decline in global cognitive functioning (β=-0.500, p=0.009), episodic memory (β=-0.411, p=0.009) and working memory (β=- 0.405, p=0.011) among individuals with AD. The neuropathological markers may mediate the association between epigenetic age and cognitive decline. Genetic comple x trait analysis (GCTA) revealed that epigenetic age acceleration is heritable (h 2 =0.41) and has significant genetic correlations with diffuse plaques (r=0.24, p=0.010) and possibly working memory (r=-0.35, p=0.065). Overall, these results suggest that the epigenetic clock may lend itself as a molecular biomarker of brain age.
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epigenetic age of the pre frontal cortex is associated with neuritic plaques amyloid load and alzheimer s disease related cognitive functioning
Aging (Albany NY), 2015Co-Authors: Morgan E Levine, David A Bennett, Steve HorvathAbstract:There is an urgent need to develop molecular biomarkers of brain age in Order to advance our understanding of age related neurodegeneration. Recently, we developed a highly accurate epigenetic biomarker of tissue age (known as epigenetic clock) which is based on DNA methylation levels. Here we use n=700 dorsolateral prefrontal cortex (DLPFC) samples from Caucasian subjects of the Religious Order Study and the Rush Memory and Aging Project to examine the association between epigenetic age and Alzheimer's disease (AD) related cognitive decline, and AD related neuropathological markers. Epigenetic age acceleration of DLPFC is correlated with several neuropathological measurements including diffuse plaques (r=0.12, p=0.0015), neuritic plaques (r=0.11, p=0.0036), and amyloid load (r=0.091, p=0.016). Further, it is associated with a decline in global cognitive functioning (β=-0.500, p=0.009), episodic memory (β=-0.411, p=0.009) and working memory (β=-0.405, p=0.011) among individuals with AD. The neuropathological markers may mediate the association between epigenetic age and cognitive decline. Genetic complex trait analysis (GCTA) revealed that epigenetic age acceleration is heritable (h2=0.41) and has significant genetic correlations with diffuse plaques (r=0.24, p=0.010) and possibly working memory (r=-0.35, p=0.065). Overall, these results suggest that the epigenetic clock may lend itself as a molecular biomarker of brain age.
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cognitive impairment decline and fluctuations in older community dwelling subjects with lewy bodies
Brain, 2012Co-Authors: Julie A Schneider, Sue Leurgans, Zoe Arvanitakis, Patricia A Boyle, David A BennettAbstract:Lewy bodies are common in the ageing brain and often co-occur with Alzheimer’s disease pathology. There is little known regarding the independent role of Lewy body pathology in cognition impairment, decline and fluctuations in community-dwelling older persons. We examined the contribution of Lewy body pathology to dementia, global cognition, cognitive domains, cognitive decline and fluctuations in 872 autopsied subjects (mean age = 87.9 years) from the Rush Religious Order Study (n = 491) and Memory and Aging Project (n = 381) longitudinal community-based clinical–pathological studies. Dementia was based on a clinical evaluation; annual cognitive performance tests were used to create a measure of global cognition and five cognitive domains. Lewy body type was determined by using α-synuclein immunostained sections of substantia nigra, limbic and neocortical regions. Statistical models included multiple regression models for dementia and cognition and mixed effects models for decline. Cognitive fluctuations were estimated by comparing standard deviations of individual residuals from mean trajectories of decline in those with and without Lewy bodies. All models controlled for age, sex, education, Alzheimer’s disease pathology and infarcts. One hundred and fifty-seven subjects (18%) exhibited Lewy body pathology (76 neocortical-type, 54 limbic-type and 27 nigra-predominant). One hundred and three (66%) subjects with Lewy body pathology had a pathologic diagnosis of Alzheimer’s disease. Neocortical-type, but not nigral-predominant or limbic-type Lewy body pathology was related to an increased odds of dementia (odds ratio = 3.21; 95% confidence interval = 1.78–5.81) and lower cognition (P < 0.001) including episodic memory function (P < 0.001) proximate to death. Neocortical-type Lewy body pathology was also related to a faster decline in global cognition (P < 0.001), decline in all five specific cognitive domains (all P-values < 0.001), and to fluctuations in decline of working and semantic memory (P-values < 0.001). Limbic-type Lewy body pathology was related to lower and faster decline in visuospatial skills (P = 0.042). The relationship of Lewy body pathology to cognition and dementia was not modified by Alzheimer’s disease pathology. Neocortical-type Lewy body pathology is associated with increased odds of dementia; lower and more rapid decline in all cognitive domains including episodic memory and fluctuations in decline in semantic and working memory. Limbic-type Lewy body pathology is specifically associated with lower and more rapid decline in visuospatial skills. The effect of Lewy body pathology on cognition appears to be independent of Alzheimer’s disease pathology.
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Cerebrovascular Disease Pathology and Parkinsonian Signs in Old Age
Stroke, 2011Co-Authors: Aron S. Buchman, David A Bennett, Sue Leurgans, Sukriti Nag, Julie A SchneiderAbstract:Background and Purpose—Mild motor symptoms including parkinsonian signs are common in old age, but their underlying neuropathology is unclear. We tested the hypothesis that cerebrovascular pathologies are related to parkinsonian signs. Methods—We studied brain autopsies from 418 deceased participants from the Religious Order Study, who underwent evaluation of parkinsonian signs with a modified version of the motor section of the Unified Parkinson's Disease Rating Scale. Brains were evaluated for macroscopic and microinfarcts and the severity of arteriolosclerosis. Regression analyses were used to examine the association of cerebrovascular pathologies with parkinsonian signs. Results—More than 35% of cases (N=149) showed macroscopic infarcts. Almost 30% of cases without macroscopic infarcts showed pathologies not detected by conventional brain imaging: microinfarcts (N=33 [7.9%]), arteriolosclerosis (N=62 [14.8%]), or both (N=24 [5.7%]). Macroscopic infarcts, specifically multiple cortical and ≥1 subcortic...
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postmortem indices linking risk factors to cognition results from the Religious Order study and the memory and aging project
Alzheimer Disease & Associated Disorders, 2006Co-Authors: David A BennettAbstract:We present data from the Religious Orders Study and the Memory and Aging Project linking risk factors to pathology and cognitive function. Both studies involve more than 1000 older persons who agreed to annual clinical evaluation and brain donation at death. Published findings from the studies to date suggest that the relationship between risk factors, pathology, and cognitive impairment is complex. In some cases, known neuropathologic indices mediate the association of risk factors to cognition. In other cases, risk factors modify the relation of pathology to cognition. Finally, some risk factors seem to be related to clinical Alzheimer disease and cognitive decline, even decline in episodic memory, in the absence of any association with amyloid plaques, neurofibrillary tangles, or other pathologic indices that can be identified and quantified at this time. The findings to date illustrate the kinds of insights that can be gained into mechanisms of disease through the incorporation of pathologic indices into well-designed, epidemiologic studies of aging and Alzheimer disease.
Missouri Province Of The Society Of Jesus - One of the best experts on this subject based on the ideXlab platform.
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Review for Religious - Issue 24.2 (March 1965)
Missouri Province of the Society of Jesus, 2012Co-Authors: Missouri Province Of The Society Of JesusAbstract:Issue 24.2 of the Review for Religious, 1965.The Major Superior an~ Her Subjects’ Vocation by Charles A. Schleck, C.S.C. 161 Approach to Mental Prayer by Thomas Dubay, S.M. 188 To Be Samaritans All by Michael M. Dorcy, S.J. 201 The Insecure Junior Sister by Sister Jean de Milan, S.G.C. 209 The Prayer of Christ by Yves M.-J. Congar, O.P, 221 Weep--There Is No Other Way by George A. Maloney, S.J. 239 Nun in the World by Mother M. Claudia, I.H.M. 244 Conte..mplation by Ladislas M. Ors’j, S.J. 248 The Superior as Community Counselor by Sister Angelina Marie, C.D.P. 265 For Teresa, Dying of Cancer by T. J. Steele, S.J. 273 Survey of Roman Documents 274 Views, News, Preview~ 280 Questions and Answers 286 Book Reviews 293 VOLUV_~ 24 NUMBER 2 March 1965 ASSOCIATE EDITORS Everett A. Diederich, S.J. Augustine G. Ellard, S.J. ASSISTANT EDITORS Ralph F. Taylor, S.J. William J. Weiler, S.J" DEPARTMENTAL EDITORS Questions and Answers Joseph F. Gallen, S.J. Woodstock College Woodstock, Mar~l~md o~ i63 Book Reviews ~ormtm Weyand, S.J. Bellarmine School of Theology of Loyola University o30 South Lincoln Way North Aurora, Illinois 6o543 ÷ ÷ Edited with ecclesiastical approval by the faculty of St. Mary’s College, the Divinity School of St. Louis University. Published bi-monthly and copyright, 1965, by Review for Religious at 428 East Preston St., Baltimore, Md. 21202. Printed in USA. Second class postage paid at Baltimore, Maryland. Single copies: 60 cents. Subscription USA and Canada: $3.00 a year, $5.75 for two years; other countries: $3.35 a year. Orders should indicate whether they are for new or renewal subscriptions and should be accompanied by check or money Order. Checks and money Orders should be made payable to Review for Religious in U. S. currency only. Pay no money to persons claiming to repre-sent Review for Religious. Change of address requesta should include former address. Renewals, new subscriptions, changes of ad-dress and business corres~ondence should be sent to: Review for Religious, 428 E. Preston Strut, Baltimore, Maryland 21902. Manu-scripts and editorial correspondence should be sent to: Review for Religious, St. Mary’s College, St. Mary’s, Kausa~ 66536. Quesdous and books for review should be sent to the respective departmental editors. MARCH I 965 VOLUME o4 NUMBER ~ CHARLES A. SCHLECK, C.S.C. The Major Superior and the Meaning of Her Subjects’ Vocation If* one were to investigate the various pontifical docu-ments having special reference to Religious communities, he would find them often referring to these as "fami-lies." This seemingly simple expression contains within itself a whole host of suggestions, and in the end would seem to be the nucleus for the spirit (and this would include even the government) and spirituality of every Religious community. For these, as we know, have their existence and strength from their communion and inti-mate connection with the end of the Church itself--to lead men to the acquisition of holiness. And how im-portant they are for the life of the Church has been clearly stated by Pope Pius XII in rather striking and forceful terms: The Church would not fully correspond to the will of our Lord, nor would the eyes of the majority of men be raised to her in hope and joy as a standard set up unto the nations or as a sign standing in the heavens, unless there were found in her some who more by example than by word, were especially re-splendent with the beauty of the Gospel? This role of the Religious community is not at all foreign to the economy of salvation established by God. All communication between God and man has tended to adopt a sacramental medium--language, representa- ¯ In the summer of 1962 Father Schleck gave a series of six lectures to the Conference of Major Superiors of the United States. The pres-ent article is a revised version of the first of these conferences. The other five conferences will be published in revised form in later issues of the REVI£W. 1Address to Superiors General, February 11, 1958, in The States o] PerIection, ed. Gaston Courtois (Westminster: Newman, 1962), pp. 317-8. Fr. Charles A. Schleck, C.8.C., teaches theology at Holy Cross College; 4001 Harewood Road, N.E.; Wash-ington, D.C. 20017. VOLUME 24, 161 ÷ ÷ ÷ Cha~es A. REVIEW FOR Religious 16~ tion, the written or the spoken word, events, customs, even garb and dress. It is in this work, that is, in bring-ing before men the visible mark of holiness characteriz-ing and setting off the true Church of Christ, that Religious superiors, especially major superiors, are as-sociated with the Church and her bishops and sovereign pontiff, either by receiving jurisdiction as is true of ~nale exempt Orders, or by receiving dominative power by reason oF the approbation of the rules and constitu-tions peculiar to a Religious institute.2 Thus, while it is the work of the Holy Spirit to begin, and to nourish and foster, and to bring to consummation the work of grace or of God’s special love for those called to the Religious life, still He associates with Himself in this work and service, so-called secondary causes or auxiliary instruments in whom He wishes to incarnate His own power and love and through whom He wishes this to be communicated to others. It is for this reason that the Apostle Peter writes: Whatever the endowment God has given you, use it in service to one another like good dispensers of God’s mercy; if one does some service, let him do it with the strength which God sup-plies, so that in everything God may be glorified through Jesus Christ? In you, however, this governing role was meant to take definite shape and form. This is evident from the very nature of a Religious community which we have called, just above, a family. For a family is a group of persons ruled or governed by those who have been established over it by God--a father and a mother. And this is most important for our present considerations. For the characteristic virtue of family life is not legal justice, or human activity on a quid pro quo basis, but rather piet)~, a potential part of the virtue of justice, adding to it the modification which is brought about by the intimacies and warmth of family life. It is the virtue of justice, we might say, with a heart. For all of you the manner of governing that is to be looked for and expected by all, both those inside the Religious life and those outside, even those who view your communi-ties from a distance, must always be that of a woman, a mother. Indeed the title which all or most of you bear quite clearly indicates this wish and ardent hope of the Church and the entire family oF God. This title is at one and the same time the measure and indicator oF your function and task and also the measure oF the crowning glory which God intends for each of you in assigning you your particular role in the Church. For if it is He who elects you or appoints you to your task as He did Ibid. 1 Pt 4:10-1. the Mother of the Lord, He at the same time, as He did for her, makes available for you all the graces both ac-cording to their extension and intensity that are de-manded in the work entrusted to you.4 God made every woman by nature generous, merciful, and compassion-ate; and He gave her the desire to offer herself for others. He implanted in her as her essential spirit and movement the spirit of giving, of molding, of forming, of clothing whatever she touches, of mothering it, and of loving it. And the most noble aspect of this mother-hood is the lifting up of those persons she calls her children to God. That is why the motherhood officially given to you by the Church is the most sublime that could possibly be given to any woman. In a Religious community of sisters the governing power is given into the hands of women that they as mothers might lead those under them to the common goal of the entire Christian community--the eternal participation of the body-person of Christ in the mar-riage feast of the Lamb. The role of anyone entrusted with shepherding others has very well been pointed out by Isaiah: It is thine to restore those bound in darkness to freedom and light; it is thine to pasture the flock of God and provide feeding grounds for them as they make their way through barren up-lands. Under your care they will neither hunger nor thirst, nor will the heat of the noon-day sun overpower them. For you will be to them a merciful shepherd that will lead them to welling fountains and give them to drink of life-giving water? In you this shepherding assumes a rather well-defined mode of expression. It is to be accomplished in accord-ance with the precise externalization which human nature takes in its being found in women rather than in men. It is precisely by using the qualities and gifts peculiar to women that you make your service contribu-tion to the glory of God and to the welfare of His Church and of your own communities. And this service contribution which you make to these ends is most im-portant today. For the Church was meant to be a mighty organization, hierarchical, structured, full of honor and dignity, having its laws and penalties and the power to enforce them. But the Church was also meant to be a Mother, patient, kind, gentle, tender, full of understanding and compassion. Both you and your subjects are always at hand to remind the Church of this maternal aspect of her mission. It is more than evident from the many writings that have appeared on the subject in recent years that a woman called to the Religious life is not at all deprived See Summa theologiae, 3, q.27, a.4. h 49:44. ÷ ÷ ÷ Superior and Vocation VOLUME 24, 1965 ]63 ÷ 4. ÷ Charles A. SchCle.c~k.C, . REVIEW FOR Religious 164 of motherhood. Rather she is called to exercise this function of her being in a much more intensive and ex-tensive manner than is possible in marriage. It is a motherhood that nourishes and molds and centers its whole activity on the life of Christ. By the grace of her vocation she receives in a single fulfillment the two deepest longings of a woman’s heart--her woman’s desire for motherhood, and her virgin’s desire to be wholly God’s, wholly surrendered to Him. All this is quite clear in the case of the ordinary Religious sister. But I wonder how often those called to exercise supreme authority in service within Religious communities of women realize that they are not at all dispensed from this work of woman but rather are called to exercise a more noble and more universal expression of this same function. They are called by God’s providence to exer-cise this same activity in reference to the "more illustri-ous portion of the flock of Christ," those who by God’s special predilection and love have been called to the vocation of virginity, which is the marriage of a human person with the Lord. Like the work of the Mother of God in redemption, yours is that of associate, con-tributing under the Spirit and with the Spirit to the work of your subjects’ sanctification as Mary did in reference to the Church--as a partner, as a woman, and as a mother. In Christ we are given to see that all is priestly. In Mary we are given to see that all is womanly, all is motherly. Her role in the sanctification of the human race was different from that of Christ. Her "merit," her sacrificial oblation, her ransom, all were those of a woman, a mother. She worked along with Christ her Son, but not as an equal, not as one engaged in the same Order of operation. Her office was addi-tional, complementary. It is true that oftentimes this work is most difficult, much more diffficult than the motherhood exercised by your subjects. But the greater the motherhood to which one is called, the more suffering and the more participa-tion in the cross-mystery must she expect to fall to her lot. Nor is this so strange. It will always be true that a mother’s greatest suffering is interior, that which cen-ters around the emotions, that which involves anxiety, worry, and concern. And usually it comes only at the end of her function when she finds herself no longer in complete control of the minds and hearts of the persons under her, when she must deal with them no longer as children but as mature adults destined to their own proper creativity and life. Since this is always the situa-tion in which major superiors are called to exercise their office of ministry and service, they know with their election or appointment the rather difficult phase of motherhood to which the5, are called. It was because of this difficulty that the late sovereign pontiff Pius XII attemped to recall the image which the major superior must attempt to cultivate in the eyes of her Religious: It is no doubt true, as psychology affirms, that the woman in-vested with authority does not succeed as easily as a man in finding the exact formula for combining strictness with kind-ness, and establishing the balance between them. This is an added reason for cultivating your motherly sentiments. You can say that the vows have exacted from your Sisters as from your-selves a great sacrifice. They have renounced their family, the happiness of marriage and the intimacy of the home. It is a sacrifice of great value, of decisive importance for the apostolate of the Church, but it is still a sacrifice. Those of your Sisters who are the most high-souled and refined, are the ones who feel this detachment most keenly. The words of Christ "no one put-ting his hand to the plough and looking back is fit for the king-dom of God" finds its application to the full, and nowadays, too, without reserve. But the Religious Order must take the place of the family as far as possible, and it is you, the superiors general, who are expected in the first instance to breathe the warmth of family affection into the community life of the Sisters. You must, therefore, yourselves be motherly in your exterior behavior, in your words and your writings, even if sometimes this calls for the exercise of self-restraint; but above all, be motherly in your innermost thoughts, your judgments, and as far as possible, your sympathetic feeling. Pray every day to Mary the Mother of Jesus and our mother, to teach you how to be motherly." It is quite evident that your motherhood is to reflect and in a sense continue to image that of Mary. And Mary’s motherhood is one that is pure, stainless, free from every trace of contamination of the shadow, of the terrible aspect of the mother-image, of the destructive wiles of the "anima," of the desire to possess or be un-scrupulous in protecting and reducing to childishness the creative powers of those under her, of refusing to give them up to their destiny which is for them also, each in her turn and each according to her own way, to give fruit to the life of the Church of God. Thus your motherhood centers around women, not girls; and it must never become maternalistic or harmful or destruc-tive to their legitimate growth as distinct persons, to their adjustments to society and adult life. It is the proper task of a real mother to foster her daughter’s competence and well-defined independence, rather than their opposites. To accomplish this task many things ought to be found in you. First, there should be a workable knowl-edge of the principles of spiritual theology, of the ~ Address to Superiors General, September 15, 1952, in The States o[ Per/ection, p. 217. 4. 4. Superior and Vocation VOLUME 24, 1965 ÷ ÷ ÷ Charles A. Schleck, C.S.C. REVIEW FOR Religious 166 history and forms of the Religious life in history, an experiential knowledge and almost the founder’s or foundress’ love for your own Religious community, its constitutions, its customs, the authors of its spirituality, and its activities or apostolates. To this there shouId also be added a practical knowledge of the canon law governing Religious communities of women, a practical knowledge of feminine psychology, and some principles of guidance. Second, there should also be present a discretion or prudence that is like wisdom, reaching from end to end. This would include tact, winning manners, knowledge of the human heart at its various levels of development--the young, the mature, the mid-die- aged, and the old. This discretion and prudence for our present consideration will also include a motherly vigilance, a dispassionate firmness that is without weak-ness, the ability to foresee and anticipate the needs of soul and body, an unfailing patience, and a zeal that is tem-perate, that knows how to wait and to seek out or receive those who come to you moved by God’s grace. A third element or ingredient that you should possess is experi. ence, of the various apostolates, actually exercised if pos-sible or at least vicarious, of the problems and the diffi-culties they normally cause to Religious; also an experience and awareness of human failings, not the least of which are your own failings and half-acknowledged shortcom-ings, a grasp of your assets and liabilities which would give you a proper and Ordered self-love, with the desire to employ the former and guard against and make up for the latter, through the normal channels of the Christian life, not the least of which is consultation and personal direction. Finally, genuine holiness ol lile is required. For you ought to be not so much a teacher or one who hands out practical rules of life, of doing, and of making, nor just an interpreter of your community’s spirit, but first and foremost a master of its life. For it is your privilege and obligation to see to it that the young life which God entrusts to you is begun correctly, or brought to birth in the novitiate, and then formed and made viable in your juniorates, and matured and intensified and deepened throughout the entire course of its existence in your Religious family. For the motherhood with which you are entrusted by the Church does not end until you are relieved of your responsibility or until one or other of your subjects closes her eyes in death in Order to greet her Lord in life. The perpetuity and continuation of a fervent community (and the life and vitality of the Church depends more upon this than upon numbers) rests with the major superiors’ capacity to maintain and deepen in their subjects the spirit of the Church and of the founder or foundress whose exemplary causes they are meant to be.7 In treating of this quality or ingredient of holiness last, it is not my intention to consider it as the least important of all. Second to prudence it occupies the most important place perhaps. Knowledge in itself is not fruitful. It must be united with love. And how else can Religious be taught the ways o[ God, schooled in the Lord’s service if their own superiors do not possess these? You must remember that your subjects have entered religion in Order to seek sanctity according to this way of life. And this is to be learned from those who are set over them in the intinaacy of their community life. It is along this line that much more stress could be laid today. The quality of the teaching of any master of the Christian life--and this is the primary role of superiors: to lead her subjects to sanctity--will be that of her own life. A young and generous soul will find no better way to learn renuncia-tion or surrender through charity than by following in the path of one who herself is practicing these same things. A secret strength goes out from her and is in some way imparted to those who come in contact with her. The ability to love the Religious life and to instill this love into others is most important today when it is so easy not only for those outside the Religious life, but even for those inside, to be or to become confused in their "vision of the special function and immutable im-portance of the Religious state within the Church." s The primary work of a superior is to teach her subjects how to love God, how to make the gift of oneself the surrender of one’s personal mystery to God and the service of the Church, a living reality. Since the Religious life is essentially a theologal life, a life of faith, hope, and love, and a sacramental repre-sentation of the transcendent goal of the Christian community--the paschal mystery--it is important that these be lived by those in charge. No long dissertation or reasoning or logic will affect others on these points. The superior must live these, for it is only by being a living exemplar of them that she can really hope to exert her teaching on others. As St. Gregory the Great writes: Like Moses, a superior ought to be seen frequently going in and out of the tabernacle and while there caught up in con-templation such that when she comes out she may give hersel[ over to the needs of her subjects and tasks. She must be known as one who truly serves God and His Church.’ T See The Gilts o[ the Holy spirit (Notre Dame: St. Mary’s College, 1961), pp. 1 ft. 8Address to All Religious, May 23, 1964; N.C.W.C. ed., pp. 6-7. 8Pastoral Care, II, 5 ("Ancient Christian Writers," v. 11 [West-minster: Newman, 1950], pp. 56-8 passim. 4. Superior and Vocation VOLUME 24, 1965 167 + + Charles A. $chleck, C.S.C. REVIEW FOR Religious 168 Such a life would be appreciated by almost all who saw it. It would be like the light shining on the moun-tain or the city built thereon. And this is as it should be. For while a superior should not seek the praise of others in conducting herself, this does not mean that she should not seek to be loved; but she should seek this in Order that this love might prove to be a path leading to the Lord. It is most ditIicult for one who is not loved by her subjects, however well she might preach, or exhort, and provide logic for the life o[ holiness, to find a sym-pathetic hearing from those who make up her audience. "!’his exhortation to holiness is always most timely for an
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Review for Religious - Issue 70.2 (2011)
Missouri Province of the Society of Jesus, 2012Co-Authors: Missouri Province Of The Society Of JesusAbstract:Issue 70.2 of the Review for Religious, 2011.Virtue Movements Ignatian Insight Consecrated Life quarterly 70.2 2011 Review for Religious fosters dialogue with God, dialogue with ourselves, and dialogue with one another about the holiness we try to live according to charisms of Catholic Religious life. As Pope Paul Vl said, our way of being church is today the way of dialogue. Review for Religious (ISSN 0034-639X) is published quarterly at Saint Louis University by the Jesuits of the Missouri Province. Editorial Office: 3601 Lindell Boulevard ¯ St. Louis, Missouri 63108-3393 Telephone: 314-633-4610 ¯ Fax: 314-633-4611 E-Maih reviewrfr@gmail.com ° Web site: www.reviewforReligious.org Manuscripts, books for review, and correspondence with the editor: Review for Religious ¯ 3601 Lindell Boulevard ° St. Louis, MO 63108-3393 POSTMASTER Send address changes to Review for Religious ° P.O. Box 6070 ¯ Duluth, MN 55806. Periodical postage paid at St. Louis, Missouri, and additional mailing offices. See inside back cover for information on subscription rates. ©2011 Review for Religious Permission is herewith granted to copy any material (articles, poems, reviews) contained in this issue Review for Religious for personal or internal use, or for the personal or internal use of specific libra~ clients within the limits outlined in Sections 107 and/or 108 of the United States Copyright Law. A copies made under this permission must bear notice of the source, date, and copyright owner on th first page. This permission is NOT extended to copying for commercial distribution, advertisinl institutional promotion, or for the creation of new collective works or anthologies. Such permissio will only be considered on written application to the Editor, Review for Religious. ~ gournal of Catholic ~piri~uali~ Celebrating 70 Years Editor Book Review Editor Scripture Scope Editorial Staff Advisory Board Michael G. Harter SJ Rosemary Jermann Eugene Hensell OSB Mary Ann Foppe Tracy Gramm Judy Sharp Paul Coutinho SJ Martin Erspamer OSB Margaret Guider OSF Kathleen Hughes RSCJ ¯ Louis and Angela Menard Bishop Terry Steib SVD quarterly 70.2 2011 contents prisms 116 Prisms 118 132 virtue movements Salesian Simplicity: How a "Little Virtue" Can Go a Long Way Thomas F. Dailey OSFS examines simplicity in the teaching of St. Francis de Sales and the Religious life of the Visitation of Holy Mary, founded in 1610. He proposes that their "hidden life" of "little virtues" provides meaning even for those beyond the monastery’s walls. Personal Reflection and/or Group Discussion Telling Ou.r Story: Movements of Transformation Beatrice M. Eichten OSF offers ideas for sharing the story of transformational moments in our lives to better under-stand what we have experienced and to allow God to be more alive and active in our lives. 146 ignatian insight 0 Approaching the Principle and Foundation from St. Ignatius’s MysticalWorldview Edward McCormack builds on the insights of Gilles Cusson and Joseph Tetlow, and sets the Foundation within the context of Ignatius’s mystical experience at Manresa and the resulting worldview in Order to better understand the role the Foundation plays in the Exercises, particularly with regard to the preparatory period. Review for Religious 165 Discerning the Spirit: A Personal Journey Richard J. Hauser SJ testifies to the importance of appropriating the discipline of the discernment of spirits in our daily Christian living. 179 194 201 consecrated life @ Apostolic Visitations: Clare of Assisi’s Insights from the Thirteenth Century John V. Kruse examines how Clare of Assisi responded nearly 800 years ago to papal visits that sought to shape the form of Religious life that Clare desired to live. Her example has tnuch to say to women Religious experiencing the Vatican visitation and investigation of women Religious in the United States. Consecrated Life in the Ecclesiology of Vatican II Amy Hereford CSJ discusses the place of consecrated life in light of the ecclesiology of the Second Vatican Council, the new Code of Canon Law, and recent developments. Personal Reflection and/or Group Discussion A Grain of Hope: Canada’s First Carmelite Nun Mary Patricia of the Holy Spirit OCD and Mary Ruth of the Sacred Heart OCD recount how deep desires and a providential encounter led to the founding of the first monastery of Discalced Carmelites in Canada. departments 209 Scripture Scope: Ezekiel: The Strangest of All the Old Testament Prophets 215 Book Reviews 115 70.2 2011 prisms 116 ~hen I was a young boy, my mother thought it would be good for me to know how to swim, so she took me to the local pool and arranged for me to take lessons. I found the whole experience a bit intimidating. But once I learned to overcome the fear of having my head underwater, I was quickly off to explore the deep end of the pool. While I am still a bit hesitant to jump into cold water, I have no fear of swimming.., or taking on new challenges. That memory returned to me as I began editing Review for Religious. And though I am older now and have much more experience, old fears occasionally lurk in the shadows. When our publication was invited to attend a recent seminar on the theology of consecrated life sponsored by the USG/UISG, the unions of superiors general of men’s and women’s Religious congregations, I began to wonder if I was getting in over my head. My long-time mentor, Dave Fleming, assured me that I would represent the Journal well and that it would be a most valuable learning experience. Twenty superiors general and thirty theolo-gians assembled in Rome between February 7 Review for Religious and 11 to "take careful stock of the situation of the the-ology of apostolic consecrated life at this present time; to identify the main questions and challenges being posed to this theology by the situation of the world and the church today, in view of the future journey of conse-crated persons and the Institutes to which they belong; and to catalyze renewed study and research in this field so as to enhance the vitality of the witness to be given by consecrated persons." The participants, equally divided between women and men, represented all the populated parts of our planet from Oceana through India, Africa, Europe, to North, Central, and South America. We looked at the context of Religious life in the cosmos from the "big bang" to the eschaton. We talked about the tensions of living our traditional vows in a post-mod-ern- even post-Christian--globalized world. We strug-gled to be mindful of ecological issues and the need for collaboration among the old Orders and with the laity and members of emerging new Religious communities. The presentations were rich in diversity and were fur-ther refined and nuanced in the ensuing conversations in small work groups or over dinner. None of the participants had clear answers or simple solutions. That was not the goal of the seminar. We did, however, pledge ourselves to keep pursuing questions, exploring mystery, and sharing our discoveries. That is what Review for Religious has been doing for 70 years in simple and profound ways. We hope to be a vital medium to enable that conversation to continue. Immersion in a pool of such rich thinking and expe-rience was invigorating. It is reassuring to be reminded, once again, that we have good company in the deep waters of Religious life. Michael .G. Harter SJ 117 70.2 2011 THOMAS E DAILEY Salesian Simplicity: How a "Little Virtue" Can Go a Long Way virtue movements Four hundred years ago, simplicity was retrieved by two saints and given a new form.~ In June 1610, Francis de Sales and Jane de Chantal established the Religious Order of the Visitation of Holy Mary in Annecy, France. Begun with three nuns who would spend their day in prayer and occasionally visit the poor and sick in town--a radically new apostolic twist at the time--the Order now has numerous monasteries throughout the world and includes those sisters who took up residence in the "Mater Ecclesiae" monastery in the Vatican in 2009. The superior there succinctly describes the particular charism of this Religious Order in Thomas E Dailey OSFS holds the Fr. Louis Brisson Chair in Salesian Spirituality and is Professor of Theology at DeSales University, where he is also the founding director of the Salesian Center for Faith & Culture. He may be addressed at DeSales University; 2755 Station Avenue; Center Valley, Pennsylvania 18034. Review for Religious terms that match the focus of the conference at which this paper was originally presented: "The spirit of the Visitation is one of profound humility toward God, and great meekness toward the neighbor--a spirit that does not put the accent on exterior austerity. The sisters must supply it with interior renunciation and with a great simplicity and joy in the common life.’’2 That spirit of simplicity aligns directly with Francis de Sales’s vision of the virtuous Christian life and takes a distinct form within the contemplative life of the Visitation Order. And, as we will suggest, this four-hundred- year-old tradition remains especially relevant for the pursuit of holiness in the hectic world of the twenty-first century. Simplicity as a Virtue in Salesian Spirituality For St. Francis de Sales, simplicity paves the way to holiness. In his classic book on that subject--an Introduction to the Devout Li~--this Doctor of the Church posited the then revolutionary idea that holiness is pos-sible for everyone, not just the professionally Religious monks and nuns, and that this holiness is realized in and through one’s vocation or state in life. In his view, what makes the possible actual is the life of virtue. Seeking to forge a middle ground for Religious devo-tion between the supereminent tendencies of spiritual mysticism and the austere practices of ascetical, discipline, he champions the exercise of "little virtues"--those vir-tues that are able to be practiced in an ordinary way amid everyday relationships. He explains that "We do not very often come across opportunities for exercising" magnificent feats of virtue (like courageously saving someone from a burning building), but little ones-- like gentleness, modesty, and humility--are continually 119 70.2 2011 Dailey ¯ Salesian Simplicity What unites the various aspects and exercises of simplicity is the notion that this virtue entails being "transparent," called for as "graces which ought to color everything we do." Thus, he encourages the practice of "the best virtues, not those which are most highly esteemed; the most excellent, not the most visible; the truest, not the most conspicuous.’’3 Concerning simplicity, which he names most often in the various lists of the "little virtues" that appear throughout his writings, de Sales suggests any number of ways in which this can be carried out in one’s daily comportment. For example, in terms of fashion, simplicity shows itself in the propriety of one’s clothing. Adding wit to his wisdom, he writes, "Old people are always ridiculous when ...... they try to make themselves pretty. Such folly can be put up with only in youth.’’4 Or, in terms of language, simplicity calls forth words that are both frank and honest, while it challenges us to hold our tongue when called upon to speak about ourselves; as the saint explains, Without doubt, whoever speaks little of himself does so extremely well; for, whether it be that we speak in accusing ourselves or in excusing ourselves, in praising ourselves or in despising ourselves, it will always happen that our speech serves to entice us to vanity. If, therefore, some great charity draws us to speak of ourselves and our relatives, we must hold our tongue about it.5 Even more so, simplicity in speech is opposed to any sort of equivocation; in Francis’s view nothing so out- Review for Religious rages truth as duplicity, "For those who attempt to shield truth by artifice actually kill and suffocate it.’’6 Finally, in terms of relationships, where, according to Wendy Wright, Francis gives to simplicity its partic-ular nuance, to be simple means to act without cunning or guile.7 It enables us to avoid prosaic illusions, those illusions of grandeur which in reality are nothing more than mental temptations: There are souls that make great plans to do excel-lent services for Our Savior, by eminent actions and extraordinary sufferings--but actions and sufferings which there is no opportunity to carry out and per-haps never will be. Based on this, these souls think they have done some great thing in love; in this they are very often deceived, for while they embrace in desire what seems to them to be great future crosses, they anxiously avoid the burden of lesser ones that are present. Is it not an extreme temptation to be so val-iant in imagination, and so cowardly in execution?’’8 Instead of being so deceived, devout persons seek simply to serve God, even if they do not experience contentment in doing so: It is necessary to consider that there is no vocation that does not have its trouble, its bitterness and its distaste; and, what is more, if this is so among those not fully resigned to the will of God, each would wish volun-tarily to change his condition to some other.... From where comes this general inquietude of spirit if not from a certain displeasure that we have about what is contrary, and a malignity of spirit that makes us think that another is better than we are? But it is all the same: whoever is not fully resigned, who turns this way and that, he will never have rest .... A person who no lon-ger has the restlessness of his own will is content with everything: provided that God be served, it does not matter in what manner God employs him: provided that he does his divine will, it is all the same to him.9 121 70.2 2011 Dailey ¯ Salesian Simplicity To use a modern term, what unites these various aspects and exercises of simplicity is the notion that this virtue entails being "transparent." As Wendy Wright describes it, in living a simple life [a]ll the ornament and artifice on the outside is peeled away; all the complicated criss-crosses of self-reflec-tion and multiple considerations on the inside are also gently relinquished and given second place .... And that transparency then is a window through which God and the deepest center of the person can come together. Nothing remains between God and person.’° But the transparency of a virtuous life that is unadorned and unpretentious does not render simplic-ity a simple thing! On the contrary, this "little" virtue, when lived to its fullest, encompasses the whole of life in its adherence to the will of God in all things. In other words, it entails a perfect correspondence between who we are and how we act. That is the way of life sought by the Visitation sisters, for whom simplicity is consti-tutive of their particular charism in the church and for the world.~l 122 Simplicity as Sanctity in the Visitation Order For the Visitation sisters, the Salesian understanding of simplicity as a virtue extends beyond the practices of everyday life to encompass the totality of their exis-tence. Simplicity, in this sense, is an attitude of being more than an attribute of action. Cultivating this atti-tude is the direction that Francis de Sales sets for the spiritual life of Jarie de Chantal and for the Religious Order she would lead. From his first encounter with her in Dijon,12 Francis emphasized the need for Jane to develop a more simple life. As the amusing story is told, he took the opportunity Review for Religious at one of their first encounters to indicate blithely that her manner of dress should reflect her state in life as a widow: One day that Madame de Chantal had come to dine, she appeared a bit more dressed up and decked out than she ordinarily did. "Madame," said the bishop, "do you have plans to remarry? .... Oh, no, Monsignor," she replied quickly. "Well then," replied the saint, "it should be necessary to take down the flag.’’13 But more important would be Jane’s interior focus; over the course of several years, his spiritual direction led her to simplify her entire life. That process of simplifi-cation- what Wendy Wright describes as St. Jane’s own "call within a call"14--would also come to characterize the entire Religious Order that she established with him. Rooted in the twin Salesian virtues of humility and gentleness, the foundation of the Visitation Order had only a simple aim, which Francis de Sales explains in a letter to the cardinal archbishop of Lyon, who objected to the sisters’ practice of leaving the monastery to visit the sick. Francis writes that the purpose of this new group of nuns is to give to God daughters of prayer and souls so interior that they be found worthy of serving his infinite Majesty and of adoring him in spirit and in truth. Leaving the grand Orders already established in the church to honor Our Lord by excellent exercises and brilliant virtues, I wish that my daughters would have no other intention than to glorify him by their abasement; that this little Institute of the Visitation be like a poor dove among innocent doves, whose care and concern is to meditate upon the law of the Lord without making themselves seen or understood by the world; that they dwell hidden in the cleft of the rock and in the secret of the recesses in Order there to give to their Beloved, by their living and dying, ’123 70.2 2011 Dailey ¯ Salesian Simplicity some proofs of the grief and the love of their hearts, expressed by their lowly and humble groaning.~s That "hiddenness" of their life discloses their sin-gularity of purpose. It also gives rise to a distinguishing feature of this new Order, namely, the practice of admit-ting as sisters women who, through age or infirmity or widowhood, were too frail to undertake the penitential austerities of other contemplative Orders. Instead, the Visitation sisters would practice an interior discipline, one cultivated through the progressive development of personal simplicity amid a joyful common life.16 The way by which the sisters would grow in simplic-ity is mapped out for them most clearly in the Spiritual Conferences--a compilation of informal question-and-answer sessions conducted in the courtyard or parlor of the monastery, in which the bishop clarified the distinctive way of life for the members of his new institute. Notwithstanding the limitations of the liter-arT form or the reliability of the published versions,17 these conferences do reveal the mindset of St. Francis de Sales, for whom simplicity is nothing less than the pursuit of perfection. That pursuit begins with the realization of what exactly this virtue is. The holy bishop tells the sisters, "Simplicity is nothing other than an act of pure and sim-ple charity that has only one goal, which is to acquire the love of God. Our spirit is simple when we have no other aim in all that we do or want."18 Then he indicates to them, by way of the biblical story of Martha and MarT, that simplicity and charity are inseparably linked, such Simplicity runs counter to any interior agitation. Review for Religious that the "act of simple charity allows us to look at and have no other goal in sight in all our actions.’’~9 And this, he claims, is a distinctively Christian virtue. He then explains that the sisters’ singularity of focus through simplicity2° will facilitate their pursuit of holiness by fleeing them from the torment of spiritual restlessness and inquietude. Born from the humility that recognizes the inevitable imperfection inherent to human nature, simplicity runs counter to any interior agitation, as the saint explains elsewhere: You know that God wishes, in general, that one serve him, by loving him above all things and our neighbor as ourselves .... That said, it is necessary to do so in good faith, without finesse or subtlety, which would be in the manner of this world, where perfection does notreside, in a human way and according to this time, while waiting to do so in the divine and angelic world and according to eternity. Neither pressure nor agitation of purpose serve any good; desire is good, but let it be without agitation. It is this pressure from which I [wish to] shield you, as the mother imperfection of all imperfections.21 In more positive terms, simplicity is the corollary of that liberty of spirit that comes from love. Speaking again to the sisters, he claims that Simplicity banishes from the human spirit both the need and the anxiety that many develop, so they say, as they search for the ability to love God by the sheer number of exercises and other means. It seems to them that if they do everything that the Saints have done, they will most certainly be satisfied. What poor people! They are to be pitied! They torment themselves to find the art of loving God. They don’t know that there is none except to love Him. They think that there is a certain ingenuity to acquire this love which is truly found only in simplicity.22 70.2 2011 Dailey ¯ Salesian Simplicity 1261 Ultimately, the sisters’ simple love for God can and should integrate all the aspects of their life. In other conferences, their founder explains how related vir-tues can help them to practice this simplicity. Through humility they learn to embrace the mortifications and abjections of everyday life, for, in his words, "our misery is the throne of God’s mercy.’’23 Through wonder about their imperfections in contrast to the divine goodness exercised in their regard, they are invited to place their confidence entirely in God.24 Through the joy this con-templation brings, they are called to exercise holy indif-ference in all matters; on this point the saint concludes his final conference with this fa
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Review for Religious - Issue 51.1 (January/February 1992)
Missouri Province of the Society of Jesus, 2012Co-Authors: Missouri Province Of The Society Of JesusAbstract:Issue 51.1 of the Review for Religious, January/February 1992.Christian Heritages and Contemporary Living JANUARY-FEBRUARY 1992 ¯ VOLUME 51 ¯ NUMBER 1 Review fl)r Religious (ISSN 0034-630X) is published bi-monthly at Saint Louis University by the Jesuits of the Missouri Province. Editorial Office: 3601 Lindell Boulevard ¯ St. Louis, Missouri 63108-3393. Telephone: 314-535 3048. Manuscripts, books fi)r reviexv, and correspondence with the editor: Review for Religious. 3601 l,indellBoulevard. St. Louis, Missouri 63108-3393. Correspondence about the "Canonical Counsel" departmeut: Elizabeth McDonough ()P ¯ 5001 Eastcrn Avenue ¯ P.O. Box 29260 Washington, I).C. 20017. P()S’I’M~XSTER Send address changes to Review for Religious ¯ P.O. Box 6070 ¯ Duluth, MN 55806. Second-class postage paid a~ S~. Louis, Missouri, and additional offices. SUBS(~RIPTI()N RATES Single copy $5.00 includes surface mailing costs. ()he-year subscription $15.00 plus mailing costs. Two-year subscription $28.00 plus mailing costs. See inside back cover fl~r subscription infl~rmation and mailing costs. ©1992 Revieu for Religious review fre° [gii ous Editor Associate Editors Canonical Counsel Editor . Assistant Editors Advisory Board David L. Fleming SJ Philip C. Fischer sJ Michael G. Harter sJ Elizabeth McDonough OP Jean Read Mary Ann Foppe David J. Hassel SJ Mary Margaret Johanning SSND Iris Ann Ledden $SND Sefin Sammon FMS Wendy Wright PhD Suzanne Zuercher OSB Christian Heritages and Contemporary Living JANUARY / FEBRUARY 1992 ¯ VOLUME 51 ¯ NUMBER 1 contents 18 24 church and ministry Ecclesial Burnout: Old Demon, New Form Richard Sparks CSP suggests some remedies for overcoming a new strain of burnout which tends to afflict church ministers. Vincent Pallotti vs. Polarization Erik Riechers SAC shares some practical steps suggested by Vincent Pallotti for spiritual regeneration in a polarized church. The Ecumenical Kernel Dennis Billy CSSR explains how church unity involves a process of committed encounter between Religious traditions whose very existence implies a relationship of concrete mutual dependence. 34 46 56 direction and discernment Elements and Dynamics of a Spiritual-Direction Practicum James Keegan SJ presents a successful way of putting together a spiritual-direction practicum and the personal and clinical issues involved. On Becoming a Discerning Person Charles Reutemann FSC describes in practical terms the meaning of spiritual direction, the person of the director, and the process of the direction session. Discernment and Decision Making Brian O’Leary SJ outlines elements for a pedagogy of discernment so necessary for our contemporary human and Christian situations. 2 Revie~ for Religious Religious life 64 Making Sense of a Revolution Se~in Sammon FMS assesses the present state of Religious life and sets an agenda for the process of renewal. 78 The Past Is Prologue Elizabeth McDonough OP identifies three interrelated phenomena which have significant influence on the direction of Religious life. 98 An Experiment in Hope Mary Carty CND and MaryJo Leddy NDS report on a carefully planned intercongregational exploration in revitalizing Religious life. 109 community and missien Internationality--At What Price? Janet Malone CND challenges any community which identifies itself as international to realize the concrete demands made on every aspect of their life together. 118 The Perils of Polarity Julia Upton RSM focuses upon the common roots from which both monastic and apostolic Religious life take their growth. 134 Evangelizing Community William F. Hogan CSC suggests that Religious who share faith in community are the best evangelizers. 140 4 144 149 Vocation as a Journey Brother Andrew shares a personal reflection on vocation as a crucifying walk in intimate union with Jesus. departments Prisms Canonical Counsel: Clerical Institutes Book Reviews January-February 1992 3 prisms As you page through this issue, you cannot help but notice the new appearance of Review for Religious. The development of this new look involved the staff, the members of the advisory board, and the Jesuit design group called Studio J in a critical assessment of everything from the important areas of content and edi-torial policies to the nitpicking aspects of the letterspac-ing of our new typeface. Our entire effort was to launch into our second half century of publication by enhancing our traditionally fine content and presenting it in a way that is truly "reader friendly." When Review for Religious began to be published in 1942, its very title gave evidence of its intended audi-ence- women and men consecrated in a special lifeform in the Catholic Church commonly called Religious life. Yet even the first editors encouraged diocesan priests to use the journal articles as helps both for growing in their spir-ituality and ministry and for appreciating the various reli-gious- life traditions. Early on, too, lay women and men, especially those identified with third-Order and sodality movements, were regular subscribers. With the burgeoning of lay ministries after Vatican II, there have been a growing number of lay readers, inter-ested particularly in developing their prayer life, under-standing their own roles as ministers of Christ, and even searching for better community models for family and parish, inspired by the internal efforts of Religious com-munities. Our journal’s contributors, too, illustrate the wide range of our readership--women, men, lay, Religious, priests, even a bishop now and then. The question arose: Should the very name Review for Religious be changed to reflect its wider audience? 4 Review for Religious After much discussion we agreed that the Religious-life empha-sis retains its central place because it focuses so well the rich spir-ituality traditions within the church. A secondary title, now evident on our cover, clearly highlights this aspect. But the pur-pose of Review for Religious remains just as current and necessary after fifty years: a forum for shared reflection on the lived expe-rience of all who find that the church’s rich heritages of spiritu-ality- Augustinian, Benedictine, Dominican, Carmelite, Ignatian, Franciscan, Salesian, and many others--support their personal and apostolic Christian lives. For readers coming from whatever spiritual tradition, the articles in the journal are meant to be infor-mative, practical, or inspirational, written from a theological or spiritual or sometimes canonical point of view. The journal’s look, then, is meant to reinforce its purpose. While you may miss the easily scanned backcover table of con-tents, we hope that you will find our Contents pages more infor-mative by their brief indication of an article’s theme and by the grouping of various articles under sectional titles. The new sec-tional titles will keep changing from issue to issue, depending on the relationships among articles published in any one issue. Both the variety of sections and the variety of articles within a section are indicative of the vision and purpose of Review for Religious. In its 1942 beginnings this journal provided a com-munication forum which was almost nonexistent among various traditions represented by Religious Orders. Still today the mix of articles contributes to the ongoing understandings, critiques, and movements in our Religious-life heritages so that we find new insight, expand our horizons, and collaborate more effectively for the good of our church life. I find a growing tendency among church people in the United States to read only the articles or books which reinforce their own views and to ignore or condemn out of hand an alternative or opposing approach. As an editor I find myself seldom (if ever) in total agreement with any one article--even in this iournal. For the healthiness of our life in Christ, we all need to appreciate and evaluate differences, changes, and developments in and among the various traditions which, contribute to the present makeup of the church. The articles in this iournal are like prisms which sub-tly nuance light into colorful and unexpected patterns. For exam-ple, some articles present contemporary ways of understanding our traditions; others probe new community forms, prayer prac- January-February 1992 5 Prisms tices, and models of ministering. You as reader may be inspired, surprised, or even annoyed by a particular theme or approach. For me the image of a prism suggests an application of the ministerial wisdom of St. Ignatius Loyola written at a time of church his-tory rife with excommunications and denunciations. Ignatius says: it should be presupposed that every good Christian ought to be more eager to put a good interpretation on a neighbor’s statement than to condemn it. Further, if one cannot inter-pret it favorably, one should ask how the other means it. If that meaning is wrong, one should correct the person with love; and if this is not enough, one should search out every appropriate means through which, by understanding the statement in a good way, it may be saved. Sp Ex 22 (Ganss’s translation) As the task of dialogue in the church takes on even greater importance, we want Review for Religious to remain a valued resource for people serious about their spiritual growth, for those involved in ministries, for members of Religious congregations, and for spiritual directors and those seeking guidance. Review for Religious is privileged to play its role in that dialogue now as it has since its beginnings. Do let us know whether you find our newly designed journal "reader friendly." David L. Fleming sJ 6 Review for Relig4ous RICHARD C. SPARKS Ecclesial Burnout Old Demon, New Form cal, emotional, intellectual, social, and even spiritual energy--is reappearing among pastoral team members with alarming frequency. In those heady years immedi-ately following Vatican II, there appeared a strain of this self-induced dysfunction among zealous priests, sisters, brothers, and lay ministers who too literally tried to fol-low Paul’s injunction "to be all things to all people." In their well-intentioned attempts to "be there" for the old and the young, the churched and the unchurched, parish-ioners and strangers alike, many in pastoral ministry "burned out." But it is not this "workaholic burnout’’1 that I intend to discuss--though it still exists. I intend to discuss what I call ecclesial burnout. Most of us professed,, ordained, or hired in the last ten to fifteen years were schooled in a revised, more col-laborative model of ministry. This model is marked by job descriptions, staff meetings, attempts at collegial dia-logue, claiming one’s personal needs and space, in short, Richard C. Sparks CSP is an editor at Paulist Press. He holds a doctorate in moral theology from Catholic University, with a specialty in biomedical ethics. He serves as an ethics consultant for several healthcare facilities and regularly offers professional and pastoral workshops on bioethics, sexuality, and moral deci-sion making. His address: Mount Paul Novitiate; Ridge Road; Oak Ridge, New Jersey 07438. church and ministry January-February 1992 7 a greater appreciation for the need of each minister to set limits and to nurture both professional and personal relationships. Ideally this leads to happier, healthier pastoral ministers, men and women who have found a better balance of work, play, prayer, exercise, rest, good nutrition habits, and so on. However, as most practitioners will admit, the team model in its all-too-human incarnations is no panacea. The lived experience of rule by com-mittee and collegial discernment does not always match the ideal. If the workshops I have given in various pastoral settings around the country are any indication, there is a new strain of ministerial burnout. It began in the early 1980s and seems to be immune to the simple correctives of prioritizing one’s schedule, keeping in touch with friends, and Religiously taking one’s day off. The power of this ecclesial burnout to corrupt and to debil-itate formerly effective pastoral ministers (lay, clergy, and reli-gious alike) comes not from an overzealous commitment to work nor from an inflated sense of Lone Ranger ministry. Rather, I think, it is rooted in an erroneous, or at least inadequate, sense of church (that is, one’s assumed ecclesiology). For the last five years I have been battling a mild-to-moderate case of it myself and am now slowly on the road to recovery. I feel it, I see it, others confide it, newcomers discern it, col-leagues transfer or leave church ministry altogether because of it--ecclesial burnout. No doubt much of it parallels other forms of psychological burnout. It certainly seems to fall within psy-chiatrist Herbert Freudenberger’s classic definition: % state of fatigue or frustration brought about by devotion to a cause, way of life, or relationship that failed to produce the expected reward.’’2 The symptoms are the same--long-term sullenness, a cynical edge, an overwhelming feeling of exhaustion, dissipated energy, forgetfulness, and depression (clinical or the everyday variety). People who suffer from ecclesial burnout frequently cite the cases of Charles Curran and Archbishop Hunthausen or the recent Vatican treatment of Rembert Weakland as precipitating their low mood. The suppression of certain catechisms, the removal of longstanding imprimaturs from books, the influence of CUF (Catholics United for the Faith) in Vatican curial circles, and the decidedly juridical tone of some CDF (Congregation for the Doctrine of the Faith) documents contribute to a certain fear that "the party’s over." For some, particular diocesan, chancery, or intracommunity ev~counters contribute to a general feeling of 8 Review for Religious malaise. It might sound like a simple case of the liberals’ lament, revisionist Catholics being disheartened by what some see as a mid-course conservative correction following a quarter century of Vatican II experimentation.3 But many who placed great hopes in the church after Vatican II increasingly feel that aggiornamento (renewal) may be short-lived, that this era of church renewal may be the aberration and not the norm, and that we may soon be back to church history’s "business as usual"--politics, legalism, inquisitions, and all. Those who suffer workaholic burnout are depressed that they personally did not measure up, could not be all things to all people, fell short of some impossible agapeic ideal. By contrast, among those who suffer ecclesial burnout, there is less a question of antipathy about personal imperfections and more of a sense of dis-illusionment with the church and its abil-ity to really be "the kingdom come." I hear story after story of frustration, that no-win Ecclesial burnout does not come from an overzealous commitment to work rlor from an inflated sense of Lone Ranger ministry. feeling of being the person caught in the middle--between the Vatican and people in the pew, between liberals and conserva-tives, between pro-school and pro-CCD proponents, between the "townies" and the university students, between right-to-lifers and everybody else, between the diocese (or one’s generalate) and the parish, between Catholics and the wider society, between a pas-tor and other team or council members. Many feel drained, impo-tent, frustrated in their attempts to mediate, to get the church’s act together, whether locally or in some larger arena of the church universal. While there are many contributing factors to this experience, I am convinced that one help toward navigating the shoals suc-cessfully is for each of us to reexamine our own ecclesial presup-positions and expectations. The insights that follow may be self-evident to some, but for me they have been eye-openers, a tremendous help on the road to recovery and reinvigoration. Much literature has been written expounding the theory that the dominant image of church in the decades, even centuries, pre-ceding Vatican II was the institutional model. In his often quoted January-February 1992 9 ~~÷~s ¯ Ecclesial Burnout Models of the Church, Avery Dulles noted in 1974 that, while all five models--hierarchical institution, mystical communion, sacrament of Christ, herald of God’s word, and servant of secular society-- coexist in the church, during any given era one or another tends to dominate.4 In the two major Vatican II documents on the church, as well as in the Final Report of the Synod of 1985, one can find all five models vying for central place,s Despite several decades of the-ologizing and deferential homiletic bows to the notions of church as people of God, mystical body, sacrament of Christ’s ongoing presence, and herald of Gospel justice, it is my contention that our pastoral efforts after Vatican II expressed, for the most part, the same model fostered earlier, namely, the institutional model. Sure, we were going to do it better: more effective liturgy in the ver-nacular; more participatory parish, diocesan, and community gov-ernance; more developmental, story-laden Religious education; more process-oriented evangelization (RCIA); more experiential approaches to reconciliation; and more social-justice-oriented ecumenism. But we were still about the task of running an insti-tution, making our little corner of the vineyard the best-struc-tured parish, Newman Center, diocesan office, or apostolate around. It seems to me that many of us made a subtle shift or trans-ference. After some initial flirtations with personal workaholism and its consequent form of burnout, we no longer expected our-selves to be supermen or superwomen, serving selflessly twenty-four hours a day, in season and out. But at the same time we did not reject the drive for perfectionism altogether. Rather, we trans-ferred it to our rejuvenated image of the church, expecting our post-Vatican II ecclesial structures to be or to become what we individually could not achieve. The church would or should become wholly Spirit-filled, renewed at all levels, from the Vatican curia, through the USCC, chancery, and intracommunity offices, right down to our own parish or center in Name-Your-City, USA (or Canada). If we all worked hard enough, whether as Lone Rangers or as collaborative partners, we could "pull this Vatican II thing off," making the Roman Catholic Church what some supposed it was intended to be, the kingdom of God incarnate on earth . . . as it is in heaven. "Oops," as one of my Catholic U. professors would have screamed, "you collapsed your eschaton." In such hopeful 10 Review for Religious expectation there seems to be no room for human sinfulness and finitude, too little room for well-intentioned visionaries, reform-ers, and sincere counterreformers to make mistakes. If we really can successfully create the reign of God on earth, then who needs redemption? We could cancel Christ’s second coming. There would be no need for his break-through return at the end of time. In our newfound Camelot-like enthusiasm, I fear that we plotted a course destined to dis-appoint. Ask those priests, Religious, and lay ministers who opted to leave. Ask those who had physical or emotional breakdowns. Ask those who are now recovering alcoholics, fooda-holics, adult children of alcoholics, or victims of other addictions and dysfunctions. Ask those who joined a Religious Order or diocese, only to be disillusioned when real life in community did not match vocation brochures or one’s own idealistic expectations. Some of them are still searching for the diocesan, Religious-Order, or denominational "promised land." For the most part we seem to have faced the fact that none of us individually is Jesus Christ (and that even he faced his own doubts, fears, and temptations). By acknowledging that worka-holic perfectionism is wrong, some of us have conquered the demon of "works righteousness," allowing God’s tender mercies to bathe us and to begin to heal our brokenness and wounds. Workaholic burnout seems to be waning, at least in the Catholic community.6 However, I do not think we have made great strides in grant-ing a similar benefit of the doubt and benevolent forgiveness to the church and its leaders (including ourselves) for not measuring up, for not ushering in the fullness of the kingdom of God. Hans Kiing, echoing the pioneering ecclesiology of Yves Congar, con-tinues to point out that the church is sinful as well as graced.7 Martin Luther, credited with coining the adage simuljustus etpec-cator, would hardly be surprised to hear that twentieth-century Roman Catholics are having trouble accepting that their church not only was, but is, and always will be sinful, in need of God’s abiding assistance, patience, redemption, and frequent forgive-ness. If we really can successfully create the reign of God on earth, then who needs redemption ? January-February 1992 11 Sparks ¯ Ecclesia~Burnout Thus, the warning sign of ecclesial burnout is the sadness, bOrdering on depression, that has deeply affected many idealistic pastoral ministers upon their discovering that the church is not, and likely never will be, synonymous with the kingdom of God. But does not church teaching say that they are supposed to be one and the same, that the church (especially in its Roman Catholic incarnation) equals the kingdom of God? No, the bish-ops and theologians gathered at Vatican II rejected such a notion in an earlier draft for Lumen Gentium, in which the church in its fullest sense (that is, God’s reign or kingdom) was to be equated with the Roman Catholic Church. In its place, the church’s official magisters declared that the "church, established and ordained as a society in this world, sub-sists in the Catholic Church’’8 (emphasis mine). Despite arguments to the contrary by some dissident co
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Review for Religious - Issue 57.1 (January/February 1998)
Missouri Province of the Society of Jesus, 2012Co-Authors: Missouri Province Of The Society Of JesusAbstract:Issue 57.1 of the Review for Religious, January/February 1998.Religious Christian Heritages and Contemporary Living JANUARY-FEBRUARY 1998 ¯ VOLUME 57 ¯ NUMBER 1 Review for Religious is a forum for. shared reflection on the lived experience~ of all who find, that the church’s rich heritages of gpirituality support their personal and apostolic ¯ Christian lives. The articles in ~he journal are meant to be informative, practical, historical, or inspirational, written from a theological or spiritual or sometimes canonical point of view. Review for Religious (1SSN 0034-639X) is published bi-monthly at Saint Louis University by the .Jesuits of the Missouri Province. Editorial Office: 3601 Lindell Boulevard ¯ St. Louis, Missouri 63108-3393. Telephone: 314-977-7363 ¯ Fax: 314-977-7362 E-Mail: FOPPEMA@SLU.EDU Manuscripts, books for review, and correspondence with the editor: Review for Religious ¯ 3601 Lindell Boulevard ° St. Louis, MO 63108-3393. Correspondence about the Canonical Counsel department: Elizabeth McDonough OP 1150 Cedar Cove Road ¯ Henderson, NC 27536 POSTMASTER Send address changes to Review for Religious ¯ P.O. Box 6070 ¯ Duluth, MN 55806. Periodical postage paid at St. Louis, Missouri, and additional mailing offices. See inside back cover for information on subscription rates. ©1998 Review for Religious Permission is herewith granted to copy any material (articles, poems, reviews) cbntained in this issue of Review for Religious for personal or internal use, or for the personal or internal use of specific library clients within the limits outlined in Sections 107 and/or 108 of the United States Copyright Law. All copies made under this perxnission must bear notice of the source, date, and copyright owner on the first page. This permission is NOT extended to copying for commercial distribu-tion, advertising, institutional promotion, or for the creation of new collective works or anthologies. Such permission will only be considered on written application to the Editor, Review for Religious. for r ligiou$ Editor Associate Editors Canonical Counsel Editor Editorial Staff Advisory Board David L. Fleming sJ Philip C. Fischer SJ Regina Siegfried ASC Elizabeth McDonough OP Mary Ann Foppe Tracy Gramm Jean Read James and Joan Felling Kathryn Richards FSP Joel Rippinger OSB Bishop Carlos A. Sevilla SJ David Werthmann CSSR Patricia Wittberg SC Christian Heritages and Contemporary Living JANUARY-FEBRUARY 1998 ¯ VOLUME 57 ¯ NUMBER 1 contents 34 48 leadership Congregational Leadership and Spirituality in the Postmodern Era Sandra M. Schneiders IHM offers an analysis of changing worldviews as an aid to understanding present-day Religious congregations and exercising effective leadership in them. Leadership for the Common Good Donna J. Markham OP focuses on three areas of leadership skill development: conflict management, guarding against "groupthink," and promoting communal efficacious action. Hearts Afire: Leadership in the New Millennium Anne Munley IHM sees congregational leadership as being the work of impassioned hearts sharing, finding, and making meaning in concert with all the members, with a view to warm cooperation in endeavors of burning urgency. 60 67 tradition Stability: A Monastic Charism Retrieved Joel Rippinger OSB explores stability as a matter of heart and place in the light of contemporary rootedness. History’s Role in Defining Spiritual Direction Steve R. Wigall proposes that contemporary spiritual direction needs to embrace openly its historical and theological variety. Review for Religious 77 88 prayer Today’s Contemplative Prayer Forms: Are They Contemplation? Ernest E. Larkin OCarm takes a discerning look at contemporary personal prayer practice and terminology against the background of centuries-long traditions. Union with God according to John of the Cross Paul J. Bernadicou SJ describes some aspects of the sanjuanist process towards intimacy with God. departments 4 Prisms 94 Canonical Counsel: Life Consecrated by Profession of the Evangelical Counsels 100 Book Reviews Jant~aty-Februat~ 1998 I believe in the Holy Spirit, the Lord, the Giver of life. prisms 4 T citizens of the United States in recent years have been reinforcing a reputation for being a people that has lost its sense of the sanctity of human life. After a brief lull in the use of the death penalty for what is considered heinous crimes, more and more individual states have been seeking execution for serious crimes committed by both men and women. Then, when we look to the beginning of life, we find that abortion in the United States, even in late term, is justified through the most permissive legal understanding allowed by any Western nation. Finally, when we consider the possible end of life, assisted suicide for the elderly or for the chron-ically ill is already legal in one state and is being promoted by a number of people who defend what is euphemisti-cally called "mercy killing." As we come ~o the last years of this millennium, this most powerful, prosperous, and well-educated nation is sadly being identified as a people that readily "takes life." The year 1998 focuses upon the Holy Spirit in our Christian preparations for entering into the third millen-nium guided by the pastoral plan presented to us by Pope John Paul. Whatever the strength of our faith, the Holy Spirit is the Trinitarian Person most difficult for us to talk about, t9 imagine, and to relate to. Spirit, breath, wind, love, fire are words that in themselves have no face nor even a substance that can be grasped. And yet these are some of the common, traditional words applied to the One we call the Third Person of our Trinitarian God. We might, though, begin this second year of our preparations for the millennium by calling in prayer upon the Spirit by a name appropriate to the times in which we live. Review for Religious In the Nicene Creed we express our belief in the Person called the Holy Spirit, professing first that he is Lord God and then designating this Person as "the Giver of life." What a wonderful identity--Giver of life--especially in regard to a people earning a reputation as "takers of life." It seems obvious that a basic gift we seek from God in this year 1998 is a renewed reverence, respect, and appreciation for human life. Throughout this year, perhaps we all need an examination of conscience on behavior involving us as "takers of life." "Takers of life" can involve an attitude which sullies our approach to any part of God’s creation--each part a gift from God. We can become so self-centered that everything--from the ecological environ-ment to the earth’s resources to human life itself--is viewed in its value now for us. Takers of life know no gratitude, for life is not seen in terms of gifting but only in terms of getting, a disease of a consumer society. Let us pray that the Holy Spirit will inspire and guide our efforts to be, like God, gi,vers of life. The age-old prayer still speaks out our desire: "Come, Holy Spirit, fill the hearts of your faithful." Review for Religious continues to have its own experience of life being given to us. New life continues to flow into our Advisory Board as some members finish their term of service, and new members join. We welcome Sister Kathryn Richards FSP, vice-provincial of the USA province of the Daughters of St. Paul and executive director of the twenty Pauline Book and Media Centers in the USA and English-speaking Canada. She is also the direc-tor of Paulinas Distribudora, the Daughters’ Hispanic media dis-tribution center, and the director of the National Association of Pauline Cooperators, the lay collaborators of the Daughters of St. Paul. In addition we welcome Bishop Carlos Sevilla SJ, bishop of the diocese of Yakima, Washington. Bishop Sevilla serves as a member of the NCCB committees on Hispanic affairs and on Religious life and ministry. Before his ordination as bishop, he had filled administration and formation roles in the Society of Jesus (California province). Farewells are always harder to express than welcomes. I want to express my appreciation to Father Edmundo Rodriguez SJ and to Sister Iris Ann Ledden $SND for their many contributions to the advisory board over the years of their service. We remain grateful for their continuing interest and support. David L. Fleming SJ January-Febr~,aot 1998 o o o o o o leadership SANDRA M. SCHNEIDERS Congregational Leadership and Spirituality in the Postmodern Era In addressing the issue of leadership in congregations which are increasingly influenced by the emergence of cultural postmodernism, I write not as one who is engaged in leadership or trained in the fields of organization and management, but as a theologian reflecting on the spiri-tuality of contemporary Religious. But part of my prepa-ration for these reflections involved talking with a number of Religious in leadership positions, asking them what were the major challenges they faced as leaders. One woman, by means of a highly symbolic vignette, epitomized what many others expressed. She said that, if one prepared an agenda for a meeting far enough ahead of time for the participants to come prepared, the first item on the agenda would be the revision of the agenda because the actual situation in the congregation would have changed so sig-nificantly that neither the items on the agenda nor their relative importance would be what they had been when the agenda was formulated. In other words, the challenges about which leaders talked were not so much specific problems but pandemic unpredictability and uncontrol-lability. While leaders face particular challenges because of Sandra M. Schneiders IHM presented this paper, here slightly revised, to the Leadership Conference of Woxnen Religious on 23 August 1997 in Rochester, New York. She is professor of New Testament Studies and Christian Spirituality at the Jesuit School of Theology at Berkeley, where her address is JSTB; 1735 LeRoy Avenue; Berkeley, California 94709. Review for Religious their public role and more global responsibilities, the situation which makes leadership so difficult today is the same one all of us in Religious life face, namely, the context of chaos within which we are trying to live Religious life coherently and minister effectively. It is this peculiarly contemporary experience and its significance for spirituality that requires analysis and engagement. Whether or not we articulate it explicitly, we are always living, thinking, working within and out of some implicit worldview which defines both the problems and the potentialities of our historical situation.~ Until we come to some understanding of that world-view, we stand little chance of developing an operative spirituality. How we understand reality in general, Religious life in particular, and our own congregation specifically determines what we think we are doing as Religious leaders or followers. A worldview is like light or a pair of glasses. We do not notice its role in what and how we see until it flickers or gets cloudy. Furthermore, until relatively recently we were unaware of the plurality of worldviews because we thought that what we saw was simply what is, rather than what is visible through a particular set of lenses which not everyone in the world is wearing. Until the mid-sixties Catholics in general and Religious in particular lived within a peculiarly schizophrenic worldview whose intrinsic con-tradictions seldom came clearly into view. Within the institution and culture of the cht~rch, we lived out of a medieval worldview in which society was organized according to an ontologically based, and therefore unchangeable, hierarchy of status and roles; in which all reality could and must be explained in the categories of an Aristotelian/Thomistic philosophy and the-ology; and in which the next world, and therefore religion, held a clear priority over the present world and its concerns. However, outside the church arena we lived out of a modern worldview in which democratic capitalism constructed an economically com-petitive society within a deceptive rhetoric of personal equality. The explanation of reality in this modern world was supplied by the confluence of the dualistic philosophy of Descartes, the mechanistic physics of Newton, the deterministic biology of Darwin, and the materia.listic hydraulics of Freudian psychology. The practical priority of this world over the afterlife was expressed in the banishing of Religious concerns from public life to the pri-vate realm of family and church. Although these two worldviews, medieval and modern, were Januat3,-Februat~y 1998 Scbneiders ¯ Congregational Leadership and Spirituality largely incompatible, what they had in common may be more sig-nificant for our present considerations than how they differed. Both of these worldviews presented chaos as the ultimate enemy and Order as the ultimate good. It is hardly surprising, then, that we are uncomfortable to the point of panic amid the unpre-dictability and uncontrollability of so much of our experience today. And, the more people, property, and projects we are respon-sible for, the more threatening and even paralyzing widespread chaos in our domain of responsibility is likely to be. However, as cultural critics are increasingly convinced, the modern worldview itself is rapidly giving way to what is being called postmodernirm, a worldview that is still largely inchoate and unarticulated, but which is actually conditioning our experience more deeply and extensively than we can yet appreciate.2 Characteristic of this emerging worldview is what is being called the "new science" or quantum physics,3 which is not only calling into question the adequacy of Newtonian science to explain the natural or physical world, but implying the necessity for a new, cosmologically based philosophy that sees much deeper connec-tions between matter and spirit, between humans and the rest of reality, between this world and whatever transcends it.4 Implied in the collapse of the classical dualisms is ~i revisioning of chaos and Order which may open up some possibilities for reinterpreting our present experience within Religious life. Although I have been reading voraciously in the new science for a while, I do not claim to understand, much less be able to explain, quantum physics. What I want to do, however, is to use a few of its basic categories, namely, autopoietic structures, fields, and strange attractors, as metaphors for thinking about contem-porary experience in Religious congregations. After exploring these categories from the new science in relation to Religious life, I will try to make’some suggestions that are theologically sound, spir-itually vital, and culturally plausible about our current experience of Religious life and leadership. Autopoietic Structures Margaret Wheatley, in her wonderfully provocative book Leadership and the New Science, brings together new ideas from biology, chemistry, and quantum physics which are analogous in suggesting that Order and chaos are not contradictories, but that Review for Religious Order emerges from chaos as from its matrix,s Furthermore, con-trol is not synonymous with Order nor does it produce stability. Rather, control causes a deadly immobility or stasis which ulti-mately dooms the structure to disintegration. This phenomenon of the constructive relationship between chaos and Order is characteristic of living organisms. Erich Jantsch, whom Wheatley cites, describes autopoiesis as "the characteristic of liv-ing systems [by which they] continu-ously renew themselves and.., regulate this process in such a way that the integrity of their structure is main-tained.’’ 6 In other words, living things maintain their integrity and identity not by eliminating change, but by continu-ous, dynamic interaction with their environment. It is equilibrium, not change, that is fatal! However, the history of Religious life in the United States from the 19th century until Vatican II was character-ized by steadily increasing equilibrium and control and steadily decreasing interaction with the environment.7 After the chaotic pioneering days--when our founders and foundresses braved the rigors of frontier life using everything that came to hand, secular and profane included, to survive personally and institutionally-- American Religious life settled into a rigidly defined and tightly controlled pattern within an increasingly battened-down eccle-siastical institution. Interchange with the environment was ever more stringently controlled and, to the extent possible, elimi-nated. We understood our congregations as Newtonian machine-like systems composed of virtually identical parts, operating according to established laws of motion codified in Rules and. customs books and functioning best when no part acted in orig-inal, that is, "singular" ways. Leaders functioned somewhat like factory managers maintaining strict control (erroneously seen as Order) for the sake of spiritual and ministerial efficiency. Newtonian physics, which supplied this machine model for all systems, also gave us the laws of thermodynamics which gov-ern such systems. The second law of thermodynamics tells us that, when a system reaches equilibrium, entropy or disintegration We are uncomfortable to the point of panic amid the unpredictability and uncontrollability of so mucl of our experience today. Janllary-Februaty 1998 Scbneiders ¯ Congregational Leadership and Spirituality sets in. We moderns learned that this law of increasing entropy or the inevitable wearing down of systems was also characteristic of living things (which we understood as basically very complicated machines) and certainly true of organizations such as Religious congregations.8 What the new science is telling us is that social organizations are not entropic like machines, but more like living organisms, which are autopoietic, that is, self-renewing. The basis of autopoiesis or self-re-creation is the openness of organisms to their environment. As Wheatley says, Each structure has a unique identity, a clear boundary, yet it is merged with its environment .... What we observe.. ¯ in all living entities, are boundaries that both preserve us from and connect us to the infinite complexity of the out-side world. Autopoiesis, then, points to a different universe. Not the fragile, fragmented world we attempt to hold together, but a universe rich in processes that support growth and coherence, individuality and community.9 When we look at Religious congregations of the 1950s, we see relatively hermetically sealed organizations operating accord-ing to the quantitative laws of mechanics. Numbers, material resources, institutional agencies of influence, and hierarchical control of all operations were the sources of efficiency. The cat-aclysm of Vatican II and its immediate predecessors in Religious life such as the Sister Formation Movement suddenly opened these closed systems to their environment. New information of all kinds flooded the system. Sisters studied new disciplines in secu-lar as well as Religious universities and interacted with a variety of people they formerly would never have encountered in any mean-ingful way. The mass media and the uncensored contents of libraries burst through the boundaries of the closed system. And then Vatican II called on congregations to reevaluate those old-world traditions which had so effectively kept Religious out of the mainstream of American culture. Ministries changed dramatically and, with them, living situations. Contacts with other Religious and with the laity, stringently rationed in previous times, broad-ened and deepened. In short, Religious congregations suddenly drew deep breaths of fresh air and discovered that they were not ecclesiastical robots but sociospiritual organisms, living systems in vital interaction with their environment. Increasingly congregations, and their relatively uniform mem-bers, began to exhibit the characteristics of autopoietic structures. Review for Religious Perhaps the most unsettling characteristic is that a healthy liv-ing system is in a continuous state of disequilibrium. New infor-mation, constantly flowing into the system from the environment, challenges it to respond, to change, and to develop without loss of integrity or identity. There is no settling down, no way to call off the bombardment of the new and just be. There are no per-manently right answers, no one correct way to do things, no abso-lute authority. The organism is always off balance. Local chaos is the normal condition out of which global Order is continuously being both threatened and resourced. Another characteristic of autopoietic structures, precisely because they are not in balance but precariously poised in the turbulence of a constantly changing ambiance, is that very small influences can have very significant effects on the system. In mechan-ical entities, significant change is usually proportionate to the mass of the influencing agents. Large groups, sizable funds, long-range plans are necessary to alter the status quo. But in a living system a small agent, for example, a virus, can have tremendous impact because it can galvanize the whole organism into response.’° The effect of one book like The Nun in the Modern World, or one speaker like Theresa Kane, is out of all proportion to the mass of the cause. One person generating negative energy can immobilize a whole assembly while one visionary chapter pro-posal can propel the whole congregation into self-renewal. A third feature of living systems is that they are programmed toward life. In this respect they are the very antithesis of the machine. Once entropy has set in, the machine inevitably and irreversibly winds down t
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Review for Religious - Issue 13.6 (November 1954)
Missouri Province of the Society of Jesus, 2012Co-Authors: Missouri Province Of The Society Of JesusAbstract:Issue 13.6 of the Review for Religious, 1954.Review for Religious NOVEMBER 15, 1954 Xaverian Pioneers .......... Brother Alois Address to Mothers General Arcadio Larraona ’ Psychology .and Judging Others . Just November~r Always7 . Sister Mar~ Joseph N. Tylenda News and Views Book Reviews Communications Questions and Answers A Good Superior Index for 19S4 VOLUME XIII NUMBER 6 REVIEW FOR RELIGIO.US VOLUME XlII NOVEMBER, 1954 NUMBER CONTENTS XAVERIAN PIONEERS---Brother Alois, C.F.X .......2..81 SOME SPECIAL PUBLICATIONS ............ 289 A GOOD SUPERIOR ................. 290 VOCATIONAL LITERATURE REQUESTED ........ 296 ADDRESS TO MOTHERS GENERAL-- Most Reverend Arcadlo Larraona, C.M.F. 297 OUR CONTRIBUTORS ................ 305 FATHER LARRAONA’S ADDRESS. ........... 306 FAMILY DAY ................... 306 THAT ’JUDGING OTHERS’ HABIT IN THE LIGHT OF MODERN PSYCHOLOGY~ister Mary, I.H.M .....307 NEWS AND VIEWS-- American Founders’ Series; Congress in Canada; Notre Dame, 1953 310 JUST NOVEMBER---OR ALWAYS?~oseph N. Tylenda, S.J. 311 COMMUNICATIONS ........ ~ ........ 315 BOOK REVIEWS-- The Promised Woman; Pio Nono; These Came Home; Mediaeval Mystical Tradition and Saint 3ohn of the Cross .... 317 BOOK’. ANNOUNCEMENTS .............. 321 NOTICE FOR PUBLISHERS .............. 324 QUESTIONS AND ANSWERS-- 31. Establishing Dowry after Solemn Profession ....... 325 32. Plenary Indulgence "in the form of a Jubilee" . ..... 325 33. Relatives on General Council ............ 326 34. Mistress of Novices as General Councilor ....." . . . 327 35. Retaining Office because of New Constitutions ...... 327 36. Books on Obedience .............. 328 INDEX FOR 1954 ................. 332 REVIEW FOR R~LIGIOUS, November, 1954. Vol. XIIL No. 6. Published bi-monthly: January, March, May, Ju!y, September, and November at the College Press, 606 Harrison Street, Topeka, Kansas, by St. Mary’s College, St. Marys, Kansas, with ecclesiastical approbation. Entered as second class matter January 15, 1942, at the Post Office. Topeka, Kansas, under the act of March 3, 1879. Editorial Board: Augustine G. Ellard, S.J., Adam C. Ellis, S.J. Gerald Kelly, S.J., Francis N. Korth, S.J. Copyright, 1954, by Adam C. Ellis, S.J. Permission is hereby granted for quota-tions of reasonable length, provided due cre~tit be given this review and the author. Subscription price: 3 dollars a year: 50 cents a copy. printed in U. S. A. Before writing to us, please consult notice on Inside beck cover. Xaverian Pioneers Brother A1ois, C.F.X. THE motto ,,o,f the Xaverian Brothers, Concordia res parvae crescunt--by harmony little things grow"--has been so perfectly fulfilled and demonstrated in [the history of the con-gregation that it is difficult to signal out o,ne Brother who was in any large way responsible for the growth ~f the Order. It had no Saint Francis or Saint Bernard to attract !followers by the very force of his magnetic sanctity, no counterp.art of Mother Cabrini or Saint Teresa to solve financial difficultie~ with a holy wizardry and bring forth numerous foundations at ithe touch of his wand of faith. Theodore Ryken (Brother Francis Xavier), the founder of the institute, was indeed a man of gr~at holiness and of the deepest faith. To him alone must be the hqnor and glory for hav-ing conceived the idea of the Brotherhood land having brought it into actuality despite difficulties that wer~ unusually great even when compared with the hardships religio~,s founders have gener-ally met. But it cannot be said that he large!y influenced the growth of the congregation. In the plan of God tl~e very existence of the new foundation was insecure as long as Brother Francis Xavier ruled it and it became firmly established onl~r after BroW:her Vincent had succeeded him as superior general. The growth and spirit of the congregation can really be accredited only to a cooperative ef-fort. Down through the years and even n’ow it has been and is difficult to select many Xaverians who stan~d out from the others. Yet the body Religious has achieved a certain prominence and has developed a particular spirit of~ Which it can be proud¯ Still it cannot be said that like a spiritual Topsy the Xaverian Brothers just grew. In this centennial year ih America the members of the congregation pay tribute not only to~ the group but also to some specific predecessors¯ And characterlstxcally most of the honor ~ . goes tO tWO heroic souls who were outstanding for neither their learning nor influence nor high positions no~ great achievements but only because they were holy, humble, obedi,ent, and loyal: Brother Francis Dondorf and Brother Stephen ~Sommer. To understand these men we must re)giew the not-too-well-known story of the foundation of the congregation. Theodore James Ryken was born in Elshout, North Brabant, 281 BROTHER ALOIS Review for Religious Holland, in 1797. Left an orphan at an early age he was brought up by a.pious uncle who instilled into theboy’s character a great zeal for souls. He seems always to have been drawn to the work of Christian education, for he worked in his native land as a cate-chist and a lay.teacher in an orphanage. In 1828 Mr. Ryken entered th~ Trappist monastery at Stras-bourg, France, but in 1829 the monks there had to disband and abandon their monastery because of the anticlerical laws of the time. He did not choose to return to Holland for a long period, however, fo~ in 1831 he journeyed to America, planning to act as a lay cate-chist in this country. What he did during all of his three-year stay in the United States has not been completely established. We do know from extant letters that he spent at least three months work-ing with the renowned missionary Father Stephen Baden among the Potawatomi in the area around what is now South Bend. In private papers left by Brother Ignatius, th~ founder’s first’ disciple, we learn that Mr. Ryken supported himself at one time by work-ing as a porter on a lumber barge, carrying planks from dawn until dusk; at another time he sold oil as a street peddler in New York City. At still another time he served as an attendant on a bishop, probably Bishop Edward Fenwick of Cincinnati. In private papers that he left Brother Ignatius sums up this period thus: "Though his vicissitudes were many and great, he still took delight in structing those about him in the truths and practices of our Holy Religion whenever a favorable opportunity presented itself." The Founding Seeing the great need for Catholic teachers, Mr. Ryken con-ceived the idea of a brotherhood devoted to this work. He returned to Belgium and laid his plans before Bishop Boussen of Bruges. The latter favored the idea but seems to have required the founder to get the approval of the American bishops, because in 1837 Mr. Ryken again went to the United States for that purpose. In six months he had obtained letters of. approval from seven members of the American hierarchy and several prominent priests and he re-turned with these to Europe. He journeyed to Rome and from Pope Gregory XVI he obtained a blessing on his p~oposed foun-dation. He then went to Bruges, secured the necessary episcopal approval, and entered the novitiate of the Redemptor!sts at Saint Trond to prepare himself for his work. At the end of his probationary period the Redemptorists re- 282 November, 195~ XAVERIAN PIONEERS ported.favorably on Mr. Ryken’s fitness, and on June 5, 1839, he established himself in a house on Ezel Street in Bruges and began to seek disciples. This date is celebrated as Fo’undation Day. But for a year Mr. Ryken was a founder without an Order. Then on June 9, 1840, one, Anthony Melis, joined him and, as Brother Ig-natius, was always considered by the founder as his eldest son. But growth continued to be slow; in 1842 there were seven members, in 1846 only ten. In the original plan he drew for the foundation of the Order, Mr. Ryken had innocently written: "Ten or twelve months after the foundation of the Congregation in Belgium, one of the Brothers is to proceed to America to prepare the house, buy ground and ar-range everything for the arrival of the first Brothers sent to Amer-ica .... " Those "ten or twelve months" were actually to extend to fifteen years before the aim of the Order could begin to be realized, but in the long meantime Ryken’s faith, courage, and determination wavered not a bit. Brother Ignatius gives us a picture of the destitution the little group endured. "House furniture of any kind and the merest home comfortg were luxuries they enjoyed not. Even the very necessaries of life were sometimes wanting. The floor was for some time their only bed, old clothes their covering; an old deal box, their table; old bed-sheets, their curtains; and an empty, stove their winter’s warmth." The founder made shoes to. obtain some income but for the most part they existed entirely on charity. They lived in an unpaid-for house hourly expecting eviction. The free school they opened in 1840 prospered but only added t.o the financial burden. Bitter criticism and strong opposition even from quarters where they had a right to expect encouragement added to the difficulties. Yet the band did grow. Another primary school was opened at Bruges and men were sent to a normal school at Saint Trond for professiohal training. In 1848 a school was opened in Bury, England, not to take the place of the American mission but be-cause Catholic education in England at that time was a true mis-sionary work and because the Brothers could improve their English there before being sent to America. In 1853 the Bishop of Louisville, Kentucky, Martin John Spalding, visited the Bishop of Bruges and through him met Brother Francis Xavier Ryken. Learning of his desire to send men to the United States, the Bishop contracted then and there for six 283 BROTHER ALOIS Reoieto [or Religious Brothers to teach in the parochial schools of Louisville. But when the Brothers reached Louisville they found that all their previous training in enduring hardships, and more, was needed to withstand the difficulties they encountered in the new country. Here they met a new kind of opposition, bigotry. Anti-Catholicism, instigated and spread by the "Know-nothings" and members of kindred organizations, was strong and active. In Louisville the fanatics who a year later, on August 5, 1855, were to instigate the terrible riots that resulted in the butchering of twenty-two Catholics and the burning of numerous Catholic homes, were thoroughly aroused by the coming to the city of these six mysterious-looking foreigners. Reports were circulated and even published in the news-papers that these men had come to train up an army to wage a bloody war on Protestants, that they had ammunition and arms stored in" their school. A thorough search of the place was demanded. After hiding their altar vessels in a cemetery, the Brothers dispersed. and lived a while with private families. Only after their school and living quarters were ransacked and the utter simplicity of their mode of life was proved to even the most fanatic opponent, could they reassemble. In contracting for the Brothers’ services, Bishop Spalding had agreed to pay one hundred and thirty dollars a year for each Brother. This proved to be too little and it was impossible to get more; hence after four years the Brothers had to be recalled. But because funds were not available for passage for all and because--so tradi-tion goes--they were the most expendable, Brother Francis Don-doff and Brother Stephen Sommer were left in Louisville. Brother Francis That Brother Francis Dondorf was a Xaverian Brother was a miracle of grace--a flood of grace that attracted him to a very unat-tractive institute when he could have joined many more promising ones, and which maintained and developed that attraction when even the congregation itself misunderstood and rejected him. He was born in 1816 in Aix-la-Chapelle. His family was well off; his home and school training were good. At twenty-six he held a good position in the post office of his native city. But his heart was not at rest and he prayed for light to know what God had in store for him. Always most devoted to the Blessed Sacra-. ment, he was accustomed to make a visit when he passed a church. One day in 1842 on leaving the Cathedral of Aix-la-Chapelle after 284 November, 1954 XAVERIAN PIONEERS one of these visits he struck up .a conversation with another man leaving at the same time. This was Brother Ignatius, Theodore Ryken’g first disciple, sent by him to Catholic- centers to seek re-cruits. As a result of this providential meeting, Francis Dondorf shortly after presented himself to the founder seeking admission to the new congregation. He was accepted and, following a pro-bationary period of a year and a half, received the habit on Easter of 1844. For two years Brother Francis attended the normal school at Saint Trond but was recalled then because of a shortage of teach-ers at Bruges. With Ryken and nine others he pronounced his temporary vows on October 22, 1846, but. when these vows ex-pired he was considered by the founder to be unsuitable for the life and told to leave the congregation. What later proved to be char-acteristic unobtrusiveness in community had been taken as morose-ness; what was only inexperience was judged to be lack of ability in the classroom. Grief-stricken, but with a wonderful courage and an unslackened devotion to and love for the congregatio.n, Fran-cis Dondorf returned home. Resolutely he enrolled at the normal school at Langenhorst in Rhenish Prussia to fit himself for his chosen and determined vocation. Two years later, without previous arrangement, he presented himself again to the founder for readmis-sion. He was accepted and pronounced his perpetual vows on De-cember 3, 1853. The next July he was chosen as one of the pioneer band emigrating to America. Brother Stephen Brother Stephen was born andreared in Attendorn, Westphalia. At fifteen he was apprenticed to a tailor and after four years took up that trade in Muenster. Attracted to youth work, even then, he formed a club for the young men of his area. He interested others in the work and they formed similar groups in other cities. Their achievements came to the attention of a priest, Father Adolph Kolp-ing, who offered to take over the direction of the work. The well-known and widespread Kolping Institute grew from this beginning. A chance reading of a newspaper story of the taking of vows by the founder of a new education society,in Bruges was the instru-ment of grace that awoke in Stephen Sommer a desire to make a like immolation of himself. He pondered the decision prayerfully for a year and at length applied for admission. He was accepted and arrived at Bruges on December 8, 1848, a very significant.date in view of his deep love of and abiding devotion to Our Blessed 285 BROTHER ALOIS Revleu~ for Religious Mother. He received the habit on April 2, 1850, and pronounced his vows on February 2, 18521 A man of great humility, Brother Stephen at first gave no ~n-. dication of the keen mind he possessed and was put to work as a tailor. The discoverer.of his intellectual ability--so the story goes-- was by one of those incidents that seem to be repeated in the histgry of every Religious Order. He was scrubbing a floor one day when two Brothers who were unable to solve a mathematical problem asked him jokingly whether he could help them. He arose from his knees, quickly and nonchalantly solved the problem, and returned to his menial work. When Brother Francis Xavier was informed of the incident, Brother Stephen was enrolled immediately at the normal school. In 1854 he was not chosen to accompany the band that set out for America but in 1856, when one of the original six died in Louisville, Brother Stephen was sent as a replacement. However, after Brother Stephen had left Bruges, the founder had written to Louisville recalling two of the men. The letter ar-rived before Brother Stephen and when he got there he found only three where he had expected five. Then, in 1858, because of the im-possibility of getting an increase in the annual, salary, two more Brothers were recalled. Brother Stephen and Brother Francis were assigned to Immaculate Conception school. They took up their abode in two small rooms at the rear of the classrooms and settled themselves to carry on in the face of any difficulties that could present themselves and for as long as obedience required them. For two years these valiant souls held the fort alone. Both humble, quiet, prayerful men, they must have been a pleasing sight in the eyes of heaven as they went through.their daily spiritual ex-ercises, did their househoId chores, cooked and ate their meager re-pasts, prepared their lessons and taught their classes. Heroically ig-noring every cause of discouragement; steadfastly resisting those who tried to persuade them to cast themselves off from the European foundation, which was precarious in itself and so very distant, and to join the priesthood or another band of Brothers; humbly living on the charity of a kind curate of the parish, they kept burning the flame of Xaverianism in America. In 1860 the pastor of Immaculate Conception parish visited Bruges to try to obtain an addition to the.community of two which was doing such fine work at his school. Brother Francis Xavier had by this time handed over the reins of government of the congrega- 286 No~embet’, 1954 XAVER/)kN PIONEERS tion. By offering a salary of two hundred and fifty dollars a year instead of the one hundred and thirty, the priest won Brother Vin-cent’s, promise of eight more Brothers; and soon these set out for the new land. It does not require much power of imagination to picture the joy of Brothers Francis and Stephen when they were again united with their Brothers in Christ. God was good, their faith had been justifie!! As His instruments they had labored as He saw fit, and great things could now come of His work. Of course a great new day did not dawn bright and clear at once. The Brothers still had to undergo numerous hardships. The ten of them, with several additions that came later, lived in ex-tremely cramped and poor quarters for four years. Knowing that financial conditions in Bruges were worse (in twenty years not a cent had been paid on the mother house), they made every sacrifice to save. Their usqal lunch was coffee and bread with molasses. They fasted on non-school days. Ultimately they were able to send to Brother Vincent the money needed to establish the congregation firml~ in its birthplace. On March 19, 1861, Michael Sullivan (later Brother 3oseph) entered the congregation as the first American postu-lant. 3ohn Quill (Brother 3ohn) entered before the year was over and others followed. Never startling, the growth nevertheless con-tinued steady. Brother Francis lived thirty-two years in religion; Brother Ste-phen sixty-six. They both had terms as novice master, but in those days that was hardly more than a side line. Brother Stephen, for instance, besides being novice master, was house tailor and a full-time teacher, too! They were both very successful teachers in class and in community. But it was their example as Religious that, as far as we can judge, bad its greatest effect and for which they are held most in esteem in the congregation today. Closing Years Brother Francis was a stern character. One of the Brothers who taught with him as a young man tolff how, as they walked the half mile to school every morning, Brother Francis would ask him how he intended to teach his classes that day, would give him valu-able suggestions on the lessons, and supply him with anecdotes on ’the subjects involved. As a man of prayer and recollection he spoke only when good would be the result. In fact the Brother used to tell how a little, boy who had frequently seen them pass hollered one 287 BROTHER ALOIS Review for Religious day: "Look! that old man and his son never talk!" In class he was a model of efficient activity. Outside of class his only pleasure was in more work. On both Saturdays and Sun-days he gathered his boys for Mass just as he did on school days. The only difference was that Sodality and games rather than classes filled in the remaining time of the week-end days. He possessed a. good voice and delighted in teaching the boys hymns and songs, not.for the music’s sake but because he loved the hymns and had a fund of songs that inculcated virtue and lauded goodness. Brother Francis, we are told, grew always in that love and de-votion to the Blessed Sacrament which we saw was the occasion of his first contact with a Xaverian Brother. In chapel he was an inspiration to all; after Holy Communion so rapt in love was he that he almost seemed to be in ecstacy. In. singing hymns the deep devotion of his soul was evident in his sincere voice, his intense expression, in the tears that frequently flowed down his cheeks. The Blessed Sacrament was the core of his existence, and the Brothers spoke often of how their own devotion to the Eucharist increased through just living with him. Like Brother Francis, Brother Stephen had a passion for work. A little man, weighing less than a hundred pounds, he nevertheless was always active. Even at the age of eighty-six he was the treasurer and bookkeeper for the large community in Louisville; he had charge of the bookstore of the high school and was tailor as well--"tailor" meaning not only that he repaired all the Brothers’ clothing but made their habits too. This latter duty he had for fifty-one years in Louis-ville, Performing the tasks far into the night after a full day of teach-ing, paper-correcting, and lesson-planning. He was tenderly devoted to our Blessed Mother. One had only to see him reci
Steve Horvath - One of the best experts on this subject based on the ideXlab platform.
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epigenetic age of the pre frontal cortex is associated with neuritic plaques amyloid load and alzheimer s disease related cognitive functioning
Aging (Albany NY), 2015Co-Authors: Morgan E Levine, David A Bennett, Ake T Lu, Steve HorvathAbstract:There is an urgent need to develop molecular biomarkers of brain age in Order to advance our understanding of age related neurodegeneration. Recently, we developed a highly accurate epigenetic biomarker of tissue age (known as epigenetic clock) which is based on DNA methylation levels. Here we use n=700 dorsolateral prefrontal cortex (DLPFC) samples from Caucasian subjects of th e Religious Order Study and the Rush Memory and Aging Project to examine the association between epigenetic age and Alzheimer's disease (AD) related cognitive decline, and AD related neuropathological markers. Epigenetic age acceleration of DLPFC is correlated with several neuropathological measurements including diffuse plaques (r=0.12, p=0.0015), neuritic plaques (r=0.11, p=0.00 36), and amyloid load (r=0.091, p=0.016). Further, it is associated with a decline in global cognitive functioning (β=-0.500, p=0.009), episodic memory (β=-0.411, p=0.009) and working memory (β=- 0.405, p=0.011) among individuals with AD. The neuropathological markers may mediate the association between epigenetic age and cognitive decline. Genetic comple x trait analysis (GCTA) revealed that epigenetic age acceleration is heritable (h 2 =0.41) and has significant genetic correlations with diffuse plaques (r=0.24, p=0.010) and possibly working memory (r=-0.35, p=0.065). Overall, these results suggest that the epigenetic clock may lend itself as a molecular biomarker of brain age.
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epigenetic age of the pre frontal cortex is associated with neuritic plaques amyloid load and alzheimer s disease related cognitive functioning
Aging (Albany NY), 2015Co-Authors: Morgan E Levine, David A Bennett, Steve HorvathAbstract:There is an urgent need to develop molecular biomarkers of brain age in Order to advance our understanding of age related neurodegeneration. Recently, we developed a highly accurate epigenetic biomarker of tissue age (known as epigenetic clock) which is based on DNA methylation levels. Here we use n=700 dorsolateral prefrontal cortex (DLPFC) samples from Caucasian subjects of the Religious Order Study and the Rush Memory and Aging Project to examine the association between epigenetic age and Alzheimer's disease (AD) related cognitive decline, and AD related neuropathological markers. Epigenetic age acceleration of DLPFC is correlated with several neuropathological measurements including diffuse plaques (r=0.12, p=0.0015), neuritic plaques (r=0.11, p=0.0036), and amyloid load (r=0.091, p=0.016). Further, it is associated with a decline in global cognitive functioning (β=-0.500, p=0.009), episodic memory (β=-0.411, p=0.009) and working memory (β=-0.405, p=0.011) among individuals with AD. The neuropathological markers may mediate the association between epigenetic age and cognitive decline. Genetic complex trait analysis (GCTA) revealed that epigenetic age acceleration is heritable (h2=0.41) and has significant genetic correlations with diffuse plaques (r=0.24, p=0.010) and possibly working memory (r=-0.35, p=0.065). Overall, these results suggest that the epigenetic clock may lend itself as a molecular biomarker of brain age.
Julie A Schneider - One of the best experts on this subject based on the ideXlab platform.
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cognitive impairment decline and fluctuations in older community dwelling subjects with lewy bodies
Brain, 2012Co-Authors: Julie A Schneider, Sue Leurgans, Zoe Arvanitakis, Patricia A Boyle, David A BennettAbstract:Lewy bodies are common in the ageing brain and often co-occur with Alzheimer’s disease pathology. There is little known regarding the independent role of Lewy body pathology in cognition impairment, decline and fluctuations in community-dwelling older persons. We examined the contribution of Lewy body pathology to dementia, global cognition, cognitive domains, cognitive decline and fluctuations in 872 autopsied subjects (mean age = 87.9 years) from the Rush Religious Order Study (n = 491) and Memory and Aging Project (n = 381) longitudinal community-based clinical–pathological studies. Dementia was based on a clinical evaluation; annual cognitive performance tests were used to create a measure of global cognition and five cognitive domains. Lewy body type was determined by using α-synuclein immunostained sections of substantia nigra, limbic and neocortical regions. Statistical models included multiple regression models for dementia and cognition and mixed effects models for decline. Cognitive fluctuations were estimated by comparing standard deviations of individual residuals from mean trajectories of decline in those with and without Lewy bodies. All models controlled for age, sex, education, Alzheimer’s disease pathology and infarcts. One hundred and fifty-seven subjects (18%) exhibited Lewy body pathology (76 neocortical-type, 54 limbic-type and 27 nigra-predominant). One hundred and three (66%) subjects with Lewy body pathology had a pathologic diagnosis of Alzheimer’s disease. Neocortical-type, but not nigral-predominant or limbic-type Lewy body pathology was related to an increased odds of dementia (odds ratio = 3.21; 95% confidence interval = 1.78–5.81) and lower cognition (P < 0.001) including episodic memory function (P < 0.001) proximate to death. Neocortical-type Lewy body pathology was also related to a faster decline in global cognition (P < 0.001), decline in all five specific cognitive domains (all P-values < 0.001), and to fluctuations in decline of working and semantic memory (P-values < 0.001). Limbic-type Lewy body pathology was related to lower and faster decline in visuospatial skills (P = 0.042). The relationship of Lewy body pathology to cognition and dementia was not modified by Alzheimer’s disease pathology. Neocortical-type Lewy body pathology is associated with increased odds of dementia; lower and more rapid decline in all cognitive domains including episodic memory and fluctuations in decline in semantic and working memory. Limbic-type Lewy body pathology is specifically associated with lower and more rapid decline in visuospatial skills. The effect of Lewy body pathology on cognition appears to be independent of Alzheimer’s disease pathology.
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Cerebrovascular Disease Pathology and Parkinsonian Signs in Old Age
Stroke, 2011Co-Authors: Aron S. Buchman, David A Bennett, Sue Leurgans, Sukriti Nag, Julie A SchneiderAbstract:Background and Purpose—Mild motor symptoms including parkinsonian signs are common in old age, but their underlying neuropathology is unclear. We tested the hypothesis that cerebrovascular pathologies are related to parkinsonian signs. Methods—We studied brain autopsies from 418 deceased participants from the Religious Order Study, who underwent evaluation of parkinsonian signs with a modified version of the motor section of the Unified Parkinson's Disease Rating Scale. Brains were evaluated for macroscopic and microinfarcts and the severity of arteriolosclerosis. Regression analyses were used to examine the association of cerebrovascular pathologies with parkinsonian signs. Results—More than 35% of cases (N=149) showed macroscopic infarcts. Almost 30% of cases without macroscopic infarcts showed pathologies not detected by conventional brain imaging: microinfarcts (N=33 [7.9%]), arteriolosclerosis (N=62 [14.8%]), or both (N=24 [5.7%]). Macroscopic infarcts, specifically multiple cortical and ≥1 subcortic...
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substantia nigra tangles are related to gait impairment in older persons
Annals of Neurology, 2006Co-Authors: Julie A Schneider, Robert S Wilson, Jeffrey H Kordower, David A BennettAbstract:Objective Parkinsonian signs, especially gait impairment, are common and associated with morbidity and mortality in older persons. Our objective was to test the hypothesis that substantia nigra neurofibrillary tangles (NFTs) are related to parkinsonian signs in older persons with and without dementia. Methods We studied 86 deceased older Catholic clergy without idiopathic Parkinson's disease from the Religious Order Study, a longitudinal clinical-pathological study. Mean age at death was 85.3 years. Signs of gait disturbance, bradykinesia, rigidity, and tremor were assessed proximate to death using a modified Unified Parkinson's Disease Rating Scale. Forty-micrometer paraffin-embedded sections of substantia nigra were bleached before tau immunohistochemistry and the optical disector was used to count NFTs. We used multivariable linear regression to examine parkinsonian signs as a function of nigra NFTs, controlling for age, sex, education, and cortical NFTs. Results Substantia nigra NFTs were present in 67 of 86 persons (77.9%). After controlling for age, sex, education, and cortical NFTs, nigra NFTs were related to gait impairment (p < 0.001), but not bradykinesia, rigidity, or tremor. Results were not confounded by dementia, Braak score, neuroleptic medication, cerebral infarcts, or Lewy bodies. Interpretation NFTs in the substantia nigra are associated with gait impairment in older persons with and without dementia. Ann Neurol 2006;59:166–173
Morgan E Levine - One of the best experts on this subject based on the ideXlab platform.
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epigenetic age of the pre frontal cortex is associated with neuritic plaques amyloid load and alzheimer s disease related cognitive functioning
Aging (Albany NY), 2015Co-Authors: Morgan E Levine, David A Bennett, Ake T Lu, Steve HorvathAbstract:There is an urgent need to develop molecular biomarkers of brain age in Order to advance our understanding of age related neurodegeneration. Recently, we developed a highly accurate epigenetic biomarker of tissue age (known as epigenetic clock) which is based on DNA methylation levels. Here we use n=700 dorsolateral prefrontal cortex (DLPFC) samples from Caucasian subjects of th e Religious Order Study and the Rush Memory and Aging Project to examine the association between epigenetic age and Alzheimer's disease (AD) related cognitive decline, and AD related neuropathological markers. Epigenetic age acceleration of DLPFC is correlated with several neuropathological measurements including diffuse plaques (r=0.12, p=0.0015), neuritic plaques (r=0.11, p=0.00 36), and amyloid load (r=0.091, p=0.016). Further, it is associated with a decline in global cognitive functioning (β=-0.500, p=0.009), episodic memory (β=-0.411, p=0.009) and working memory (β=- 0.405, p=0.011) among individuals with AD. The neuropathological markers may mediate the association between epigenetic age and cognitive decline. Genetic comple x trait analysis (GCTA) revealed that epigenetic age acceleration is heritable (h 2 =0.41) and has significant genetic correlations with diffuse plaques (r=0.24, p=0.010) and possibly working memory (r=-0.35, p=0.065). Overall, these results suggest that the epigenetic clock may lend itself as a molecular biomarker of brain age.
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epigenetic age of the pre frontal cortex is associated with neuritic plaques amyloid load and alzheimer s disease related cognitive functioning
Aging (Albany NY), 2015Co-Authors: Morgan E Levine, David A Bennett, Steve HorvathAbstract:There is an urgent need to develop molecular biomarkers of brain age in Order to advance our understanding of age related neurodegeneration. Recently, we developed a highly accurate epigenetic biomarker of tissue age (known as epigenetic clock) which is based on DNA methylation levels. Here we use n=700 dorsolateral prefrontal cortex (DLPFC) samples from Caucasian subjects of the Religious Order Study and the Rush Memory and Aging Project to examine the association between epigenetic age and Alzheimer's disease (AD) related cognitive decline, and AD related neuropathological markers. Epigenetic age acceleration of DLPFC is correlated with several neuropathological measurements including diffuse plaques (r=0.12, p=0.0015), neuritic plaques (r=0.11, p=0.0036), and amyloid load (r=0.091, p=0.016). Further, it is associated with a decline in global cognitive functioning (β=-0.500, p=0.009), episodic memory (β=-0.411, p=0.009) and working memory (β=-0.405, p=0.011) among individuals with AD. The neuropathological markers may mediate the association between epigenetic age and cognitive decline. Genetic complex trait analysis (GCTA) revealed that epigenetic age acceleration is heritable (h2=0.41) and has significant genetic correlations with diffuse plaques (r=0.24, p=0.010) and possibly working memory (r=-0.35, p=0.065). Overall, these results suggest that the epigenetic clock may lend itself as a molecular biomarker of brain age.