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Qing Zhang - One of the best experts on this subject based on the ideXlab platform.

  • multislice spiral computed tomography signs of invasion of the Renal Capsule by Renal cell carcinoma
    Medicine, 2018
    Co-Authors: Yanman Zhang, Hao Tian, Siqi Zhang, Qing Zhang
    Abstract:

    Capsular invasion is frequently detected in localized Renal cell carcinoma (RCC) specimens and is associated with a poor prognosis, but the pretreatment imaging features are poorly known. This study aimed to explore the positions and margin types of RCC and various computed tomography (CT) signs, as well as the correlations with the presence/absence of RCC invasion of the Renal Capsule. This was a retrospective study of 158 consecutive patients treated for pathologically confirmed RCC between January 2013 and December 2016 at the Nantong University Affiliated Hospital. The patients were divided into the Capsule invasion and noninvasion groups. The CT signs were analyzed (position type, margin type, and CT findings in the periRenal fat). There were 92 (58.2%) men and 66 (41.8%) women; mean age was 59.1 ± 12.8. Renal Capsule invasion was confirmed in 45 cases. There was no difference in the position types between the 2 groups (all P > .05). The smooth margin was more common in the noninvasion group (53.1% vs 15.6%, P < .01). The deep lobulated type and the saw tooth sign were more common in the invasion group (57.8% vs 7.1%; and 40.0% vs 6.2%; both P < .01). The deep lobulated (OR = 2.03, 95%CI: 1.21–3.39, P = .007) and saw tooth (OR = 1.036, 95%CI: 1.008–1.065, P = .011) signs were independently associated with Renal Capsule invasion. Smooth tumor margin suggests the absence of Renal Capsule invasion, while the deep lobulated and the saw tooth signs strongly suggest the presence of Renal Capsule invasion in patients with RCC.

  • Multislice spiral computed tomography signs of invasion of the Renal Capsule by Renal cell carcinoma.
    Medicine, 2018
    Co-Authors: Yanman Zhang, Hao Tian, Siqi Zhang, Qing Zhang
    Abstract:

    Capsular invasion is frequently detected in localized Renal cell carcinoma (RCC) specimens and is associated with a poor prognosis, but the pretreatment imaging features are poorly known. This study aimed to explore the positions and margin types of RCC and various computed tomography (CT) signs, as well as the correlations with the presence/absence of RCC invasion of the Renal Capsule. This was a retrospective study of 158 consecutive patients treated for pathologically confirmed RCC between January 2013 and December 2016 at the Nantong University Affiliated Hospital. The patients were divided into the Capsule invasion and noninvasion groups. The CT signs were analyzed (position type, margin type, and CT findings in the periRenal fat). There were 92 (58.2%) men and 66 (41.8%) women; mean age was 59.1 ± 12.8. Renal Capsule invasion was confirmed in 45 cases. There was no difference in the position types between the 2 groups (all P > .05). The smooth margin was more common in the noninvasion group (53.1% vs 15.6%, P 

Céline Colnot - One of the best experts on this subject based on the ideXlab platform.

Noel Weidner - One of the best experts on this subject based on the ideXlab platform.

  • solitary fibrous tumor involving the Renal Capsule
    The American Journal of Surgical Pathology, 1996
    Co-Authors: Arnold B Gelb, Martha L Simmons, Noel Weidner
    Abstract:

    Solitary fibrous tumors are spindle-cell neoplasms that originally were described in the pleura but that can occur in a large variety of sites. We report a well-circumscribed tumor, apparently involving the Renal Capsule, clinically thought to be a Renal-cell carcinoma or oncocytoma. It was composed

Yanman Zhang - One of the best experts on this subject based on the ideXlab platform.

  • multislice spiral computed tomography signs of invasion of the Renal Capsule by Renal cell carcinoma
    Medicine, 2018
    Co-Authors: Yanman Zhang, Hao Tian, Siqi Zhang, Qing Zhang
    Abstract:

    Capsular invasion is frequently detected in localized Renal cell carcinoma (RCC) specimens and is associated with a poor prognosis, but the pretreatment imaging features are poorly known. This study aimed to explore the positions and margin types of RCC and various computed tomography (CT) signs, as well as the correlations with the presence/absence of RCC invasion of the Renal Capsule. This was a retrospective study of 158 consecutive patients treated for pathologically confirmed RCC between January 2013 and December 2016 at the Nantong University Affiliated Hospital. The patients were divided into the Capsule invasion and noninvasion groups. The CT signs were analyzed (position type, margin type, and CT findings in the periRenal fat). There were 92 (58.2%) men and 66 (41.8%) women; mean age was 59.1 ± 12.8. Renal Capsule invasion was confirmed in 45 cases. There was no difference in the position types between the 2 groups (all P > .05). The smooth margin was more common in the noninvasion group (53.1% vs 15.6%, P < .01). The deep lobulated type and the saw tooth sign were more common in the invasion group (57.8% vs 7.1%; and 40.0% vs 6.2%; both P < .01). The deep lobulated (OR = 2.03, 95%CI: 1.21–3.39, P = .007) and saw tooth (OR = 1.036, 95%CI: 1.008–1.065, P = .011) signs were independently associated with Renal Capsule invasion. Smooth tumor margin suggests the absence of Renal Capsule invasion, while the deep lobulated and the saw tooth signs strongly suggest the presence of Renal Capsule invasion in patients with RCC.

  • Multislice spiral computed tomography signs of invasion of the Renal Capsule by Renal cell carcinoma.
    Medicine, 2018
    Co-Authors: Yanman Zhang, Hao Tian, Siqi Zhang, Qing Zhang
    Abstract:

    Capsular invasion is frequently detected in localized Renal cell carcinoma (RCC) specimens and is associated with a poor prognosis, but the pretreatment imaging features are poorly known. This study aimed to explore the positions and margin types of RCC and various computed tomography (CT) signs, as well as the correlations with the presence/absence of RCC invasion of the Renal Capsule. This was a retrospective study of 158 consecutive patients treated for pathologically confirmed RCC between January 2013 and December 2016 at the Nantong University Affiliated Hospital. The patients were divided into the Capsule invasion and noninvasion groups. The CT signs were analyzed (position type, margin type, and CT findings in the periRenal fat). There were 92 (58.2%) men and 66 (41.8%) women; mean age was 59.1 ± 12.8. Renal Capsule invasion was confirmed in 45 cases. There was no difference in the position types between the 2 groups (all P > .05). The smooth margin was more common in the noninvasion group (53.1% vs 15.6%, P 

Leif Jansson - One of the best experts on this subject based on the ideXlab platform.

  • Mast cells accumulate in the Renal Capsule adjacent to transplanted pancreatic islets in rats.
    Cell biology international, 2006
    Co-Authors: Caroline Kampf, Leif Jansson
    Abstract:

    Mast cells are important mediators of normal angiogenesis, and participate in normal would healing, i.e. processes involved in pancreatic islet engraftment. The aim of the study was to evaluate if mast cells are present in islet grafts. For this purpose, male nonnoglycaemic Wistar-Furth rats were either untreated or syngeneically implanted with 250 islets under the Renal Capsule. The animals were killed 1 month later, and the kidneys and endogenous pancreas were removed, fixed and embedded in paraffin. The distribution of mast cells was studied in Alcian Blue stained sections. Mast cells were rarely encountered in endogenous islets, but were frequent in the Renal Capsule adjacent to islet grafts. Mast cells interspersed between graft endocrine cells were as rare as in the endogenous pancreas. We conclude that mast cells may contribute to the engraftment after islet transplantation.

  • Lymphatic Vessels in Pancreatic Islets Implanted Under the Renal Capsule of Rats
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2006
    Co-Authors: Örjan Källskog, Caroline Kampf, Agneta Andersson, Per-ola Carlsson, Peter Hansell, Magnus Johansson, Leif Jansson
    Abstract:

    Transplantation of pancreatic islets necessitates an engraftment process, including revascularization of the graft. Studies of graft vasculature have demonstrated that islets become revascularized during the first post-transplant week through an angiogenic process. If this also involves lymphatic vessels is unknown. The aim of the present study was to functionally evaluate if lymphatic vessels, which are absent in endogenous islets, form after islet transplantation. To achieve this, inbred Wistar-Furth rats were transplanted with 250 syngeneic islets under the Renal Capsule. Intra-vital microscopy of the graft in combination with interstitial injection of Evans Blue was performed 1 week, 1 month or 9-12 months later. In all animals studied, there was drainage through intra-graft lymphatic capillaries emptying into larger lymphatic vessels associated with the Renal Capsule. The number was slightly lower 1 week post-transplantation. Most of the lymphatic capillaries were present in the graft stroma, rather than interspersed among the endocrine cells. In some animals, we were able to demonstrate dye in regional lymph nodes. We conclude that unlike endogenous islets, islet grafts develop a lymphatic drainage. Its functional importance and characteristics remain to be established. However, it can be speculated that immune reactions may be facilitated by the presence of lymphatic vessels.

  • Microcirculation of human pancreatic islets transplanted under the Renal Capsule of nude mice.
    Transplantation, 2001
    Co-Authors: Leif Jansson, Per-ola Carlsson, Björn Tyrberg, Astrid Nordin, Arne Andersson, Örjan Källskog
    Abstract:

    Background. The aim was to measure the capillary blood pressure in transplanted human islets. Methods. Human islets were isolated at the Central Unit of the β-cell Transplant in Brussels, Belgium. After transport to our laboratory, the islets were implanted under the Renal Capsule of normoglycemic nude mice. Two weeks later the capillary and venous blood pressures in the islet graft and adjacent Renal parenchyma were measured with a micropuncture technique. Results. Capillary blood pressure was approximately 5-8 mmHg in both graft and Renal capillaries: twice as high as in native islets. Venous blood pressures were similar (4-5 mmHg) in the veins draining the graft and in the Renal interlobular veins. All veins leading from the graft emptied into the Renal parenchyma, that is, into interlobular veins. Conclusions. The capillary hypertension seen in transplanted human islets is probably necessary to secure adequate drainage through the Renal veins. Whether this contributes to the poor results of long-term islet graft survival is unknown.

  • Capillary blood pressure in syngeneic rat islets transplanted under the Renal Capsule is similar to that of the implantation organ.
    Diabetes, 1998
    Co-Authors: Per-ola Carlsson, Leif Jansson, Agneta Andersson, Örjan Källskog
    Abstract:

    The aim of the present study was to measure capillary blood pressure and interstitial pressure in transplanted pancreatic islets and to correlate these measurements to capillary and tubular pressures in the adjacent kidney. For this purpose, 250 syngeneic islets were implanted under the Renal Capsule of WF rats and studied 1, 2, or 6 months after transplantation. Some of the animals studied after 1 and 2 months were streptozotocin (STZ)-induced diabetic. Measurements were performed during basal conditions or after an acute glucose-stimulation of insulin release. The hydrostatic pressures were determined in vivo by direct micropuncture. The islet transplant capillary pressure in normoglycemic animals was 6.9 +/- 0.4 mmHg (n = 9), 10.0 +/- 0.8 mmHg (n = 7), and 12.4 +/- 0.8 mmHg (n = 7) when measured 1, 2, and 6 months after implantation, respectively. Previous data from our laboratory showed that the normal capillary pressure of native rat pancreatic islets is approximately 3 mmHg. The blood pressure in kidney peritubular capillaries was 10-12 mmHg in both transplanted and control animals. Islet transplant interstitial pressures were 4-6 mmHg in the normoglycemic recipients at 1, 2, and 6 months after transplantation. Acute glucose stimulation had no effect on islet transplant interstitial pressure or peritubular or transplant capillary blood pressures. Capillary pressures in the islet grafts were slightly increased 1 month after transplantation in STZ-induced diabetic rats, and this was associated with an increased blood perfusion of the transplants. However, 2 months after transplantation there were no differences in transplant capillary blood pressure between diabetic and normoglycemic animals. The graft interstitial pressure was, on the contrary, decreased in the diabetic animals 2 months after transplantation. We concluded that the capillary blood pressure in islets implanted under the Renal Capsule was similar to that of the implantation organ, which was three to four times higher than that normally found in native islets.