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Yongming Luo - One of the best experts on this subject based on the ideXlab platform.
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microplastics in an agricultural soil following Repeated Application of three types of sewage sludge a field study
Environmental Pollution, 2021Co-Authors: Jie Yang, Peter Christie, Yichen Shen, Yongming LuoAbstract:Abstract Microplastics were investigated in an agricultural soil to which three types of sludge were Repeatedly applied: fresh municipal sludge (FSS1), fresh mixed sludge (mainly industrial sludge) (FSS2), and dry heat-treated municipal sludge (DSS). The percentages of microplastics
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abundance and morphology of microplastics in an agricultural soil following long term Repeated Application of pig manure
Environmental Pollution, 2021Co-Authors: Jie Yang, Peter Christie, Qian Zhou, Xinyue Zhao, Kuanxu Xiong, Yongming LuoAbstract:Abstract Microplastics occur widely in the terrestrial environment and they currently occur in organic fertilizers applied to agricultural land. However, there is little information available on the accumulation of microplastics in soils fertilized over the long term. Here, we investigate the characteristics of microplastics in both pig manure and soil following long-term manure Application in an attempt to assess their accumulation and the potential risk to agricultural soils of Repeated Application of pig manure. Microplastics were separated from soil and pig manure samples using a sequential flow separation and flotation method. The abundances of microplastics were 16.4 ± 2.7 and 43.8 ± 16.2 particles kg−1 in control plots (CK, no manure applied) and plots amended annually with pig manure for 22 years (PM), respectively. The microplastics (especially fragments) were significantly enriched in PM-amended soil compared with the control plots. The average annual abundance of microplastics was 1250 ± 640 particles kg−1 in manure. Interestingly, the type and polymer composition of microplastics were very similar in the soil and manure. Differences in color and particle size indicate that microplastics sourced from pig manure may be gradually weathered and degraded after incorporation into the soil. The average accumulation rate of microplastics in the agricultural soil with long-term Application of pig manure was estimated to be 3.50 ± 1.71 million particles ha−1 a−1. The microplastics in the manured soil displayed complicated weathered surfaces. The presence of carbonyl groups suggests that the weathered microplastics in soil may have the potential to adsorb contaminants.
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cumulative effects of Repeated chlorothalonil Application on soil microbial activity and community in contrasting soils
Journal of Soils and Sediments, 2016Co-Authors: Manyun Zhang, Ying Teng, Jun Wang, Peter Christie, Yongming LuoAbstract:Purpose Chlorothalonil (CTN) has received much attention due to its broad-spectrum antifungal function and Repeated Applications in agriculture production practice. An incubation experiment was conducted to study the accumulating effects of CTN Repeated Application on soil microbial activities, biomass, and community and to contrast the discrepancy of effects in contrasting soils.
Akinori Arimura - One of the best experts on this subject based on the ideXlab platform.
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contribution of itch associated scratch behavior to the development of skin lesions in dermatophagoides farinae induced dermatitis model in nc nga mice
Archives of Dermatological Research, 2009Co-Authors: Mina Yamamoto, Takayo Haruna, Chihiro Ueda, Yumi Asano, Hisashi Takahashi, Miho Iduhara, Shigeki Takaki, Kiyoshi Yasui, Yoshiyuki Matsuo, Akinori ArimuraAbstract:Recently, we have reported that the pathophysiological features of dermatitis induced by the Repeated Application with Dermatophagoides farinae (Df) extract ointment in NC/Nga mice were similar to those observed in the patients with atopic dermatitis. In the present study, we first examined whether the Application of Df in other mouse strains could induce dermatitis. The Repeated Application of Df body (Dfb) ointment to the barrier-disrupted back of ICR, C57BL/6, and Balb/c mice did not cause any apparent skin lesions, although transient increase in serum immunoglobulin E (IgE) levels during antigen Application was observed. On the other hand, in NC/Nga mice, dermatitis scores and serum IgE levels increased remarkably, and then these changes sustained for at least 10 days after stopping of antigen elicitation. Using NC/Nga mice, we investigated the contribution of scratching behavior to the development and maintenance of Dfb-induced dermatitis. In correlation with the increase in scratching behavior, erythema, hemorrhage, edema, scarring, erosion and excoriation were observed. Cutting off the hind toenails of mice exhibiting chronic skin lesions dramatically alleviated the dermatitis. From these findings, the onset of skin lesions and its chronically sustained course in Dfb-induced dermatitis in NC/Nga mice were closely associated with increased scratching behavior.
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a novel atopic dermatitis model induced by topical Application with dermatophagoides farinae extract in nc nga mice
Allergology International, 2007Co-Authors: Mina Yamamoto, Takayo Haruna, Hisashi Takahashi, Miho Iduhara, Shigeki Takaki, Kiyoshi Yasui, Masashi Deguchi, Akinori ArimuraAbstract:ABSTRACT Background Atopic dermatitis is a chronically relapsing inflammatory skin disease. Animal models induced by relevant allergens play a very important role in the elucidation of the disease. The patients with atopic dermatitis are highly sensitized with mite allergens such as Dermatophagoides farinae (Df). Therefore, in the present study, we tried to develop a novel model for atopic dermatitis by Repeated Application with Df extract ointment. Methods Df extract ointment was Repeatedly applied to the back of NC/Nga mice together with barrier disruption. Atopic dermatitis-like skin lesions were evaluated by dermatitis scores, skin histology and immunological parameters. The effect of corticosteroid and calcineurin inhibitor was also examined. Results Repeated Application of Df extract ointment caused rapid increase in dermatitis scores. Clinical (skin dryness, erythema, edema and erosion) and histological symptoms (dermal and epidermal thickening, hyperkeratosis, parakeratosis and inflammatory cell infiltration) in this model were very similar to those in human atopic dermatitis. Serum total and Df-specific IgE levels were elevated in this model compared with normal mice, and draining lymph node cells isolated from the mice that exhibited dermatitis produced significant amounts of interleukin-5, interleukin-13 and interferon-γ after re-stimulation with Df. Furthermore, current first-line drugs for the treatment of human atopic dermatitis, corticosteroid and tacrolimus ointments, were effective against the clinical and histological symptoms in this model. Conclusions These results suggest that the model we have established is useful for not only elucidating the pathogenesis of atopic dermatitis but also for evaluating therapeutic agents.
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a novel atopic dermatitis model induced by topical Application with dermatophagoides farinae extract in nc nga mice
Allergology International, 2007Co-Authors: Mina Yamamoto, Takayo Haruna, Hisashi Takahashi, Miho Iduhara, Shigeki Takaki, Kiyoshi Yasui, Masashi Deguchi, Akinori ArimuraAbstract:ABSTRACT Background Atopic dermatitis is a chronically relapsing inflammatory skin disease. Animal models induced by relevant allergens play a very important role in the elucidation of the disease. The patients with atopic dermatitis are highly sensitized with mite allergens such as Dermatophagoides farinae (Df). Therefore, in the present study, we tried to develop a novel model for atopic dermatitis by Repeated Application with Df extract ointment. Methods Df extract ointment was Repeatedly applied to the back of NC/Nga mice together with barrier disruption. Atopic dermatitis-like skin lesions were evaluated by dermatitis scores, skin histology and immunological parameters. The effect of corticosteroid and calcineurin inhibitor was also examined. Results Repeated Application of Df extract ointment caused rapid increase in dermatitis scores. Clinical (skin dryness, erythema, edema and erosion) and histological symptoms (dermal and epidermal thickening, hyperkeratosis, parakeratosis and inflammatory cell infiltration) in this model were very similar to those in human atopic dermatitis. Serum total and Df-specific IgE levels were elevated in this model compared with normal mice, and draining lymph node cells isolated from the mice that exhibited dermatitis produced significant amounts of interleukin-5, interleukin-13 and interferon-γ after re-stimulation with Df. Furthermore, current first-line drugs for the treatment of human atopic dermatitis, corticosteroid and tacrolimus ointments, were effective against the clinical and histological symptoms in this model. Conclusions These results suggest that the model we have established is useful for not only elucidating the pathogenesis of atopic dermatitis but also for evaluating therapeutic agents.
Mina Yamamoto - One of the best experts on this subject based on the ideXlab platform.
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contribution of itch associated scratch behavior to the development of skin lesions in dermatophagoides farinae induced dermatitis model in nc nga mice
Archives of Dermatological Research, 2009Co-Authors: Mina Yamamoto, Takayo Haruna, Chihiro Ueda, Yumi Asano, Hisashi Takahashi, Miho Iduhara, Shigeki Takaki, Kiyoshi Yasui, Yoshiyuki Matsuo, Akinori ArimuraAbstract:Recently, we have reported that the pathophysiological features of dermatitis induced by the Repeated Application with Dermatophagoides farinae (Df) extract ointment in NC/Nga mice were similar to those observed in the patients with atopic dermatitis. In the present study, we first examined whether the Application of Df in other mouse strains could induce dermatitis. The Repeated Application of Df body (Dfb) ointment to the barrier-disrupted back of ICR, C57BL/6, and Balb/c mice did not cause any apparent skin lesions, although transient increase in serum immunoglobulin E (IgE) levels during antigen Application was observed. On the other hand, in NC/Nga mice, dermatitis scores and serum IgE levels increased remarkably, and then these changes sustained for at least 10 days after stopping of antigen elicitation. Using NC/Nga mice, we investigated the contribution of scratching behavior to the development and maintenance of Dfb-induced dermatitis. In correlation with the increase in scratching behavior, erythema, hemorrhage, edema, scarring, erosion and excoriation were observed. Cutting off the hind toenails of mice exhibiting chronic skin lesions dramatically alleviated the dermatitis. From these findings, the onset of skin lesions and its chronically sustained course in Dfb-induced dermatitis in NC/Nga mice were closely associated with increased scratching behavior.
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a novel atopic dermatitis model induced by topical Application with dermatophagoides farinae extract in nc nga mice
Allergology International, 2007Co-Authors: Mina Yamamoto, Takayo Haruna, Hisashi Takahashi, Miho Iduhara, Shigeki Takaki, Kiyoshi Yasui, Masashi Deguchi, Akinori ArimuraAbstract:ABSTRACT Background Atopic dermatitis is a chronically relapsing inflammatory skin disease. Animal models induced by relevant allergens play a very important role in the elucidation of the disease. The patients with atopic dermatitis are highly sensitized with mite allergens such as Dermatophagoides farinae (Df). Therefore, in the present study, we tried to develop a novel model for atopic dermatitis by Repeated Application with Df extract ointment. Methods Df extract ointment was Repeatedly applied to the back of NC/Nga mice together with barrier disruption. Atopic dermatitis-like skin lesions were evaluated by dermatitis scores, skin histology and immunological parameters. The effect of corticosteroid and calcineurin inhibitor was also examined. Results Repeated Application of Df extract ointment caused rapid increase in dermatitis scores. Clinical (skin dryness, erythema, edema and erosion) and histological symptoms (dermal and epidermal thickening, hyperkeratosis, parakeratosis and inflammatory cell infiltration) in this model were very similar to those in human atopic dermatitis. Serum total and Df-specific IgE levels were elevated in this model compared with normal mice, and draining lymph node cells isolated from the mice that exhibited dermatitis produced significant amounts of interleukin-5, interleukin-13 and interferon-γ after re-stimulation with Df. Furthermore, current first-line drugs for the treatment of human atopic dermatitis, corticosteroid and tacrolimus ointments, were effective against the clinical and histological symptoms in this model. Conclusions These results suggest that the model we have established is useful for not only elucidating the pathogenesis of atopic dermatitis but also for evaluating therapeutic agents.
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a novel atopic dermatitis model induced by topical Application with dermatophagoides farinae extract in nc nga mice
Allergology International, 2007Co-Authors: Mina Yamamoto, Takayo Haruna, Hisashi Takahashi, Miho Iduhara, Shigeki Takaki, Kiyoshi Yasui, Masashi Deguchi, Akinori ArimuraAbstract:ABSTRACT Background Atopic dermatitis is a chronically relapsing inflammatory skin disease. Animal models induced by relevant allergens play a very important role in the elucidation of the disease. The patients with atopic dermatitis are highly sensitized with mite allergens such as Dermatophagoides farinae (Df). Therefore, in the present study, we tried to develop a novel model for atopic dermatitis by Repeated Application with Df extract ointment. Methods Df extract ointment was Repeatedly applied to the back of NC/Nga mice together with barrier disruption. Atopic dermatitis-like skin lesions were evaluated by dermatitis scores, skin histology and immunological parameters. The effect of corticosteroid and calcineurin inhibitor was also examined. Results Repeated Application of Df extract ointment caused rapid increase in dermatitis scores. Clinical (skin dryness, erythema, edema and erosion) and histological symptoms (dermal and epidermal thickening, hyperkeratosis, parakeratosis and inflammatory cell infiltration) in this model were very similar to those in human atopic dermatitis. Serum total and Df-specific IgE levels were elevated in this model compared with normal mice, and draining lymph node cells isolated from the mice that exhibited dermatitis produced significant amounts of interleukin-5, interleukin-13 and interferon-γ after re-stimulation with Df. Furthermore, current first-line drugs for the treatment of human atopic dermatitis, corticosteroid and tacrolimus ointments, were effective against the clinical and histological symptoms in this model. Conclusions These results suggest that the model we have established is useful for not only elucidating the pathogenesis of atopic dermatitis but also for evaluating therapeutic agents.
Achim Gass - One of the best experts on this subject based on the ideXlab platform.
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diffusion weighted imaging of the dentate nucleus after Repeated Application of gadolinium based contrast agents in multiple sclerosis
Magnetic Resonance Imaging, 2019Co-Authors: Philipp Eisele, Kristina Szabo, Anne D Ebert, Stefan O Schoenberg, Alexander Radbruch, Michael Platten, Achim GassAbstract:Abstract Objective Over the last years several studies reported an increased signal intensity (SI) of the dentate nucleus (DN) on unenhanced T1-weighted images after Repeated Application of gadolinium-based contrast agents (GBCAs), suggesting gadolinium deposition. The aim of this study was to investigate with diffusion-weighted MRI possible tissue abnormalities of the DN in multiple sclerosis (MS) patients. Material and methods We retrospectively identified seventeen patients with at least six contrast-enhanced MRI examinations by using the linear GBCA gadopentate dimeglumine and twenty-three patients with the exclusive use of the macrocyclic contrast agent gadoterate meglumine followed by another 3 Tesla MRI scan including unenhanced T1-weighted and diffusion-weighted images. Results In the linear GBCA group, we found significant differences of the DN-to-pons SI ratio on unenhanced T1-weighted images (1.13 ± 0.05) when compared to the macrocyclic GBCA group (0.97 ± 0.03; p Conclusions Our results do not suggest that there is any difference in ADC values in the T1-hyperintense DN, which does not indicate a difference in tissue integrity between patients exposed to macrocyclic or linear GBCAs.
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lack of increased signal intensity in the dentate nucleus after Repeated administration of a macrocyclic contrast agent in multiple sclerosis an observational study
Medicine, 2016Co-Authors: Philipp Eisele, Angelika Alonso, Kristina Szabo, Anne D Ebert, Stefan O Schoenberg, Achim GassAbstract:AbstractRecently, several studies reported increased signal intensity (SI) in the dentate nucleus (DN) after Repeated Application of gadolinium-based contrast agents (GBCAs), suggesting a deposition of gadolinium in this location. Patients with relapsing–remitting multiple sclerosis (RRMS) frequentl
Peter Christie - One of the best experts on this subject based on the ideXlab platform.
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microplastics in an agricultural soil following Repeated Application of three types of sewage sludge a field study
Environmental Pollution, 2021Co-Authors: Jie Yang, Peter Christie, Yichen Shen, Yongming LuoAbstract:Abstract Microplastics were investigated in an agricultural soil to which three types of sludge were Repeatedly applied: fresh municipal sludge (FSS1), fresh mixed sludge (mainly industrial sludge) (FSS2), and dry heat-treated municipal sludge (DSS). The percentages of microplastics
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abundance and morphology of microplastics in an agricultural soil following long term Repeated Application of pig manure
Environmental Pollution, 2021Co-Authors: Jie Yang, Peter Christie, Qian Zhou, Xinyue Zhao, Kuanxu Xiong, Yongming LuoAbstract:Abstract Microplastics occur widely in the terrestrial environment and they currently occur in organic fertilizers applied to agricultural land. However, there is little information available on the accumulation of microplastics in soils fertilized over the long term. Here, we investigate the characteristics of microplastics in both pig manure and soil following long-term manure Application in an attempt to assess their accumulation and the potential risk to agricultural soils of Repeated Application of pig manure. Microplastics were separated from soil and pig manure samples using a sequential flow separation and flotation method. The abundances of microplastics were 16.4 ± 2.7 and 43.8 ± 16.2 particles kg−1 in control plots (CK, no manure applied) and plots amended annually with pig manure for 22 years (PM), respectively. The microplastics (especially fragments) were significantly enriched in PM-amended soil compared with the control plots. The average annual abundance of microplastics was 1250 ± 640 particles kg−1 in manure. Interestingly, the type and polymer composition of microplastics were very similar in the soil and manure. Differences in color and particle size indicate that microplastics sourced from pig manure may be gradually weathered and degraded after incorporation into the soil. The average accumulation rate of microplastics in the agricultural soil with long-term Application of pig manure was estimated to be 3.50 ± 1.71 million particles ha−1 a−1. The microplastics in the manured soil displayed complicated weathered surfaces. The presence of carbonyl groups suggests that the weathered microplastics in soil may have the potential to adsorb contaminants.
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cumulative effects of Repeated chlorothalonil Application on soil microbial activity and community in contrasting soils
Journal of Soils and Sediments, 2016Co-Authors: Manyun Zhang, Ying Teng, Jun Wang, Peter Christie, Yongming LuoAbstract:Purpose Chlorothalonil (CTN) has received much attention due to its broad-spectrum antifungal function and Repeated Applications in agriculture production practice. An incubation experiment was conducted to study the accumulating effects of CTN Repeated Application on soil microbial activities, biomass, and community and to contrast the discrepancy of effects in contrasting soils.
