The Experts below are selected from a list of 43791 Experts worldwide ranked by ideXlab platform

Töresin Karakoyun - One of the best experts on this subject based on the ideXlab platform.

  • Clinical Research Informatics (CRI): overview over new tools and services.
    Journal of Clinical Bioinformatics, 2015
    Co-Authors: Wolfgang Kuchinke, Töresin Karakoyun
    Abstract:

    In many ESFRI infrastructures [1] and EU projects, tools to support data sharing and biomedical Research are being developed. At the Clinical Research Informatics Solutions Day (May 26-27, 2014 at Heinrich-Heine University, Dusseldorf, Germany) new tool developments, their interoperability and sustainability issues in connection with EU projects, like BioMedBridges, BBMRI, ECRIN, EATRIS, ELIXIR, TRANSFoRm, p-medicine and EHR4CR, were discussed. These discussions resulted in three main insights: first, biomedical Research increasingly needs the sharing of data from electronic health records (EHR), reinforcing the necessity for trust and privacy protection; second, requirements are increasing for semantic integration of data from very heterogeneous resources (clinical records, biosamples, images, genetic repositories); third, big data and health care data will be used more intensively to determine patient subgroups, for better patient recruitment and to improve trial feasibility [2]. The graphic method developed by the TRANSFoRm project to describe and analyse data privacy frameworks using a zone model [3] addresses this development and may be useful for all projects that have to deal with sharing care and Research data. Tools and services that support similar functionalities were presented in joint workshops allowing developers and users to interact and compare tools. CRI has chosen this format to give developers and users opportunities to collaborate with each other to improve usability of tools. In separate workshops tools for clinical data management (OpenClinica, ObTiMA, VISTA), for bridging experimental and clinical Research data (tranSMART, MOLGENIS, i2b2), for the reuse of EHR data for clinical Research (Feasibility Service, Patient Screening Tool, Recruitment and Feasibility Tools); for advanced clinical data management (TRANSFoRm eCRF, mobile eHealth Solution), for imaging in clinical Research (XNAT, DoctorEye), and for biobanking in clinical Research (p-BioSPRE, Biobanking Catalogue, BBMRI Catalogue) were presented and discussed.

  • First Clinical Research Informatics (CRI) Solutions Day: advanced IT support from EU projects for clinical trials
    Journal of Clinical Bioinformatics, 2015
    Co-Authors: Wolfgang Kuchinke, Töresin Karakoyun, Simon Gengler, Christian Ohmann
    Abstract:

    Necessity for a novel form of interactive conference Clinical trials are the foundation for the advancement of medical Research, but they are also complex, time consuming and expensive. To ensure scientific validity, clinical trials must record large amounts of data on health and treatment of a carefully selected group of patients or trial participants. That is why a robust and highly flexible IT infrastructure that permits rapid reconfiguration to support different trials while maintaining consistent data models is needed to ensure that clinical data can be shared and used for analysis. Recently, EU projects, like TRANSFoRm, p-medicine, EHR4CR and BioMedBridges, are creating advanced clinical Research information systems consisting of sets of tools that assist in the preparation and conduct of clinical trials and the re-use of care data for Research purposes. These tools are also able to assemble data from heterogeneous sources to answer complex Research questions, including functions for data mining and support of Research process workflows to meet the needs of translational and personalized medical Research [1]. Because the translation of biomedical discoveries into clinical applications is an aim of the EU Commission, clinical Research support is expected to be a major component of EU funded projects [2]. In this context, the EU Framework Program 7 (FP7, http://ec.europa.eu/ Research/fp7/index_en.cfm) has promoted translational Research, the so-called ‘from bench-to-bedside’ approach, that is expected to have practical benefits and improvements of the quality of life for patients. In this context, it is planned that many of the tools developed in ESFRI (European Strategy Forum on Research Infrastructures) and IMI projects will be used by ECRIN, the European Clinical Research Infrastructures Network [3] to advance clinical trials. To provide information on these new Research tools and to evaluate their usability for the clinical Research community, the CRI Solutions Day was organised by ECRIN together with other EUfunded projects (TRANSFoRm, EHR4CR, p-medicine, BioMedBridges and ECRIN-IA) providing interactive “hands-on” sessions to allow visitors to see these tools in action. The necessity for such a solutions day was based on the experience of ECRIN that the conventional, class room style presentation of Research tools is not sufficient to demonstrate comparability and usability to many Researchers. Thus, presenters from academia, Research infrastructures and EU projects presented their developments with interactive sessions embedded in a framework of presentations and joint discussions. The CRI solutions day took place at Heinrich-Heine University Dusseldorf, in Dusseldorf, Germany, 26-27 May 2014.

Wolfgang Kuchinke - One of the best experts on this subject based on the ideXlab platform.

  • Clinical Research Informatics (CRI): overview over new tools and services.
    Journal of Clinical Bioinformatics, 2015
    Co-Authors: Wolfgang Kuchinke, Töresin Karakoyun
    Abstract:

    In many ESFRI infrastructures [1] and EU projects, tools to support data sharing and biomedical Research are being developed. At the Clinical Research Informatics Solutions Day (May 26-27, 2014 at Heinrich-Heine University, Dusseldorf, Germany) new tool developments, their interoperability and sustainability issues in connection with EU projects, like BioMedBridges, BBMRI, ECRIN, EATRIS, ELIXIR, TRANSFoRm, p-medicine and EHR4CR, were discussed. These discussions resulted in three main insights: first, biomedical Research increasingly needs the sharing of data from electronic health records (EHR), reinforcing the necessity for trust and privacy protection; second, requirements are increasing for semantic integration of data from very heterogeneous resources (clinical records, biosamples, images, genetic repositories); third, big data and health care data will be used more intensively to determine patient subgroups, for better patient recruitment and to improve trial feasibility [2]. The graphic method developed by the TRANSFoRm project to describe and analyse data privacy frameworks using a zone model [3] addresses this development and may be useful for all projects that have to deal with sharing care and Research data. Tools and services that support similar functionalities were presented in joint workshops allowing developers and users to interact and compare tools. CRI has chosen this format to give developers and users opportunities to collaborate with each other to improve usability of tools. In separate workshops tools for clinical data management (OpenClinica, ObTiMA, VISTA), for bridging experimental and clinical Research data (tranSMART, MOLGENIS, i2b2), for the reuse of EHR data for clinical Research (Feasibility Service, Patient Screening Tool, Recruitment and Feasibility Tools); for advanced clinical data management (TRANSFoRm eCRF, mobile eHealth Solution), for imaging in clinical Research (XNAT, DoctorEye), and for biobanking in clinical Research (p-BioSPRE, Biobanking Catalogue, BBMRI Catalogue) were presented and discussed.

  • First Clinical Research Informatics (CRI) Solutions Day: advanced IT support from EU projects for clinical trials
    Journal of Clinical Bioinformatics, 2015
    Co-Authors: Wolfgang Kuchinke, Töresin Karakoyun, Simon Gengler, Christian Ohmann
    Abstract:

    Necessity for a novel form of interactive conference Clinical trials are the foundation for the advancement of medical Research, but they are also complex, time consuming and expensive. To ensure scientific validity, clinical trials must record large amounts of data on health and treatment of a carefully selected group of patients or trial participants. That is why a robust and highly flexible IT infrastructure that permits rapid reconfiguration to support different trials while maintaining consistent data models is needed to ensure that clinical data can be shared and used for analysis. Recently, EU projects, like TRANSFoRm, p-medicine, EHR4CR and BioMedBridges, are creating advanced clinical Research information systems consisting of sets of tools that assist in the preparation and conduct of clinical trials and the re-use of care data for Research purposes. These tools are also able to assemble data from heterogeneous sources to answer complex Research questions, including functions for data mining and support of Research process workflows to meet the needs of translational and personalized medical Research [1]. Because the translation of biomedical discoveries into clinical applications is an aim of the EU Commission, clinical Research support is expected to be a major component of EU funded projects [2]. In this context, the EU Framework Program 7 (FP7, http://ec.europa.eu/ Research/fp7/index_en.cfm) has promoted translational Research, the so-called ‘from bench-to-bedside’ approach, that is expected to have practical benefits and improvements of the quality of life for patients. In this context, it is planned that many of the tools developed in ESFRI (European Strategy Forum on Research Infrastructures) and IMI projects will be used by ECRIN, the European Clinical Research Infrastructures Network [3] to advance clinical trials. To provide information on these new Research tools and to evaluate their usability for the clinical Research community, the CRI Solutions Day was organised by ECRIN together with other EUfunded projects (TRANSFoRm, EHR4CR, p-medicine, BioMedBridges and ECRIN-IA) providing interactive “hands-on” sessions to allow visitors to see these tools in action. The necessity for such a solutions day was based on the experience of ECRIN that the conventional, class room style presentation of Research tools is not sufficient to demonstrate comparability and usability to many Researchers. Thus, presenters from academia, Research infrastructures and EU projects presented their developments with interactive sessions embedded in a framework of presentations and joint discussions. The CRI solutions day took place at Heinrich-Heine University Dusseldorf, in Dusseldorf, Germany, 26-27 May 2014.

Lucila Ohno-machado - One of the best experts on this subject based on the ideXlab platform.

  • A journal's role in resource sharing and reproducibility.
    Journal of the American Medical Informatics Association : JAMIA, 2015
    Co-Authors: Lucila Ohno-machado
    Abstract:

    The role of a scientific journal is to disseminate generalizable knowledge that can be applied to new settings and advance science. This is an exciting landmark for the current editorial team: after about 4.5 years of service we are celebrating the acceptance of our 1,000th article. Through hundreds of articles, JAMIA has documented the rise of new subspecialties of Informatics, the launch of large targeted funding initiatives, and the many ways in which patients participate in their own care and in health-related Research. Informatics is growing faster than we are able to train new professionals, and hence everyone is facing increasing demands and new responsibilities in their jobs. I remain impressed by the dedication of associate editors, editorial board members, and reviewers. Their contributions are critical to ensure a quality product, so I urge leaders in our field to give high, proper credit to reviewer contributions when assessments for appointments, promotions, and overall stature in the field are requested, especially since …

  • Big science, big data, and a big role for biomedical Informatics.
    Journal of the American Medical Informatics Association : JAMIA, 2012
    Co-Authors: Lucila Ohno-machado
    Abstract:

    The role of biomedical Informatics in science has never been so prominent, and we strive to make this journal a vehicle for wide dissemination of the best biomedical Informatics work well beyond our own field. This issue of the journal is dedicated to translational science enabled by Informatics. It combines the topics of AMIA's Joint Summits on Translational Science—Translational BioInformatics and Clinical Research Informatics—and presents the best articles from the conference, as well as several other related articles that have been submitted to JAMIA through the regular journal process. As the readers can verify, the outstanding quality of the articles selected from the conference make them indistinguishable from the regular articles. It was particularly exciting to work with our guest editors Nigam Shah, Michael Kahn, and Chunhua Weng to edit this special issue. This was true not only because we learned much from each other's perspectives, but also because JAMIA was able make its contribution to the success of the Joint Summits, by motivating authors to submit their best work to the conference for potential publication in the journal. As director of a biomedical Informatics academic unit within a medical school, I appreciate that trainees and junior faculty have the option to submit their best papers for publication in conference proceedings, but may hesitate given the unequal weights assigned by promotion committees to proceedings and journal publications. On the other hand, everyone in our community wants to have an opportunity to see live presentations and interact with the authors who are producing the best work in our field. By inviting the best conference papers to be submitted to this special issue of the journal, we hope we are contributing to both these goals. As the readers will notice, even though the articles in this issue are categorized as primarily representing translational bioInformatics or clinical Research Informatics, these boundaries are fuzzy. Shah and Tenembaum (see page e2) describe how Informatics analysis of Big Data has already started to be translated to the bedside and to influence patient outcomes. They describe how translational bioInformatics has bridged the gap between Research and clinical practice, in ways that resemble how basic science discoveries have been translated into healthcare. With a strong, but not exclusive, focus on whole genome sequencing analysis, translational bioInformatics articles are increasingly appearing in JAMIA, reflecting the growth of a critical sub-specialty of Informatics that is attracting a large number of new trainees to our field. Two of our prior issues (July 2011 and March 2012) were focused on translational bioInformatics and were very well received by our readers. Another one of our notable prior issues (December 2011) was focused on clinical Research Informatics. In this issue, Kahn and Weng (see page e36) propose a conceptual model to highlight how several articles relate to the translational continuum of basic Research to clinical trials. As Kahn and Weng report, clinical Research Informatics' presence in JAMIA has experienced exponential growth, reflecting the growth of the consortium of Clinical and Translational Science Awards, and the recognition that, without Informatics, it is not possible to implement ‘Big Science.’ Enjoy this issue and spread the word: biomedical Informatics has a key role in Big Science, and Big Data. JAMIA has a big role in disseminating the scholarly work of our community.

  • Innovative approaches to support patient decision making, improve safety, and enable large-scale clinical Research.
    Journal of the American Medical Informatics Association, 2011
    Co-Authors: Lucila Ohno-machado
    Abstract:

    The Patient-Centered Outcomes Research Institute recently announced several funding opportunities for Research focused on empowering patients to make informed decisions. The literature on patient-centered systems has been increasingly present in JAMIA , and we anticipate receiving several submissions on this topic in the upcoming year. Another topic of continued interest is patient safety: the recent IOM report on health IT and patient safety makes important recommendations regarding actions that federal agencies and the private sector should take to maximize the safety of electronic health record systems and other health IT software. It recognizes that, although one of the most impactful areas is medication safety, there are important gaps in the literature. JAMIA helps fill some of these gaps, featuring the outstanding work by the Informatics community to address patient safety challenges. Finally, the ongoing discussion related to the new National Center for Advancing Translational Sciences (NCATS) at NIH illustrates the critical role translational Research now plays in biomedical sciences, which would not be possible without the developments in clinical Research Informatics . Together with translational bioInformatics, this is …

Peter J. Embi - One of the best experts on this subject based on the ideXlab platform.

  • Sustainability considerations for clinical and translational Research Informatics infrastructure.
    Journal of clinical and translational science, 2018
    Co-Authors: Jihad S. Obeid, Paul A Harris, William K. Barnett, Peter J. Embi, Peter Tarczy-hornoch, Nicholas R. Anderson, William R. Hogan, Douglas S. Bell, Leslie D. Mcintosh, Boyd M. Knosp
    Abstract:

    A robust biomedical Informatics infrastructure is essential for academic health centers engaged in translational Research. There are no templates for what such an infrastructure encompasses or how it is funded. An Informatics workgroup within the Clinical and Translational Science Awards network conducted an analysis to identify the scope, governance, and funding of this infrastructure. After we identified the essential components of an Informatics infrastructure, we surveyed Informatics leaders at network institutions about the governance and sustainability of the different components. Results from 42 survey respondents showed significant variations in governance and sustainability; however, some trends also emerged. Core Informatics components such as electronic data capture systems, electronic health records data repositories, and related tools had mixed models of funding including, fee-for-service, extramural grants, and institutional support. Several key components such as regulatory systems (e.g., electronic Institutional Review Board [IRB] systems, grants, and contracts), security systems, data warehouses, and clinical trials management systems were overwhelmingly supported as institutional infrastructure. The findings highlighted in this report are worth noting for academic health centers and funding agencies involved in planning current and future Informatics infrastructure, which provides the foundation for a robust, data-driven clinical and translational Research program.

  • The Emerging Role of the Chief Research Informatics Officer in Academic Health Centers.
    Applied clinical informatics, 2017
    Co-Authors: L. Nelson Sanchez-pinto, Abu Saleh Mohammad Mosa, Kate Fultz-hollis, Umberto Tachinardi, William K. Barnett, Peter J. Embi
    Abstract:

    Background: The role of the Chief Research Informatics Officer (CRIO) is emerging in academic health centers to address the challenges clinical Researchers face in the increasingly digitalized, data-intensive healthcare system. Most current CRIOs are the first officers in their institutions to hold that role. To date there is very little published information about this role and the individuals who serve it. Objective: To increase our understanding of the CRIO role, the leaders who serve it, and the factors associated with their success in their organizations. Methods: The Clinical Research Informatics Working Group of the American Medical Informatics Association (AMIA) conducted a national survey of CRIOs in the United States and convened an expert panel of CRIOs to discuss their experience during the 2016 AMIA Annual Symposium. Results: CRIOs come from diverse academic backgrounds. Most have advance training and extensive experience in biomedical Informatics but the majority have been CRIOs for less than three years. CRIOs identify funding, data governance, and advancing data analytics as their major challenges. Conclusion: CRIOs play an important role in helping shape the future of clinical Research, innovation, and data analytics in healthcare in their organizations. They share many of the same challenges and see the same opportunities for the future of the field. Better understanding the background and experience of current CRIOs can help define and develop the role in other organizations and enhance their influence in the field of Research Informatics. Citation: Sanchez-Pinto LN, Mosa ASM, Fultz-Hollis K, Tachinardi U, Barnett WK, Embi PJ. The Emerging Role of the Chief Research Informatics Officer in Academic Health Centers. Appl Clin Inform 2017; 8: 845–853 https://doi.org/10.4338/ACI-2017-04-RA-0062

  • Clinical and Translational Research Informatics Education and Training
    Health Informatics, 2013
    Co-Authors: Peter J. Embi, Philip R. O. Payne
    Abstract:

    Clinical and translational Research often involves the generation, collection, storage, management, analysis, and dissemination of heterogeneous and multi-dimensional data, information, and knowledge resources. Addressing such fundamental Informatics needs and requirements is a challenging problem that usually requires the collaboration of multi-disciplinary teams. Central to the ability to form and operate such teams is the development of a workforce with sufficient expertise at the basic and applied science levels as relevant to the clinical and translational science domain. Over the last decade, significant advances have been made in education and training programs targeting such workforce development. While still early in their maturity, such efforts have already begun to impact the advancement of biomedical science and human health, and serve to illustrate the critical nature of computational and Informatics theories and methodologies across the broader translational Research spectrum.

  • Integrating Governance of Research Informatics and Health Care IT Across an Enterprise: Experiences from the Trenches.
    AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, 2013
    Co-Authors: Peter J. Embi, Umberto Tachinardi, Yves A. Lussier, Justin Starren, Jonathan C. Silverstein
    Abstract:

    Advances in health information technology and biomedical Informatics have laid the groundwork for significant improvements in healthcare and biomedical Research. For instance, Electronic Health Records can help improve the delivery of evidence-based care, enhance quality, and contribute to discoveries and evidence generation. Despite this promise, there are many challenges to achieving the vision and missions of our healthcare and Research enterprises. Given the challenges inherent in doing so, institutions are increasingly moving to establish dedicated leadership and governance models charged with designing, deploying and leveraging various information resources to advance Research and advanced care activities at AHCs. Some institutions have even created a new leadership position to oversee such activities, such as the Chief Research Information Officer. This panel will include Research Informatics leaders discussing their experiences from the proverbial trenches as they work to operationalize such cross-mission governance models. Panelists will start by providing an overview their respective positions and environments, discuss their experiences, and share lessons learned through their work at the intersection of clinical and translational Research Informatics and Health IT.

  • Clinical Research Informatics: survey of recent advances and trends in a maturing field.
    Yearbook of medical informatics, 2013
    Co-Authors: Peter J. Embi
    Abstract:

    OBJECTIVES To provide a survey of the field of clinical Research Informatics (CRI), focusing in particular on significant developments over the past 3 years and the insights they provide about the progress and state of the field. METHODS An iterative "scoping review" of the literature published in scientific journals and conference proceedings that are relevant to CRI, from late 2009 to early 2013. RESULTS 212 articles were identified, and 64 were selected to illustrate recent advances in the field. Based on those, six categories of CRI activity were identified: Data and Knowledge Management, Discovery and Standards; Clinical Data Re-Use for Research; Researcher Support and Resources; Participant Recruitment; Patients/Consumers and CRI; Policy, Regulatory and Fiscal Matters. CONCLUSIONS This survey demonstrates that the field of CRI has matured and is now well established. The ongoing work is essential to overcome many of the challenges the clinical Research enterprise is facing and more work is needed. Even as work continues to establish necessary infrastructure, methods, and best practices, CRI Researchers should strive for more rigorous study designs to evaluate the impacts of the work in the field. There is little doubt that the field is poised for rapid growth, and that the CRI literature will continue to reflect that growth in years to come.

R. Choquet - One of the best experts on this subject based on the ideXlab platform.

  • Clinical Research Informatics: Contributions from 2016.
    Yearb Med Inform, 2017
    Co-Authors: C Daniel, R. Choquet
    Abstract:

    Objectives: To summarize key contributions to current Research in the field of Clinical Research Informatics (CRI) and to select the best papers published in 2016. Methods: A bibliographic search using a combination of MeSH and free terms on CRI was performed using PubMed, followed by a double-blind review in order to select a list of candidate best papers to be then peer-reviewed by external reviewers. A consensus meeting between the two section editors and the editorial team was organized to finally conclude on the selection of best papers. Results: Among the 452 papers published in 2016 in the various areas of CRI and returned by the query, the full review process selected four best papers. The authors of the first paper utilized a comprehensive representation of the patient medical record and semi-automatically labeled training sets to create phenotype models via a machine learning process. The second selected paper describes an open source tool chain securely connecting ResearchKit compatible applications (Apps) to the widely-used clinical Research infrastructure Informatics for Integrating Biology and the Bedside (i2b2). The third selected paper describes the FAIR Guiding Principles for scientific data management and stewardship. The fourth selected paper focuses on the evaluation of the risk of privacy breaches in releasing genomics datasets. Conclusions: A major trend in the 2016 publications is the variety of Research on “real-world data” – healthcare-generated data, person health data, and patient-reported outcomes - highlighting the opportunities provided by new machine learning techniques as well as new potential risks of privacy breaches.

  • Clinical Research Informatics Contributions from 2015.
    Yearbook of medical informatics, 2016
    Co-Authors: Christel Daniel, R. Choquet
    Abstract:

    Objectives: To summarize key contributions to current Research in the field of Clinical Research Informatics (CRI) and to select best papers published in 2015. Method: A bibliographic search using a combination of MeSH and free terms search over PubMed on Clinical Research Informatics (CRI) was performed followed by a double-blind review in order to select a list of candidate best papers to be then peer-reviewed by external reviewers. A consensus meeting between the two section editors and the editorial team was finally organized to conclude on the selection of best papers. Results: Among the 579 returned papers published in the past year in the various areas of Clinical Research Informatics (CRI) - i) methods supporting clinical Research, ii) data sharing and interoperability, iii) re-use of healthcare data for Research, iv) patient recruitment and engagement, v) data privacy, security and regulatory issues and vi) policy and perspectives - the full review process selected four best papers. The first selected paper evaluates the capability of the Clinical Data Interchange Standards Consortium (CDISC) Operational Data Model (ODM) to support the representation of case report forms (in both the design stage and with patient level data) during a complete clinical study lifecycle. The second selected paper describes a prototype for secondary use of electronic health records data captured in non-standardized text. The third selected paper presents a privacy preserving electronic health record linkage tool and the last selected paper describes how big data use in US relies on access to health information governed by varying and often misunderstood legal requirements and ethical considerations. Conclusions: A major trend in the 2015 publications is the analysis of observational, “nonexperimental” information and the potential biases and confounding factors hidden in the data that will have to be carefully taken into account to validate new predictive models. In addiction, Researchers have to understand complicated and sometimes contradictory legal requirements and to consider ethical obligations in order to balance privacy and promoting discovery.

  • Information Technology for Clinical, Translational and Comparative Effectiveness Research. Findings from the Yearbook 2015 Section on Clinical Research Informatics.
    Yearbook of medical informatics, 2015
    Co-Authors: Christel Daniel, R. Choquet
    Abstract:

    Objectives: To summarize excellent current Research in the field of BioInformatics and Translational Informatics with application in the health domain and clinical care. Method: We provide a synopsis of the articles selected for the IMIA Yearbook 2015, from which we attempt to derive a synthetic overview of current and future activities in the field. As last year, a first step of selection was performed by querying MEDLINE with a list of MeSH descriptors completed by a list of terms adapted to the section. Each section editor has evaluated separately the set of 1,594 articles and the evaluation results were merged for retaining 15 articles for peer-review. Results: The selection and evaluation process of this Yearbook's section on BioInformatics and Translational Informatics yielded four excellent articles regarding data management and genome medicine that are mainly tool-based papers. In the first article, the authors present PPISURV a tool for uncovering the role of specific genes in cancer survival outcome. The second article describes the classifier PredictSNP which combines six performing tools for predicting disease-related mutations. In the third article, by presenting a high-coverage map of the human proteome using high resolution mass spectrometry, the authors highlight the need for using mass spectrometry to complement genome annotation. The fourth article is also related to patient survival and decision support. The authors present datamining methods of large-scale datasets of past transplants. The objective is to identify chances of survival. Conclusions: The current Research activities still attest the continuous convergence of BioInformatics and Medical Informatics, with a focus this year on dedicated tools and methods to advance clinical care. Indeed, there is a need for powerful tools for managing and interpreting complex, large-scale genomic and biological datasets, but also a need for user-friendly tools developed for the clinicians in their daily practice. All the recent Research and development efforts contribute to the challenge of impacting clinically the obtained results towards a personalized medicine.

  • Information Technology for Clinical, Translational and Comparative Effectiveness Research
    Yearbook of Medical Informatics, 2015
    Co-Authors: R. Choquet, C Daniel
    Abstract:

    Summary Objectives: To select and summarize key constributions to current Research and to select best papers published in 2014 in the field of Clinical Research Informatics (CRI).Method: A bibliographic search using a combination of MeSH and free terms search over PubMed on Clinical Research Informatics (CRI) was performed followed by a double-blind literature review. Results: The review process yielded four papers, illustrating various aspects of current Research efforts done in the area of CRI. The first paper exemplifies the process of developping a domain ontology for integrating structured, unstructured, and signal data into a coherent structure for patient care as well as clinical Research. In the second paper, the authors analysed in five sites’ hospital information system environments in Germany the possibility of implementing a patient recruitment process and provided recommendations for the development of dedicated patient recruitment modules. The third paper describes the IMI EHR4CR project which developed an instance of a platform, providing communication, security and semantic interoperability services to the eleven participating hospitals and ten pharmaceutical companies located in seven European countries. The last paper describes the relation between health status severity and the availability of data in EHR systems. They demonstrate that it introduces a biasis in patient selection for clinical Research. Conclusions: Distributed Research networks are growing in importance for clinical Research and population health surveillance and current Research demonstartes that different projects and initiatives could be well placed to deliver international scale solutions to enable the reuse of hospital EHR data to support clinical Research studies. Selected articles demonstrate the potential of formal representation of multimodal and multi-level data in supporting data interoperability across clinical Research and care domains. With the development of pragmatic Research, designed with input from health systems and producing evidence that can be readily used to improve care, a key issue for “learning health care organizations” is to systematically assess the quality of their data.

  • Information technology for clinical, translational and comparative effectiveness Research. Findings from the section clinical Research Informatics.
    Yearbook of medical informatics, 2014
    Co-Authors: Christel Daniel, R. Choquet
    Abstract:

    OBJECTIVE To select and summarize key contributions to current Research in the field of Clinical Research Informatics (CRI). METHOD A bibliographic search using a combination of MeSH and free terms search over PubMed was performed followed by a blinded review. RESULTS The review process resulted in the selection of four papers illustrating various aspects of current Research efforts in the area of CRI. The first paper tackles the challenge of extracting accurate phenotypes from Electronic Healthcare Records (EHRs). Privacy protection within shared de-identified, patient-level Research databases is the focus of the second selected paper. Two other papers exemplify the growing role of formal representation of clinical data - in metadata repositories - and knowledge - in ontologies - for supporting the process of reusing data for clinical Research. CONCLUSIONS The selected articles demonstrate how concrete platforms are currently achieving interoperability across clinical Research and care domains and have reached the evaluation phase. When EHRs linked to genetic data have the potential to shift the Research focus from Research driven patient recruitment to phenotyping in large population, a key issue is to lower patient re-identification risks for biomedical Research databases. Current Research illustrates the potential of knowledge engineering to support, in the coming years, the scientific lifecycle of clinical Research.