The Experts below are selected from a list of 450 Experts worldwide ranked by ideXlab platform

Jiro Fujita - One of the best experts on this subject based on the ideXlab platform.

  • Pulmonary strongyloidiasis: assessment between manifestation and radiological findings in 16 severe strongyloidiasis cases
    BMC Infectious Diseases, 2017
    Co-Authors: Daijiro Nabeya, Shusaku Haranaga, Takeshi Kinjo, Saifun Nahar, Teruhisa Tanaka, Tetsuo Hirata, Masao Tateyama, Gretchen Lynn Parrott, Akira Hokama, Jiro Fujita
    Abstract:

    Background Strongyloidiasis is a chronic parasitic infection caused by Strongyloides stercoralis. Severe cases such as, hyperinfection syndrome (HS) and disseminated strongyloidiasis (DS), can involve pulmonary manifestations. These manifestations frequently aid the diagnosis of strongyloidiasis. Here, we present the pulmonary manifestations and radiological findings of severe strongyloidiasis. Methods From January 2004 to December 2014, all patients diagnosed with severe strongyloidiasis at the University of the Ryukyus Hospital or affiliated hospitals in Okinawa, Japan, were included in this retrospective study. All diagnoses were confirmed by the microscopic or histopathological identification of larvae. Severe strongyloidiasis was defined by the presence of any of the following: 1) the identification of S. stercoralis from extra gastrointestinal specimens, 2) sepsis, 3) meningitis, 4) acute Respiratory failure, or 5) Respiratory Tract Hemorrhage. Patients were assigned to either HS or DS. Medical records were further reviewed to exTract related clinical features and radiological findings. Results Sixteen severe strongyloidiasis cases were included. Of those, fifteen cases had pulmonary manifestations, eight had acute Respiratory distress syndrome (ARDS) (53%), seven had enteric bacterial pneumonia (46%) and five had pulmonary Hemorrhage (33%). Acute Respiratory failure was a common indicator for pulmonary manifestation (87%). Chest X-ray findings frequently showed diffuse shadows (71%). Additionally, ileum gas was detected for ten of the sixteen cases in the upper abdomen during assessment with chest X-ray. While, chest CT findings frequently showed ground-glass opacity (GGO) in 89% of patients. Interlobular septal thickening was also frequently shown (67%), always accompanying GGO in upper lobes. Conclusions In summary, our study described HS/DS cases with pulmonary manifestations including, ARDS, bacterial pneumonia and pulmonary Hemorrhage. Chest X-ray findings in HS/DS cases frequently showed diffuse shadows, and the combination of GGO and interlobular septal thickening in chest CT was common in HS/DS, regardless of accompanying pulmonary manifestations. This CT finding suggests alveolar Hemorrhage could be used as a potential marker indicating the transition from latent to symptomatic state. Respiratory specimens are especially useful for detecting larvae in cases of HS/DS.

  • Pulmonary strongyloidiasis: assessment between manifestation and radiological findings in 16 severe strongyloidiasis cases
    BMC infectious diseases, 2017
    Co-Authors: Daijiro Nabeya, Shusaku Haranaga, Takeshi Kinjo, Gretchen Parrott, Saifun Nahar, Teruhisa Tanaka, Tetsuo Hirata, Masao Tateyama, Akira Hokama, Jiro Fujita
    Abstract:

    Strongyloidiasis is a chronic parasitic infection caused by Strongyloides stercoralis. Severe cases such as, hyperinfection syndrome (HS) and disseminated strongyloidiasis (DS), can involve pulmonary manifestations. These manifestations frequently aid the diagnosis of strongyloidiasis. Here, we present the pulmonary manifestations and radiological findings of severe strongyloidiasis. From January 2004 to December 2014, all patients diagnosed with severe strongyloidiasis at the University of the Ryukyus Hospital or affiliated hospitals in Okinawa, Japan, were included in this retrospective study. All diagnoses were confirmed by the microscopic or histopathological identification of larvae. Severe strongyloidiasis was defined by the presence of any of the following: 1) the identification of S. stercoralis from extra gastrointestinal specimens, 2) sepsis, 3) meningitis, 4) acute Respiratory failure, or 5) Respiratory Tract Hemorrhage. Patients were assigned to either HS or DS. Medical records were further reviewed to exTract related clinical features and radiological findings. Sixteen severe strongyloidiasis cases were included. Of those, fifteen cases had pulmonary manifestations, eight had acute Respiratory distress syndrome (ARDS) (53%), seven had enteric bacterial pneumonia (46%) and five had pulmonary Hemorrhage (33%). Acute Respiratory failure was a common indicator for pulmonary manifestation (87%). Chest X-ray findings frequently showed diffuse shadows (71%). Additionally, ileum gas was detected for ten of the sixteen cases in the upper abdomen during assessment with chest X-ray. While, chest CT findings frequently showed ground-glass opacity (GGO) in 89% of patients. Interlobular septal thickening was also frequently shown (67%), always accompanying GGO in upper lobes. In summary, our study described HS/DS cases with pulmonary manifestations including, ARDS, bacterial pneumonia and pulmonary Hemorrhage. Chest X-ray findings in HS/DS cases frequently showed diffuse shadows, and the combination of GGO and interlobular septal thickening in chest CT was common in HS/DS, regardless of accompanying pulmonary manifestations. This CT finding suggests alveolar Hemorrhage could be used as a potential marker indicating the transition from latent to symptomatic state. Respiratory specimens are especially useful for detecting larvae in cases of HS/DS.

Daijiro Nabeya - One of the best experts on this subject based on the ideXlab platform.

  • Pulmonary strongyloidiasis: assessment between manifestation and radiological findings in 16 severe strongyloidiasis cases
    BMC infectious diseases, 2017
    Co-Authors: Daijiro Nabeya, Shusaku Haranaga, Takeshi Kinjo, Gretchen Parrott, Saifun Nahar, Teruhisa Tanaka, Tetsuo Hirata, Masao Tateyama, Akira Hokama, Jiro Fujita
    Abstract:

    Strongyloidiasis is a chronic parasitic infection caused by Strongyloides stercoralis. Severe cases such as, hyperinfection syndrome (HS) and disseminated strongyloidiasis (DS), can involve pulmonary manifestations. These manifestations frequently aid the diagnosis of strongyloidiasis. Here, we present the pulmonary manifestations and radiological findings of severe strongyloidiasis. From January 2004 to December 2014, all patients diagnosed with severe strongyloidiasis at the University of the Ryukyus Hospital or affiliated hospitals in Okinawa, Japan, were included in this retrospective study. All diagnoses were confirmed by the microscopic or histopathological identification of larvae. Severe strongyloidiasis was defined by the presence of any of the following: 1) the identification of S. stercoralis from extra gastrointestinal specimens, 2) sepsis, 3) meningitis, 4) acute Respiratory failure, or 5) Respiratory Tract Hemorrhage. Patients were assigned to either HS or DS. Medical records were further reviewed to exTract related clinical features and radiological findings. Sixteen severe strongyloidiasis cases were included. Of those, fifteen cases had pulmonary manifestations, eight had acute Respiratory distress syndrome (ARDS) (53%), seven had enteric bacterial pneumonia (46%) and five had pulmonary Hemorrhage (33%). Acute Respiratory failure was a common indicator for pulmonary manifestation (87%). Chest X-ray findings frequently showed diffuse shadows (71%). Additionally, ileum gas was detected for ten of the sixteen cases in the upper abdomen during assessment with chest X-ray. While, chest CT findings frequently showed ground-glass opacity (GGO) in 89% of patients. Interlobular septal thickening was also frequently shown (67%), always accompanying GGO in upper lobes. In summary, our study described HS/DS cases with pulmonary manifestations including, ARDS, bacterial pneumonia and pulmonary Hemorrhage. Chest X-ray findings in HS/DS cases frequently showed diffuse shadows, and the combination of GGO and interlobular septal thickening in chest CT was common in HS/DS, regardless of accompanying pulmonary manifestations. This CT finding suggests alveolar Hemorrhage could be used as a potential marker indicating the transition from latent to symptomatic state. Respiratory specimens are especially useful for detecting larvae in cases of HS/DS.

  • Pulmonary strongyloidiasis: assessment between manifestation and radiological findings in 16 severe strongyloidiasis cases
    BMC Infectious Diseases, 2017
    Co-Authors: Daijiro Nabeya, Shusaku Haranaga, Takeshi Kinjo, Saifun Nahar, Teruhisa Tanaka, Tetsuo Hirata, Masao Tateyama, Gretchen Lynn Parrott, Akira Hokama, Jiro Fujita
    Abstract:

    Background Strongyloidiasis is a chronic parasitic infection caused by Strongyloides stercoralis. Severe cases such as, hyperinfection syndrome (HS) and disseminated strongyloidiasis (DS), can involve pulmonary manifestations. These manifestations frequently aid the diagnosis of strongyloidiasis. Here, we present the pulmonary manifestations and radiological findings of severe strongyloidiasis. Methods From January 2004 to December 2014, all patients diagnosed with severe strongyloidiasis at the University of the Ryukyus Hospital or affiliated hospitals in Okinawa, Japan, were included in this retrospective study. All diagnoses were confirmed by the microscopic or histopathological identification of larvae. Severe strongyloidiasis was defined by the presence of any of the following: 1) the identification of S. stercoralis from extra gastrointestinal specimens, 2) sepsis, 3) meningitis, 4) acute Respiratory failure, or 5) Respiratory Tract Hemorrhage. Patients were assigned to either HS or DS. Medical records were further reviewed to exTract related clinical features and radiological findings. Results Sixteen severe strongyloidiasis cases were included. Of those, fifteen cases had pulmonary manifestations, eight had acute Respiratory distress syndrome (ARDS) (53%), seven had enteric bacterial pneumonia (46%) and five had pulmonary Hemorrhage (33%). Acute Respiratory failure was a common indicator for pulmonary manifestation (87%). Chest X-ray findings frequently showed diffuse shadows (71%). Additionally, ileum gas was detected for ten of the sixteen cases in the upper abdomen during assessment with chest X-ray. While, chest CT findings frequently showed ground-glass opacity (GGO) in 89% of patients. Interlobular septal thickening was also frequently shown (67%), always accompanying GGO in upper lobes. Conclusions In summary, our study described HS/DS cases with pulmonary manifestations including, ARDS, bacterial pneumonia and pulmonary Hemorrhage. Chest X-ray findings in HS/DS cases frequently showed diffuse shadows, and the combination of GGO and interlobular septal thickening in chest CT was common in HS/DS, regardless of accompanying pulmonary manifestations. This CT finding suggests alveolar Hemorrhage could be used as a potential marker indicating the transition from latent to symptomatic state. Respiratory specimens are especially useful for detecting larvae in cases of HS/DS.

  • Pulmonary manifestations in severe strongyloidiasis: Review of 17 cases
    1.3 Imaging, 2015
    Co-Authors: Daijiro Nabeya, Shusaku Haranaga, Takeshi Kinjo, Gretchen Parrott, Ayako Uehara, Saifun Nahar, Teruhisa Tanaka, Tetsuo Hirata, Futoshi Higa, Masao Tateyama
    Abstract:

    Rationale: Strongyloidiasis is a chronic parasitic infection caused by Strongyloides stercoralis and is recognized as “neglected tropical disease”. Therefore, diagnosis of the infection may become problematic in non-endemic areas of the globalized society. Because severe strongyloidiasis often involves pulmonary manifestations, we reason that pulmonary manifestations are noteworthy characteristics in the diagnosis of strongyloidiasis. Here, we present observations of pulmonary manifestations in cases of severe strongyloidiasis. Methods: Our retrospective study included all patients with severe strongyloidiasis diagnosed in Ryukyu University Hospital and affiliated hospitals in Okinawa, Japan, from January 2004 to December 2014. All diagnoses were confirmed by the microscopic identification of S. stercoralis larvae. Severe infection was defined as 1) the identification of S. stercoralis from extra gastrointestinal specimens, 2) sepsis, 3) meningitis, 4) acute Respiratory failure or 5) Respiratory Tract Hemorrhage. Medical records were reviewed to exTract related clinical features. Results: In total 17 severe Strongyloidiasis cases were collected. The mean age of patients was 74.9 years. Sixteen cases had pulmonary manifestations, 8 with bacterial pneumonia, 8 with ARDS and 5 with Respiratory Hemorrhage. Chest CT was performed in 5 cases and all findings showed bilateral ground glass opacities and consolidation with interlobular septal thickening. Conclusion: Severe strongyloidiasis tends to develop some type of pulmonary manifestation; bacterial pneumonia, ARDS and Respiratory Hemorrhage are common. CT findings from all cases showed same pattern regardless of their pulmonary manifestations.

Masao Tateyama - One of the best experts on this subject based on the ideXlab platform.

  • Pulmonary strongyloidiasis: assessment between manifestation and radiological findings in 16 severe strongyloidiasis cases
    BMC infectious diseases, 2017
    Co-Authors: Daijiro Nabeya, Shusaku Haranaga, Takeshi Kinjo, Gretchen Parrott, Saifun Nahar, Teruhisa Tanaka, Tetsuo Hirata, Masao Tateyama, Akira Hokama, Jiro Fujita
    Abstract:

    Strongyloidiasis is a chronic parasitic infection caused by Strongyloides stercoralis. Severe cases such as, hyperinfection syndrome (HS) and disseminated strongyloidiasis (DS), can involve pulmonary manifestations. These manifestations frequently aid the diagnosis of strongyloidiasis. Here, we present the pulmonary manifestations and radiological findings of severe strongyloidiasis. From January 2004 to December 2014, all patients diagnosed with severe strongyloidiasis at the University of the Ryukyus Hospital or affiliated hospitals in Okinawa, Japan, were included in this retrospective study. All diagnoses were confirmed by the microscopic or histopathological identification of larvae. Severe strongyloidiasis was defined by the presence of any of the following: 1) the identification of S. stercoralis from extra gastrointestinal specimens, 2) sepsis, 3) meningitis, 4) acute Respiratory failure, or 5) Respiratory Tract Hemorrhage. Patients were assigned to either HS or DS. Medical records were further reviewed to exTract related clinical features and radiological findings. Sixteen severe strongyloidiasis cases were included. Of those, fifteen cases had pulmonary manifestations, eight had acute Respiratory distress syndrome (ARDS) (53%), seven had enteric bacterial pneumonia (46%) and five had pulmonary Hemorrhage (33%). Acute Respiratory failure was a common indicator for pulmonary manifestation (87%). Chest X-ray findings frequently showed diffuse shadows (71%). Additionally, ileum gas was detected for ten of the sixteen cases in the upper abdomen during assessment with chest X-ray. While, chest CT findings frequently showed ground-glass opacity (GGO) in 89% of patients. Interlobular septal thickening was also frequently shown (67%), always accompanying GGO in upper lobes. In summary, our study described HS/DS cases with pulmonary manifestations including, ARDS, bacterial pneumonia and pulmonary Hemorrhage. Chest X-ray findings in HS/DS cases frequently showed diffuse shadows, and the combination of GGO and interlobular septal thickening in chest CT was common in HS/DS, regardless of accompanying pulmonary manifestations. This CT finding suggests alveolar Hemorrhage could be used as a potential marker indicating the transition from latent to symptomatic state. Respiratory specimens are especially useful for detecting larvae in cases of HS/DS.

  • Pulmonary strongyloidiasis: assessment between manifestation and radiological findings in 16 severe strongyloidiasis cases
    BMC Infectious Diseases, 2017
    Co-Authors: Daijiro Nabeya, Shusaku Haranaga, Takeshi Kinjo, Saifun Nahar, Teruhisa Tanaka, Tetsuo Hirata, Masao Tateyama, Gretchen Lynn Parrott, Akira Hokama, Jiro Fujita
    Abstract:

    Background Strongyloidiasis is a chronic parasitic infection caused by Strongyloides stercoralis. Severe cases such as, hyperinfection syndrome (HS) and disseminated strongyloidiasis (DS), can involve pulmonary manifestations. These manifestations frequently aid the diagnosis of strongyloidiasis. Here, we present the pulmonary manifestations and radiological findings of severe strongyloidiasis. Methods From January 2004 to December 2014, all patients diagnosed with severe strongyloidiasis at the University of the Ryukyus Hospital or affiliated hospitals in Okinawa, Japan, were included in this retrospective study. All diagnoses were confirmed by the microscopic or histopathological identification of larvae. Severe strongyloidiasis was defined by the presence of any of the following: 1) the identification of S. stercoralis from extra gastrointestinal specimens, 2) sepsis, 3) meningitis, 4) acute Respiratory failure, or 5) Respiratory Tract Hemorrhage. Patients were assigned to either HS or DS. Medical records were further reviewed to exTract related clinical features and radiological findings. Results Sixteen severe strongyloidiasis cases were included. Of those, fifteen cases had pulmonary manifestations, eight had acute Respiratory distress syndrome (ARDS) (53%), seven had enteric bacterial pneumonia (46%) and five had pulmonary Hemorrhage (33%). Acute Respiratory failure was a common indicator for pulmonary manifestation (87%). Chest X-ray findings frequently showed diffuse shadows (71%). Additionally, ileum gas was detected for ten of the sixteen cases in the upper abdomen during assessment with chest X-ray. While, chest CT findings frequently showed ground-glass opacity (GGO) in 89% of patients. Interlobular septal thickening was also frequently shown (67%), always accompanying GGO in upper lobes. Conclusions In summary, our study described HS/DS cases with pulmonary manifestations including, ARDS, bacterial pneumonia and pulmonary Hemorrhage. Chest X-ray findings in HS/DS cases frequently showed diffuse shadows, and the combination of GGO and interlobular septal thickening in chest CT was common in HS/DS, regardless of accompanying pulmonary manifestations. This CT finding suggests alveolar Hemorrhage could be used as a potential marker indicating the transition from latent to symptomatic state. Respiratory specimens are especially useful for detecting larvae in cases of HS/DS.

  • Pulmonary manifestations in severe strongyloidiasis: Review of 17 cases
    1.3 Imaging, 2015
    Co-Authors: Daijiro Nabeya, Shusaku Haranaga, Takeshi Kinjo, Gretchen Parrott, Ayako Uehara, Saifun Nahar, Teruhisa Tanaka, Tetsuo Hirata, Futoshi Higa, Masao Tateyama
    Abstract:

    Rationale: Strongyloidiasis is a chronic parasitic infection caused by Strongyloides stercoralis and is recognized as “neglected tropical disease”. Therefore, diagnosis of the infection may become problematic in non-endemic areas of the globalized society. Because severe strongyloidiasis often involves pulmonary manifestations, we reason that pulmonary manifestations are noteworthy characteristics in the diagnosis of strongyloidiasis. Here, we present observations of pulmonary manifestations in cases of severe strongyloidiasis. Methods: Our retrospective study included all patients with severe strongyloidiasis diagnosed in Ryukyu University Hospital and affiliated hospitals in Okinawa, Japan, from January 2004 to December 2014. All diagnoses were confirmed by the microscopic identification of S. stercoralis larvae. Severe infection was defined as 1) the identification of S. stercoralis from extra gastrointestinal specimens, 2) sepsis, 3) meningitis, 4) acute Respiratory failure or 5) Respiratory Tract Hemorrhage. Medical records were reviewed to exTract related clinical features. Results: In total 17 severe Strongyloidiasis cases were collected. The mean age of patients was 74.9 years. Sixteen cases had pulmonary manifestations, 8 with bacterial pneumonia, 8 with ARDS and 5 with Respiratory Hemorrhage. Chest CT was performed in 5 cases and all findings showed bilateral ground glass opacities and consolidation with interlobular septal thickening. Conclusion: Severe strongyloidiasis tends to develop some type of pulmonary manifestation; bacterial pneumonia, ARDS and Respiratory Hemorrhage are common. CT findings from all cases showed same pattern regardless of their pulmonary manifestations.

Shusaku Haranaga - One of the best experts on this subject based on the ideXlab platform.

  • Pulmonary strongyloidiasis: assessment between manifestation and radiological findings in 16 severe strongyloidiasis cases
    BMC infectious diseases, 2017
    Co-Authors: Daijiro Nabeya, Shusaku Haranaga, Takeshi Kinjo, Gretchen Parrott, Saifun Nahar, Teruhisa Tanaka, Tetsuo Hirata, Masao Tateyama, Akira Hokama, Jiro Fujita
    Abstract:

    Strongyloidiasis is a chronic parasitic infection caused by Strongyloides stercoralis. Severe cases such as, hyperinfection syndrome (HS) and disseminated strongyloidiasis (DS), can involve pulmonary manifestations. These manifestations frequently aid the diagnosis of strongyloidiasis. Here, we present the pulmonary manifestations and radiological findings of severe strongyloidiasis. From January 2004 to December 2014, all patients diagnosed with severe strongyloidiasis at the University of the Ryukyus Hospital or affiliated hospitals in Okinawa, Japan, were included in this retrospective study. All diagnoses were confirmed by the microscopic or histopathological identification of larvae. Severe strongyloidiasis was defined by the presence of any of the following: 1) the identification of S. stercoralis from extra gastrointestinal specimens, 2) sepsis, 3) meningitis, 4) acute Respiratory failure, or 5) Respiratory Tract Hemorrhage. Patients were assigned to either HS or DS. Medical records were further reviewed to exTract related clinical features and radiological findings. Sixteen severe strongyloidiasis cases were included. Of those, fifteen cases had pulmonary manifestations, eight had acute Respiratory distress syndrome (ARDS) (53%), seven had enteric bacterial pneumonia (46%) and five had pulmonary Hemorrhage (33%). Acute Respiratory failure was a common indicator for pulmonary manifestation (87%). Chest X-ray findings frequently showed diffuse shadows (71%). Additionally, ileum gas was detected for ten of the sixteen cases in the upper abdomen during assessment with chest X-ray. While, chest CT findings frequently showed ground-glass opacity (GGO) in 89% of patients. Interlobular septal thickening was also frequently shown (67%), always accompanying GGO in upper lobes. In summary, our study described HS/DS cases with pulmonary manifestations including, ARDS, bacterial pneumonia and pulmonary Hemorrhage. Chest X-ray findings in HS/DS cases frequently showed diffuse shadows, and the combination of GGO and interlobular septal thickening in chest CT was common in HS/DS, regardless of accompanying pulmonary manifestations. This CT finding suggests alveolar Hemorrhage could be used as a potential marker indicating the transition from latent to symptomatic state. Respiratory specimens are especially useful for detecting larvae in cases of HS/DS.

  • Pulmonary strongyloidiasis: assessment between manifestation and radiological findings in 16 severe strongyloidiasis cases
    BMC Infectious Diseases, 2017
    Co-Authors: Daijiro Nabeya, Shusaku Haranaga, Takeshi Kinjo, Saifun Nahar, Teruhisa Tanaka, Tetsuo Hirata, Masao Tateyama, Gretchen Lynn Parrott, Akira Hokama, Jiro Fujita
    Abstract:

    Background Strongyloidiasis is a chronic parasitic infection caused by Strongyloides stercoralis. Severe cases such as, hyperinfection syndrome (HS) and disseminated strongyloidiasis (DS), can involve pulmonary manifestations. These manifestations frequently aid the diagnosis of strongyloidiasis. Here, we present the pulmonary manifestations and radiological findings of severe strongyloidiasis. Methods From January 2004 to December 2014, all patients diagnosed with severe strongyloidiasis at the University of the Ryukyus Hospital or affiliated hospitals in Okinawa, Japan, were included in this retrospective study. All diagnoses were confirmed by the microscopic or histopathological identification of larvae. Severe strongyloidiasis was defined by the presence of any of the following: 1) the identification of S. stercoralis from extra gastrointestinal specimens, 2) sepsis, 3) meningitis, 4) acute Respiratory failure, or 5) Respiratory Tract Hemorrhage. Patients were assigned to either HS or DS. Medical records were further reviewed to exTract related clinical features and radiological findings. Results Sixteen severe strongyloidiasis cases were included. Of those, fifteen cases had pulmonary manifestations, eight had acute Respiratory distress syndrome (ARDS) (53%), seven had enteric bacterial pneumonia (46%) and five had pulmonary Hemorrhage (33%). Acute Respiratory failure was a common indicator for pulmonary manifestation (87%). Chest X-ray findings frequently showed diffuse shadows (71%). Additionally, ileum gas was detected for ten of the sixteen cases in the upper abdomen during assessment with chest X-ray. While, chest CT findings frequently showed ground-glass opacity (GGO) in 89% of patients. Interlobular septal thickening was also frequently shown (67%), always accompanying GGO in upper lobes. Conclusions In summary, our study described HS/DS cases with pulmonary manifestations including, ARDS, bacterial pneumonia and pulmonary Hemorrhage. Chest X-ray findings in HS/DS cases frequently showed diffuse shadows, and the combination of GGO and interlobular septal thickening in chest CT was common in HS/DS, regardless of accompanying pulmonary manifestations. This CT finding suggests alveolar Hemorrhage could be used as a potential marker indicating the transition from latent to symptomatic state. Respiratory specimens are especially useful for detecting larvae in cases of HS/DS.

  • Pulmonary manifestations in severe strongyloidiasis: Review of 17 cases
    1.3 Imaging, 2015
    Co-Authors: Daijiro Nabeya, Shusaku Haranaga, Takeshi Kinjo, Gretchen Parrott, Ayako Uehara, Saifun Nahar, Teruhisa Tanaka, Tetsuo Hirata, Futoshi Higa, Masao Tateyama
    Abstract:

    Rationale: Strongyloidiasis is a chronic parasitic infection caused by Strongyloides stercoralis and is recognized as “neglected tropical disease”. Therefore, diagnosis of the infection may become problematic in non-endemic areas of the globalized society. Because severe strongyloidiasis often involves pulmonary manifestations, we reason that pulmonary manifestations are noteworthy characteristics in the diagnosis of strongyloidiasis. Here, we present observations of pulmonary manifestations in cases of severe strongyloidiasis. Methods: Our retrospective study included all patients with severe strongyloidiasis diagnosed in Ryukyu University Hospital and affiliated hospitals in Okinawa, Japan, from January 2004 to December 2014. All diagnoses were confirmed by the microscopic identification of S. stercoralis larvae. Severe infection was defined as 1) the identification of S. stercoralis from extra gastrointestinal specimens, 2) sepsis, 3) meningitis, 4) acute Respiratory failure or 5) Respiratory Tract Hemorrhage. Medical records were reviewed to exTract related clinical features. Results: In total 17 severe Strongyloidiasis cases were collected. The mean age of patients was 74.9 years. Sixteen cases had pulmonary manifestations, 8 with bacterial pneumonia, 8 with ARDS and 5 with Respiratory Hemorrhage. Chest CT was performed in 5 cases and all findings showed bilateral ground glass opacities and consolidation with interlobular septal thickening. Conclusion: Severe strongyloidiasis tends to develop some type of pulmonary manifestation; bacterial pneumonia, ARDS and Respiratory Hemorrhage are common. CT findings from all cases showed same pattern regardless of their pulmonary manifestations.

Takeshi Kinjo - One of the best experts on this subject based on the ideXlab platform.

  • Pulmonary strongyloidiasis: assessment between manifestation and radiological findings in 16 severe strongyloidiasis cases
    BMC infectious diseases, 2017
    Co-Authors: Daijiro Nabeya, Shusaku Haranaga, Takeshi Kinjo, Gretchen Parrott, Saifun Nahar, Teruhisa Tanaka, Tetsuo Hirata, Masao Tateyama, Akira Hokama, Jiro Fujita
    Abstract:

    Strongyloidiasis is a chronic parasitic infection caused by Strongyloides stercoralis. Severe cases such as, hyperinfection syndrome (HS) and disseminated strongyloidiasis (DS), can involve pulmonary manifestations. These manifestations frequently aid the diagnosis of strongyloidiasis. Here, we present the pulmonary manifestations and radiological findings of severe strongyloidiasis. From January 2004 to December 2014, all patients diagnosed with severe strongyloidiasis at the University of the Ryukyus Hospital or affiliated hospitals in Okinawa, Japan, were included in this retrospective study. All diagnoses were confirmed by the microscopic or histopathological identification of larvae. Severe strongyloidiasis was defined by the presence of any of the following: 1) the identification of S. stercoralis from extra gastrointestinal specimens, 2) sepsis, 3) meningitis, 4) acute Respiratory failure, or 5) Respiratory Tract Hemorrhage. Patients were assigned to either HS or DS. Medical records were further reviewed to exTract related clinical features and radiological findings. Sixteen severe strongyloidiasis cases were included. Of those, fifteen cases had pulmonary manifestations, eight had acute Respiratory distress syndrome (ARDS) (53%), seven had enteric bacterial pneumonia (46%) and five had pulmonary Hemorrhage (33%). Acute Respiratory failure was a common indicator for pulmonary manifestation (87%). Chest X-ray findings frequently showed diffuse shadows (71%). Additionally, ileum gas was detected for ten of the sixteen cases in the upper abdomen during assessment with chest X-ray. While, chest CT findings frequently showed ground-glass opacity (GGO) in 89% of patients. Interlobular septal thickening was also frequently shown (67%), always accompanying GGO in upper lobes. In summary, our study described HS/DS cases with pulmonary manifestations including, ARDS, bacterial pneumonia and pulmonary Hemorrhage. Chest X-ray findings in HS/DS cases frequently showed diffuse shadows, and the combination of GGO and interlobular septal thickening in chest CT was common in HS/DS, regardless of accompanying pulmonary manifestations. This CT finding suggests alveolar Hemorrhage could be used as a potential marker indicating the transition from latent to symptomatic state. Respiratory specimens are especially useful for detecting larvae in cases of HS/DS.

  • Pulmonary strongyloidiasis: assessment between manifestation and radiological findings in 16 severe strongyloidiasis cases
    BMC Infectious Diseases, 2017
    Co-Authors: Daijiro Nabeya, Shusaku Haranaga, Takeshi Kinjo, Saifun Nahar, Teruhisa Tanaka, Tetsuo Hirata, Masao Tateyama, Gretchen Lynn Parrott, Akira Hokama, Jiro Fujita
    Abstract:

    Background Strongyloidiasis is a chronic parasitic infection caused by Strongyloides stercoralis. Severe cases such as, hyperinfection syndrome (HS) and disseminated strongyloidiasis (DS), can involve pulmonary manifestations. These manifestations frequently aid the diagnosis of strongyloidiasis. Here, we present the pulmonary manifestations and radiological findings of severe strongyloidiasis. Methods From January 2004 to December 2014, all patients diagnosed with severe strongyloidiasis at the University of the Ryukyus Hospital or affiliated hospitals in Okinawa, Japan, were included in this retrospective study. All diagnoses were confirmed by the microscopic or histopathological identification of larvae. Severe strongyloidiasis was defined by the presence of any of the following: 1) the identification of S. stercoralis from extra gastrointestinal specimens, 2) sepsis, 3) meningitis, 4) acute Respiratory failure, or 5) Respiratory Tract Hemorrhage. Patients were assigned to either HS or DS. Medical records were further reviewed to exTract related clinical features and radiological findings. Results Sixteen severe strongyloidiasis cases were included. Of those, fifteen cases had pulmonary manifestations, eight had acute Respiratory distress syndrome (ARDS) (53%), seven had enteric bacterial pneumonia (46%) and five had pulmonary Hemorrhage (33%). Acute Respiratory failure was a common indicator for pulmonary manifestation (87%). Chest X-ray findings frequently showed diffuse shadows (71%). Additionally, ileum gas was detected for ten of the sixteen cases in the upper abdomen during assessment with chest X-ray. While, chest CT findings frequently showed ground-glass opacity (GGO) in 89% of patients. Interlobular septal thickening was also frequently shown (67%), always accompanying GGO in upper lobes. Conclusions In summary, our study described HS/DS cases with pulmonary manifestations including, ARDS, bacterial pneumonia and pulmonary Hemorrhage. Chest X-ray findings in HS/DS cases frequently showed diffuse shadows, and the combination of GGO and interlobular septal thickening in chest CT was common in HS/DS, regardless of accompanying pulmonary manifestations. This CT finding suggests alveolar Hemorrhage could be used as a potential marker indicating the transition from latent to symptomatic state. Respiratory specimens are especially useful for detecting larvae in cases of HS/DS.

  • Pulmonary manifestations in severe strongyloidiasis: Review of 17 cases
    1.3 Imaging, 2015
    Co-Authors: Daijiro Nabeya, Shusaku Haranaga, Takeshi Kinjo, Gretchen Parrott, Ayako Uehara, Saifun Nahar, Teruhisa Tanaka, Tetsuo Hirata, Futoshi Higa, Masao Tateyama
    Abstract:

    Rationale: Strongyloidiasis is a chronic parasitic infection caused by Strongyloides stercoralis and is recognized as “neglected tropical disease”. Therefore, diagnosis of the infection may become problematic in non-endemic areas of the globalized society. Because severe strongyloidiasis often involves pulmonary manifestations, we reason that pulmonary manifestations are noteworthy characteristics in the diagnosis of strongyloidiasis. Here, we present observations of pulmonary manifestations in cases of severe strongyloidiasis. Methods: Our retrospective study included all patients with severe strongyloidiasis diagnosed in Ryukyu University Hospital and affiliated hospitals in Okinawa, Japan, from January 2004 to December 2014. All diagnoses were confirmed by the microscopic identification of S. stercoralis larvae. Severe infection was defined as 1) the identification of S. stercoralis from extra gastrointestinal specimens, 2) sepsis, 3) meningitis, 4) acute Respiratory failure or 5) Respiratory Tract Hemorrhage. Medical records were reviewed to exTract related clinical features. Results: In total 17 severe Strongyloidiasis cases were collected. The mean age of patients was 74.9 years. Sixteen cases had pulmonary manifestations, 8 with bacterial pneumonia, 8 with ARDS and 5 with Respiratory Hemorrhage. Chest CT was performed in 5 cases and all findings showed bilateral ground glass opacities and consolidation with interlobular septal thickening. Conclusion: Severe strongyloidiasis tends to develop some type of pulmonary manifestation; bacterial pneumonia, ARDS and Respiratory Hemorrhage are common. CT findings from all cases showed same pattern regardless of their pulmonary manifestations.