The Experts below are selected from a list of 3843 Experts worldwide ranked by ideXlab platform
Fernando Salvador - One of the best experts on this subject based on the ideXlab platform.
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imported Strongyloidiasis data from 1245 cases registered in the redivi spanish collaborative network 2009 2017
PLOS Neglected Tropical Diseases, 2019Co-Authors: Fernando Salvador, Begoña Treviño, Diego Torrús, Josune Goikoetxea, Sandra Chamorrotojeiro, Adrian Sanchezmontalva, Juan Maria Herreromartinez, Azucena Rodriguezguardado, Nuria Serredelcor, Zuriñe ZuberoAbstract:Background Imported Strongyloidiasis is increasingly being diagnosed in non-endemic areas. The aim of this study was to describe the epidemiological, clinical and microbiological characteristics of patients with imported Strongyloidiasis in Spain. Methodology This is an observational retrospective study that included all patients diagnosed of Strongyloidiasis registered in the +REDIVI Collaborative Network from 2009 to 2017. Demographic, epidemiological and clinical information was collected from the +REDIVI database, and extra information regarding microbiological techniques, treatment and follow-up was requested to participant centers. Findings Overall, 1245 cases were included. Most of them were immigrants (66.9%), and South America was the most frequent area of origin. Detection of larvae in stool samples was observed in 21.9% of the patients, and serological tests allowed making the diagnosis in the rest of the cases. Eosinophilia was present in 82.2% of cases. Treatment with ivermectin (compared with albendazole) was the most strongly associated factor to achieve the cure (OR 2.34). Conclusions Given the long latency of the infection and the risk of developing a severe presentation, screening of S. stercoralis infection should be mandatory in patients coming from or had traveling to endemic areas, especially in those with immunosuppressant conditions.
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Factors associated to definite diagnosis in patients with Strongyloidiasis in +REDIVI with available extra information (2009–2017).
2019Co-Authors: Fernando Salvador, Begoña Treviño, Sandra Chamorro-tojeiro, Adrián Sánchez-montalvá, Juan María Herrero-martínez, Azucena Rodríguez-guardado, Núria Serre-delcor, Diego Torrús, Josune Goikoetxea, Zuriñe ZuberoAbstract:Factors associated to definite diagnosis in patients with Strongyloidiasis in +REDIVI with available extra information (2009–2017).
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Clinical and demographic characteristics of patients with Strongyloidiasis in +REDIVI (2009–2017).
2019Co-Authors: Fernando Salvador, Begoña Treviño, Sandra Chamorro-tojeiro, Adrián Sánchez-montalvá, Juan María Herrero-martínez, Azucena Rodríguez-guardado, Núria Serre-delcor, Diego Torrús, Josune Goikoetxea, Zuriñe ZuberoAbstract:Clinical and demographic characteristics of patients with Strongyloidiasis in +REDIVI (2009–2017).
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Laboratorial and microbiological information at the time of diagnosis of patients with Strongyloidiasis in +REDIVI with available extra information (2009–2017).
2019Co-Authors: Fernando Salvador, Begoña Treviño, Sandra Chamorro-tojeiro, Adrián Sánchez-montalvá, Juan María Herrero-martínez, Azucena Rodríguez-guardado, Núria Serre-delcor, Diego Torrús, Josune Goikoetxea, Zuriñe ZuberoAbstract:Laboratorial and microbiological information at the time of diagnosis of patients with Strongyloidiasis in +REDIVI with available extra information (2009–2017).
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surveillance of Strongyloidiasis in spanish in patients 1998 2014
PLOS ONE, 2017Co-Authors: Moncef Belhassengarcia, Montserrat Alonsosardon, Angela Martinezperez, Cristina Soler, Cristina Carranzarodriguez, J L Perezarellano, Antonio Muro, Fernando SalvadorAbstract:Background Strongyloides stercoralis is a parasite that causes Strongyloidiasis, a neglected tropical disease. S. stercoralis is a soil-transmitted helminth that is widely distributed in tropical and subtropical regions of the world. Strongyloidiasis can occur without any symptoms or as a chronic infection characterized by mild, unspecific symptoms such as pruritus, abdominal pain or discomfort; respiratory impairment also may manifest as a potentially fatal hyperinfection or disseminated infection. Most studies on Strongyloidiasis in Spain have been related to chronic forms in immigrants or travellers from endemic zones and have mainly analysed out-patient populations. Studies of the impact of Strongyloidiasis cases admitted to hospitals in Spain are lacking. Therefore, the aim of this study was to analyse the impact of Strongyloidiasis in hospital care in Spain. Methodology We designed a retrospective descriptive study using the Minimum Basic Data Set (MBDS, CMBD in Spanish) for inpatients with ICD-9: 127.2 (Strongyloidiasis) diagnoses admitted to hospitals in the Spanish National Health System between 1998 and 2014. Principal findings A total of 507 hospitalizations with diagnosis of Strongyloidiasis were recorded, 324 cases (63.9%) were males. The mean (±SD) age was 42.1±20.1 years. The impact of Strongyloidiasis on the total population of Spain was 0.06 cases per 105 person-years, and the infection burden increased progressively over time (from 0.01 cases per 105 person-years in 1999 to 0.10 cases per 105 person-years in 2014). 40 cases (7.9%) died. The total cost was approximately €8,681,062.3, and the mean cost per patient was €17,122.4±97,968.8. Conclusions Our data suggest that Strongyloidiasis is frequent in Spain and is increasing in incidence. Therefore, it would be desirable to improve the oversight and surveillance of this condition. Due to the fact that Strongyloidiasis can be fatal, we believe that there is a need to establish risk categories for inclusion in national guidelines/protocols for screening individuals at risk of developing Strongyloidiasis.
Zuriñe Zubero - One of the best experts on this subject based on the ideXlab platform.
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imported Strongyloidiasis data from 1245 cases registered in the redivi spanish collaborative network 2009 2017
PLOS Neglected Tropical Diseases, 2019Co-Authors: Fernando Salvador, Begoña Treviño, Diego Torrús, Josune Goikoetxea, Sandra Chamorrotojeiro, Adrian Sanchezmontalva, Juan Maria Herreromartinez, Azucena Rodriguezguardado, Nuria Serredelcor, Zuriñe ZuberoAbstract:Background Imported Strongyloidiasis is increasingly being diagnosed in non-endemic areas. The aim of this study was to describe the epidemiological, clinical and microbiological characteristics of patients with imported Strongyloidiasis in Spain. Methodology This is an observational retrospective study that included all patients diagnosed of Strongyloidiasis registered in the +REDIVI Collaborative Network from 2009 to 2017. Demographic, epidemiological and clinical information was collected from the +REDIVI database, and extra information regarding microbiological techniques, treatment and follow-up was requested to participant centers. Findings Overall, 1245 cases were included. Most of them were immigrants (66.9%), and South America was the most frequent area of origin. Detection of larvae in stool samples was observed in 21.9% of the patients, and serological tests allowed making the diagnosis in the rest of the cases. Eosinophilia was present in 82.2% of cases. Treatment with ivermectin (compared with albendazole) was the most strongly associated factor to achieve the cure (OR 2.34). Conclusions Given the long latency of the infection and the risk of developing a severe presentation, screening of S. stercoralis infection should be mandatory in patients coming from or had traveling to endemic areas, especially in those with immunosuppressant conditions.
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Clinical and demographic characteristics of patients with Strongyloidiasis in +REDIVI (2009–2017).
2019Co-Authors: Fernando Salvador, Begoña Treviño, Sandra Chamorro-tojeiro, Adrián Sánchez-montalvá, Juan María Herrero-martínez, Azucena Rodríguez-guardado, Núria Serre-delcor, Diego Torrús, Josune Goikoetxea, Zuriñe ZuberoAbstract:Clinical and demographic characteristics of patients with Strongyloidiasis in +REDIVI (2009–2017).
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Factors associated to definite diagnosis in patients with Strongyloidiasis in +REDIVI with available extra information (2009–2017).
2019Co-Authors: Fernando Salvador, Begoña Treviño, Sandra Chamorro-tojeiro, Adrián Sánchez-montalvá, Juan María Herrero-martínez, Azucena Rodríguez-guardado, Núria Serre-delcor, Diego Torrús, Josune Goikoetxea, Zuriñe ZuberoAbstract:Factors associated to definite diagnosis in patients with Strongyloidiasis in +REDIVI with available extra information (2009–2017).
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Laboratorial and microbiological information at the time of diagnosis of patients with Strongyloidiasis in +REDIVI with available extra information (2009–2017).
2019Co-Authors: Fernando Salvador, Begoña Treviño, Sandra Chamorro-tojeiro, Adrián Sánchez-montalvá, Juan María Herrero-martínez, Azucena Rodríguez-guardado, Núria Serre-delcor, Diego Torrús, Josune Goikoetxea, Zuriñe ZuberoAbstract:Laboratorial and microbiological information at the time of diagnosis of patients with Strongyloidiasis in +REDIVI with available extra information (2009–2017).
Kirstin Ross - One of the best experts on this subject based on the ideXlab platform.
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detection of classic and cryptic strongyloides genotypes by deep amplicon sequencing a preliminary survey of dog and human specimens collected from remote australian communities
PLOS Neglected Tropical Diseases, 2019Co-Authors: Meruyert Beknazarova, Joel Barratt, Richard S Bradbury, Meredith Lane, Harriet Whiley, Kirstin RossAbstract:Strongyloidiasis is caused by the human infective nematodes Strongyloides stercoralis, Strongyloides fuelleborni subsp. fuelleborni and Strongyloides fuelleborni subsp. kellyi. The zoonotic potential of S. stercoralis and the potential role of dogs in the maintenance of Strongyloidiasis transmission has been a topic of interest and discussion for many years. In Australia, Strongyloidiasis is prevalent in remote socioeconomically disadvantaged communities in the north of the continent. Being an isolated continent that has been separated from other regions for a long geological period, description of diversity of Australian Strongyloides genotypes adds to our understanding of the genetic diversity within the genus. Using PCR and amplicon sequencing (Illumina sequencing technology), we sequenced the Strongyloides SSU rDNA hyper-variable I and hyper-variable IV regions using Strongyloides-specific primers, and a fragment of the mtDNA cox1 gene using primers that are broadly specific for Strongyloides sp. and hookworms. These loci were amplified from DNA extracted from Australian human and dog faeces, and one human sputum sample. Using this approach, we confirm for the first time that potentially zoonotic S. stercoralis populations are present in Australia, suggesting that dogs represent a potential reservoir of human Strongyloidiasis in remote Australian communities.
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detection of classic and cryptic strongyloides genotypes by deep amplicon sequencing a preliminary survey of dog and human specimens collected from remote australian communities
bioRxiv, 2019Co-Authors: Meruyert Beknazarova, Joel Barratt, Richard S Bradbury, Meredith Lane, Harriet Whiley, Kirstin RossAbstract:Strongyloidiasis is a neglected disease caused by the human infective nematodes Strongyloides stercoralis, Strongyloides fuelleborni subsp. fuelleborni and Strongyloides fuelleborni subsp. kellyi. The zoonotic potential of S. stercoralis and the potential role of dogs in the maintenance of Strongyloidiasis transmission has been a topic of interest and discussion for many years. In Australia, Strongyloidiasis is prevalent in remote socioeconomically disadvantaged communities in the north of the continent. Being an isolated continent that has been separated from other regions for a long geological period, knowledge on the diversity of Australian Strongyloides genotypes is an important addition to our understanding of the genetic diversity within the genus. Using PCR enrichment combined with Illumina sequencing technology, we sequenced the Strongyloides SSU 18S rDNA hyper-variable I and hyper-variable IV regions using Strongyloides-specific primers, and a fragment of the mtDNA cox1 gene using primers that are broadly specific for Strongyloides sp. and hookworms. These loci were amplified from DNA extracted from human and dog faeces, and one human sputum sample. Using this approach, we confirm for the first time that potentially zoonotic S. stercoralis genotypes are present in Australia, suggesting that dogs represent a potential reservoir of human Strongyloidiasis in remote Australian communities.
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Strongyloidiasis a disease of socioeconomic disadvantage
International Journal of Environmental Research and Public Health, 2016Co-Authors: Meruyert Beknazarova, Harriet Whiley, Kirstin RossAbstract:Strongyloidiasis is a disease caused by soil transmitted helminths of the Strongyloides genus. Currently, it is predominately described as a neglected tropical disease. However, this description is misleading as it focuses on the geographical location of the disease and not the primary consideration, which is the socioeconomic conditions and poor infrastructure found within endemic regions. This classification may result in misdiagnosis and mistreatment by physicians, but more importantly, it influences how the disease is fundamentally viewed. Strongyloidiasis must be first and foremost considered as a disease of disadvantage, to ensure the correct strategies and control measures are used to prevent infection. Changing how Strongyloidiasis is perceived from a geographic and clinical issue to an environmental health issue represents the first step in identifying appropriate long term control measures. This includes emphasis on environmental health controls, such as better infrastructure, sanitation and living conditions. This review explores the global prevalence of Strongyloidiasis in relation to its presence in subtropical, tropical and temperate climate zones with mild and cold winters, but also explores the corresponding socioeconomic conditions of these regions. The evidence shows that Strongyloidiasis is primarily determined by the socioeconomic status of the communities rather than geographic or climatic conditions. It demonstrates that Strongyloidiasis should no longer be referred to as a "tropical" disease but rather a disease of disadvantage. This philosophical shift will promote the development of correct control strategies for preventing this disease of disadvantage.
Antonio Muro - One of the best experts on this subject based on the ideXlab platform.
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surveillance of Strongyloidiasis in spanish in patients 1998 2014
PLOS ONE, 2017Co-Authors: Moncef Belhassengarcia, Montserrat Alonsosardon, Angela Martinezperez, Cristina Soler, Cristina Carranzarodriguez, J L Perezarellano, Antonio Muro, Fernando SalvadorAbstract:Background Strongyloides stercoralis is a parasite that causes Strongyloidiasis, a neglected tropical disease. S. stercoralis is a soil-transmitted helminth that is widely distributed in tropical and subtropical regions of the world. Strongyloidiasis can occur without any symptoms or as a chronic infection characterized by mild, unspecific symptoms such as pruritus, abdominal pain or discomfort; respiratory impairment also may manifest as a potentially fatal hyperinfection or disseminated infection. Most studies on Strongyloidiasis in Spain have been related to chronic forms in immigrants or travellers from endemic zones and have mainly analysed out-patient populations. Studies of the impact of Strongyloidiasis cases admitted to hospitals in Spain are lacking. Therefore, the aim of this study was to analyse the impact of Strongyloidiasis in hospital care in Spain. Methodology We designed a retrospective descriptive study using the Minimum Basic Data Set (MBDS, CMBD in Spanish) for inpatients with ICD-9: 127.2 (Strongyloidiasis) diagnoses admitted to hospitals in the Spanish National Health System between 1998 and 2014. Principal findings A total of 507 hospitalizations with diagnosis of Strongyloidiasis were recorded, 324 cases (63.9%) were males. The mean (±SD) age was 42.1±20.1 years. The impact of Strongyloidiasis on the total population of Spain was 0.06 cases per 105 person-years, and the infection burden increased progressively over time (from 0.01 cases per 105 person-years in 1999 to 0.10 cases per 105 person-years in 2014). 40 cases (7.9%) died. The total cost was approximately €8,681,062.3, and the mean cost per patient was €17,122.4±97,968.8. Conclusions Our data suggest that Strongyloidiasis is frequent in Spain and is increasing in incidence. Therefore, it would be desirable to improve the oversight and surveillance of this condition. Due to the fact that Strongyloidiasis can be fatal, we believe that there is a need to establish risk categories for inclusion in national guidelines/protocols for screening individuals at risk of developing Strongyloidiasis.
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strong lamp a lamp assay for strongyloides spp detection in stool and urine samples towards the diagnosis of human Strongyloidiasis starting from a rodent model
PLOS Neglected Tropical Diseases, 2016Co-Authors: Pedro Fernandezsoto, Alicia Sanchezhernandez, Javier Gandasegui, Cristina Bajo Santos, Julio Lopezaban, Jose Maria Saugar, Esperanza Rodriguez, Belen Vicente, Antonio MuroAbstract:Background Strongyloides stercoralis, the chief causative agent of human Strongyloidiasis, is a nematode globally distributed but mainly endemic in tropical and subtropical regions. Chronic infection is often clinically asymptomatic but it can result in severe hyperinfection syndrome or disseminated Strongyloidiasis in immunocompromised patients. There is a great diversity of techniques used in diagnosing the disease, but definitive diagnosis is accomplished by parasitological examination of stool samples for morphological identification of parasite. Until now, no molecular method has been tested in urine samples as an alternative to stool samples for diagnosing Strongyloidiasis. This study aimed to evaluate the use of a new molecular LAMP assay in a well-established Wistar rat experimental infection model using both stool and, for the first time, urine samples. The LAMP assay was also clinically evaluated in patients´ stool samples.
Begoña Treviño - One of the best experts on this subject based on the ideXlab platform.
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imported Strongyloidiasis data from 1245 cases registered in the redivi spanish collaborative network 2009 2017
PLOS Neglected Tropical Diseases, 2019Co-Authors: Fernando Salvador, Begoña Treviño, Diego Torrús, Josune Goikoetxea, Sandra Chamorrotojeiro, Adrian Sanchezmontalva, Juan Maria Herreromartinez, Azucena Rodriguezguardado, Nuria Serredelcor, Zuriñe ZuberoAbstract:Background Imported Strongyloidiasis is increasingly being diagnosed in non-endemic areas. The aim of this study was to describe the epidemiological, clinical and microbiological characteristics of patients with imported Strongyloidiasis in Spain. Methodology This is an observational retrospective study that included all patients diagnosed of Strongyloidiasis registered in the +REDIVI Collaborative Network from 2009 to 2017. Demographic, epidemiological and clinical information was collected from the +REDIVI database, and extra information regarding microbiological techniques, treatment and follow-up was requested to participant centers. Findings Overall, 1245 cases were included. Most of them were immigrants (66.9%), and South America was the most frequent area of origin. Detection of larvae in stool samples was observed in 21.9% of the patients, and serological tests allowed making the diagnosis in the rest of the cases. Eosinophilia was present in 82.2% of cases. Treatment with ivermectin (compared with albendazole) was the most strongly associated factor to achieve the cure (OR 2.34). Conclusions Given the long latency of the infection and the risk of developing a severe presentation, screening of S. stercoralis infection should be mandatory in patients coming from or had traveling to endemic areas, especially in those with immunosuppressant conditions.
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Clinical and demographic characteristics of patients with Strongyloidiasis in +REDIVI (2009–2017).
2019Co-Authors: Fernando Salvador, Begoña Treviño, Sandra Chamorro-tojeiro, Adrián Sánchez-montalvá, Juan María Herrero-martínez, Azucena Rodríguez-guardado, Núria Serre-delcor, Diego Torrús, Josune Goikoetxea, Zuriñe ZuberoAbstract:Clinical and demographic characteristics of patients with Strongyloidiasis in +REDIVI (2009–2017).
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Factors associated to definite diagnosis in patients with Strongyloidiasis in +REDIVI with available extra information (2009–2017).
2019Co-Authors: Fernando Salvador, Begoña Treviño, Sandra Chamorro-tojeiro, Adrián Sánchez-montalvá, Juan María Herrero-martínez, Azucena Rodríguez-guardado, Núria Serre-delcor, Diego Torrús, Josune Goikoetxea, Zuriñe ZuberoAbstract:Factors associated to definite diagnosis in patients with Strongyloidiasis in +REDIVI with available extra information (2009–2017).
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Laboratorial and microbiological information at the time of diagnosis of patients with Strongyloidiasis in +REDIVI with available extra information (2009–2017).
2019Co-Authors: Fernando Salvador, Begoña Treviño, Sandra Chamorro-tojeiro, Adrián Sánchez-montalvá, Juan María Herrero-martínez, Azucena Rodríguez-guardado, Núria Serre-delcor, Diego Torrús, Josune Goikoetxea, Zuriñe ZuberoAbstract:Laboratorial and microbiological information at the time of diagnosis of patients with Strongyloidiasis in +REDIVI with available extra information (2009–2017).
