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Yasuhiro Kon - One of the best experts on this subject based on the ideXlab platform.
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quantitative trait locus analysis of ovarian cysts derived from Rete Ovarii in mrl mpj mice
Mammalian Genome, 2010Co-Authors: Shinhyo Lee, Yoshiharu Hashimoto, Osamu Ichii, Saori Otsuka, Yasuhiro KonAbstract:MRL/MpJ (MRL) is a model mouse for autoimmune diseases such as dermatitis, vasculitis, arthritis, and glomerulonephritis. In addition to these immune-associated disorders, we found that older MRL mice develop ovarian cysts originating from the Rete Ovarii, which is lined by ciliated or nonciliated epithelium and considered remnants of mesonephric tubules. Ovarian cysts, which are reported to have several sources, are associated with female infertility, but information regarding the genetic etiology of ovarian cysts originating from the Rete Ovarii is rare. In this study, to elucidate the genetic background of development of ovarian cysts, we performed quantitative trait locus (QTL) analysis using 120 microsatellite markers, which cover the whole genome of murine chromosomes, and 213 backcross progenies between female MRL and male C57BL/6N mice. The quantitative trait measured was the circumferences of Rete Ovarii or ovarian cysts. As a result, suggestive linkages were detected on Chrs 3, 4, 6, and 11, but significant linkages were located on Chr 14 by interval mapping. We thereby designated the 27.5-cM region of Chr 14 “MRL Rete Ovarian Cysts (mroc).” The peak regions of Chrs 4 and 14 in particular showed a close additive interaction (p < 0.00001). From these results we concluded that multiple loci on Chrs 3, 4, 6, 11, and 14 interact to result in development of ovarian cysts in MRL mice.
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ovarian cysts in mrl mpj mice originate from Rete Ovarii
Anatomia Histologia Embryologia, 2007Co-Authors: Yasuhiro Kon, Akihiro Konno, Yoshiharu Hashimoto, Daiji EndohAbstract:Summary In MRL mice aged more than 1 year, but not in C57BL/6 mice, ovaries had grossly visible cysts presenting unilaterally or bilaterally. Postnatally, all MRL mice developed ovarian cysts by 8 months of age. Observations by light microscopy, including lectin histochemistry, indicated that the cysts sometimes included papillomatous tissues located at the hilar region and were similar to the Rete Ovarii system, but not to follicles. Two types of epithelial cells, ciliated and non-ciliated, were arranged on the cysts, in which both cell types had many microvilli projecting in various directions and random ramifications in the cystic lumen. These characteristics suggest that ovarian cysts developing in MRL mice originate mostly from the Rete Ovarii. Cysts derived from the Rete Ovarii at 8 months of age were histologically detected in all C3H mice as well as MRL mice, with variable incidence in ICR, AKR, CBA/N and ddY, and none in C57L/6, DBA/2, BALB and A/J mice. However, measurement of the maximum diameters of the ovarian cysts indicated that MRL mice regularly possessed the largest cysts visible to the naked eye. This is the first report of ovarian cysts in this inbred strain, suggesting that ovarian cysts in MRL mice appear with stable incidence and development.
M K Heatley - One of the best experts on this subject based on the ideXlab platform.
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structural and cell surface antigen expression in the Rete Ovarii and epoophoron differs from that in the fallopian tube and in endometriosis
Histopathology, 2000Co-Authors: L Russo, E Woolmough, M K HeatleyAbstract:Aims We compared the immunohistochemical profiles of the Rete Ovarii and endometriosis in order to identify a panel which distinguishes between these structures. The immune profiles of the epoophoron, Fallopian tube and ovarian surface epithelium were also studied. Materials and methods Twenty-four women with no evidence of endometriosis and seven who had endometriosis in the uterine adnexae were studied using nine antibodies to intermediate filament proteins and cell surface markers. None of the structures studied shared an identical profile of immunohistochemical reaction. The immunoprofile of endometriosis showed some similarities to that of the Fallopian tube, but differed from that of the Rete Ovarii, epoophoron and ovarian surface epithelium Conclusions A panel including Ca-125, epithelial membrane antigen and the epithelial glycoprotein BerEp4 would permit the distinction between endometriosis and the Rete Ovarii in problematic cases. The study showed some commonality in reaction between endometriosis and the Fallopian tube which indicates that they may share a common (paramesonephric) origin. There was little commonality in the immunoprofile of endometriosis and the ovarian surface epithelium implying that endometriosis is unlikely to develop as a result of serosal metaplasia.
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ki 67 oestrogen receptor and progesterone receptor proteins in the human Rete Ovarii and in endometriosis
Journal of Clinical Pathology, 1999Co-Authors: M S Khan, A R Dodson, M K HeatleyAbstract:AIM: To examine proliferative activity using the Ki-67 protein, oestrogen receptor protein, and progesterone receptor protein expression in the Rete Ovarii, and to make comparisons with their expression in endometriosis. METHODS: Immunohistochemistry was used to study the Rete Ovarii in 24 cases and endometriosis in seven cases, using antibodies to Ki-67 protein (growth fraction (GF) quantified using a point score method) and oestrogen receptor and progesterone receptor (quantified using the H score method). RESULTS: There was no evidence of a significant difference in the Ki-67 protein, oestrogen receptor, and progesterone receptor in the Rete Ovarii in different phases of the menstrual cycle (proliferative phase: GF = 1.052, oestrogen receptor H score = 13.4, progesterone receptor H score = 15.32; secretory phase: GF = 0.736, oestrogen receptor H score = 7.5, progesterone receptor H score = 1.84). The expression of all three proteins was greater in the foci of endometriosis (GF = 6.99, oestrogen receptor H score = 152.02, progesterone receptor H score = 127.36) than in the Rete Ovarii (p < 0.0005-0.0008, Mann-Whitney U test). CONCLUSIONS: There is a low rate of cellular proliferation in the Rete Ovarii and this structure shows less responsiveness to hormone stimulation than foci of endometriosis. These differences may provide a useful tool to distinguish the Rete Ovarii from endometriosis in cases of diagnostic difficulty.
Joanna Kleckowskanawrot - One of the best experts on this subject based on the ideXlab platform.
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mast cells and kurloff cells their detection throughout the oestrous cycle in normal guinea pig ovaries and in guinea pigs with cystic Rete Ovarii
Research in Veterinary Science, 2021Co-Authors: Pavla Hamouzova, Petr Cizek, Vladimir Jekl, Karolina Gozdziewskaharlajczuk, Joanna KleckowskanawrotAbstract:Abstract Mast cells (MCs) and Kurloff cells (KCs) were detected in guinea pig ovaries in the follicular and luteal phases of the oestrous cycle. The samples of ovaries were fixed in Mota's basic lead acetate. Toluidine blue was used for detection of MCs and periodic acid-Schiff for detection of KCs. The percentage of KCs in a differential leukocyte count was determined in blood smears stained according to the Pappenheim method. Non-pregnant females with normal ovaries and with cystic Rete Ovarii were included in the study and the numbers of MCs and KCs were compared in these two groups and in follicular and luteal phases of the oestrous cycle. MCs' distribution in ovaries was different in the guinea pig in comparison to previously studied species: MCs were found exclusively in the superficial layers of cortical stroma and no significant difference was found between the number of MCs in the follicular and luteal phases, neither in normal ovaries, nor in ovaries with cystic Rete Ovarii. Significantly lower numbers of MCs were found in ovaries with cystic Rete Ovarii (P
Louis Dubeau - One of the best experts on this subject based on the ideXlab platform.
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the cell of origin of ovarian epithelial tumors and the ovarian surface epithelium dogma does the emperor have no clothes
Gynecologic Oncology, 1999Co-Authors: Louis DubeauAbstract:The widely favored hypothesis that ovarian epithelial tumors arise from the mesothelial cell layer lining the ovarian surface fails to explain the resemblance of these tumors to those arising in organs that are embryologically derived from the Mullerian ducts such as fallopian tubes, endometrium, and endocervix. In addition, this theory cannot account for the fact that tumors that are morphologically identical to ovarian carcinomas can sometimes be found outside the ovary. A suggestion is made that components of the secondary Mullerian system, which include paraovarian/paratubal cysts, Rete Ovarii, endosalpingiosis, endometriosis, and endomucinosis, merit some consideration as to their possible role in ovarian tumorigenesis.
Ramya P Masand - One of the best experts on this subject based on the ideXlab platform.
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brenner tumor associated with Rete Ovarii a histologic and immunohistochemical analysis of six cases exploring the relationship between these entities
Human Pathology, 2021Co-Authors: Hanna Siatecka, Ramya P MasandAbstract:The association of Brenner tumor (BT) with Rete Ovarii (RO) has been rarely alluded to in the literature. Both entities have debatable histogenesis. In this study of six cases of BT associated with RO, we describe the morphologic features and performed immunohistochemical staining for markers of Mullerian, Wolffian, mesothelial, and sex cord stromal derivation to explore the relationship between these entities. Histologically, all BTs were benign, microscopic, and incidental. RO was prominent and hyperplastic with gradual or abrupt transition to BT. In addition, focal areas of Rete entrapped between BT nests were seen. All BTs were positive for GATA-3 and negative for PAX-8. Conversely, the RO in all cases was negative for GATA-3 and positive for PAX-8. WT-1 was positive in both entities. Sex cord stromal and mesothelial markers (other than WT-1) were negative in BT and RO. Although morphologically, BTs seem to arise from RO in these cases, they have a distinct immunophenotype. It is possible that at least some BTs arise from metaplastic changes in RO epithelium.