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Sangeeta Kaul - One of the best experts on this subject based on the ideXlab platform.

  • Influence of Retinol Deficiency and curcumin/turmeric feeding on tissue microsomal membrane lipid peroxidation and fatty acids in rats
    Molecular and Cellular Biochemistry, 1997
    Co-Authors: Sangeeta Kaul, T P Krishnakantha
    Abstract:

    The effect of Retinol Deficiency and curcumin/turmeric on lipid peroxidation and fatty acid profile was studied in liver, kidney, spleen and brain microsomes of rats. Results revealed an increase in lipid peroxidation in Retinol deficient liver by 32%, kidney 30%, spleen 24% and brain 43% compared to the controls. Feeding 0.1% curcumin or turmeric for three weeks in diet to Retinol deficient rats reduced the lipid peroxidation respectively to 12.5 or 22.6%, in liver, 23.7 or 24.1% in kidney, 14.4 or 18.0% spleen and 16.0 or 31.4% in brain. Retinol Deficiency lead to a reduction in the essential fatty acids. In liver C18:1 showed a reduction by 45.6%, C18:2 by 31.6% and C20:4 by 22.8%. In kidney C18:1 was reduced by 33.6%, 18:2 by 24.6% and 20:4 by 13.7%. In spleen and brain C18:1 showed a reduction by 10.2% and 33.9%, C18:2 by 37.9% and 12.1% and C20:4 by 15.7% and 35.3% respectively. Curcumin and turmeric fed group showed a significant increase in the abnormally reduced fatty acid levels. (Mol Cell Biochem 175: 43–48, 1997)

  • influence of Retinol Deficiency and curcumin turmeric feeding on tissue microsomal membrane lipid peroxidation and fatty acids in rats
    Molecular and Cellular Biochemistry, 1997
    Co-Authors: Sangeeta Kaul, T P Krishnakantha
    Abstract:

    The effect of Retinol Deficiency and curcumin/turmeric on lipid peroxidation and fatty acid profile was studied in liver, kidney, spleen and brain microsomes of rats. Results revealed an increase in lipid peroxidation in Retinol deficient liver by 32%, kidney 30%, spleen 24% and brain 43% compared to the controls. Feeding 0.1% curcumin or turmeric for three weeks in diet to Retinol deficient rats reduced the lipid peroxidation respectively to 12.5 or 22.6%, in liver, 23.7 or 24.1% in kidney, 14.4 or 18.0% spleen and 16.0 or 31.4% in brain. Retinol Deficiency lead to a reduction in the essential fatty acids. In liver C18:1 showed a reduction by 45.6%, C18:2 by 31.6% and C20:4 by 22.8%. In kidney C18:1 was reduced by 33.6%, 18:2 by 24.6% and 20:4 by 13.7%. In spleen and brain C18:1 showed a reduction by 10.2% and 33.9%, C18:2 by 37.9% and 12.1% and C20:4 by 15.7% and 35.3% respectively. Curcumin and turmeric fed group showed a significant increase in the abnormally reduced fatty acid levels. (Mol Cell Biochem 175: 43–48, 1997)

  • EFFECT OF Retinol Deficiency AND CURCUMIN OR TURMERIC FEEDING ON BRAIN NA+-K+ ADENOSINE TRIPHOSPHATASE ACTIVITY
    Molecular and cellular biochemistry, 1994
    Co-Authors: Sangeeta Kaul, T. P. Krishnakanth
    Abstract:

    The effect of Retinol Deficiency and curcumin and turmeric feeding on brain microsomal Na+-K+ ATPase activity was investigated. The brain Na+−K+ ATPase activity registered an increase of 148.5% as compared to the control group. Upon treating Retinol deficient rats with curcumin or turmeric, the abnormally elevated activity showed a decrease of 36.9 and 47.1%, respectively, when compared to the Retinol deficient group. An increase in Vmax by 67% and Km by 66% for ATP was observed in the Retinol deficient group. Curcumin or turmeric fed Retinol-deficient groups reduced the Vmax by 25 and 33%, while Km was reduced by 25 and 31%, respectively, compared to the Retinol deficient group. Arrhenius plot of Na+−K+ ATPase showed a typical bi-phasic pattern in all the groups. Cholesterol: Phospholipid ratio showed a decrease in the Retinol-deficient group by 67.8%, which showed a marked increase in curcumin or turmeric treated groups. Detergents could increase the Na+−K+ ATPase activity more in the control group than in the Retinol deficient groups. Curcumin or turmeric improved the detergent action on the enzyme. Subsequent freezing and thawing over a period of 30 min decreased the enzyme activity by 22.8% in the Retinol deficient group compared to 15.9% decrease in the control group. Curcumin or turmeric treated groups showed a decrease in the enzyme activity by 22.0 and 19.2%, respectively, when compared to the zero time in each group. In the presence of concanavalin-A (Con-A) there was only 52.4% stimulation in the enzyme activity in Retinol deficient groups, compared to 108.0% in the control group. Curcumin or turmeric treated Retinol-deficient groups showed a stimulation in the presence of con-A by 70 and 99.5%, respectively.

  • effect of Retinol Deficiency and curcumin or turmeric feeding on brain na k adenosine triphosphatase activity
    Molecular and Cellular Biochemistry, 1994
    Co-Authors: Sangeeta Kaul, T. P. Krishnakanth
    Abstract:

    The effect of Retinol Deficiency and curcumin and turmeric feeding on brain microsomal Na+-K+ ATPase activity was investigated. The brain Na+−K+ ATPase activity registered an increase of 148.5% as compared to the control group. Upon treating Retinol deficient rats with curcumin or turmeric, the abnormally elevated activity showed a decrease of 36.9 and 47.1%, respectively, when compared to the Retinol deficient group. An increase in Vmax by 67% and Km by 66% for ATP was observed in the Retinol deficient group. Curcumin or turmeric fed Retinol-deficient groups reduced the Vmax by 25 and 33%, while Km was reduced by 25 and 31%, respectively, compared to the Retinol deficient group. Arrhenius plot of Na+−K+ ATPase showed a typical bi-phasic pattern in all the groups. Cholesterol: Phospholipid ratio showed a decrease in the Retinol-deficient group by 67.8%, which showed a marked increase in curcumin or turmeric treated groups. Detergents could increase the Na+−K+ ATPase activity more in the control group than in the Retinol deficient groups. Curcumin or turmeric improved the detergent action on the enzyme. Subsequent freezing and thawing over a period of 30 min decreased the enzyme activity by 22.8% in the Retinol deficient group compared to 15.9% decrease in the control group. Curcumin or turmeric treated groups showed a decrease in the enzyme activity by 22.0 and 19.2%, respectively, when compared to the zero time in each group. In the presence of concanavalin-A (Con-A) there was only 52.4% stimulation in the enzyme activity in Retinol deficient groups, compared to 108.0% in the control group. Curcumin or turmeric treated Retinol-deficient groups showed a stimulation in the presence of con-A by 70 and 99.5%, respectively.

  • Effect of Retinol Deficiency and curcumin or turmeric feeding on brain Na^+−K^+ adenosine triphosphatase activity
    Molecular and Cellular Biochemistry, 1994
    Co-Authors: Sangeeta Kaul, T. P. Krishnakanth
    Abstract:

    The effect of Retinol Deficiency and curcumin and turmeric feeding on brain microsomal Na^+-K^+ ATPase activity was investigated. The brain Na^+−K^+ ATPase activity registered an increase of 148.5% as compared to the control group. Upon treating Retinol deficient rats with curcumin or turmeric, the abnormally elevated activity showed a decrease of 36.9 and 47.1%, respectively, when compared to the Retinol deficient group. An increase in V_max by 67% and K_m by 66% for ATP was observed in the Retinol deficient group. Curcumin or turmeric fed Retinol-deficient groups reduced the V_max by 25 and 33%, while K_m was reduced by 25 and 31%, respectively, compared to the Retinol deficient group. Arrhenius plot of Na^+−K^+ ATPase showed a typical bi-phasic pattern in all the groups. Cholesterol: Phospholipid ratio showed a decrease in the Retinol-deficient group by 67.8%, which showed a marked increase in curcumin or turmeric treated groups. Detergents could increase the Na^+−K^+ ATPase activity more in the control group than in the Retinol deficient groups. Curcumin or turmeric improved the detergent action on the enzyme. Subsequent freezing and thawing over a period of 30 min decreased the enzyme activity by 22.8% in the Retinol deficient group compared to 15.9% decrease in the control group. Curcumin or turmeric treated groups showed a decrease in the enzyme activity by 22.0 and 19.2%, respectively, when compared to the zero time in each group. In the presence of concanavalin-A (Con-A) there was only 52.4% stimulation in the enzyme activity in Retinol deficient groups, compared to 108.0% in the control group. Curcumin or turmeric treated Retinol-deficient groups showed a stimulation in the presence of con-A by 70 and 99.5%, respectively.

T P Krishnakantha - One of the best experts on this subject based on the ideXlab platform.

  • Influence of Retinol Deficiency and curcumin/turmeric feeding on tissue microsomal membrane lipid peroxidation and fatty acids in rats
    Molecular and Cellular Biochemistry, 1997
    Co-Authors: Sangeeta Kaul, T P Krishnakantha
    Abstract:

    The effect of Retinol Deficiency and curcumin/turmeric on lipid peroxidation and fatty acid profile was studied in liver, kidney, spleen and brain microsomes of rats. Results revealed an increase in lipid peroxidation in Retinol deficient liver by 32%, kidney 30%, spleen 24% and brain 43% compared to the controls. Feeding 0.1% curcumin or turmeric for three weeks in diet to Retinol deficient rats reduced the lipid peroxidation respectively to 12.5 or 22.6%, in liver, 23.7 or 24.1% in kidney, 14.4 or 18.0% spleen and 16.0 or 31.4% in brain. Retinol Deficiency lead to a reduction in the essential fatty acids. In liver C18:1 showed a reduction by 45.6%, C18:2 by 31.6% and C20:4 by 22.8%. In kidney C18:1 was reduced by 33.6%, 18:2 by 24.6% and 20:4 by 13.7%. In spleen and brain C18:1 showed a reduction by 10.2% and 33.9%, C18:2 by 37.9% and 12.1% and C20:4 by 15.7% and 35.3% respectively. Curcumin and turmeric fed group showed a significant increase in the abnormally reduced fatty acid levels. (Mol Cell Biochem 175: 43–48, 1997)

  • influence of Retinol Deficiency and curcumin turmeric feeding on tissue microsomal membrane lipid peroxidation and fatty acids in rats
    Molecular and Cellular Biochemistry, 1997
    Co-Authors: Sangeeta Kaul, T P Krishnakantha
    Abstract:

    The effect of Retinol Deficiency and curcumin/turmeric on lipid peroxidation and fatty acid profile was studied in liver, kidney, spleen and brain microsomes of rats. Results revealed an increase in lipid peroxidation in Retinol deficient liver by 32%, kidney 30%, spleen 24% and brain 43% compared to the controls. Feeding 0.1% curcumin or turmeric for three weeks in diet to Retinol deficient rats reduced the lipid peroxidation respectively to 12.5 or 22.6%, in liver, 23.7 or 24.1% in kidney, 14.4 or 18.0% spleen and 16.0 or 31.4% in brain. Retinol Deficiency lead to a reduction in the essential fatty acids. In liver C18:1 showed a reduction by 45.6%, C18:2 by 31.6% and C20:4 by 22.8%. In kidney C18:1 was reduced by 33.6%, 18:2 by 24.6% and 20:4 by 13.7%. In spleen and brain C18:1 showed a reduction by 10.2% and 33.9%, C18:2 by 37.9% and 12.1% and C20:4 by 15.7% and 35.3% respectively. Curcumin and turmeric fed group showed a significant increase in the abnormally reduced fatty acid levels. (Mol Cell Biochem 175: 43–48, 1997)

  • Influence of Retinol Deficiency and curcumin/turmeric feeding on tissue microsomal membrane lipid peroxidation and fatty acids in rats.
    Molecular and cellular biochemistry, 1997
    Co-Authors: S Kaul, T P Krishnakantha
    Abstract:

    The effect of Retinol Deficiency and curcumin/turmeric on lipid peroxidation and fatty acid profile was studied in liver, kidney, spleen and brain microsomes of rats. Results revealed an increase in lipid peroxidation in Retinol deficient liver by 32%, kidney 30%, spleen 24% and brain 43% compared to the controls. Feeding 0.1% curcumin or turmeric for three weeks in diet to Retinol deficient rats reduced the lipid peroxidation respectively to 12.5 or 22.6%, in liver, 23.7 or 24.1% in kidney, 14.4 or 18.0% in spleen and 16.0 or 31.4% in brain. Retinol Deficiency lead to a reduction in the essential fatty acids. In liver C18:1 showed a reduction by 45.6%, C18:2 by 31.6% and C20:4 by 22.8%. In kidney C18:1 was reduced by 33.6%, 18:2 by 24.6% and 20:4 by 13.7%. In spleen and brain C18:1 showed a reduction by 10.2% and 33.9%, C18:2 by 37.9% and 12.1% and C20:4 by 15.7% and 35.3% respectively. Curcumin and turmeric fed group showed a significant increase in the abnormally reduced fatty acid levels.

  • 5'-Nucleotidase activity in Retinol Deficiency induced albino rats.
    Indian journal of experimental biology, 1993
    Co-Authors: S Kaul, T P Krishnakantha
    Abstract:

    Retinol deficient rat liver, kidney and spleen showed a significant decrease in their enzyme activity (36% to 50%) compared to controls. The lectins could stimulate the enzyme activity in Retinol deficient group by 57.6 to 92%, compared to controls (13.3% to 74%). Detergents increased the enzyme activity in Retinol deficient tissue microsomes by 4.5%-80% in comparison to controls (10.3% to 119%). The results reveal alterations in membrane structure induced by Retinol Deficiency.

  • Microsomal alkaline phosphatase activity in Retinol Deficiency induced albino rats
    Die Nahrung, 1993
    Co-Authors: Sangeeta Kaul, T P Krishnakantha
    Abstract:

    The investigations showed a significant decrease in the alkaline phosphatase activity of Retinol deficient liver (48.6%), kidney (65.8%) and spleen (61.9%), as compared to the controls (100%). An increase in Vmax and Km by 12 to 51.5% and 90.4 to 189%, respectively, was observed in all the tissues in the Retinol deficient group, as compared to the controls. Subsequent freezing and thawing reduced the activity of alkaline phosphatase by 22.5 to 35.8% in the experimental group; whereas the reduction in the control group ranged from 8.8 to 21.5%. In the presence of lectins and detergents the activity of alkaline phosphatase decreased in both the groups to different levels.

T. P. Krishnakanth - One of the best experts on this subject based on the ideXlab platform.

  • effect of Retinol Deficiency and curcumin or turmeric feeding on brain na k adenosine triphosphatase activity
    Molecular and Cellular Biochemistry, 1994
    Co-Authors: Sangeeta Kaul, T. P. Krishnakanth
    Abstract:

    The effect of Retinol Deficiency and curcumin and turmeric feeding on brain microsomal Na+-K+ ATPase activity was investigated. The brain Na+−K+ ATPase activity registered an increase of 148.5% as compared to the control group. Upon treating Retinol deficient rats with curcumin or turmeric, the abnormally elevated activity showed a decrease of 36.9 and 47.1%, respectively, when compared to the Retinol deficient group. An increase in Vmax by 67% and Km by 66% for ATP was observed in the Retinol deficient group. Curcumin or turmeric fed Retinol-deficient groups reduced the Vmax by 25 and 33%, while Km was reduced by 25 and 31%, respectively, compared to the Retinol deficient group. Arrhenius plot of Na+−K+ ATPase showed a typical bi-phasic pattern in all the groups. Cholesterol: Phospholipid ratio showed a decrease in the Retinol-deficient group by 67.8%, which showed a marked increase in curcumin or turmeric treated groups. Detergents could increase the Na+−K+ ATPase activity more in the control group than in the Retinol deficient groups. Curcumin or turmeric improved the detergent action on the enzyme. Subsequent freezing and thawing over a period of 30 min decreased the enzyme activity by 22.8% in the Retinol deficient group compared to 15.9% decrease in the control group. Curcumin or turmeric treated groups showed a decrease in the enzyme activity by 22.0 and 19.2%, respectively, when compared to the zero time in each group. In the presence of concanavalin-A (Con-A) there was only 52.4% stimulation in the enzyme activity in Retinol deficient groups, compared to 108.0% in the control group. Curcumin or turmeric treated Retinol-deficient groups showed a stimulation in the presence of con-A by 70 and 99.5%, respectively.

  • EFFECT OF Retinol Deficiency AND CURCUMIN OR TURMERIC FEEDING ON BRAIN NA+-K+ ADENOSINE TRIPHOSPHATASE ACTIVITY
    Molecular and cellular biochemistry, 1994
    Co-Authors: Sangeeta Kaul, T. P. Krishnakanth
    Abstract:

    The effect of Retinol Deficiency and curcumin and turmeric feeding on brain microsomal Na+-K+ ATPase activity was investigated. The brain Na+−K+ ATPase activity registered an increase of 148.5% as compared to the control group. Upon treating Retinol deficient rats with curcumin or turmeric, the abnormally elevated activity showed a decrease of 36.9 and 47.1%, respectively, when compared to the Retinol deficient group. An increase in Vmax by 67% and Km by 66% for ATP was observed in the Retinol deficient group. Curcumin or turmeric fed Retinol-deficient groups reduced the Vmax by 25 and 33%, while Km was reduced by 25 and 31%, respectively, compared to the Retinol deficient group. Arrhenius plot of Na+−K+ ATPase showed a typical bi-phasic pattern in all the groups. Cholesterol: Phospholipid ratio showed a decrease in the Retinol-deficient group by 67.8%, which showed a marked increase in curcumin or turmeric treated groups. Detergents could increase the Na+−K+ ATPase activity more in the control group than in the Retinol deficient groups. Curcumin or turmeric improved the detergent action on the enzyme. Subsequent freezing and thawing over a period of 30 min decreased the enzyme activity by 22.8% in the Retinol deficient group compared to 15.9% decrease in the control group. Curcumin or turmeric treated groups showed a decrease in the enzyme activity by 22.0 and 19.2%, respectively, when compared to the zero time in each group. In the presence of concanavalin-A (Con-A) there was only 52.4% stimulation in the enzyme activity in Retinol deficient groups, compared to 108.0% in the control group. Curcumin or turmeric treated Retinol-deficient groups showed a stimulation in the presence of con-A by 70 and 99.5%, respectively.

  • Effect of Retinol Deficiency and curcumin or turmeric feeding on brain Na^+−K^+ adenosine triphosphatase activity
    Molecular and Cellular Biochemistry, 1994
    Co-Authors: Sangeeta Kaul, T. P. Krishnakanth
    Abstract:

    The effect of Retinol Deficiency and curcumin and turmeric feeding on brain microsomal Na^+-K^+ ATPase activity was investigated. The brain Na^+−K^+ ATPase activity registered an increase of 148.5% as compared to the control group. Upon treating Retinol deficient rats with curcumin or turmeric, the abnormally elevated activity showed a decrease of 36.9 and 47.1%, respectively, when compared to the Retinol deficient group. An increase in V_max by 67% and K_m by 66% for ATP was observed in the Retinol deficient group. Curcumin or turmeric fed Retinol-deficient groups reduced the V_max by 25 and 33%, while K_m was reduced by 25 and 31%, respectively, compared to the Retinol deficient group. Arrhenius plot of Na^+−K^+ ATPase showed a typical bi-phasic pattern in all the groups. Cholesterol: Phospholipid ratio showed a decrease in the Retinol-deficient group by 67.8%, which showed a marked increase in curcumin or turmeric treated groups. Detergents could increase the Na^+−K^+ ATPase activity more in the control group than in the Retinol deficient groups. Curcumin or turmeric improved the detergent action on the enzyme. Subsequent freezing and thawing over a period of 30 min decreased the enzyme activity by 22.8% in the Retinol deficient group compared to 15.9% decrease in the control group. Curcumin or turmeric treated groups showed a decrease in the enzyme activity by 22.0 and 19.2%, respectively, when compared to the zero time in each group. In the presence of concanavalin-A (Con-A) there was only 52.4% stimulation in the enzyme activity in Retinol deficient groups, compared to 108.0% in the control group. Curcumin or turmeric treated Retinol-deficient groups showed a stimulation in the presence of con-A by 70 and 99.5%, respectively.

Salvador Villalpando - One of the best experts on this subject based on the ideXlab platform.

  • Serum Retinol but Not 25(OH)D Status Is Associated With Serum Hepcidin Levels in Older Mexican Adults
    Nutrients, 2019
    Co-Authors: Vanessa De La Cruz-góngora, Aarón Salinas-rodríguez, Salvador Villalpando, Mario Flores-aldana
    Abstract:

    (1) Background: Elevated hepcidin levels have been linked to anemia of inflammation (AI). Retinol Deficiency has shown to upregulate hepcidin expression in animals, while conflicting evidence links VD status with hepcidin concentration in humans. The purpose of the study is to explore if VA and VD status are associated with hepcidin concentrations in older Mexican adults (OA). (2) Methods: A cross-sectional study was conducted in summer 2015, using serum samples from 783 fasting OA ages 60 and above residents from Campeche and Yucatan. VA Deficiency (VAD) was defined as serum Retinol concentration

  • Serum Retinol but Not 25(OH)D Status Is Associated With Serum Hepcidin Levels in Older Mexican Adults
    MDPI AG, 2019
    Co-Authors: Vanessa De La Cruz-góngora, Aarón Salinas-rodríguez, Salvador Villalpando, Mario Flores-aldana
    Abstract:

    (1) Background: Elevated hepcidin levels have been linked to anemia of inflammation (AI). Retinol Deficiency has shown to upregulate hepcidin expression in animals, while conflicting evidence links VD status with hepcidin concentration in humans. The purpose of the study is to explore if VA and VD status are associated with hepcidin concentrations in older Mexican adults (OA). (2) Methods: A cross-sectional study was conducted in summer 2015, using serum samples from 783 fasting OA ages 60 and above residents from Campeche and Yucatán. VA Deficiency (VAD) was defined as serum Retinol concentration <20 μg/dL and VD Deficiency (VDD) as 25(OH)D <50 nmol/L. The log-hepcidin was the outcome variable expressed as continuous and tertiles of its distribution. Linear and ordinal regression models were used. (3) Results: VAD was present in 3.4% and VDD in 9.5% of OA. Log-Retinol was inversely associated with log-hepcidin (coeff.: −0.15, 95%CI: −0.2, −0.09). VAD status shown a higher probability than non-VAD for higher hepcidin tertiles (OR = 2.15, 95%CI: 1.24, 3.74). VDD states was not associated with hepcidin in the linear (coeff.: 0.16, 95%CI: −0.02, 0.34) nor the ordinal model (OR = 0.74, 95%CI: 0.42, 1.28). (4) Conclusions: VAD, but not VDD, status was inversely associated with hepcidin concentrations in OA

  • Low Serum Retinol Concentration Explain Higher Hepcidin Levels In Mexican Older Adults
    The FASEB Journal, 2017
    Co-Authors: Vanessa De La Cruz-góngora, Aarón Salinas-rodríguez, Salvador Villalpando
    Abstract:

    BackgroundElevated hepcidin levels have been linked to anemia of inflammation (AI). Retinol Deficiency has shown to modulate hepcidin expression in animals; however, no studies have explored low se...

Vanessa De La Cruz-góngora - One of the best experts on this subject based on the ideXlab platform.

  • Serum Retinol but Not 25(OH)D Status Is Associated With Serum Hepcidin Levels in Older Mexican Adults
    Nutrients, 2019
    Co-Authors: Vanessa De La Cruz-góngora, Aarón Salinas-rodríguez, Salvador Villalpando, Mario Flores-aldana
    Abstract:

    (1) Background: Elevated hepcidin levels have been linked to anemia of inflammation (AI). Retinol Deficiency has shown to upregulate hepcidin expression in animals, while conflicting evidence links VD status with hepcidin concentration in humans. The purpose of the study is to explore if VA and VD status are associated with hepcidin concentrations in older Mexican adults (OA). (2) Methods: A cross-sectional study was conducted in summer 2015, using serum samples from 783 fasting OA ages 60 and above residents from Campeche and Yucatan. VA Deficiency (VAD) was defined as serum Retinol concentration

  • Serum Retinol but Not 25(OH)D Status Is Associated With Serum Hepcidin Levels in Older Mexican Adults
    MDPI AG, 2019
    Co-Authors: Vanessa De La Cruz-góngora, Aarón Salinas-rodríguez, Salvador Villalpando, Mario Flores-aldana
    Abstract:

    (1) Background: Elevated hepcidin levels have been linked to anemia of inflammation (AI). Retinol Deficiency has shown to upregulate hepcidin expression in animals, while conflicting evidence links VD status with hepcidin concentration in humans. The purpose of the study is to explore if VA and VD status are associated with hepcidin concentrations in older Mexican adults (OA). (2) Methods: A cross-sectional study was conducted in summer 2015, using serum samples from 783 fasting OA ages 60 and above residents from Campeche and Yucatán. VA Deficiency (VAD) was defined as serum Retinol concentration <20 μg/dL and VD Deficiency (VDD) as 25(OH)D <50 nmol/L. The log-hepcidin was the outcome variable expressed as continuous and tertiles of its distribution. Linear and ordinal regression models were used. (3) Results: VAD was present in 3.4% and VDD in 9.5% of OA. Log-Retinol was inversely associated with log-hepcidin (coeff.: −0.15, 95%CI: −0.2, −0.09). VAD status shown a higher probability than non-VAD for higher hepcidin tertiles (OR = 2.15, 95%CI: 1.24, 3.74). VDD states was not associated with hepcidin in the linear (coeff.: 0.16, 95%CI: −0.02, 0.34) nor the ordinal model (OR = 0.74, 95%CI: 0.42, 1.28). (4) Conclusions: VAD, but not VDD, status was inversely associated with hepcidin concentrations in OA

  • Low Serum Retinol Concentration Explain Higher Hepcidin Levels In Mexican Older Adults
    The FASEB Journal, 2017
    Co-Authors: Vanessa De La Cruz-góngora, Aarón Salinas-rodríguez, Salvador Villalpando
    Abstract:

    BackgroundElevated hepcidin levels have been linked to anemia of inflammation (AI). Retinol Deficiency has shown to modulate hepcidin expression in animals; however, no studies have explored low se...