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Antonio Capone - One of the best experts on this subject based on the ideXlab platform.

  • Retinal Development and the Pathogenesis of Retinopathy of Prematurity
    2012
    Co-Authors: Antonio Capone
    Abstract:

    Survival of high-risk neonates has improved, with ophthalmologists encountering profoundly premature infants with greater frequency. There is a greater understanding of the pathophysiology and genetics of Retinopathy of Prematurity, and screening strategies continue to evolve. This chapter discusses those advances and their implications for evaluation and treatment of Retinopathy of Prematurity.

  • Aggressive posterior Retinopathy of Prematurity.
    Retina (Philadelphia Pa.), 2010
    Co-Authors: Kimberly A Drenser, Michael T. Trese, Antonio Capone
    Abstract:

    The purpose of this study was to review the anatomic and functional outcomes of aggressive posterior Retinopathy of Prematurity occurring at the authors' institution. This is a retrospective chart review of inborn infants developing aggressive posterior Retinopathy of Prematurity from January 2004 through January 2008. Birth histories, interventions, and outcomes were reviewed. Twenty-two infants were identified as having aggressive posterior Retinopathy of Prematurity. All eyes underwent peripheral laser ablation. Seven infants (14 eyes) required a second session of laser. Five infants (eight eyes) progressed to retinal detachment that was successfully repaired by lens-sparing vitrectomy. Seven eyes developed stage 4a detachments, and 1 eye developed a stage 4b detachment. Forty-three eyes (43 of 44) demonstrated a good anatomic outcome with minimal posterior pole distortion. The management of aggressive posterior Retinopathy of Prematurity requires frequent screening examinations and timely intervention as outlined in the Early Treatment Retinopathy of Prematurity Study. Eyes progressing to retinal detachment may still have a good structural outcome with lens-sparing vitrectomy.

  • Aggressive posterior Retinopathy of Prematurity.
    Retina, 2010
    Co-Authors: Kimberly A Drenser, Michael T. Trese, Antonio Capone
    Abstract:

    PURPOSE The purpose of this study was to review the anatomic and functional outcomes of aggressive posterior Retinopathy of Prematurity occurring at the authors' institution. METHODS This is a retrospective chart review of inborn infants developing aggressive posterior Retinopathy of Prematurity from January 2004 through January 2008. Birth histories, interventions, and outcomes were reviewed. RESULTS Twenty-two infants were identified as having aggressive posterior Retinopathy of Prematurity. All eyes underwent peripheral laser ablation. Seven infants (14 eyes) required a second session of laser. Five infants (eight eyes) progressed to retinal detachment that was successfully repaired by lens-sparing vitrectomy. Seven eyes developed stage 4a detachments, and 1 eye developed a stage 4b detachment. Forty-three eyes (43 of 44) demonstrated a good anatomic outcome with minimal posterior pole distortion. CONCLUSION The management of aggressive posterior Retinopathy of Prematurity requires frequent screening examinations and timely intervention as outlined in the Early Treatment Retinopathy of Prematurity Study. Eyes progressing to retinal detachment may still have a good structural outcome with lens-sparing vitrectomy.

  • Current understanding and management of Retinopathy of Prematurity.
    Current opinion in ophthalmology, 2007
    Co-Authors: Polly A. Quiram, Antonio Capone
    Abstract:

    PURPOSE of REVIEW Retinopathy of Prematurity is the leading cause of childhood blindness in industrialized countries and is the fifth leading cause of bilateral childhood blindness worldwide. There have been new insights into understanding the factors involved in the pathogenesis of Retinopathy of Prematurity and related retinal detachment. This review outlines the current recommendations for initiation, frequency, and duration of screening examinations and describes the infants at the highest risk for developing complications from Retinopathy of Prematurity. The rationale and timing of treatment are also discussed. RECENT FINDINGS Infants who undergo early screening and treatment for Retinopathy of Prematurity have improved long-term functional and structural outcomes compared with those who receive conventional screening and treatment. Patients undergoing surgical repair of Retinopathy of Prematurity-related detachments (stage 4A, 4B and 5) can have favorable anatomical and functional outcomes. The increased survival of lower birth weight infants has increased the prevalence of aggressive, posterior Retinopathy of Prematurity that may be unresponsive to conventional treatment. SUMMARY While full understanding of the mechanisms that underlie the formation of Retinopathy of Prematurity and related detachments is not complete, progress has been made in identifying risk factors, screening of high-risk patients, and optimizing the timing of surgical interventions to improve structural and functional outcomes.

  • The international classification of Retinopathy of Prematurity revisited
    Archives of ophthalmology (Chicago Ill. : 1960), 2005
    Co-Authors: Glen A Gole, Antonio Capone, J.t. Flynn, Anna L Ells, Ximena Katz, Gerd Holmstrom, Alistair R Fielder, William G Good, Jonathan M Holmes, J. Arch Mcnamara
    Abstract:

    The International Classification of Retinopathy of Prematurity Revisited : An International Committee for the Classification of Retinopathy of Prematurity

Michael T. Trese - One of the best experts on this subject based on the ideXlab platform.

  • Screening and treatments using telemedicine in Retinopathy of Prematurity
    Eye and brain, 2016
    Co-Authors: Aristomenis Thanos, Yoshihiro Yonekawa, Bozho Todorich, Darius M. Moshfeghi, Michael T. Trese
    Abstract:

    Several studies have validated the role of telemedicine as a new powerful screening and diagnostic tool for retinal disorders, such as diabetic Retinopathy and Retinopathy of Prematurity. With regard to Retinopathy of Prematurity, bedside examination with binocular indirect ophthalmoscopy has been the gold standard technique for screening, yet with several limitations. Herein, we review the current evidence that supports the role of telemedicine for the screening of infants with Retinopathy of Prematurity.

  • Vitreoretinal Surgery for Retinopathy of Prematurity
    2012
    Co-Authors: Michael T. Trese
    Abstract:

    Surgical therapy has grown to become a very effective management for Retinopathy of Prematurity. Both laser therapy early on as well as early vitrectomy therapy in a lens-sparing fashion can yield excellent anatomic and visual results. Certainly the visual result in children with ROP may be dependent on more than ocular changes alone and central nervous system lesions such as leukomalacia must also be considered when assessing the etiology of the child’s visual result. The management of Retinopathy of Prematurity children requires the availability of excellent pediatric anesthesia to reduce risk as much as possible from general anesthetic for at least vitrectomy and in many places general anesthetic is used for laser treatment as well. This brief chapter will outline the steps of utilization of vitreous surgery for Retinopathy of Prematurity.

  • Retinopathy of Prematurity: Laser Treatment and Intravitreal Injections
    2012
    Co-Authors: Michael T. Trese
    Abstract:

    Retinopathy of Prematurity has been linked to excess vascular endothelial growth factor in the second phase of ROP for a long time. This phase is the phase in which neovascularization exudation and retinal detachment develop. It has been found that peripheral ablation can reduce VEGF production and therefore reduce the incidence of retinal detachment and blindness from Retinopathy of Prematurity. In addition, anti-VEGF therapy, which pharmacologically blocks VEGF, can also be used as a potential therapeutic measure, again blocking VEGF activity. This section discusses the pros and cons of both therapies and outlines the use of each therapy.

  • Aggressive posterior Retinopathy of Prematurity.
    Retina (Philadelphia Pa.), 2010
    Co-Authors: Kimberly A Drenser, Michael T. Trese, Antonio Capone
    Abstract:

    The purpose of this study was to review the anatomic and functional outcomes of aggressive posterior Retinopathy of Prematurity occurring at the authors' institution. This is a retrospective chart review of inborn infants developing aggressive posterior Retinopathy of Prematurity from January 2004 through January 2008. Birth histories, interventions, and outcomes were reviewed. Twenty-two infants were identified as having aggressive posterior Retinopathy of Prematurity. All eyes underwent peripheral laser ablation. Seven infants (14 eyes) required a second session of laser. Five infants (eight eyes) progressed to retinal detachment that was successfully repaired by lens-sparing vitrectomy. Seven eyes developed stage 4a detachments, and 1 eye developed a stage 4b detachment. Forty-three eyes (43 of 44) demonstrated a good anatomic outcome with minimal posterior pole distortion. The management of aggressive posterior Retinopathy of Prematurity requires frequent screening examinations and timely intervention as outlined in the Early Treatment Retinopathy of Prematurity Study. Eyes progressing to retinal detachment may still have a good structural outcome with lens-sparing vitrectomy.

  • Aggressive posterior Retinopathy of Prematurity.
    Retina, 2010
    Co-Authors: Kimberly A Drenser, Michael T. Trese, Antonio Capone
    Abstract:

    PURPOSE The purpose of this study was to review the anatomic and functional outcomes of aggressive posterior Retinopathy of Prematurity occurring at the authors' institution. METHODS This is a retrospective chart review of inborn infants developing aggressive posterior Retinopathy of Prematurity from January 2004 through January 2008. Birth histories, interventions, and outcomes were reviewed. RESULTS Twenty-two infants were identified as having aggressive posterior Retinopathy of Prematurity. All eyes underwent peripheral laser ablation. Seven infants (14 eyes) required a second session of laser. Five infants (eight eyes) progressed to retinal detachment that was successfully repaired by lens-sparing vitrectomy. Seven eyes developed stage 4a detachments, and 1 eye developed a stage 4b detachment. Forty-three eyes (43 of 44) demonstrated a good anatomic outcome with minimal posterior pole distortion. CONCLUSION The management of aggressive posterior Retinopathy of Prematurity requires frequent screening examinations and timely intervention as outlined in the Early Treatment Retinopathy of Prematurity Study. Eyes progressing to retinal detachment may still have a good structural outcome with lens-sparing vitrectomy.

Chetan K. Patel - One of the best experts on this subject based on the ideXlab platform.

J.t. Flynn - One of the best experts on this subject based on the ideXlab platform.

  • The international classification of Retinopathy of Prematurity revisited
    Archives of ophthalmology (Chicago Ill. : 1960), 2005
    Co-Authors: Glen A Gole, Antonio Capone, J.t. Flynn, Anna L Ells, Ximena Katz, Gerd Holmstrom, Alistair R Fielder, William G Good, Jonathan M Holmes, J. Arch Mcnamara
    Abstract:

    The International Classification of Retinopathy of Prematurity Revisited : An International Committee for the Classification of Retinopathy of Prematurity

  • the international classification of Retinopathy of Prematurity revisited an international committee for the classification of Retinopathy of Prematurity
    Archives of Ophthalmology, 2005
    Co-Authors: Glen A Gole, Antonio Capone, J.t. Flynn, Anna L Ells, Ximena Katz, Gerd Holmstrom, Alistair R Fielder, William G Good, Jonathan M Holmes, Arch J Mcnamara
    Abstract:

    The International Classification of Retinopathy of Prematurity Revisited : An International Committee for the Classification of Retinopathy of Prematurity

  • Retinopathy of Prematurity in multiple-gestation pregnancies
    American journal of ophthalmology, 1998
    Co-Authors: Louis C. Blumenfeld, R. Michael Siatkowski, Rose Anne Johnson, William J. Feuer, J.t. Flynn
    Abstract:

    Purpose To determine differences in incidence of Retinopathy of Prematurity between neonates of multiple-gestation and single-gestation pregnancies and to analyze differences in severity of Retinopathy of Prematurity among siblings of multiple-gestation pregnancies. Methods We reviewed the records of 149 neonates of multiple-gestation pregnancies and 691 single-gestation neonates screened for Retinopathy of Prematurity at one hospital from January 1, 1992, through December 31, 1995. The peak stage of Retinopathy of Prematurity was recorded for all infants. The multiple-gestation infants were then separated into concordant and discordant Retinopathy of Prematurity groups, with discordance defined as a difference of at least 2 stages of Retinopathy of Prematurity between siblings. Between siblings with discordant Retinopathy of Prematurity, multiple factors were compared. Results Retinopathy of Prematurity was present in 69 (46%) of the multiple-gestation neonates. Retinopathy of Prematurity was present in 312 (45%) of single-birth neonates. The percentage of multiple-gestation neonates with stages 1, 2, or 3 (prethreshold) or threshold Retinopathy of Prematurity was similar to that of single-gestation neonates. Stage 4 or 5 Retinopathy of Prematurity did not occur in either group. Conclusions There was no significant difference in stage of Retinopathy of Prematurity between infants of single-gestation pregnancies vs those of multiple-gestation pregnancies. The majority (84%) of infants of multiple-gestation pregnancies had concordant Retinopathy of Prematurity. In those infants with discordant disease, zygosity and postgestational factors other than lowest serum glucose were not related to severity of Retinopathy of Prematurity.

Arch J Mcnamara - One of the best experts on this subject based on the ideXlab platform.