The Experts below are selected from a list of 66 Experts worldwide ranked by ideXlab platform
Olízio Claudino Da Silva - One of the best experts on this subject based on the ideXlab platform.
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TÉTANO CANINO – RELATO DE UM CASO CANINE TETANUS - A CASE STUDY
Universidade Federal de Goiás, 2007Co-Authors: Francisco Das Chagas Costa Dos Santos, Guido Fontgalland C. Linhares, Olízio Claudino Da SilvaAbstract:<!-- @page { margin: 2cm } --> <p class="western" align="justify">Relata-se um caso de Tétano em um cão, o qual foi apresentado para consulta com os seguintes sinais clínicos: rigidez muscular generalizada (paralisia espástica), trismus, “Risus sardonicus”, hiperexcitabilidade reflexa, ereção das orelhas, enrigamento da pele na região frontal da cabeça e “cauda em bandeira”. O diagnóstico foi exclusivamente clínico, sendo que não foi encontrada a porta de entrada para a infecção pelo C. tetani.</p> <!-- @page { margin: 2cm } --> <p class="western" align="justify">A tetanics occurrence in a dog is described, the animal displaying at consultation the following clinical indications: generalized muscular rigidity (spastic paralysis), trismus, ";Risus sardonicus";, reflex hyperexcitability, erection of ears, skin wrinkling in frontal region of head and “bannertail”. Diagnosis was exclusively clinical, infection introduction by C. tetani was not detected.</p>
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CANINE TETANUS - A CASE STUDY TÉTANO CANINO – RELATO DE UM CASO
Universidade Federal de Goiás, 2007Co-Authors: Guido Fontgalland C. Linhares, Francisco Das Chagas Costa Dos Santos, Olízio Claudino Da SilvaAbstract:<!-- @page { margin: 2cm } --> <p class="western" align="justify">A tetanics occurrence in a dog is described, the animal displaying at consultation the following clinical indications: generalized muscular rigidity (spastic paralysis), trismus, ";Risus sardonicus";, reflex hyperexcitability, erection of ears, skin wrinkling in frontal region of head and “bannertail”. Diagnosis was exclusively clinical, infection introduction by C. tetani was not detected.</p><!-- @page { margin: 2cm } --> <p class="western" align="justify">Relata-se um caso de Tétano em um cão, o qual foi apresentado para consulta com os seguintes sinais clínicos: rigidez muscular generalizada (paralisia espástica), trismus, “Risus sardonicus”, hiperexcitabilidade reflexa, ereção das orelhas, enrigamento da pele na região frontal da cabeça e “cauda em bandeira”. O diagnóstico foi exclusivamente clínico, sendo que não foi encontrada a porta de entrada para a infecção pelo C. tetani.</p>
Orazio Taglialatela-scafati - One of the best experts on this subject based on the ideXlab platform.
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Polyacetylenes from Sardinian Oenanthe fistulosa: A Molecular Clue to Risus sardonicus
Journal of Natural Products, 2009Co-Authors: Giovanni Appendino, Federica Pollastro, Luisella Verotta, Mauro Ballero, Adriana Romano, Paulina Wyrembek, Katarzyna Szczuraszek, Jerzy W. Mozrzymas, Orazio Taglialatela-scafatiAbstract:An investigation of Oenanthe fistulosa from Sardinia afforded oenanthotoxin (1a) and dihydrooenanthotoxin (1b) from the roots and the diacetylenic epoxydiol 2 from the seeds. The absolute configuration of 1a and 1b was established as R by the modified Mosher’s method, and the structure of 2 by chemical correlation with (+)-(3R,8S)-falcarindiol. Oenanthotoxin (1a) and dihydrooenanthotoxin (1b) were found to potently block GABAergic responses, providing a molecular rationale for the symptoms of poisoning from water-dropwort (Oenanthe crocata) and related plants. These observations bear relevance for a series of historical and ethnopharmacological observations on the identification of the Sardonic herb and the molecular details of the facial muscular contraction caused by its ingestion (Risus sardonicus).
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Polyacetylenes from Sardinian Oenanthe fistulosa: A Molecular Clue to Risus sardonicus
2008Co-Authors: Federica Pollastro, Luisella Verotta, Mauro Ballero, Adriana Romano, Paulina Wyrembek, Katarzyna Szczuraszek, Jerzy W. Mozrzymas, Orazio Taglialatela-scafatiAbstract:An investigation of Oenanthe fistulosa from Sardinia afforded oenanthotoxin (1a) and dihydrooenanthotoxin (1b) from the roots and the diacetylenic epoxydiol 2 from the seeds. The absolute configuration of 1a and 1b was established as R by the modified Mosher’s method, and the structure of 2 by chemical correlation with (+)-(3R,8S)-falcarindiol. Oenanthotoxin (1a) and dihydrooenanthotoxin (1b) were found to potently block GABAergic responses, providing a molecular rationale for the symptoms of poisoning from water-dropwort (Oenanthe crocata) and related plants. These observations bear relevance for a series of historical and ethnopharmacological observations on the identification of the Sardonic herb and the molecular details of the facial muscular contraction caused by its ingestion (Risus sardonicus). Plants from the genus Oenanthe (Umbelliferae family) are among the most poisonous species of the European flora.1 They bear a general resemblance to parsnip and carrot and are still a cause of often fatal human poisonings.1 Sardinian Oenanthe species have a special ethnopharmacological relevance, being considered the most likely candidate for the (in)famous sardonic herb, a neurotoxic plant used in pre-Roman Sardinia for the ritual killing of elderly people.2 According to the ancient historians, elderly people unable to suppor
Guido Fontgalland C. Linhares - One of the best experts on this subject based on the ideXlab platform.
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TÉTANO CANINO – RELATO DE UM CASO CANINE TETANUS - A CASE STUDY
Universidade Federal de Goiás, 2007Co-Authors: Francisco Das Chagas Costa Dos Santos, Guido Fontgalland C. Linhares, Olízio Claudino Da SilvaAbstract:<!-- @page { margin: 2cm } --> <p class="western" align="justify">Relata-se um caso de Tétano em um cão, o qual foi apresentado para consulta com os seguintes sinais clínicos: rigidez muscular generalizada (paralisia espástica), trismus, “Risus sardonicus”, hiperexcitabilidade reflexa, ereção das orelhas, enrigamento da pele na região frontal da cabeça e “cauda em bandeira”. O diagnóstico foi exclusivamente clínico, sendo que não foi encontrada a porta de entrada para a infecção pelo C. tetani.</p> <!-- @page { margin: 2cm } --> <p class="western" align="justify">A tetanics occurrence in a dog is described, the animal displaying at consultation the following clinical indications: generalized muscular rigidity (spastic paralysis), trismus, ";Risus sardonicus";, reflex hyperexcitability, erection of ears, skin wrinkling in frontal region of head and “bannertail”. Diagnosis was exclusively clinical, infection introduction by C. tetani was not detected.</p>
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CANINE TETANUS - A CASE STUDY TÉTANO CANINO – RELATO DE UM CASO
Universidade Federal de Goiás, 2007Co-Authors: Guido Fontgalland C. Linhares, Francisco Das Chagas Costa Dos Santos, Olízio Claudino Da SilvaAbstract:<!-- @page { margin: 2cm } --> <p class="western" align="justify">A tetanics occurrence in a dog is described, the animal displaying at consultation the following clinical indications: generalized muscular rigidity (spastic paralysis), trismus, ";Risus sardonicus";, reflex hyperexcitability, erection of ears, skin wrinkling in frontal region of head and “bannertail”. Diagnosis was exclusively clinical, infection introduction by C. tetani was not detected.</p><!-- @page { margin: 2cm } --> <p class="western" align="justify">Relata-se um caso de Tétano em um cão, o qual foi apresentado para consulta com os seguintes sinais clínicos: rigidez muscular generalizada (paralisia espástica), trismus, “Risus sardonicus”, hiperexcitabilidade reflexa, ereção das orelhas, enrigamento da pele na região frontal da cabeça e “cauda em bandeira”. O diagnóstico foi exclusivamente clínico, sendo que não foi encontrada a porta de entrada para a infecção pelo C. tetani.</p>
Francisco Das Chagas Costa Dos Santos - One of the best experts on this subject based on the ideXlab platform.
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TÉTANO CANINO – RELATO DE UM CASO CANINE TETANUS - A CASE STUDY
Universidade Federal de Goiás, 2007Co-Authors: Francisco Das Chagas Costa Dos Santos, Guido Fontgalland C. Linhares, Olízio Claudino Da SilvaAbstract:<!-- @page { margin: 2cm } --> <p class="western" align="justify">Relata-se um caso de Tétano em um cão, o qual foi apresentado para consulta com os seguintes sinais clínicos: rigidez muscular generalizada (paralisia espástica), trismus, “Risus sardonicus”, hiperexcitabilidade reflexa, ereção das orelhas, enrigamento da pele na região frontal da cabeça e “cauda em bandeira”. O diagnóstico foi exclusivamente clínico, sendo que não foi encontrada a porta de entrada para a infecção pelo C. tetani.</p> <!-- @page { margin: 2cm } --> <p class="western" align="justify">A tetanics occurrence in a dog is described, the animal displaying at consultation the following clinical indications: generalized muscular rigidity (spastic paralysis), trismus, ";Risus sardonicus";, reflex hyperexcitability, erection of ears, skin wrinkling in frontal region of head and “bannertail”. Diagnosis was exclusively clinical, infection introduction by C. tetani was not detected.</p>
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CANINE TETANUS - A CASE STUDY TÉTANO CANINO – RELATO DE UM CASO
Universidade Federal de Goiás, 2007Co-Authors: Guido Fontgalland C. Linhares, Francisco Das Chagas Costa Dos Santos, Olízio Claudino Da SilvaAbstract:<!-- @page { margin: 2cm } --> <p class="western" align="justify">A tetanics occurrence in a dog is described, the animal displaying at consultation the following clinical indications: generalized muscular rigidity (spastic paralysis), trismus, ";Risus sardonicus";, reflex hyperexcitability, erection of ears, skin wrinkling in frontal region of head and “bannertail”. Diagnosis was exclusively clinical, infection introduction by C. tetani was not detected.</p><!-- @page { margin: 2cm } --> <p class="western" align="justify">Relata-se um caso de Tétano em um cão, o qual foi apresentado para consulta com os seguintes sinais clínicos: rigidez muscular generalizada (paralisia espástica), trismus, “Risus sardonicus”, hiperexcitabilidade reflexa, ereção das orelhas, enrigamento da pele na região frontal da cabeça e “cauda em bandeira”. O diagnóstico foi exclusivamente clínico, sendo que não foi encontrada a porta de entrada para a infecção pelo C. tetani.</p>
Basak Dokuzoguz - One of the best experts on this subject based on the ideXlab platform.
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analysis of the case fatality rate of tetanus among adults in a tertiary hospital in turkey
European Journal of Clinical Microbiology & Infectious Diseases, 2003Co-Authors: Onder Ergonul, Ayse Erbay, Sebnem Eren, Basak DokuzoguzAbstract:The aim of this study was to present the epidemiological and clinical characteristics of tetanus as related to case fatality in 43 adult patients hospitalized between 1990 and 2000 in Turkey's largest state tertiary hospital. All patients were ≥15 years of age, with the mean age being 45 years. Sixty-five percent of the patients were male. Most patients (77%) were from rural Anatolia. The most common clinical manifestations were trismus (100%), abdominal rigidity (93%), dysphagia (81%), and Risus sardonicus (72%). The overall case fatality rate was 58%. In a multivariable logistic regression model an incubation period of ≤8 days versus >8 days was a significant predictor of case fatality (odds ratio, 4.8; P=0.044; 95%CI, 1.04–22.26), as was each day of delay between onset of symptoms and admission to the hospital (odds ratio, 7.4; P=0.035; 95%CI, 1.15–48.28). Although the case fatality rate of tetanus in our clinic has declined in the last 5 years, the overall rate was high. This suggests a need for adult vaccination programs and/or a plan to educate the public to recognize symptoms early and then rapidly seek medical care.
